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$433+ Cheap flights from Des Moines (DSM) to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BRU
Jun 5 — Jun 121
Fri 6/5
Fri 6/12
1 adult, Economy
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Cheap flight deals from Des Moines to Brussels

Cheapest flights from Des Moines to Brussels
Explore the most affordable flight options available from Des Moines to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.

This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2611:23 am
DSM
-
BRU
2 stops12h 47m
Air Canada
Wed 9/29:40 am
BRU
-
DSM
2 stops45h 15m
Air Canada
Deal found 5/6$972
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2611:23 am
DSM
-
BRU
2 stops18h 52m
United Airlines
Wed 9/210:15 am
BRU
-
DSM
1 stop17h 57m
United Airlines
Deal found 5/6$986
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/55:35 am
DSM
-
BRU
1 stop19h 05m
Delta
Tue 7/219:45 am
BRU
-
DSM
1 stop19h 44m
Delta
Deal found 5/6$997
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/44:47 pm
DSM
-
BRU
1 stop31h 53m
Delta
Tue 7/219:45 am
BRU
-
DSM
1 stop19h 44m
Delta
Deal found 5/6$1,003
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/55:35 am
DSM
-
BRU
1 stop19h 05m
Delta
Fri 7/1710:25 am
BRU
-
DSM
2 stops19h 04m
Delta
Deal found 5/6$1,006
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:00 am
DSM
-
BRU
1 stop20h 00m
United Airlines
Tue 7/2110:30 am
BRU
-
DSM
2 stops17h 00m
United Airlines
Deal found 5/6$1,007
This Flighttix deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:05 pm
DSM
-
BRU
2 stops14h 10m
Lufthansa
Sun 5/1010:15 am
BRU
-
DSM
1 stop14h 50m
Lufthansa
Deal found 5/3$1,012
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:50 pm
DSM
-
BRU
1 stop31h 10m
United Airlines
Tue 7/2110:30 am
BRU
-
DSM
2 stops17h 00m
United Airlines
Deal found 5/6$1,013
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/43:20 pm
DSM
-
BRU
2 stops21h 40m
United Airlines
Sun 5/1012:00 pm
BRU
-
DSM
2 stops16h 23m
United Airlines
Deal found 5/3$1,015

Find flight deals from Des Moines to Brussels

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Brussels (BR1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 6, 2026.

Round-trip from

$1,091

One-way from

$433
(United Airlines)
From Des Moines to Brussels
Search Deals
One-way flight from Des Moines to Brussels
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from Des Moines to Brussels that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sun 7/5

2:45 pm-2:40 pm

2 stops16h 55m

Brussels Bruxelles-National

Fri 7/17

10:25 am-8:49 pm

2 stops17h 24m

$1,136

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 6/16

6:50 pm-7:10 am

2 stops29h 20m

Brussels Bruxelles-National

Tue 6/23

9:40 am-7:25 pm

3 stops16h 45m

$1,245

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 6/15

11:26 am-8:00 pm

2 stops25h 34m

Brussels Bruxelles-National

Mon 6/22

9:40 am-10:30 am

2 stops31h 50m

$1,282

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 6/15

6:00 am-7:10 am

2 stops18h 10m

Brussels Bruxelles-National

Mon 6/22

9:40 am-10:30 am

2 stops31h 50m

$1,304

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 6/15

5:35 am-7:40 am

1 stop19h 05m

Brussels Bruxelles-National

Mon 6/22

9:45 am-10:31 pm

1 stop19h 46m

$1,305

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 6/16

6:39 pm-7:40 am

1 stop30h 01m

Brussels Bruxelles-National

Tue 6/23

9:45 am-10:31 pm

1 stop19h 46m

$1,339
Quickest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 6/17

10:54 am-7:40 am

2 stops13h 46m

Brussels Bruxelles-National

Wed 6/24

9:45 am-10:31 pm

1 stop19h 46m

$1,339
Cheapest one-way

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 8/15

6:50 pm-7:15 am

2 stops29h 25m

$433

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 8/15

3:24 pm-7:10 am

2 stops32h 46m

$442

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 6/4

6:00 am-4:45 pm

3 stops51h 45m

$480

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/5

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

Best time to book a flight from Des Moines to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Brussels
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Brussels

Get insights into the airlines that provide service to Brussels. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Brussels. Reviews last updated May 6, 2026.
See what other customers who have flown with United Airlines from Des Moines to Brussels have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,684 reviews

Entertainment

7.1

Comfort

7.3

Boarding

7.7

Crew

8.1

Food

6.6

Overall

7.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.
United Airlines
7.4
Good
9,684 reviews
United Airlines
7.4
Good
9,684 reviews

Entertainment

7.1

Comfort

7.3

Boarding

7.7

Crew

8.1

Food

6.6

Overall

7.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Brussels?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Brussels. 1 airline have flights from Des Moines to Brussels on a regular basis. Booking flights from Des Moines to Brussels should not be difficult; the airport handles an average of 0 outbound flights to Brussels per day.

  • How long is the flight from Des Moines to Brussels?

    There are many flights that can get you from Des Moines to Brussels in 16h 55m. Fly via Delta, Air Canada, or United Airlines to get the fastest option. The distance from Des Moines to Brussels is about 4377 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Des Moines to Brussels round-trip?

    According to our current data, United Airlines ($707), offers the cheapest pricing from Des Moines to Brussels.

  • Can I find deals for flights from Des Moines to Brussels that include hotel bookings?

    Yes. In addition to deals on Des Moines to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Brussels.

  • Can I find deals for business class flights from Des Moines to Brussels?

    Yes. Cheapflights offers flight deals from Des Moines to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Des Moines to Brussels

Discover the top airline that operate flights from Des Moines to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$707Average$1,444FlexibilityNo cancel feeOn-time69%

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