$179+ Cheap flights from Harrisburg to St. Louis (MDT - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/24. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — STL
Mar 14 — Mar 211
1 adult, Economy
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Find cheap flights from Harrisburg to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Harrisburg to St. Louis
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Best
Last-minute
One-way
Cheapest flights from Harrisburg to St. LouisExplore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:31 pm
MDT
- STL
1 stop6h 13m
American Airlines
Wed 3/182:29 pm
STL
- MDT
1 stop6h 49m
American Airlines
Deal found 2/9![American Airlines logo]()
$251
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:31 pm
MDT
- STL
1 stop6h 17m
American Airlines
Wed 3/49:37 am
STL
- MDT
1 stop7h 13m
American Airlines
Deal found 2/9![American Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:31 pm
MDT
- STL
1 stop6h 04m
American Airlines
Mon 2/232:19 pm
STL
- MDT
1 stop6h 59m
American Airlines
Deal found 2/9![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:29 am
MDT
- STL
1 stop5h 07m
United Airlines
Wed 3/49:55 am
STL
- MDT
1 stop5h 49m
United Airlines
Deal found 2/8![United Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2511:09 am
MDT
- STL
1 stop12h 18m
Multiple Airlines
Fri 2/278:22 pm
STL
- MDT
2 stops21h 04m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:31 pm
MDT
- STL
1 stop6h 04m
American Airlines
Sun 2/156:00 am
STL
- MDT
1 stop5h 19m
American Airlines
Deal found 2/9![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:48 pm
MDT
- STL
1 stop4h 59m
United Airlines
Sun 4/269:10 am
STL
- MDT
1 stop6h 41m
United Airlines
Deal found 2/10![United Airlines logo]()
$378
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/167:35 pm
MDT
- STL
1 stop4h 29m
American Airlines
Mon 2/232:19 pm
STL
- MDT
1 stop6h 59m
American Airlines
Deal found 2/11![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:40 pm
MDT
- STL
1 stop6h 19m
United Airlines
Wed 3/47:41 am
STL
- MDT
2 stops29h 10m
United Airlines
Deal found 2/9![United Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:31 pm
MDT
- STL
1 stop6h 04m
American Airlines
Sun 3/296:13 am
STL
- MDT
1 stop4h 19m
American Airlines
Deal found 2/10![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:36 pm
MDT
- STL
1 stop4h 31m
United Airlines
Wed 3/253:23 pm
STL
- MDT
1 stop4h 42m
United Airlines
Deal found 2/9![United Airlines logo]()
$423
Best flights from Harrisburg to St. LouisDiscover carefully curated flight deals from Harrisburg to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
Discover carefully curated flight deals from Harrisburg to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:00 am
MDT
- STL
1 stop5h 03m
American Airlines
Sat 3/287:05 am
STL
- MDT
1 stop6h 44m
American Airlines
Deal found 2/10![American Airlines logo]()
$251
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:40 pm
MDT
- STL
1 stop4h 25m
United Airlines
Sat 2/288:17 am
STL
- MDT
1 stop4h 10m
United Airlines
Deal found 2/9![United Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2511:09 am
MDT
- STL
1 stop12h 18m
Multiple Airlines
Fri 2/278:22 pm
STL
- MDT
2 stops21h 04m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:30 am
MDT
- STL
1 stop7h 03m
American Airlines
Tue 3/102:00 pm
STL
- MDT
1 stop4h 10m
American Airlines
Deal found 2/10![American Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/312:51 pm
MDT
- STL
1 stop7h 01m
American Airlines
Sat 3/711:50 am
STL
- MDT
1 stop6h 10m
American Airlines
Deal found 2/11![American Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:31 pm
MDT
- STL
1 stop6h 17m
American Airlines
Wed 3/49:37 am
STL
- MDT
1 stop7h 13m
American Airlines
Deal found 2/9![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:29 am
MDT
- STL
1 stop5h 07m
United Airlines
Wed 3/49:55 am
STL
- MDT
1 stop5h 49m
United Airlines
Deal found 2/8![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:31 pm
MDT
- STL
1 stop6h 04m
American Airlines
Wed 3/46:00 am
STL
- MDT
1 stop5h 01m
American Airlines
Deal found 2/9![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:48 pm
MDT
- STL
1 stop4h 59m
United Airlines
Sun 4/269:10 am
STL
- MDT
1 stop6h 41m
United Airlines
Deal found 2/10![United Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:40 pm
MDT
- STL
1 stop6h 19m
United Airlines
Wed 3/47:41 am
STL
- MDT
2 stops29h 10m
United Airlines
Deal found 2/9![United Airlines logo]()
$387
Last-minute flights from Harrisburg to St. LouisDiscover last-minute flight deals from Harrisburg to St. Louis. Data last updated February 12, 2026 and is based on user searches.
Discover last-minute flight deals from Harrisburg to St. Louis. Data last updated February 12, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:31 pm
MDT
- STL
1 stop6h 04m
American Airlines
Mon 2/232:19 pm
STL
- MDT
1 stop6h 59m
American Airlines
Deal found 2/9![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:31 pm
MDT
- STL
1 stop6h 04m
American Airlines
Sun 2/156:00 am
STL
- MDT
1 stop5h 19m
American Airlines
Deal found 2/9![American Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/167:35 pm
MDT
- STL
1 stop4h 29m
American Airlines
Mon 2/232:19 pm
STL
- MDT
1 stop6h 59m
American Airlines
Deal found 2/11![American Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2511:09 am
MDT
- STL
1 stop12h 18m
Multiple Airlines
Fri 2/278:22 pm
STL
- MDT
2 stops21h 04m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:31 pm
MDT
- STL
1 stop6h 17m
American Airlines
Wed 3/49:37 am
STL
- MDT
1 stop7h 13m
American Airlines
Deal found 2/9![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:40 pm
MDT
- STL
1 stop6h 19m
United Airlines
Wed 3/47:41 am
STL
- MDT
2 stops29h 10m
United Airlines
Deal found 2/9![United Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:29 am
MDT
- STL
1 stop5h 07m
United Airlines
Wed 3/49:55 am
STL
- MDT
1 stop5h 49m
United Airlines
Deal found 2/8![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:31 pm
MDT
- STL
1 stop6h 13m
American Airlines
Wed 3/182:29 pm
STL
- MDT
1 stop6h 49m
American Airlines
Deal found 2/9![American Airlines logo]()
$251
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:36 pm
MDT
- STL
1 stop4h 31m
United Airlines
Wed 3/253:23 pm
STL
- MDT
1 stop4h 42m
United Airlines
Deal found 2/9![United Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:31 pm
MDT
- STL
1 stop6h 04m
American Airlines
Sun 3/296:13 am
STL
- MDT
1 stop4h 19m
American Airlines
Deal found 2/10![American Airlines logo]()
$399
One-way flights from Harrisburg to St. LouisSearch for one-way flight options from Harrisburg to St. Louis. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
Search for one-way flight options from Harrisburg to St. Louis. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:03 pm
MDT
- STL
3 stops24h 09m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2511:09 am
MDT
- STL
1 stop12h 18m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$194
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:48 pm
MDT
- STL
1 stop4h 59m
United Airlines
Deal found 2/10![United Airlines logo]()
$237
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:39 pm
MDT
- STL
1 stop6h 20m
United Airlines
Deal found 2/10![United Airlines logo]()
$249
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:33 pm
MDT
- STL
2 stops9h 26m
United Airlines
Deal found 2/11![United Airlines logo]()
$498
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:33 am
MDT
- STL
2 stops8h 17m
American Airlines
Deal found 2/10![American Airlines logo]()
$619
Find flight deals from Harrisburg to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $251 (American Airlines) |
One-way from | $179 (Kiwi.com) |
Popular in | December |
Cheapest in | April |
Average price | $383 |
Cheapflights Fare Finder
Customize your flight search to find flights from Harrisburg to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.
Fly from
Harrisburg
Fly to
St. Louis
Route
Depart
Return
Price
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Wed 3/25
6:00 am-10:03 am
1 stop5h 03m
Lambert-St Louis
Sat 3/28
7:05 am-2:49 pm
1 stop6h 44m
$251
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Wed 3/4
6:30 am-12:33 pm
1 stop7h 03m
Lambert-St Louis
Tue 3/10
2:00 pm-7:10 pm
1 stop4h 10m
$269
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Tue 3/3
12:51 pm-6:52 pm
1 stop7h 01m
Lambert-St Louis
Sat 3/7
11:50 am-7:00 pm
1 stop6h 10m
$269
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Thu 2/26
6:31 pm-11:48 pm
1 stop6h 17m
Lambert-St Louis
Wed 3/4
9:37 am-5:50 pm
1 stop7h 13m
$269
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Fri 2/27
6:31 pm-11:35 pm
1 stop6h 04m
Lambert-St Louis
Wed 3/4
6:00 am-12:01 pm
1 stop5h 01m
$269
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Tue 2/24
5:40 pm-9:05 pm
1 stop4h 25m
Lambert-St Louis
Sat 2/28
8:17 am-1:27 pm
1 stop4h 10m
$339
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Sat 2/28
6:29 am-10:36 am
1 stop5h 07m
Lambert-St Louis
Wed 3/4
9:55 am-4:44 pm
1 stop5h 49m
$339
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Wed 2/25
11:09 am-10:27 pm
1 stop12h 18m
Lambert-St Louis
Fri 2/27
8:22 pm-6:26 pm
2 stops21h 04m
$359
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Fri 4/24
5:48 pm-9:47 pm
1 stop4h 59m
Lambert-St Louis
Sun 4/26
9:10 am-4:51 pm
1 stop6h 41m
$378
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Fri 2/27
5:40 pm-10:59 pm
1 stop6h 19m
Lambert-St Louis
Wed 3/4
7:41 am-1:51 pm
2 stops29h 10m
$387
Showing 1-10 of 16 results
Compare providers for flights from Harrisburg to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to St. Louis in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Harrisburg-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Harrisburg-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Harrisburg to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Harrisburg with our price prediction graph.
MDT-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Harrisburg to St. Louis
What is the cheapest month to book a flight from Harrisburg to St. Louis?
Currently, September is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $109). Flying from Harrisburg to St. Louis in January is currently the most expensive (average of $272). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Harrisburg to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated February 12, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Harrisburg to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus
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Top 3 airlines flying from Harrisburg to St. Louis
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$369 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$320 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$323 | FlexibilityNo cancel fee | On-timeN/A |