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$249+ Cheap flights from Roanoke to St. Louis (ROA - STL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — STL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Roanoke to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$249
(Delta)

Popular in

May

Cheapest in

August

Average price

$368
From Roanoke to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
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Find flight deals from Roanoke to St. Louis

Cheapest flights from Roanoke to St. Louis
Explore the most affordable flight options available from Roanoke to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/46:00 amROA - STL
1 stop3h 44mDelta
Sat 10/115:25 pmSTL - ROA
1 stop5h 44mDelta
Deal found 9/10$249
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:00 amROA - STL
1 stop4h 59mDelta
Mon 9/295:11 pmSTL - ROA
1 stop6h 14mDelta
Deal found 9/9$259
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:05 amROA - STL
1 stop6h 35mDelta
Sun 11/167:02 pmSTL - ROA
1 stop4h 19mDelta
Deal found 9/11$279
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/267:51 pmROA - STL
1 stop4h 33mDelta
Tue 9/305:11 pmSTL - ROA
1 stop6h 14mDelta
Deal found 9/11$284
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/98:18 pmROA - STL
1 stop4h 40mAmerican Airlines
Sun 10/125:30 amSTL - ROA
1 stop4h 12mAmerican Airlines
Deal found 9/11$309
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:45 amROA - STL
1 stop5h 04mUnited Airlines
Thu 10/235:00 amSTL - ROA
1 stop4h 17mUnited Airlines
Deal found 9/10$376
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/410:52 amROA - STL
1 stop4h 35mUnited Airlines
Sat 10/113:23 pmSTL - ROA
2 stops21h 41mUnited Airlines
Deal found 9/9$379
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:28 pmROA - STL
2 stops7h 20mAmerican Airlines
Mon 9/296:00 amSTL - ROA
1 stop7h 34mAmerican Airlines
Deal found 9/9$387
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1110:52 amROA - STL
1 stop5h 52mUnited Airlines
Sat 10/188:25 amSTL - ROA
2 stops13h 59mUnited Airlines
Deal found 9/11$412
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2610:52 amROA - STL
1 stop5h 52mUnited Airlines
Tue 9/303:23 pmSTL - ROA
1 stop5h 18mUnited Airlines
Deal found 9/10$413
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/108:18 pmROA - STL
1 stop4h 40mAmerican Airlines
Mon 10/135:30 amSTL - ROA
1 stop4h 12mAmerican Airlines
Deal found 9/9$422
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1610:52 amROA - STL
1 stop4h 35mUnited Airlines
Sun 10/195:00 amSTL - ROA
1 stop4h 17mUnited Airlines
Deal found 9/10$433

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Roanoke to St. Louis that are best for you.

Fly from

Roanoke

Fly to

St. Louis

Route

Depart

Return

Price

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 11/19

7:05 am-12:40 pm

1 stop6h 35m

Lambert-St Louis

Mon 12/1

7:02 pm-12:21 am

1 stop4h 19m

$249

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 2/21

7:50 pm-11:40 pm

1 stop4h 50m

Lambert-St Louis

Tue 2/24

10:00 am-2:39 pm

1 stop3h 39m

$249

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 10/4

6:00 am-8:44 am

1 stop3h 44m

Lambert-St Louis

Sat 10/11

5:25 pm-12:09 am

1 stop5h 44m

$249

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 9/25

6:00 am-9:59 am

1 stop4h 59m

Lambert-St Louis

Mon 9/29

5:11 pm-12:25 am

1 stop6h 14m

$259

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 11/13

6:00 am-10:49 am

1 stop5h 49m

Lambert-St Louis

Sun 11/16

7:02 pm-12:21 am

1 stop4h 19m

$279

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 9/26

7:51 pm-11:24 pm

1 stop4h 33m

Lambert-St Louis

Tue 9/30

5:11 pm-12:25 am

1 stop6h 14m

$284

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 10/15

6:45 am-10:49 am

1 stop5h 04m

Lambert-St Louis

Thu 10/23

5:00 am-10:17 am

1 stop4h 17m

$376

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 10/4

10:52 am-2:27 pm

1 stop4h 35m

Lambert-St Louis

Sat 10/11

3:23 pm-2:04 pm

2 stops21h 41m

$379

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 9/17

6:00 am-9:59 am

1 stop4h 59m

$345

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Mon 10/13

6:45 am-2:27 pm

1 stop8h 42m

$448

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 12 results
1
2

Best time to book a flight from Roanoke to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to St. Louis

What is the cheapest month to book a flight from Roanoke to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Roanoke to St. Louis (average of $311). Flying from Roanoke to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ROA to STL?

Find hourly flight availability from Roanoke to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s optimal to fly from Roanoke to St. Louis in the evening. By choosing this option you can save up to 42% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Roanoke to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Roanoke to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Roanoke to St. Louis?

    Departing from Roanoke to St. Louis will take you 6h 35m. Airlines will cover a distance of 574 mi.

  • What are the cheapest airlines flying from Roanoke to St. Louis round-trip?

    Cheapflights users have booked flights from Roanoke to St. Louis round-trip from $248. Other airlines that can offer you cheap pricing are Delta, from $248, and United Airlines, from $248. These flights start at 29% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Roanoke to St. Louis one-way?

    One-way options have recently been found by users for as low as $345 on Delta. Other airlines that offer cheap prices include United Airlines from $448 and American Airlines from $761 one-way.

  • Can I find deals for flights from Roanoke to St. Louis that include hotel bookings?

    Yes. In addition to deals on Roanoke to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to St. Louis.

  • Can I find deals for business class flights from Roanoke to St. Louis?

    Yes. Cheapflights offers flight deals from Roanoke to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Roanoke to St. Louis (average of $311). Flying from Roanoke to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Alternative routes for Roanoke to St. Louis

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Top 3 airlines flying from Roanoke to St. Louis

Discover the top 3 airlines that operate flights from Roanoke to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$338FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$331FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$354FlexibilityNo cancel feeOn-time69%

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