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$126+ Cheap flights from Harrisburg to St. Louis (MDT - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — STL
Jul 7 — Jul 141
Mon 7/7
Mon 7/14
1 adult, Economy
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Cheapflights Tip: The best prices from Harrisburg to Lambert-St Louis are usually found in September or April, booked 63 days in advance, depart on a Thursday or Saturday and return on a Thursday

Cheap flight deals from Harrisburg to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 2, 2025.

Round-trip from

$249
(American Airlines)

One-way from

$126
(Delta)

Popular in

March

Cheapest in

September

Average price

$368
From Harrisburg to Lambert-St Louis
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One-way flight from Harrisburg to Lambert-St Louis
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Highest demand for flights based on searches. 2% potential increase in price ($9 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Harrisburg to St. Louis

Cheapest flights from Harrisburg to St. Louis
Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:00 amMDT - STL
1 stop8h 04mAmerican Airlines
Mon 11/174:39 pmSTL - MDT
1 stop3h 45mAmerican Airlines
Deal found 6/30$249
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/56:10 amMDT - STL
1 stop4h 27mDelta
Tue 7/89:27 amSTL - MDT
1 stop7h 03mDelta
Deal found 6/30$280
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/156:30 amMDT - STL
1 stop6h 57mUnited Airlines
Sat 7/195:30 pmSTL - MDT
1 stop4h 27mUnited Airlines
Deal found 6/30$329
This Mytrip deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2112:10 pmMDT - STL
3 stops26h 22mMultiple Airlines
Sun 8/2410:37 amSTL - MDT
2 stops24h 09mMultiple Airlines
Deal found 7/1$400

Cheapflights Fare Finder

Customize your flight search to find flights from Harrisburg to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.

Fly from

Harrisburg

Fly to

St. Louis

Route

Depart

Return

Price

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Wed 11/12

6:00 am-1:04 pm

1 stop8h 04m

Lambert-St Louis

Mon 11/17

4:39 pm-9:24 pm

1 stop3h 45m

$249

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Tue 7/22

6:25 pm-11:53 pm

1 stop6h 28m

Lambert-St Louis

Sat 7/26

1:23 pm-10:59 pm

2 stops8h 36m

$319

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Tue 7/15

6:30 am-12:27 pm

1 stop6h 57m

Lambert-St Louis

Sat 7/19

5:30 pm-10:57 pm

1 stop4h 27m

$329

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Thu 8/21

12:10 pm-1:32 pm

3 stops26h 22m

Lambert-St Louis

Sun 8/24

10:37 am-11:46 am

2 stops24h 09m

$400

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Tue 10/7

6:00 am-12:25 pm

1 stop7h 25m

$126

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sun 7/13

11:06 am-11:47 pm

1 stop13h 41m

$145

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sun 7/13

7:00 pm-6:41 pm

3 stops24h 41m

$213

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Mon 7/14

7:59 pm-4:45 pm

3 stops21h 46m

$661

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Harrisburg to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to St. Louis

How far ahead should I book a flight from Harrisburg to St. Louis?

Use this chart to determine the optimal time to book a round-trip flight from Harrisburg to St. Louis. Price data was last updated on June 27, 2025.

Booking 63 days in advance of your planned departure date is, on average, the best time to get cheap flights from Harrisburg to St. Louis. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Harrisburg to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $311). Flying from Harrisburg to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to STL?

Find hourly flight availability from Harrisburg to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 17% on flights from Harrisburg to St. Louis by exploring options for tickets at noon.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated July 2, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,975 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,975 reviews
Delta
8.0
Very good
7,975 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,861 reviews
Delta
8.0
Very good
7,975 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,975 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.9
Fair
3,286 reviews
Delta
8.0
Very good
7,975 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Harrisburg to St. Louis round-trip?

    American Airlines, at $249, was found to be the cheapest airline from Harrisburg to St. Louis.Alternate airlines to your destination round-trip include Delta and United Airlines. American Airlines is currently priced 25% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Harrisburg to St. Louis one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $126. Frontier flights start at $145 while deals on United Airlines start at $661 one-way.

  • Can I find deals for flights from Harrisburg to St. Louis that include hotel bookings?

    Yes. In addition to deals on Harrisburg to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to St. Louis.

  • Can I find deals for business class flights from Harrisburg to St. Louis?

    Yes. Cheapflights offers flight deals from Harrisburg to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $311). Flying from Harrisburg to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Harrisburg?

Book flights to Harrisburg if you plan to visit one of these locations
O'Fallon
Maryland Heights
Fairview Heights
Collinsville
Eureka
St. Peters
Glencoe
Alton
Festus
Chesterfield
Farmington

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Alternative routes for Harrisburg to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Harrisburg to St. Louis

Discover the top 3 airlines that operate flights from Harrisburg to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$238Average$320FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$339FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$258Average$362FlexibilityNo cancel feeOn-time69%

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