$291+ Cheap flights from Harrisburg to St. Louis (MDT - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/3. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — STL
Jun 8 — Jun 151
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Harrisburg to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Harrisburg to St. Louis
Cheapest
Best
Last-minute
Cheapest flights from Harrisburg to St. LouisExplore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 9, 2026.
Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 9, 2026.
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:45 pm
MDT
- STL
1 stop5h 31m
American Airlines
Tue 7/76:14 am
STL
- MDT
1 stop6h 46m
American Airlines
Deal found 5/8![American Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:20 am
MDT
- STL
1 stop4h 09m
Delta
Tue 6/210:19 am
STL
- MDT
1 stop4h 58m
Delta
Deal found 5/6![Delta logo]()
$300
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:52 pm
MDT
- STL
1 stop4h 29m
United Airlines
Sun 5/317:05 pm
STL
- MDT
1 stop4h 38m
United Airlines
Deal found 5/7![United Airlines logo]()
$305
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:33 pm
MDT
- STL
1 stop6h 26m
Delta
Sun 6/76:00 am
STL
- MDT
1 stop4h 11m
Delta
Deal found 5/6![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:22 pm
MDT
- STL
1 stop6h 34m
Delta
Sun 6/146:10 pm
STL
- MDT
1 stop4h 00m
Delta
Deal found 5/8![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:04 am
MDT
- STL
1 stop4h 42m
Delta
Fri 6/2610:20 am
STL
- MDT
1 stop5h 34m
Delta
Deal found 5/6![Delta logo]()
$344
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:00 am
MDT
- STL
1 stop4h 31m
Delta
Sun 7/126:04 pm
STL
- MDT
1 stop4h 05m
Delta
Deal found 5/6![Delta logo]()
$355
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:17 pm
MDT
- STL
1 stop5h 37m
American Airlines
Sun 5/315:14 am
STL
- MDT
1 stop5h 23m
American Airlines
Deal found 5/6![American Airlines logo]()
$360
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:43 pm
MDT
- STL
1 stop4h 36m
American Airlines
Tue 5/195:21 pm
STL
- MDT
1 stop5h 31m
American Airlines
Deal found 5/5![American Airlines logo]()
$364
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:45 pm
MDT
- STL
1 stop5h 31m
American Airlines
Mon 7/66:14 am
STL
- MDT
1 stop6h 46m
American Airlines
Deal found 5/6![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:40 pm
MDT
- STL
1 stop5h 19m
American Airlines
Sun 6/76:15 am
STL
- MDT
1 stop6h 45m
American Airlines
Deal found 5/5![American Airlines logo]()
$369
Best flights from Harrisburg to St. LouisDiscover carefully curated flight deals from Harrisburg to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 9, 2026.
Discover carefully curated flight deals from Harrisburg to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 9, 2026.
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:22 pm
MDT
- STL
1 stop6h 34m
Delta
Sat 6/136:10 pm
STL
- MDT
1 stop4h 00m
Delta
Deal found 5/5![Delta logo]()
$300
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:52 pm
MDT
- STL
1 stop4h 29m
United Airlines
Sat 5/307:05 pm
STL
- MDT
1 stop4h 22m
United Airlines
Deal found 5/7![United Airlines logo]()
$385
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:22 pm
MDT
- STL
1 stop6h 34m
Delta
Fri 6/2610:20 am
STL
- MDT
1 stop5h 34m
Delta
Deal found 5/4![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
MDT
- STL
1 stop4h 44m
Delta
Sun 6/76:00 am
STL
- MDT
1 stop4h 11m
Delta
Deal found 5/5![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:30 am
MDT
- STL
1 stop6h 41m
United Airlines
Sat 6/271:13 pm
STL
- MDT
1 stop5h 35m
United Airlines
Deal found 5/9![United Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:15 am
MDT
- STL
2 stops10h 31m
United Airlines
Sun 5/315:29 pm
STL
- MDT
1 stop6h 14m
United Airlines
Deal found 5/4![United Airlines logo]()
$472
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:52 pm
MDT
- STL
1 stop4h 29m
United Airlines
Tue 6/21:13 pm
STL
- MDT
3 stops23h 37m
United Airlines
Deal found 5/8![United Airlines logo]()
$519
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:59 pm
MDT
- STL
3 stops17h 12m
United Airlines
Sun 6/71:13 pm
STL
- MDT
1 stop7h 16m
United Airlines
Deal found 5/5![United Airlines logo]()
$610
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:59 pm
MDT
- STL
3 stops17h 12m
United Airlines
Sat 6/131:13 pm
STL
- MDT
1 stop7h 16m
United Airlines
Deal found 5/5![United Airlines logo]()
$610
Last-minute flights from Harrisburg to St. LouisDiscover last-minute flight deals from Harrisburg to St. Louis. Data last updated May 9, 2026 and is based on user searches.
Discover last-minute flight deals from Harrisburg to St. Louis. Data last updated May 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:43 pm
MDT
- STL
1 stop4h 36m
American Airlines
Tue 5/195:21 pm
STL
- MDT
1 stop5h 31m
American Airlines
Deal found 5/5![American Airlines logo]()
$364
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:43 pm
MDT
- STL
1 stop6h 13m
American Airlines
Sat 5/165:21 pm
STL
- MDT
1 stop5h 31m
American Airlines
Deal found 5/8![American Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:17 pm
MDT
- STL
1 stop5h 37m
American Airlines
Sun 5/315:14 am
STL
- MDT
1 stop5h 23m
American Airlines
Deal found 5/6![American Airlines logo]()
$360
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:52 pm
MDT
- STL
1 stop4h 29m
United Airlines
Sat 5/307:05 pm
STL
- MDT
1 stop4h 22m
United Airlines
Deal found 5/7![United Airlines logo]()
$385
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:52 pm
MDT
- STL
1 stop4h 29m
United Airlines
Sun 5/317:05 pm
STL
- MDT
1 stop4h 38m
United Airlines
Deal found 5/7![United Airlines logo]()
$305
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:20 am
MDT
- STL
1 stop4h 09m
Delta
Tue 6/210:19 am
STL
- MDT
1 stop4h 58m
Delta
Deal found 5/6![Delta logo]()
$300
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:33 pm
MDT
- STL
1 stop6h 26m
Delta
Sun 6/76:00 am
STL
- MDT
1 stop4h 11m
Delta
Deal found 5/6![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:40 pm
MDT
- STL
1 stop5h 19m
American Airlines
Sun 6/76:15 am
STL
- MDT
1 stop6h 45m
American Airlines
Deal found 5/5![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:22 pm
MDT
- STL
1 stop6h 34m
Delta
Sun 6/146:10 pm
STL
- MDT
1 stop4h 00m
Delta
Deal found 5/8![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:04 am
MDT
- STL
1 stop4h 42m
Delta
Fri 6/2610:20 am
STL
- MDT
1 stop5h 34m
Delta
Deal found 5/6![Delta logo]()
$344
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:30 am
MDT
- STL
1 stop6h 41m
United Airlines
Sat 6/271:13 pm
STL
- MDT
1 stop5h 35m
United Airlines
Deal found 5/9![United Airlines logo]()
$394
Find flight deals from Harrisburg to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $291 (American Airlines) |
Popular in | March |
Cheapest in | January |
Average price | $329 |
Cheapflights Fare Finder
Customize your flight search to find flights from Harrisburg to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 9, 2026.
Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Thu 6/11
6:22 pm-11:56 pm
1 stop6h 34m
Lambert-St Louis
Sat 6/13
6:10 pm-11:10 pm
1 stop4h 00m
$300
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Fri 6/19
6:22 pm-11:56 pm
1 stop6h 34m
Lambert-St Louis
Fri 6/26
10:20 am-4:54 pm
1 stop5h 34m
$309
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Wed 6/3
6:00 am-9:44 am
1 stop4h 44m
Lambert-St Louis
Sun 6/7
6:00 am-11:11 am
1 stop4h 11m
$309
Quickest round-trip
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Wed 5/27
5:52 pm-9:21 pm
1 stop4h 29m
Lambert-St Louis
Sat 5/30
7:05 pm-12:27 am
1 stop4h 22m
$385
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Sat 6/20
6:30 am-12:11 pm
1 stop6h 41m
Lambert-St Louis
Sat 6/27
1:13 pm-7:48 pm
1 stop5h 35m
$394
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Wed 5/27
6:15 am-3:46 pm
2 stops10h 31m
Lambert-St Louis
Sun 5/31
5:29 pm-12:43 am
1 stop6h 14m
$472
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Fri 5/29
5:52 pm-9:21 pm
1 stop4h 29m
Lambert-St Louis
Tue 6/2
1:13 pm-1:50 pm
3 stops23h 37m
$519
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Wed 6/3
7:59 pm-12:11 pm
3 stops17h 12m
Lambert-St Louis
Sun 6/7
1:13 pm-9:29 pm
1 stop7h 16m
$610
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Thu 6/11
7:59 pm-12:11 pm
3 stops17h 12m
Lambert-St Louis
Sat 6/13
1:13 pm-9:29 pm
1 stop7h 16m
$610
Sorted by cheapest first
Compare providers for flights from Harrisburg to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to St. Louis in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Harrisburg-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Harrisburg-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Harrisburg to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Harrisburg with our price prediction graph.
MDT-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Harrisburg to St. Louis
What is the cheapest month to book a flight from Harrisburg to St. Louis?
Currently, January is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $304). Flying from Harrisburg to St. Louis in March is currently the most expensive (average of $469). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Harrisburg to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated May 9, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Harrisburg to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Overall
7.9
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Overall
7.9
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Overall
7.9
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Overall
7.9
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Harrisburg to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
St. Louis flight routes
Alternative routes for Harrisburg to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Harrisburg to St. Louis by cabin class
Find flights from Harrisburg to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Harrisburg and St. Louis flights
Browse other Harrisburg and St. Louis flight options. Last updated on May 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 9, 2026.
Top 3 airlines flying from Harrisburg to St. Louis
Discover the top 3 airlines that operate flights from Harrisburg to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$418 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$368 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$364 | FlexibilityNo cancel fee | On-timeN/A |