HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

$249+ Cheap flights from Roanoke to St. Louis (ROA - STL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — STL
ene. 11 — ene. 181
dom. 1/11
dom. 1/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Roanoke to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Roanoke to St. Louis

Cheapest flights from Roanoke to St. Louis
Explore the most affordable flight options available from Roanoke to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/319:08 amROA - STL
1 stop5h 06mAmerican Airlines
sáb. 1/34:53 pmSTL - ROA
1 stop5h 46mAmerican Airlines
Deal found 12/10$289
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/277:08 amROA - STL
1 stop7h 30mAmerican Airlines
sáb. 1/35:00 amSTL - ROA
1 stop4h 31mAmerican Airlines
Deal found 12/11$304
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/198:14 amROA - STL
1 stop5h 15mAmerican Airlines
sáb. 12/205:16 pmSTL - ROA
1 stop5h 23mAmerican Airlines
Deal found 12/10$462
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/316:15 amROA - STL
2 stops16h 28mUnited Airlines
sáb. 1/311:05 amSTL - ROA
1 stop4h 56mUnited Airlines
Deal found 12/10$472
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/276:40 amROA - STL
1 stop6h 47mUnited Airlines
sáb. 1/36:35 pmSTL - ROA
2 stops23h 16mUnited Airlines
Deal found 12/10$550

Find flight deals from Roanoke to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated diciembre 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

Popular in

May

Cheapest in

December

Average price

$248
Provider with most accurate pricing for Roanoke-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Roanoke-Lambert-St Louis flights.
Search Deals
From Roanoke to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($49 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
Use the filters below to find and compare flights from Roanoke to St. Louis that are best for you.

Fly from

Roanoke

Fly to

St. Louis

Route

Depart

Return

Price

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

sáb. 1/17

6:00 am-11:02 am

1 stop6h 02m

Lambert-St Louis

sáb. 1/24

5:04 pm-12:04 am

1 stop6h 00m

$249

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

vie. 1/9

2:23 pm-5:50 pm

1 stop4h 27m

Lambert-St Louis

dom. 1/11

6:55 pm-12:04 am

1 stop4h 09m

$249

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

mié. 12/31

9:08 am-1:14 pm

1 stop5h 06m

Lambert-St Louis

sáb. 1/3

4:53 pm-11:39 pm

1 stop5h 46m

$289

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

vie. 1/9

10:10 am-3:04 pm

1 stop5h 54m

Lambert-St Louis

dom. 1/11

8:13 am-4:59 pm

2 stops7h 46m

$299

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

sáb. 12/27

7:08 am-1:38 pm

1 stop7h 30m

Lambert-St Louis

sáb. 1/3

4:53 pm-11:39 pm

1 stop5h 46m

$339

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

sáb. 1/17

5:39 pm-9:13 pm

1 stop4h 34m

Lambert-St Louis

sáb. 1/24

4:49 pm-2:09 pm

2 stops20h 20m

$394

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

mié. 1/14

7:05 am-12:33 pm

1 stop6h 28m

Lambert-St Louis

sáb. 1/17

5:00 pm-12:04 am

1 stop6h 04m

$449

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

jue. 1/15

8:50 am-3:04 pm

1 stop7h 14m

Lambert-St Louis

dom. 1/18

6:52 am-12:09 pm

1 stop4h 17m

$452

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

mié. 12/31

6:15 am-9:43 pm

2 stops16h 28m

Lambert-St Louis

sáb. 1/3

11:05 am-5:01 pm

1 stop4h 56m

$472

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

mié. 1/14

10:15 am-10:58 pm

2 stops13h 43m

Lambert-St Louis

sáb. 1/17

6:30 am-12:05 pm

1 stop4h 35m

$516

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 15 results
1
2

Compare providers for flights from Roanoke to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Roanoke to St. Louis in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Roanoke-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Roanoke-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Roanoke-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Roanoke-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Roanoke-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Roanoke to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to St. Louis

What is the cheapest month to book a flight from Roanoke to St. Louis?

Currently, February is the cheapest month in which you can book a flight from Roanoke to St. Louis (average of $216). Flying from Roanoke to St. Louis in November is currently the most expensive (average of $260). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ROA to STL?

Find hourly flight availability from Roanoke to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 12, 2025.

It’s optimal to fly from Roanoke to St. Louis in the evening. By choosing this option you can save up to 41% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated diciembre 12, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Roanoke to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Roanoke to St. Louis?

    Departing from Roanoke to St. Louis will take you 5h 06m. Airlines will cover a distance of 574 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Roanoke to St. Louis round-trip?

    Cheapflights users have booked flights from Roanoke to St. Louis round-trip from $248. Other airlines that can offer you cheap pricing are United Airlines, from $248, and Delta, from $248. These flights start at 28% lower than the current average price 3 months from now.

  • Can I find deals for flights from Roanoke to St. Louis that include hotel bookings?

    Yes. In addition to deals on Roanoke to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to St. Louis.

  • Can I find deals for business class flights from Roanoke to St. Louis?

    Yes. Cheapflights offers flight deals from Roanoke to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to St. Louis?

    Currently, February is the cheapest month in which you can book a flight from Roanoke to St. Louis (average of $216). Flying from Roanoke to St. Louis in November is currently the most expensive (average of $260). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Swansea
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Roanoke to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Dulles Intl to Kansas City flights
Dulles Intl to St. Louis flights
Reagan-National to Kansas City flights
Raleigh to Kansas City flights
Reagan-National to St. Louis flights
Raleigh to St. Louis flights
Dulles Intl to Springfield flights
Reagan-National to Springfield flights
Richmond to St. Louis flights
Greensboro to Kansas City flights
Richmond to Kansas City flights
Greensboro to St. Louis flights
Norfolk to St. Louis flights
Norfolk to Kansas City flights
Dulles Intl to Columbia flights
Charlottesville to Kansas City flights
Raleigh to Springfield flights
Reagan-National to Columbia flights
Norfolk to Springfield flights
Reagan-National to Joplin flights
Roanoke to Kansas City flights
Richmond to Springfield flights
Dulles Intl to Joplin flights
Roanoke to Springfield flights
Blountville to Kansas City flights
Raleigh to Joplin flights
Charlottesville to Springfield flights
Greensboro to Columbia flights
Charlottesville to St. Louis flights
Norfolk to Columbia flights
Norfolk to Joplin flights
Richmond to Columbia flights
Raleigh to Columbia flights
Lynchburg to Springfield flights
Greensboro to Joplin flights
Newport News to St. Louis flights
Richmond to Joplin flights
Dulles Intl to Fort Leonard Wood flights
Blountville to St. Louis flights
Dulles Intl to Kirksville flights
Greensboro to Fort Leonard Wood flights
Newport News to Joplin flights
Norfolk to Fort Leonard Wood flights
Lynchburg to Kansas City flights
Norfolk to Branson flights
Dulles Intl to Branson flights
Lewisburg to Kansas City flights
Reagan-National to Branson flights

Top 3 airlines flying from Roanoke to St. Louis

Discover the top 3 airlines that operate flights from Roanoke to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$354FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$338FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$323FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.