HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

Cheap flights from Odessa, TX to St. Louis (STL)

MAF — STL
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Odessa to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Odessa to St. Louis

Keep the following information in mind while searching for Odessa to St. Louis flight deals. Data was last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Popular in

July

Cheapest in

September
Provider with most accurate pricing for Midland Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Midland Intl-Lambert-St Louis flights.
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($41 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 16, 2025.
See what other customers who have flown with Southwest from Odessa to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Comfort

8.0

Overall

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Comfort

8.0

Overall

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Odessa to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from Odessa?

    Most people fly into Lambert-St Louis (STL) if they book a flight to St. Louis from Odessa. On average, Lambert-St Louis has 0 inbound flights from Odessa per day from 1 airline. Lambert-St Louis is conveniently located just 12.7 mi from St. Louis’s city center.

  • Can I find deals for flights from Odessa to St. Louis that include hotel bookings?

    Yes. In addition to deals on Odessa to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to St. Louis.

  • Can I find deals for business class flights from Odessa to St. Louis?

    Yes. Cheapflights offers flight deals from Odessa to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Odessa to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Hobby to Kansas City flights
Dallas/Fort Worth to St. Louis flights
Dallas/Fort Worth to Kansas City flights
George Bush Intcntl to Kansas City flights
Hobby to St. Louis flights
George Bush Intcntl to St. Louis flights
Dallas/Fort Worth to Columbia flights
Love Field to St. Louis flights
Dallas/Fort Worth to Springfield flights
Love Field to Kansas City flights
Austin to Kansas City flights
Austin to St. Louis flights
Hobby to Springfield flights
George Bush Intcntl to Springfield flights
San Antonio to St. Louis flights
San Antonio to Kansas City flights
Midland to Springfield flights
El Paso to St. Louis flights
McAllen to Kansas City flights
Austin to Springfield flights
El Paso to Kansas City flights
Love Field to Springfield flights
San Antonio to Springfield flights
El Paso to Springfield flights
Laredo to Kansas City flights
McAllen to Springfield flights
Austin to Columbia flights
Corpus Christi to St. Louis flights
Dallas/Fort Worth to Joplin flights
George Bush Intcntl to Columbia flights
Hobby to Columbia flights
Lubbock to Kansas City flights
Hobby to Joplin flights
Killeen to St. Louis flights
Lubbock to St. Louis flights
Lubbock to Columbia flights
Killeen to Kansas City flights
Dallas/Fort Worth to Branson flights
Lubbock to Springfield flights
Amarillo to Springfield flights
Austin to Joplin flights
McAllen to Joplin flights
Corpus Christi to Columbia flights
Beaumont to Kansas City flights
Beaumont to St. Louis flights
San Antonio to Joplin flights
El Paso to Branson flights
Abilene to Springfield flights
Waco to St. Louis flights
San Angelo to Kansas City flights

Top airline flying from Odessa to St. Louis

Discover the top airline that operate flights from Odessa to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$196Average$382FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.