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$334+ Cheap flights from Des Moines (DSM) to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BRU
Aug 4 — Aug 111
Tue 8/4
Tue 8/11
1 adult, Economy
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Cheap flight deals from Des Moines to Brussels

Cheapest flights from Des Moines to Brussels
Explore the most affordable flight options available from Des Moines to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 5, 2026.

This FlightHub deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/28:00 am
DSM
-
BRU
2 stops16h 50m
Air Canada
Wed 12/910:00 am
BRU
-
DSM
2 stops44h 01m
Air Canada
Deal found 7/3$773
This United Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:15 pm
DSM
-
BRU
2 stops15h 00m
United Airlines
Wed 12/910:10 am
BRU
-
DSM
1 stop19h 51m
United Airlines
Deal found 7/3$786
This Air Canada deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/28:00 am
DSM
-
BRU
3 stops16h 50m
Multiple Airlines
Wed 12/910:00 am
BRU
-
DSM
2 stops20h 01m
Multiple Airlines
Deal found 7/1$804
This Bravofly deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:20 pm
DSM
-
BRU
2 stops36h 00m
Lufthansa
Tue 8/258:35 am
BRU
-
DSM
2 stops15h 43m
Lufthansa
Deal found 7/4$875
This United Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:00 am
DSM
-
BRU
2 stops22h 15m
United Airlines
Tue 8/259:30 am
BRU
-
DSM
2 stops38h 58m
United Airlines
Deal found 7/5$878
This United Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:00 am
DSM
-
BRU
2 stops18h 25m
United Airlines
Wed 8/269:30 am
BRU
-
DSM
2 stops31h 56m
United Airlines
Deal found 7/5$882
This Bravofly deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:20 pm
DSM
-
BRU
2 stops17h 55m
Lufthansa
Mon 8/244:25 pm
BRU
-
DSM
2 stops35h 58m
Lufthansa
Deal found 7/3$887
This KLM deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1911:28 am
DSM
-
BRU
1 stop13h 12m
KLM
Wed 8/269:45 am
BRU
-
DSM
1 stop15h 05m
KLM
Deal found 7/4$892
This Air France deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:35 pm
DSM
-
BRU
1 stop30h 05m
Multiple Airlines
Tue 8/259:45 am
BRU
-
DSM
1 stop19h 52m
Multiple Airlines
Deal found 7/4$897

Find flight deals from Des Moines to Brussels

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Brussels (BR1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 5, 2026.

Round-trip from

$773
(FlightHub)

One-way from

$334
(Kiwi.com)
From Des Moines to Brussels
Search Deals
One-way flight from Des Moines to Brussels
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 5, 2026.
Use the filters below to find and compare flights from Des Moines to Brussels that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/2

1:45 pm-1:15 pm

2 stops16h 30m

Brussels Bruxelles-National

Wed 12/9

10:00 am-11:01 pm

2 stops20h 01m

$789

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/2

8:00 am-7:50 am

3 stops16h 50m

Brussels Bruxelles-National

Wed 12/9

7:00 am-7:25 pm

3 stops19h 25m

$815

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 8/19

11:28 am-7:40 am

1 stop13h 12m

Brussels Bruxelles-National

Wed 8/26

9:45 am-5:50 pm

1 stop15h 05m

$892

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 8/18

3:20 pm-1:15 pm

2 stops14h 55m

Brussels Bruxelles-National

Tue 8/25

10:15 am-5:18 pm

1 stop14h 03m

$898

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 10/7

3:11 pm-1:15 pm

2 stops15h 04m

Brussels Bruxelles-National

Wed 10/14

9:10 am-10:31 am

2 stops32h 21m

$900
Quickest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 8/19

1:21 pm-9:00 am

1 stop12h 39m

Brussels Bruxelles-National

Wed 8/26

10:15 am-5:28 pm

1 stop14h 13m

$902

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 10/6

6:00 am-9:00 am

1 stop20h 00m

Brussels Bruxelles-National

Tue 10/13

9:10 am-10:31 am

2 stops32h 21m

$903
Cheapest one-way

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 8/31

6:30 am-9:55 am

3 stops44h 25m

$334

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 8/19

3:20 pm-1:15 pm

2 stops14h 55m

$456

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 8/14

6:00 am-7:10 am

2 stops18h 10m

$513

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/3

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Best time to book a flight from Des Moines to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Brussels
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Brussels

Get insights into the airlines that provide service to Brussels. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Brussels. Reviews last updated July 5, 2026.
See what other customers who have flown with United Airlines from Des Moines to Brussels have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,933 reviews

Food

6.7

Overall

7.4

Comfort

7.3

Boarding

7.7

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
United Airlines
7.4
Good
9,933 reviews
United Airlines
7.4
Good
9,933 reviews

Food

6.7

Overall

7.4

Comfort

7.3

Boarding

7.7

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Brussels?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Brussels. 1 airline have flights from Des Moines to Brussels on a regular basis. Booking flights from Des Moines to Brussels should not be difficult; the airport handles an average of 0 outbound flights to Brussels per day.

  • How long is the flight from Des Moines to Brussels?

    There are many flights that can get you from Des Moines to Brussels in 15h. Fly via United Airlines to get the fastest option. The distance from Des Moines to Brussels is about 4377 mi.

  • What is the cheapest airline to fly from Des Moines to Brussels round-trip?

    According to our current data, United Airlines ($707), offers the cheapest pricing from Des Moines to Brussels.

  • Can I find deals for flights from Des Moines to Brussels that include hotel bookings?

    Yes. In addition to deals on Des Moines to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Brussels.

  • Can I find deals for business class flights from Des Moines to Brussels?

    Yes. Cheapflights offers flight deals from Des Moines to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Des Moines to Brussels

Discover the top airline that operate flights from Des Moines to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$707Average$1,446FlexibilityNo cancel feeOn-time69%

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