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St. Louis

$66+ Cheap flights from Mesa, AZ to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — STL
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Lambert-St Louis are usually found in August or September, booked 87 days in advance, depart on a Tuesday or Wednesday and return on a Wednesday

Cheap flight deals from Mesa to St. Louis

Keep the following information in mind while searching for Mesa to St. Louis flight deals. Data was last updated September 16, 2025.

Round-trip from

$211
(CheapOair)

One-way from

$66
(Cheapflightsfares)

Popular in

January

Cheapest in

August

Average price

$345
From Mesa to Lambert-St Louis
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One-way flight from Mesa to Lambert-St Louis
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Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Mesa to St. Louis

Cheapest flights from Mesa to St. Louis
Explore the most affordable flight options available from Mesa to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This CheapOair deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/237:59 pmPHX - STL
1 stop11h 08mFrontier
Sun 10/2610:17 amSTL - PHX
2 stops36h 02mFrontier
Deal found 9/15$211
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/98:58 pmPHX - STL
1 stop12h 45mFrontier
Tue 10/217:52 pmSTL - PHX
2 stops25h 13mFrontier
Deal found 9/15$217
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:50 pmPHX - STL
Nonstop3h 07mAmerican Airlines
Mon 10/206:21 pmSTL - PHX
Nonstop3h 21mAmerican Airlines
Deal found 9/15$219
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/66:00 amPHX - STL
1 stop7h 04mFrontier
Thu 10/911:32 amSTL - PHX
2 stops37h 55mFrontier
Deal found 9/15$220
This CheapOair deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/308:00 amPHX - STL
1 stop23h 06mFrontier
Wed 10/87:52 pmSTL - PHX
2 stops20h 20mFrontier
Deal found 9/16$226
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1712:18 amPHX - STL
1 stop5h 51mAmerican Airlines
Sat 10/257:31 amSTL - PHX
Nonstop3h 34mAmerican Airlines
Deal found 9/15$228
This CheapOair deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/134:10 pmPHX - STL
2 stops14h 57mFrontier
Mon 10/207:52 pmSTL - PHX
2 stops42h 07mFrontier
Deal found 9/15$229
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/84:14 pmPHX - STL
2 stops15h 08mFrontier
Sat 10/114:51 pmSTL - PHX
1 stop8h 50mFrontier
Deal found 9/15$230
This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/186:00 amPHX - STL
1 stop5h 53mFrontier
Mon 9/227:55 pmSTL - PHX
1 stop6h 02mFrontier
Deal found 9/16$231
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/188:20 pmPHX - STL
1 stop10h 46mFrontier
Sun 9/217:55 pmSTL - PHX
1 stop6h 02mFrontier
Deal found 9/14$234
This CheapOair deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:18 pmPHX - STL
1 stop12h 48mFrontier
Sun 9/2810:39 amSTL - PHX
2 stops34h 46mFrontier
Deal found 9/15$236

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Mesa to St. Louis that are best for you.

Fly from

Mesa

Fly to

St. Louis

Route

Depart

Return

Price

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Fri 10/17

12:40 am-8:51 am

1 stop6h 11m

Lambert-St Louis

Sat 10/25

4:45 pm-11:04 pm

1 stop8h 19m

$237

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Wed 10/15

3:25 pm-8:27 pm

Nonstop3h 02m

Lambert-St Louis

Sun 10/19

7:31 am-9:05 am

Nonstop3h 34m

$238

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Thu 10/9

6:50 pm-11:57 pm

Nonstop3h 07m

Lambert-St Louis

Tue 10/21

7:00 am-8:34 am

Nonstop3h 34m

$255

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Mon 12/1

8:30 pm-12:25 am

Nonstop2h 55m

Lambert-St Louis

Thu 12/4

8:15 pm-10:40 pm

Nonstop3h 25m

$273

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Mon 11/24

6:22 pm-12:46 am

1 stop5h 24m

Lambert-St Louis

Wed 12/3

7:56 pm-12:44 am

1 stop5h 48m

$277

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Tue 10/7

12:18 am-8:09 am

1 stop5h 51m

Lambert-St Louis

Tue 10/21

7:00 am-8:34 am

Nonstop3h 34m

$278

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Mon 10/13

12:40 am-8:51 am

1 stop6h 11m

Lambert-St Louis

Tue 10/21

2:29 pm-6:09 pm

1 stop5h 40m

$288

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Wed 10/22

12:40 am-8:51 am

1 stop6h 11m

Lambert-St Louis

Sat 10/25

4:45 pm-11:04 pm

1 stop8h 19m

$288

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Wed 12/10

12:59 am-9:10 am

1 stop7h 11m

Lambert-St Louis

Sun 12/14

2:20 pm-6:53 pm

1 stop5h 33m

$297

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Sat 10/18

6:15 am-11:10 am

Nonstop2h 55m

Lambert-St Louis

Sun 10/26

9:05 am-1:35 pm

1 stop6h 30m

$301

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 21 results
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Best time to book a flight from Mesa to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to St. Louis

How far ahead should I book a flight from Mesa to St. Louis?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to St. Louis. Price data was last updated on September 12, 2025.

Booking 87 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mesa to St. Louis. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mesa to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Mesa to St. Louis (average of $311). Flying from Mesa to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to STL?

Find hourly flight availability from Mesa to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

When flying from Mesa to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Mesa to St. Louis?

Use this chart to determine the cheapest time to fly round-trip from Mesa to St. Louis. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mesa to St. Louis flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 16, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Mesa to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Crew

8.6

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Crew

8.6

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,954 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Crew

8.6

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,929 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Crew

8.6

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Crew

8.6

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Frontier
5.8
Fair
3,172 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Crew

8.6

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Mesa to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from Mesa?

    For a flight from Mesa to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city. Lambert-St Louis is the only St. Louis airport and it handles 5 inbound flights from Mesa per day. 5 airlines have flights to Lambert-St Louis from Mesa on a regular basis.

  • How long is the flight from Mesa to St. Louis?

    For as low as $273, Delta can have you in St. Louis from Mesa in 2h 55m. The distance between Mesa and St. Louis is about 1258 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most reliable airlines from Mesa to St. Louis?

    No one likes to see their flight delayed. When booking a flight from Mesa to St. Louis consider choosing American Airlines (84%), Alaska Airlines (84%) or SkyWest Airlines (82%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Mesa to St. Louis?

    On average you can expect to pay $287 for a flight from Mesa to St. Louis. The cheapest flight overall is $148 while the most popular route, (Phoenix Sky Harbor Intl - Lambert-St Louis) is currently priced at $139.

  • Can I find deals for flights from Mesa to St. Louis that include hotel bookings?

    Yes. In addition to deals on Mesa to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to St. Louis.

  • Can I find deals for business class flights from Mesa to St. Louis?

    Yes. Cheapflights offers flight deals from Mesa to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Mesa to St. Louis (average of $311). Flying from Mesa to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Mesa to St. Louis

Discover the top 5 airlines that operate flights from Mesa to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$118Average$228FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$198Average$395FlexibilityNo cancel feeOn-time69%
DeltaCheapest$236Average$352FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$275Average$406FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$278Average$411FlexibilityNo cancel feeOn-time63%

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