How long is the flight from Des Moines to Brussels?

There are many flights that can get you from Des Moines to Brussels in 22h 15m. Fly via United Airlines to get the fastest option. The distance from Des Moines to Brussels is about 4377 mi.

What is the cheapest airline to fly from Des Moines to Brussels round-trip?

According to our current data, United Airlines ($757), offers the cheapest pricing from Des Moines to Brussels.

In terms of precipitation, rainfall in Brussels ranges from 1.6 - 3.1 inches per month. January is typically the wettest month, when rainfall can reach 3.1 in. August is typically the driest time to visit Brussels when rainfall is around 1.6 in.

If weather is an important factor for your trip to Brussels, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 37.4 F).

What is the cheapest time of day to fly from DSM to BRU?

When flying from Des Moines to Brussels, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What airport do you fly from for flights from Des Moines to Brussels?

Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Brussels. 1 airline have flights from Des Moines to Brussels on a regular basis. Booking flights from Des Moines to Brussels should not be difficult; the airport handles an average of 0 outbound flights to Brussels per day.

Can I find deals for flights from Des Moines to Brussels that include hotel bookings?

Yes. In addition to deals on Des Moines to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Brussels?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Brussels.

Can I find deals for business class flights from Des Moines to Brussels?

Yes. Cheapflights offers flight deals from Des Moines to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$515+ Cheap Flights from Des Moines to Brussels

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Cheap flight deals from Des Moines to Brussels

Cheapest

Best

Last-minute

One-way

Cheapest flights from Des Moines to Brussels
Explore the most affordable flight options available from Des Moines to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.

Mon 12/78:00 am -

2 stops16h 50m

Wed 12/910:00 am -

2 stops31h 20m

Deal found 8/16

$773

Thu 12/311:30 am -

2 stops25h 25m

Fri 12/1110:00 am -

2 stops35h 11m

Deal found 8/18

$777

Sun 11/19:55 am -

1 stop16h 00m

Sun 11/1510:00 am -

2 stops38h 28m

Deal found 8/21

$778

Wed 9/306:00 am -

2 stops18h 10m

Wed 10/79:10 am -

2 stops21h 25m

Deal found 8/16

$783

Mon 12/79:00 am -

2 stops21h 15m

Wed 12/910:10 am -

1 stop18h 15m

Deal found 8/20

$787

Thu 12/33:15 pm -

2 stops15h 00m

Fri 12/1110:10 am -

1 stop18h 07m

Deal found 8/18

$794

Wed 9/3011:31 am -

1 stop13h 09m

Wed 10/79:45 am -

1 stop19h 48m

Deal found 8/16

$799

Best flights from Des Moines to Brussels
Discover carefully curated flight deals from Des Moines to Brussels that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.

Sun 11/18:00 am -

2 stops22h 15m

Sun 11/1510:00 am -

2 stops38h 28m

Deal found 8/21

$774

Wed 9/3011:31 am -

1 stop13h 09m

Wed 10/79:45 am -

1 stop19h 48m

Deal found 8/16

$799

Wed 9/305:35 pm -

2 stops14h 05m

Wed 10/79:45 am -

1 stop19h 48m

Deal found 8/16

$807

Mon 12/79:00 am -

2 stops21h 15m

Wed 12/910:10 am -

1 stop18h 15m

Deal found 8/20

$787

Thu 12/33:15 pm -

2 stops15h 00m

Fri 12/1110:10 am -

1 stop18h 07m

Deal found 8/18

$794

Last-minute flights from Des Moines to Brussels
Discover last-minute flight deals from Des Moines to Brussels. Data last updated August 21, 2026 and is based on user searches.

Wed 9/161:23 pm -

2 stops16h 52m

Tue 9/229:10 am -

2 stops36h 10m

Deal found 8/17

$957

Wed 9/306:00 am -

2 stops18h 10m

Wed 10/79:10 am -

2 stops21h 25m

Deal found 8/16

$783

Wed 9/3011:31 am -

1 stop13h 09m

Wed 10/79:45 am -

1 stop19h 48m

Deal found 8/16

$799

Wed 9/305:35 pm -

2 stops14h 05m

Wed 10/79:45 am -

1 stop19h 48m

Deal found 8/16

$807

One-way flights from Des Moines to Brussels
Search for one-way flight options from Des Moines to Brussels. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.

Thu 10/15:56 pm -

2 stops15h 14m

Deal found 8/17

$515

Thu 10/15:45 am -

1 stop18h 55m

Deal found 8/17

$519

Thu 10/11:24 pm -

3 stops16h 51m

Deal found 8/17

$619

Thu 9/105:45 am -

1 stop18h 55m

Deal found 8/19

$726

Thu 9/108:00 am -

2 stops16h 10m

Deal found 8/19

$729

Find flight deals from Des Moines to Brussels

Round-trip from	$770 (Ticket)
One-way from	$515 (American Airlines)

From Des Moines to Brussels

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One-way flight from Des Moines to Brussels

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Brussels that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Sun 11/1

8:00 am-1:15 pm

2 stops22h 15m

Brussels Bruxelles-National

Sun 11/15

10:00 am-5:28 pm

2 stops38h 28m

$774

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Mon 12/7

9:00 am-1:15 pm

2 stops21h 15m

Brussels Bruxelles-National

Wed 12/9

10:10 am-9:25 pm

1 stop18h 15m

$787

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Thu 12/3

3:15 pm-1:15 pm

2 stops15h 00m

Brussels Bruxelles-National

Fri 12/11

10:10 am-9:17 pm

1 stop18h 07m

$794

Quickest round-trip

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Wed 9/30

11:31 am-7:40 am

1 stop13h 09m

Brussels Bruxelles-National

Wed 10/7

9:45 am-10:33 pm

1 stop19h 48m

$799

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Wed 9/30

5:35 pm-2:40 pm

2 stops14h 05m

Brussels Bruxelles-National

Wed 10/7

9:45 am-10:33 pm

1 stop19h 48m

$807

Cheapest one-way

Quickest one-way

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Thu 10/1

5:56 pm-4:10 pm

2 stops15h 14m

$515

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Thu 10/1

5:45 am-7:40 am

1 stop18h 55m

$519

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Thu 10/1

1:24 pm-1:15 pm

3 stops16h 51m

$619

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Thu 9/10

8:00 am-7:10 am

2 stops16h 10m

$729

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Sorted by cheapest first

Best time to book a flight from Des Moines to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Des Moines with our price prediction graph.

DSM-BR1

DSM-BRU

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Brussels

DSM-BR1

DSM-BRU

No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Brussels

See what other customers who have flown with United Airlines from Des Moines to Brussels have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

United Airlines

7.4

Good

10,106 reviews

Reviews

1 / 20

4.0

Okay

Chris,Aug 2026

MIA - ORD

Had to go through TSA again, already purchased bottle drink. TSA would not let through, United changed gates last minute. This experience bad for everyone. Staff rude, not our fault. Staff from Chicago to Wichita excellent!

United Airlines

7.4

Good

10,106 reviews

United Airlines

7.4

Good

10,106 reviews

Reviews

1 / 20

4.0

Okay

Chris,Aug 2026

MIA - ORD

Related info for your journey

What airport do you fly from for flights from Des Moines to Brussels?
Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Brussels. 1 airline have flights from Des Moines to Brussels on a regular basis. Booking flights from Des Moines to Brussels should not be difficult; the airport handles an average of 0 outbound flights to Brussels per day.
How long is the flight from Des Moines to Brussels?
There are many flights that can get you from Des Moines to Brussels in 22h 15m. Fly via United Airlines to get the fastest option. The distance from Des Moines to Brussels is about 4377 mi.
What is the cheapest airline to fly from Des Moines to Brussels round-trip?
According to our current data, United Airlines ($757), offers the cheapest pricing from Des Moines to Brussels.
Can I find deals for flights from Des Moines to Brussels that include hotel bookings?
Yes. In addition to deals on Des Moines to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Brussels?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Brussels.
Can I find deals for business class flights from Des Moines to Brussels?
Yes. Cheapflights offers flight deals from Des Moines to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top airline flying from Des Moines to Brussels

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$757	Average$1,447	FlexibilityNo cancel fee	On-time69%

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$515+ Cheap flights from Des Moines (DSM) to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/1. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Brussels with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Brussels

Cheapest flights from Des Moines to BrusselsExplore the most affordable flight options available from Des Moines to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.

Explore the most affordable flight options available from Des Moines to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.

Best flights from Des Moines to BrusselsDiscover carefully curated flight deals from Des Moines to Brussels that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.

Discover carefully curated flight deals from Des Moines to Brussels that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.

Last-minute flights from Des Moines to BrusselsDiscover last-minute flight deals from Des Moines to Brussels. Data last updated August 21, 2026 and is based on user searches.

Discover last-minute flight deals from Des Moines to Brussels. Data last updated August 21, 2026 and is based on user searches.

One-way flights from Des Moines to BrusselsSearch for one-way flight options from Des Moines to Brussels. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.

Search for one-way flight options from Des Moines to Brussels. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.

Find flight deals from Des Moines to Brussels

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Brussels that are best for you.

Best time to book a flight from Des Moines to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Des Moines with our price prediction graph.

Cheapflights Insights

Reviews of airlines servicing Brussels

See what other customers who have flown with United Airlines from Des Moines to Brussels have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly from for flights from Des Moines to Brussels?

How long is the flight from Des Moines to Brussels?

What is the cheapest airline to fly from Des Moines to Brussels round-trip?

Can I find deals for flights from Des Moines to Brussels that include hotel bookings?

How can I find direct flights from Des Moines to Brussels?

Can I find deals for business class flights from Des Moines to Brussels?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Brussels by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Des Moines to Brussels by cabin class

Find flights from Des Moines to Brussels, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Des Moines and Brussels flights

Browse other Des Moines and Brussels flight options. Last updated on August 21, 2026.

Other flights from Des Moines

Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on August 21, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Top airline flying from Des Moines to Brussels

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Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to Brussels
Explore the most affordable flight options available from Des Moines to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.

Best flights from Des Moines to Brussels
Discover carefully curated flight deals from Des Moines to Brussels that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.

Last-minute flights from Des Moines to Brussels
Discover last-minute flight deals from Des Moines to Brussels. Data last updated August 21, 2026 and is based on user searches.

One-way flights from Des Moines to Brussels
Search for one-way flight options from Des Moines to Brussels. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.