$172+ Cheap flights from Harrisburg to St. Louis (MDT - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/21. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — STL
May 13 — May 201
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Harrisburg to St. LouisExplore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 13, 2026.
Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 13, 2026.
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:33 pm
MDT
- STL
1 stop6h 26m
Delta
Tue 6/26:45 am
STL
- MDT
1 stop4h 27m
Delta
Deal found 4/10![Delta logo]()
$291
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:43 pm
MDT
- STL
1 stop4h 34m
American Airlines
Wed 5/136:29 am
STL
- MDT
1 stop6h 49m
American Airlines
Deal found 4/8![American Airlines logo]()
$310
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:54 pm
MDT
- STL
1 stop5h 56m
United Airlines
Tue 5/56:30 am
STL
- MDT
1 stop6h 03m
United Airlines
Deal found 4/10![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2311:56 am
MDT
- STL
1 stop5h 18m
Delta
Sat 8/16:30 am
STL
- MDT
1 stop4h 01m
Delta
Deal found 4/12![Delta logo]()
$335
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:53 pm
MDT
- STL
1 stop4h 20m
United Airlines
Sun 4/199:10 am
STL
- MDT
1 stop6h 41m
United Airlines
Deal found 4/8![United Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:04 am
MDT
- STL
1 stop4h 39m
Delta
Sun 8/26:00 am
STL
- MDT
1 stop4h 10m
Delta
Deal found 4/12![Delta logo]()
$354
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:36 pm
MDT
- STL
1 stop6h 43m
American Airlines
Mon 5/186:54 pm
STL
- MDT
1 stop4h 37m
American Airlines
Deal found 4/12![American Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:19 pm
MDT
- STL
1 stop6h 17m
Delta
Sun 4/196:00 am
STL
- MDT
1 stop4h 11m
Delta
Deal found 4/8![Delta logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/159:20 am
MDT
- STL
1 stop16h 01m
Multiple Airlines
Sun 5/173:33 pm
STL
- MDT
2 stops15h 57m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$370
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:50 pm
MDT
- STL
1 stop4h 26m
United Airlines
Sun 6/76:55 pm
STL
- MDT
1 stop4h 35m
United Airlines
Deal found 4/9![United Airlines logo]()
$373
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/268:50 pm
MDT
- STL
1 stop4h 44m
United Airlines
Thu 7/21:13 pm
STL
- MDT
1 stop5h 35m
United Airlines
Deal found 4/10![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:43 pm
MDT
- STL
1 stop6h 13m
American Airlines
Mon 5/186:54 pm
STL
- MDT
1 stop4h 37m
American Airlines
Deal found 4/12![American Airlines logo]()
$376
Best flights from Harrisburg to St. LouisDiscover carefully curated flight deals from Harrisburg to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 13, 2026.
Discover carefully curated flight deals from Harrisburg to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 13, 2026.
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:33 pm
MDT
- STL
1 stop6h 26m
Delta
Tue 6/26:45 am
STL
- MDT
1 stop4h 27m
Delta
Deal found 4/9![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:54 pm
MDT
- STL
1 stop4h 19m
United Airlines
Mon 5/185:28 pm
STL
- MDT
1 stop6h 27m
United Airlines
Deal found 4/10![United Airlines logo]()
$310
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:43 pm
MDT
- STL
1 stop6h 13m
American Airlines
Mon 5/186:54 pm
STL
- MDT
1 stop4h 37m
American Airlines
Deal found 4/12![American Airlines logo]()
$376
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3011:56 am
MDT
- STL
1 stop5h 18m
Delta
Sun 8/26:30 am
STL
- MDT
1 stop4h 11m
Delta
Deal found 4/8![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:50 pm
MDT
- STL
1 stop4h 26m
United Airlines
Sun 6/76:55 pm
STL
- MDT
1 stop4h 35m
United Airlines
Deal found 4/9![United Airlines logo]()
$373
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:34 pm
MDT
- STL
1 stop4h 05m
Delta
Sun 6/286:00 am
STL
- MDT
1 stop4h 11m
Delta
Deal found 4/10![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2311:56 am
MDT
- STL
1 stop5h 18m
Delta
Mon 8/36:30 am
STL
- MDT
1 stop4h 11m
Delta
Deal found 4/12![Delta logo]()
$379
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/275:55 pm
MDT
- STL
1 stop4h 31m
United Airlines
Wed 7/291:13 pm
STL
- MDT
1 stop6h 48m
United Airlines
Deal found 4/9![United Airlines logo]()
$508
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:30 am
MDT
- STL
1 stop6h 41m
United Airlines
Sat 6/139:23 am
STL
- MDT
2 stops13h 07m
United Airlines
Deal found 4/12![United Airlines logo]()
$536
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:15 am
MDT
- STL
1 stop7h 07m
United Airlines
Thu 4/3010:25 am
STL
- MDT
1 stop5h 27m
United Airlines
Deal found 4/10![United Airlines logo]()
$649
Last-minute flights from Harrisburg to St. LouisDiscover last-minute flight deals from Harrisburg to St. Louis. Data last updated April 13, 2026 and is based on user searches.
Discover last-minute flight deals from Harrisburg to St. Louis. Data last updated April 13, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:52 pm
MDT
- STL
1 stop4h 21m
United Airlines
Sat 4/188:30 am
STL
- MDT
1 stop4h 25m
United Airlines
Deal found 4/12![United Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:00 am
MDT
- STL
1 stop6h 56m
Delta
Sat 4/186:00 am
STL
- MDT
1 stop6h 52m
Delta
Deal found 4/11![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:53 pm
MDT
- STL
1 stop4h 59m
United Airlines
Sat 4/188:30 am
STL
- MDT
1 stop4h 25m
United Airlines
Deal found 4/8![United Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:19 pm
MDT
- STL
1 stop6h 17m
Delta
Sun 4/196:00 am
STL
- MDT
1 stop4h 11m
Delta
Deal found 4/8![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:54 pm
MDT
- STL
1 stop5h 56m
United Airlines
Tue 5/56:30 am
STL
- MDT
1 stop6h 03m
United Airlines
Deal found 4/10![United Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:43 pm
MDT
- STL
1 stop4h 34m
American Airlines
Wed 5/136:29 am
STL
- MDT
1 stop6h 49m
American Airlines
Deal found 4/8![American Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:01 pm
MDT
- STL
2 stops39h 54m
Multiple Airlines
Thu 5/144:19 pm
STL
- MDT
1 stop15h 11m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$390
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:43 pm
MDT
- STL
1 stop6h 13m
American Airlines
Mon 5/186:54 pm
STL
- MDT
1 stop4h 37m
American Airlines
Deal found 4/12![American Airlines logo]()
$376
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/159:20 am
MDT
- STL
1 stop16h 01m
Multiple Airlines
Sun 5/173:33 pm
STL
- MDT
2 stops15h 57m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$370
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:36 pm
MDT
- STL
1 stop6h 43m
American Airlines
Mon 5/186:54 pm
STL
- MDT
1 stop4h 37m
American Airlines
Deal found 4/12![American Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:43 pm
MDT
- STL
1 stop6h 13m
American Airlines
Sun 5/245:40 pm
STL
- MDT
1 stop4h 33m
American Airlines
Deal found 4/9![American Airlines logo]()
$386
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:33 pm
MDT
- STL
1 stop6h 26m
Delta
Tue 6/26:45 am
STL
- MDT
1 stop4h 27m
Delta
Deal found 4/10![Delta logo]()
$291
One-way flights from Harrisburg to St. LouisSearch for one-way flight options from Harrisburg to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 13, 2026.
Search for one-way flight options from Harrisburg to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:57 pm
MDT
- STL
2 stops39h 58m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$172
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:00 am
MDT
- STL
1 stop4h 44m
Delta
Deal found 4/9![Delta logo]()
$242
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:00 am
MDT
- STL
1 stop7h 20m
Delta
Deal found 4/9![Delta logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:33 pm
MDT
- STL
3 stops26h 03m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$279
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:15 am
MDT
- STL
2 stops9h 08m
United Airlines
Deal found 4/12![United Airlines logo]()
$462
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:15 am
MDT
- STL
2 stops6h 56m
United Airlines
Deal found 4/8![United Airlines logo]()
$492
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1310:40 am
MDT
- STL
2 stops6h 59m
United Airlines
Deal found 4/9![United Airlines logo]()
$627
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:00 pm
MDT
- STL
3 stops46h 39m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$879
Find flight deals from Harrisburg to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $291 (American Airlines) |
One-way from | $172 (Kiwi.com) |
Popular in | March |
Cheapest in | January |
Average price | $362 |
Cheapflights Fare Finder
Customize your flight search to find flights from Harrisburg to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 13, 2026.
Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Fri 5/29
6:33 pm-11:59 pm
1 stop6h 26m
Lambert-St Louis
Tue 6/2
6:45 am-12:12 pm
1 stop4h 27m
$291
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Sat 5/16
5:54 pm-9:13 pm
1 stop4h 19m
Lambert-St Louis
Mon 5/18
5:28 pm-12:55 am
1 stop6h 27m
$310
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Thu 7/30
11:56 am-4:14 pm
1 stop5h 18m
Lambert-St Louis
Sun 8/2
6:30 am-11:41 am
1 stop4h 11m
$349
Quickest round-trip
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Sat 6/27
5:34 pm-8:39 pm
1 stop4h 05m
Lambert-St Louis
Sun 6/28
6:00 am-11:11 am
1 stop4h 11m
$354
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Tue 6/2
5:50 pm-9:16 pm
1 stop4h 26m
Lambert-St Louis
Sun 6/7
6:55 pm-12:30 am
1 stop4h 35m
$373
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Thu 5/14
6:43 pm-11:56 pm
1 stop6h 13m
Lambert-St Louis
Mon 5/18
6:54 pm-12:31 am
1 stop4h 37m
$376
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Thu 7/23
11:56 am-4:14 pm
1 stop5h 18m
Lambert-St Louis
Mon 8/3
6:30 am-11:41 am
1 stop4h 11m
$379
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Mon 7/27
5:55 pm-9:26 pm
1 stop4h 31m
Lambert-St Louis
Wed 7/29
1:13 pm-9:01 pm
1 stop6h 48m
$508
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Thu 6/11
6:30 am-12:11 pm
1 stop6h 41m
Lambert-St Louis
Sat 6/13
9:23 am-11:30 pm
2 stops13h 07m
$536
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Sun 4/26
6:15 am-12:22 pm
1 stop7h 07m
Lambert-St Louis
Thu 4/30
10:25 am-4:52 pm
1 stop5h 27m
$649
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Harrisburg to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to St. Louis in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Harrisburg-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Harrisburg-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Harrisburg to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Harrisburg with our price prediction graph.
MDT-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Harrisburg to St. Louis
What is the cheapest month to book a flight from Harrisburg to St. Louis?
Currently, September is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $109). Flying from Harrisburg to St. Louis in January is currently the most expensive (average of $272). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Harrisburg to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated April 13, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Harrisburg to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Food
7.2
Overall
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Food
7.2
Overall
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Food
7.2
Overall
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Food
7.2
Overall
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Harrisburg to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
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Top 3 airlines flying from Harrisburg to St. Louis
Discover the top 3 airlines that operate flights from Harrisburg to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$418 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$342 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$323 | FlexibilityNo cancel fee | On-timeN/A |