St. Louis

$59+ Cheap flights from Mesa, AZ to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/11. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — STL
Mar 27 — Apr 31
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Cheapflights Tip: The best prices from Mesa to Lambert-St Louis are usually found in January or December, booked 25 days in advance, depart on a Friday or Tuesday and return on a Wednesday

Cheap flight deals from Mesa to St. Louis

Cheapest flights from Mesa to St. Louis
Explore the most affordable flight options available from Mesa to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 25, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/189:52 am
PHX
-
STL
1 stop7h 40m
Frontier
Sat 4/258:17 pm
STL
-
PHX
1 stop13h 19m
Frontier
Deal found 2/21$132
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:27 pm
PHX
-
STL
1 stop17h 52m
Frontier
Sat 4/111:06 pm
STL
-
PHX
Nonstop3h 35m
Frontier
Deal found 2/23$159
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:24 pm
PHX
-
STL
1 stop10h 24m
Frontier
Mon 4/68:19 pm
STL
-
PHX
1 stop17h 26m
Frontier
Deal found 2/23$161
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:24 pm
PHX
-
STL
1 stop10h 24m
Frontier
Mon 4/138:19 pm
STL
-
PHX
1 stop23h 28m
Frontier
Deal found 2/23$163
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:09 pm
PHX
-
STL
Nonstop2h 53m
Frontier
Mon 3/308:12 pm
STL
-
PHX
1 stop19h 49m
Frontier
Deal found 2/23$164
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:09 pm
PHX
-
STL
Nonstop2h 53m
Frontier
Sun 3/2910:49 pm
STL
-
PHX
Nonstop3h 41m
Frontier
Deal found 2/21$166
This Super.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/125:09 pm
PHX
-
STL
Nonstop2h 53m
Frontier
Mon 3/165:46 pm
STL
-
PHX
Nonstop3h 41m
Frontier
Deal found 2/23$168
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/249:24 pm
PHX
-
STL
1 stop20h 08m
Frontier
Mon 4/278:17 pm
STL
-
PHX
1 stop5h 30m
Frontier
Deal found 2/22$171
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:45 pm
PHX
-
STL
1 stop13h 03m
Frontier
Tue 4/711:21 am
STL
-
PHX
2 stops38h 26m
Frontier
Deal found 2/22$173
This Kiwi.com deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:45 pm
PHX
-
STL
1 stop13h 04m
Frontier
Tue 3/3111:27 am
STL
-
PHX
2 stops29h 06m
Frontier
Deal found 2/24$174

Find flight deals from Mesa to St. Louis

Keep the following information in mind while searching for Mesa to St. Louis flight deals. Data was last updated February 25, 2026.

Round-trip from

$132
(Kiwi.com)

One-way from

$59
(Booking.com)

Popular in

April

Cheapest in

January

Average price

$365
From Mesa to Lambert-St Louis
One-way flight from Mesa to Lambert-St Louis
Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Average for round-trip flights in February 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 25, 2026.
Use the filters below to find and compare flights from Mesa to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Wed 4/8

5:35 am-10:25 am

Nonstop2h 50m

Lambert-St Louis

Mon 4/13

6:00 pm-7:25 pm

Nonstop3h 25m

$260

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Tue 3/31

5:55 am-10:40 am

Nonstop2h 45m

Lambert-St Louis

Tue 4/7

5:35 pm-7:00 pm

Nonstop3h 25m

$315

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Thu 4/16

5:00 am-12:50 pm

1 stop5h 50m

Lambert-St Louis

Sun 4/19

9:55 pm-11:20 pm

Nonstop3h 25m

$333

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Thu 4/30

5:15 am-10:05 am

Nonstop2h 50m

Lambert-St Louis

Sun 5/3

5:35 am-7:00 am

Nonstop3h 25m

$355

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Fri 4/24

4:10 pm-9:05 pm

Nonstop2h 55m

Lambert-St Louis

Mon 4/27

9:40 pm-11:05 pm

Nonstop3h 25m

$355

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Fri 3/27

5:00 am-9:50 am

Nonstop2h 50m

Lambert-St Louis

Mon 3/30

5:15 am-6:50 am

Nonstop3h 35m

$355

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Fri 5/15

5:15 am-10:05 am

Nonstop2h 50m

Lambert-St Louis

Sun 5/17

9:55 pm-11:20 pm

Nonstop3h 25m

$355

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Thu 4/9

2:05 pm-10:05 pm

1 stop6h 00m

Lambert-St Louis

Mon 4/13

6:00 pm-7:25 pm

Nonstop3h 25m

$365

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Thu 4/30

11:30 pm-8:39 am

1 stop7h 09m

Lambert-St Louis

Sun 5/3

7:45 am-1:10 pm

1 stop7h 25m

$375

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Sat 2/28

12:35 pm-6:00 pm

1 stop4h 25m

Lambert-St Louis

Tue 3/3

3:50 pm-8:15 pm

1 stop5h 25m

$410

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/25

Showing 1-10 of 22 resultsSorted by cheapest first
1
2
3

Best time to book a flight from Mesa to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to St. Louis

How far ahead should I book a flight from Mesa to St. Louis?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to St. Louis. Price data was last updated on February 20, 2026.

Booking 25 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mesa to St. Louis. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mesa to St. Louis?

Currently, January is the cheapest month in which you can book a flight from Mesa to St. Louis (average of $93). Flying from Mesa to St. Louis in April is currently the most expensive (average of $310). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to STL?

Find hourly flight availability from Mesa to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 25, 2026.

A simple way to save on the total cost of your ticket is to fly from Mesa to St. Louis in the afternoon. If you’re flexible enough to do this you can expect to save up to 6% on your trip compared to booking a flight in the evening.

What is the cheapest day to fly from Mesa to St. Louis?

Use this chart to determine the cheapest time to fly round-trip from Mesa to St. Louis. Price data was last updated on February 21, 2026.

Travelers seeking maximum savings on their Mesa to St. Louis flight should consider departing on Monday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mesa to St. Louis

Explore weekly flight availability from Mesa to St. Louis. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 25, 2026.

The most flights from MS9 to STL are scheduled on a Wednesday (10 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated February 25, 2026.
Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Mesa to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Overall

8.0

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Overall

8.0

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Overall

8.0

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Overall

8.0

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Overall

8.0

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Mesa to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to St. Louis from Mesa?

    For a flight from Mesa to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city. Lambert-St Louis is the only St. Louis airport and it handles 6 inbound flights from Mesa per day. 4 airlines have flights to Lambert-St Louis from Mesa on a regular basis.

  • How long is the flight from Mesa to St. Louis?

    For as low as $260, Southwest can have you in St. Louis from Mesa in 2h 50m. The distance between Mesa and St. Louis is about 1258 mi. Most flights are nonstop.

  • What are the cheapest airlines to fly from Mesa to St. Louis one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $70. Users have also found prices from $120 and $128 on American Airlines and United Airlines, respectively.

  • What are the most reliable airlines from Mesa to St. Louis?

    No one likes to see their flight delayed. When booking a flight from Mesa to St. Louis consider choosing Volaris (100%), Frontier (93%) or Alaska Airlines (87%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Mesa to St. Louis?

    On average you can expect to pay $307 for a flight from Mesa to St. Louis. The cheapest flight overall is $93 while the most popular route, (Phoenix Sky Harbor Intl - Lambert-St Louis) is currently priced at $188.

  • Can I find deals for flights from Mesa to St. Louis that include hotel bookings?

    Yes. In addition to deals on Mesa to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to St. Louis.

  • Can I find deals for business class flights from Mesa to St. Louis?

    Yes. Cheapflights offers flight deals from Mesa to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to St. Louis?

    Currently, January is the cheapest month in which you can book a flight from Mesa to St. Louis (average of $93). Flying from Mesa to St. Louis in April is currently the most expensive (average of $310). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Fenton
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 4 airlines flying from Mesa to St. Louis

Discover the top 4 airlines that operate flights from Mesa to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 25, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$101Average$217FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$229Average$387FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$346FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$257Average$394FlexibilityNo cancel feeOn-time63%

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