$49+ Cheap flights from Mesa, AZ to St. Louis (STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Mesa to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Lambert-St Louis are usually found in November or October, booked 87 days in advance, depart on a Tuesday or Friday and return on a Wednesday
Cheap flight deals from Mesa to St. Louis
Cheapest flights from Mesa to St. LouisExplore the most affordable flight options available from Mesa to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 22, 2025.
Explore the most affordable flight options available from Mesa to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 22, 2025.
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Frontier deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Frontier deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Frontier deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Expedia deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Frontier deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Find flight deals from Mesa to St. Louis
Keep the following information in mind while searching for Mesa to St. Louis flight deals. Data was last updated December 22, 2025.
Round-trip from | $163 (Kiwi.com) |
|---|---|
One-way from | $49 (Frontier) |
Popular in | April |
Cheapest in | November |
Average price | $374 |
Cheapflights Fare Finder
Use the filters below to find and compare flights from Mesa to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Fri 2/6
9:22 am-6:44 pm
1 stop8h 22m
Lambert-St Louis
Sat 2/7
3:46 pm-8:12 am
1 stop17h 26m
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Thu 1/22
4:41 pm-6:44 pm
2 stops25h 03m
Lambert-St Louis
Sun 1/25
9:27 pm-8:20 am
1 stop11h 53m
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Fri 2/27
7:00 am-9:26 pm
2 stops13h 26m
Lambert-St Louis
Sun 3/1
10:11 pm-9:10 am
1 stop11h 59m
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Thu 1/22
11:47 am-9:06 pm
1 stop8h 19m
Lambert-St Louis
Mon 1/26
1:40 pm-12:40 am
1 stop12h 00m
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Sun 1/18
6:00 am-6:51 am
1 stop23h 51m
Lambert-St Louis
Sun 1/25
9:27 pm-8:20 am
1 stop11h 53m
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Fri 1/9
9:22 pm-10:02 am
1 stop11h 40m
Lambert-St Louis
Sun 1/11
9:46 pm-8:58 am
1 stop12h 12m
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Wed 2/18
6:00 am-3:53 pm
1 stop8h 53m
Lambert-St Louis
Sat 2/21
2:51 pm-10:40 pm
2 stops32h 49m
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Fri 1/16
9:30 am-9:14 pm
1 stop10h 44m
Lambert-St Louis
Mon 1/19
7:36 pm-10:22 am
2 stops15h 46m
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Sun 1/18
2:34 pm-9:14 pm
1 stop5h 40m
Lambert-St Louis
Sun 1/25
9:27 pm-2:56 pm
2 stops18h 29m
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Thu 1/22
12:05 pm-11:25 pm
2 stops10h 20m
Lambert-St Louis
Wed 1/28
6:10 am-5:35 pm
2 stops12h 25m
Best time to book a flight from Mesa to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Mesa with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Mesa to St. Louis
How far ahead should I book a flight from Mesa to St. Louis?
Use this chart to determine the optimal time to book a round-trip flight from Mesa to St. Louis. Price data was last updated on December 19, 2025.
Booking 87 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mesa to St. Louis. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Mesa to St. Louis?
Currently, October is the cheapest month in which you can book a flight from Mesa to St. Louis (average of $122). Flying from Mesa to St. Louis in April is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MS9 to STL?
Find hourly flight availability from Mesa to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 22, 2025.
A simple way to save on the total cost of your ticket is to fly from Mesa to St. Louis in the afternoon. If you’re flexible enough to do this you can expect to save up to 56% on your trip compared to booking a flight in the morning.
What is the cheapest day to fly from Mesa to St. Louis?
Use this chart to determine the cheapest time to fly round-trip from Mesa to St. Louis. Price data was last updated on December 16, 2024.
Travelers seeking maximum savings on their Mesa to St. Louis flight should consider departing on Friday afternoons when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated December 22, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Mesa to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
Overall
Boarding
Food
Crew
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Entertainment
Overall
Boarding
Food
Crew
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Entertainment
Overall
Boarding
Food
Crew
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Entertainment
Overall
Boarding
Food
Crew
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Entertainment
Overall
Boarding
Food
Crew
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Entertainment
Overall
Boarding
Food
Crew
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Mesa to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
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Alternative routes for Mesa to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Top 5 airlines flying from Mesa to St. Louis
Discover the top 5 airlines that operate flights from Mesa to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$120 | Average$222 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$198 | Average$386 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$229 | Average$394 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$259 | Average$367 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$262 | Average$398 | FlexibilityNo cancel fee | On-time63% |