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$448+ Cheap flights from Medford to St. Louis (MFR - STL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — STL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Medford to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$448
(Delta)

Popular in

March

Cheapest in

October

Average price

$473
From Medford to Lambert-St Louis
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High demand for flights, 4% potential price rise
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Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Medford to St. Louis

Cheapest flights from Medford to St. Louis
Explore the most affordable flight options available from Medford to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2511:41 amMFR - STL
2 stops11h 05mDelta
Tue 12/27:56 pmSTL - MFR
1 stop6h 03mDelta
Deal found 9/11$448
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:00 amMFR - STL
1 stop8h 27mUnited Airlines
Tue 12/25:30 pmSTL - MFR
1 stop7h 27mUnited Airlines
Deal found 9/10$468
This Hawaiian Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Hawaiian Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/261:32 pmMFR - STL
1 stop8h 27mHawaiian Airlines
Tue 9/306:00 amSTL - MFR
1 stop7h 25mHawaiian Airlines
Deal found 9/10$502
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:15 amMFR - STL
1 stop6h 18mDelta
Tue 9/303:30 pmSTL - MFR
2 stops9h 20mDelta
Deal found 9/10$508
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1312:40 pmMFR - STL
1 stop6h 41mDelta
Mon 9/227:40 amSTL - MFR
1 stop6h 20mDelta
Deal found 9/9$515
This Hawaiian Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Hawaiian Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/253:35 pmMFR - STL
1 stop6h 19mHawaiian Airlines
Tue 12/27:00 amSTL - MFR
1 stop8h 16mHawaiian Airlines
Deal found 9/11$546
This Alaska Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/178:20 amMFR - STL
2 stops12h 27mAlaska Airlines
Tue 12/307:00 amSTL - MFR
1 stop9h 53mAlaska Airlines
Deal found 9/11$562
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:00 amMFR - STL
3 stops14h 00mUnited Airlines
Tue 9/301:40 pmSTL - MFR
1 stop25h 27mUnited Airlines
Deal found 9/10$575

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Medford to St. Louis that are best for you.

Fly from

Medford

Fly to

St. Louis

Route

Depart

Return

Price

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Tue 11/25

11:41 am-12:46 am

2 stops11h 05m

Lambert-St Louis

Tue 12/2

7:56 pm-11:59 pm

1 stop6h 03m

$448

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Tue 11/25

6:00 am-4:27 pm

1 stop8h 27m

Lambert-St Louis

Tue 12/2

5:30 pm-10:57 pm

1 stop7h 27m

$468

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Fri 9/26

1:32 pm-11:59 pm

1 stop8h 27m

Lambert-St Louis

Tue 9/30

6:00 am-11:25 am

1 stop7h 25m

$502

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Fri 9/26

5:15 am-1:33 pm

1 stop6h 18m

Lambert-St Louis

Tue 9/30

3:30 pm-10:50 pm

2 stops9h 20m

$508

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Tue 11/25

3:35 pm-11:54 pm

1 stop6h 19m

Lambert-St Louis

Tue 12/2

7:00 am-1:16 pm

1 stop8h 16m

$546

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Wed 12/17

8:20 am-10:47 pm

2 stops12h 27m

Lambert-St Louis

Tue 12/30

7:00 am-2:53 pm

1 stop9h 53m

$562

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Fri 9/26

6:00 am-10:00 pm

3 stops14h 00m

Lambert-St Louis

Tue 9/30

1:40 pm-1:07 pm

1 stop25h 27m

$575

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Medford to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to St. Louis

What is the cheapest month to book a flight from Medford to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Medford to St. Louis (average of $311). Flying from Medford to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MFR to STL?

Find hourly flight availability from Medford to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s optimal to fly from Medford to St. Louis at noon. By choosing this option you can save up to 5% on the cost of your flight, compared to a flight in the afternoon.

How much does it cost to fly round-trip from Medford to St. Louis?

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Alaska Airlines, Delta, and United Airlines from Medford to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Overall

8.0

Entertainment

7.0

Comfort

7.8

Food

7.1

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Overall

8.0

Entertainment

7.0

Comfort

7.8

Food

7.1

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
8.0
Very good
7,960 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Overall

8.0

Entertainment

7.0

Comfort

7.8

Food

7.1

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
8,937 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Overall

8.0

Entertainment

7.0

Comfort

7.8

Food

7.1

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Overall

8.0

Entertainment

7.0

Comfort

7.8

Food

7.1

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from Medford to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to St. Louis?

    For as low as $468, Delta can have you in St. Louis from Medford in 8h 27m. There are 1712 mi between Medford and St. Louis. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Medford to St. Louis round-trip?

    Cheapflights users have booked flights from Medford to St. Louis round-trip from $192. Other airlines that can offer you cheap pricing are Alaska Airlines, from $303, and American Airlines, from $368. Delta is priced at 64% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Medford to St. Louis that include hotel bookings?

    Yes. In addition to deals on Medford to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to St. Louis.

  • Can I find deals for business class flights from Medford to St. Louis?

    Yes. Cheapflights offers flight deals from Medford to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Medford to St. Louis (average of $311). Flying from Medford to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 4 airlines flying from Medford to St. Louis

Discover the top 4 airlines that operate flights from Medford to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$192Average$483FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$303Average$495FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$368Average$411FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$426Average$596FlexibilityNo cancel feeOn-time69%

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