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$186+ Cheap flights from Roanoke to St. Louis (ROA - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — STL
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Find flight deals from Roanoke to St. Louis

Cheapest flights from Roanoke to St. Louis
Explore the most affordable flight options available from Roanoke to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:05 amROA - STL
1 stop6h 35mDelta
Tue 12/91:59 pmSTL - ROA
1 stop4h 16mDelta
Deal found 10/26$249
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:59 pmROA - STL
1 stop4h 45mDelta
Sun 11/167:02 pmSTL - ROA
1 stop4h 13mDelta
Deal found 10/26$254
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:05 amROA - STL
1 stop4h 22mAmerican Airlines
Sun 11/166:45 pmSTL - ROA
1 stop4h 20mAmerican Airlines
Deal found 10/27$259
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/117:05 amROA - STL
1 stop6h 35mDelta
Tue 11/181:55 pmSTL - ROA
1 stop4h 20mDelta
Deal found 10/28$264
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:00 amROA - STL
1 stop4h 15mDelta
Sat 11/1511:39 amSTL - ROA
1 stop6h 36mDelta
Deal found 10/26$289
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:05 amROA - STL
1 stop6h 17mDelta
Sat 11/85:15 pmSTL - ROA
1 stop5h 54mDelta
Deal found 10/26$304
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:38 pmROA - STL
1 stop6h 07mUnited Airlines
Sun 11/166:30 amSTL - ROA
1 stop4h 29mUnited Airlines
Deal found 10/26$324
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:03 pmROA - STL
1 stop7h 04mAmerican Airlines
Sun 11/95:00 amSTL - ROA
1 stop4h 31mAmerican Airlines
Deal found 10/27$334
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:00 amROA - STL
1 stop4h 35mAmerican Airlines
Mon 11/106:52 amSTL - ROA
1 stop5h 42mAmerican Airlines
Deal found 10/27$359
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:07 amROA - STL
1 stop4h 25mAmerican Airlines
Tue 12/96:52 amSTL - ROA
2 stops8h 32mAmerican Airlines
Deal found 10/26$363

Cheap flight deals from Roanoke to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

One-way from

$186
(Kiwi.com)

Popular in

May

Cheapest in

August

Average price

$343
Provider with most accurate pricing for Roanoke-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Roanoke-Lambert-St Louis flights.
Search Deals
From Roanoke to Lambert-St Louis
Search Deals
One-way flight from Roanoke to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Roanoke to St. Louis that are best for you.

Fly from

Roanoke

Fly to

St. Louis

Route

Depart

Return

Price

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 12/3

7:05 am-12:40 pm

1 stop6h 35m

Lambert-St Louis

Tue 12/9

1:59 pm-7:15 pm

1 stop4h 16m

$249

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 12/4

8:00 pm-11:42 pm

1 stop4h 42m

Lambert-St Louis

Tue 12/9

5:15 pm-11:19 pm

1 stop5h 04m

$249

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 2/18

7:50 pm-11:40 pm

1 stop4h 50m

Lambert-St Louis

Sat 2/21

7:30 am-2:39 pm

1 stop6h 09m

$249

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 11/13

7:59 pm-11:44 pm

1 stop4h 45m

Lambert-St Louis

Sun 11/16

7:02 pm-12:15 am

1 stop4h 13m

$254

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 11/11

7:05 am-12:40 pm

1 stop6h 35m

Lambert-St Louis

Tue 11/18

1:55 pm-7:15 pm

1 stop4h 20m

$264

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 11/8

2:47 pm-7:29 pm

1 stop5h 42m

Lambert-St Louis

Sat 11/15

2:08 pm-9:46 pm

1 stop6h 38m

$289

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 11/8

6:00 am-9:15 am

1 stop4h 15m

Lambert-St Louis

Sat 11/15

11:39 am-7:15 pm

1 stop6h 36m

$289

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 3/27

7:00 am-11:55 am

1 stop5h 55m

Lambert-St Louis

Sat 3/28

7:00 am-1:11 pm

1 stop5h 11m

$314

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 11/14

5:38 pm-10:45 pm

1 stop6h 07m

Lambert-St Louis

Sun 11/16

6:30 am-11:59 am

1 stop4h 29m

$324

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 11/7

5:03 pm-11:07 pm

1 stop7h 04m

Lambert-St Louis

Sun 11/9

5:00 am-10:31 am

1 stop4h 31m

$334

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 21 results
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Compare providers for flights from Roanoke to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Roanoke to St. Louis in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Roanoke-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Roanoke-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Roanoke-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Roanoke-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Roanoke-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Roanoke to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to St. Louis

What is the cheapest month to book a flight from Roanoke to St. Louis?

Currently, September is the cheapest month in which you can book a flight from Roanoke to St. Louis (average of $217). Flying from Roanoke to St. Louis in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ROA to STL?

Find hourly flight availability from Roanoke to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

It’s optimal to fly from Roanoke to St. Louis in the evening. By choosing this option you can save up to 41% on the cost of your flight, compared to a flight in the afternoon.

How much does it cost to fly round-trip from Roanoke to St. Louis?

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 28, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Roanoke to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Roanoke to St. Louis?

    Departing from Roanoke to St. Louis will take you 6h 35m. Airlines will cover a distance of 574 mi.

  • What are the cheapest airlines flying from Roanoke to St. Louis round-trip?

    Cheapflights users have booked flights from Roanoke to St. Louis round-trip from $248. Other airlines that can offer you cheap pricing are United Airlines, from $248, and Delta, from $248. These flights start at 27% lower than the current average price 3 months from now.

  • Can I find deals for flights from Roanoke to St. Louis that include hotel bookings?

    Yes. In addition to deals on Roanoke to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to St. Louis.

  • Can I find deals for business class flights from Roanoke to St. Louis?

    Yes. Cheapflights offers flight deals from Roanoke to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to St. Louis?

    Currently, September is the cheapest month in which you can book a flight from Roanoke to St. Louis (average of $217). Flying from Roanoke to St. Louis in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Alternative routes for Roanoke to St. Louis

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Top 3 airlines flying from Roanoke to St. Louis

Discover the top 3 airlines that operate flights from Roanoke to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$354FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$338FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$323FlexibilityNo cancel feeOn-timeN/A

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