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St. Louis

$237+ Cheap flights from Harrisburg to St. Louis (MDT - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/16. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — STL
Nov 12 — Nov 191
Wed 11/12
Wed 11/19
1 adult, Economy
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Find flight deals from Harrisburg to St. Louis

Cheapest flights from Harrisburg to St. Louis
Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2025.

This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1212:41 pmMDT - STL
1 stop5h 28mDelta
Mon 11/1711:39 amSTL - MDT
1 stop5h 37mDelta
Deal found 10/12$249
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:00 amMDT - STL
1 stop7h 35mDelta
Mon 10/205:15 pmSTL - MDT
1 stop4h 53mDelta
Deal found 10/13$324
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:15 amMDT - STL
1 stop4h 41mAmerican Airlines
Sat 10/184:25 pmSTL - MDT
1 stop5h 54mAmerican Airlines
Deal found 10/12$328
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:30 amMDT - STL
1 stop6h 58mUnited Airlines
Thu 11/276:30 amSTL - MDT
2 stops10h 45mUnited Airlines
Deal found 10/10$374
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/128:15 amMDT - STL
1 stop5h 13mUnited Airlines
Mon 11/176:43 pmSTL - MDT
2 stops13h 52mUnited Airlines
Deal found 10/12$413
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:00 amMDT - STL
1 stop4h 27mAmerican Airlines
Sun 11/306:45 pmSTL - MDT
1 stop4h 37mAmerican Airlines
Deal found 10/12$465
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2810:47 amMDT - STL
1 stop6h 00mUnited Airlines
Sat 11/111:05 amSTL - MDT
1 stop7h 10mUnited Airlines
Deal found 10/13$585
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:30 amMDT - STL
1 stop6h 45mUnited Airlines
Sun 12/75:27 pmSTL - MDT
3 stops15h 03mUnited Airlines
Deal found 10/12$627
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/196:30 amMDT - STL
1 stop5h 19mUnited Airlines
Fri 10/248:05 amSTL - MDT
1 stop24h 24mUnited Airlines
Deal found 10/13$642
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/168:15 amMDT - STL
1 stop7h 12mUnited Airlines
Mon 10/205:28 pmSTL - MDT
2 stops15h 01mUnited Airlines
Deal found 10/13$647
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:25 pmMDT - STL
1 stop4h 39mDelta
Fri 10/176:14 pmSTL - MDT
1 stop3h 46mDelta
Deal found 10/13$656

Cheap flight deals from Harrisburg to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 13, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Delta)

One-way from

$237
(Delta)

Popular in

December

Cheapest in

April

Average price

$308
Provider with most accurate pricing for Harrisburg-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Lambert-St Louis flights.
Search Deals
From Harrisburg to Lambert-St Louis
Search Deals
One-way flight from Harrisburg to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($5 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 13, 2025.
Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.

Fly from

Harrisburg

Fly to

St. Louis

Route

Depart

Return

Price

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Fri 12/5

7:27 pm-11:40 pm

1 stop5h 13m

Lambert-St Louis

Sun 12/7

6:05 pm-11:07 pm

1 stop4h 02m

$249

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sun 11/23

6:30 am-12:28 pm

1 stop6h 58m

Lambert-St Louis

Thu 11/27

8:25 am-1:58 pm

1 stop4h 33m

$249

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Wed 11/12

11:44 am-4:07 pm

1 stop5h 23m

Lambert-St Louis

Mon 11/17

6:09 pm-11:04 pm

1 stop3h 55m

$249

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sat 12/6

6:00 am-10:24 am

1 stop5h 24m

Lambert-St Louis

Mon 12/8

5:12 pm-11:13 pm

1 stop5h 01m

$249

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Thu 10/16

6:00 am-10:26 am

1 stop5h 26m

Lambert-St Louis

Mon 10/20

5:15 pm-11:08 pm

1 stop4h 53m

$324

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sat 11/15

8:15 am-2:24 pm

1 stop7h 09m

Lambert-St Louis

Tue 11/18

6:43 pm-9:35 am

2 stops13h 52m

$413

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sat 12/6

6:30 am-12:15 pm

1 stop6h 45m

Lambert-St Louis

Mon 12/8

5:44 pm-9:30 am

2 stops14h 46m

$413

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Fri 1/16

6:25 pm-11:40 pm

1 stop6h 15m

$237

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Fri 1/16

2:28 pm-12:29 pm

2 stops23h 01m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/11

Compare providers for flights from Harrisburg to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to St. Louis in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to St. Louis

What is the cheapest month to book a flight from Harrisburg to St. Louis?

Currently, September is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $109). Flying from Harrisburg to St. Louis in June is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to STL?

Find hourly flight availability from Harrisburg to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 13, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 16% on flights from Harrisburg to St. Louis by exploring options for tickets at noon.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 13, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,971 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,971 reviews
Delta
8.0
Very good
7,971 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,970 reviews
Delta
8.0
Very good
7,971 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,046 reviews
Delta
8.0
Very good
7,971 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to St. Louis?

    Departing from Harrisburg to St. Louis will take you 5h 13m. Harrisburg and St. Louis are separated by a distance of 731 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Harrisburg to St. Louis round-trip?

    American Airlines, at $248, was found to be the cheapest airline from Harrisburg to St. Louis.Alternate airlines to your destination round-trip include United Airlines and Delta. American Airlines is currently priced 26% below the average price you’ll pay for this route.

  • Can I find deals for flights from Harrisburg to St. Louis that include hotel bookings?

    Yes. In addition to deals on Harrisburg to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to St. Louis.

  • Can I find deals for business class flights from Harrisburg to St. Louis?

    Yes. Cheapflights offers flight deals from Harrisburg to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to St. Louis?

    Currently, September is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $109). Flying from Harrisburg to St. Louis in June is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Alternative routes for Harrisburg to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Harrisburg to St. Louis

Discover the top 3 airlines that operate flights from Harrisburg to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$359FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$344FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$328FlexibilityNo cancel feeOn-timeN/A

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