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St. Louis

$231+ Cheap flights from Harrisburg to St. Louis (MDT - STL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — STL
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Find flight deals from Harrisburg to St. Louis

Cheapest flights from Harrisburg to St. Louis
Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/209:33 amMDT - STL
2 stops10h 03mMultiple Airlines
Fri 11/214:13 pmSTL - MDT
1 stop17h 00mMultiple Airlines
Deal found 11/11$231
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:00 amMDT - STL
1 stop4h 35mAmerican Airlines
Sun 12/216:35 pmSTL - MDT
1 stop4h 44mAmerican Airlines
Deal found 11/11$249
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/247:23 pmMDT - STL
1 stop4h 41mAmerican Airlines
Fri 11/286:45 pmSTL - MDT
1 stop4h 37mAmerican Airlines
Deal found 11/11$260
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:00 amMDT - STL
1 stop4h 46mDelta
Sun 11/236:40 amSTL - MDT
1 stop4h 15mDelta
Deal found 11/11$269
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:40 amMDT - STL
1 stop6h 39mAmerican Airlines
Mon 12/16:45 pmSTL - MDT
1 stop4h 37mAmerican Airlines
Deal found 11/12$280
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/237:23 pmMDT - STL
1 stop29h 34mMultiple Airlines
Tue 11/254:13 pmSTL - MDT
1 stop26h 44mMultiple Airlines
Deal found 11/12$293
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:44 amMDT - STL
1 stop5h 23mDelta
Mon 11/175:17 pmSTL - MDT
1 stop4h 54mDelta
Deal found 11/10$313
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2410:04 amMDT - STL
2 stops36h 05mMultiple Airlines
Fri 11/284:13 pmSTL - MDT
1 stop17h 00mMultiple Airlines
Deal found 11/11$465
This United Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:30 amMDT - STL
1 stop5h 31mUnited Airlines
Fri 12/51:00 pmSTL - MDT
1 stop4h 43mUnited Airlines
Deal found 11/13$471

Cheap flight deals from Harrisburg to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

One-way from

$237
(Delta)

Popular in

December

Cheapest in

April

Average price

$324
Provider with most accurate pricing for Harrisburg-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Lambert-St Louis flights.
Search Deals
From Harrisburg to Lambert-St Louis
Search Deals
One-way flight from Harrisburg to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.

Fly from

Harrisburg

Fly to

St. Louis

Route

Depart

Return

Price

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Thu 12/18

5:00 am-8:35 am

1 stop4h 35m

Lambert-St Louis

Tue 12/30

5:30 am-1:17 pm

1 stop6h 47m

$249

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Tue 3/24

6:25 pm-11:40 pm

1 stop6h 15m

Lambert-St Louis

Sat 3/28

5:00 pm-11:40 pm

1 stop5h 40m

$249

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Thu 12/18

5:00 am-8:35 am

1 stop4h 35m

Lambert-St Louis

Sun 12/21

6:35 pm-12:19 am

1 stop4h 44m

$249

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Mon 11/24

7:23 pm-11:04 pm

1 stop4h 41m

Lambert-St Louis

Fri 11/28

6:45 pm-12:22 am

1 stop4h 37m

$260

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Thu 4/16

5:00 am-8:05 am

1 stop4h 05m

Lambert-St Louis

Thu 7/23

6:29 am-2:30 pm

1 stop7h 01m

$279

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Thu 11/27

6:40 am-12:19 pm

1 stop6h 39m

Lambert-St Louis

Mon 12/1

6:45 pm-12:22 am

1 stop4h 37m

$280

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sun 11/23

7:23 pm-11:57 pm

1 stop29h 34m

Lambert-St Louis

Tue 11/25

9:50 am-9:41 pm

2 stops10h 51m

$350

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Mon 11/24

10:04 am-9:09 pm

2 stops36h 05m

Lambert-St Louis

Fri 11/28

4:13 pm-10:13 am

1 stop17h 00m

$465

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Mon 3/16

5:31 pm-9:00 pm

1 stop4h 29m

Lambert-St Louis

Fri 3/20

5:00 am-9:55 am

1 stop3h 55m

$475

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Fri 1/16

5:30 pm-9:13 pm

1 stop4h 43m

$237

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/10

Showing 1-10 of 17 results
1
2

Compare providers for flights from Harrisburg to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to St. Louis in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Harrisburg-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Harrisburg-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to St. Louis

What is the cheapest month to book a flight from Harrisburg to St. Louis?

Currently, September is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $109). Flying from Harrisburg to St. Louis in June is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to STL?

Find hourly flight availability from Harrisburg to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 16% on flights from Harrisburg to St. Louis by exploring options for tickets at noon.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated November 13, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,017 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to St. Louis?

    Departing from Harrisburg to St. Louis will take you 4h 35m. Harrisburg and St. Louis are separated by a distance of 731 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Harrisburg to St. Louis round-trip?

    American Airlines, at $248, was found to be the cheapest airline from Harrisburg to St. Louis.Alternate airlines to your destination round-trip include United Airlines and Delta. American Airlines is currently priced 27% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Harrisburg to St. Louis one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $237. Delta flights start at $237 while deals on Frontier start at $252 one-way.

  • Can I find deals for flights from Harrisburg to St. Louis that include hotel bookings?

    Yes. In addition to deals on Harrisburg to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to St. Louis.

  • Can I find deals for business class flights from Harrisburg to St. Louis?

    Yes. Cheapflights offers flight deals from Harrisburg to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to St. Louis?

    Currently, September is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $109). Flying from Harrisburg to St. Louis in June is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Alternative routes for Harrisburg to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Harrisburg to St. Louis

Discover the top 3 airlines that operate flights from Harrisburg to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$365FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$342FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$325FlexibilityNo cancel feeOn-timeN/A

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