Out of all the popular cities in Czech Republic, Prague is the cheapest city to rent a car in at just $13/day. Renting a car in Prague is 86% cheaper than renting one in Carlsbad where the per day rate is around $87. Other fairly inexpensive cities in Czech Republic to get a rental car in are: Brno ($14/day), Ostrava ($17/day), and Pardubice ($18/day). While these cities typically have cheaper prices than the rest of the country, travelers looking to rent a car in Prague should expect to spend around $13/day on their transportation. The most popular city to rent a car in Czech Republic is Prague.