$220+ Cheap flights from Harrisburg to St. Louis (MDT - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — STL
Aug 26 — Sep 21
Round-trip
1 adult, Economy
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Find cheap flights from Harrisburg to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Harrisburg to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Harrisburg to St. LouisExplore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 27, 2026.
Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 27, 2026.
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:34 pm
MDT
- STL
1 stop5h 00m
American Airlines
Mon 9/76:00 am
STL
- MDT
1 stop6h 58m
American Airlines
Deal found 7/22![American Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:34 pm
MDT
- STL
1 stop5h 00m
American Airlines
Tue 8/256:00 am
STL
- MDT
1 stop5h 45m
American Airlines
Deal found 7/26![American Airlines logo]()
$310
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:00 am
MDT
- STL
1 stop4h 20m
Delta
Mon 9/75:23 pm
STL
- MDT
1 stop5h 20m
Delta
Deal found 7/23![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/57:34 pm
MDT
- STL
1 stop5h 00m
American Airlines
Sat 8/155:42 pm
STL
- MDT
1 stop4h 21m
American Airlines
Deal found 7/22![American Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:55 pm
MDT
- STL
1 stop6h 34m
United Airlines
Thu 8/139:30 am
STL
- MDT
1 stop6h 22m
United Airlines
Deal found 7/22![United Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:55 pm
MDT
- STL
1 stop4h 31m
United Airlines
Mon 8/103:22 pm
STL
- MDT
1 stop5h 07m
United Airlines
Deal found 7/23![United Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:25 pm
MDT
- STL
1 stop6h 23m
Delta
Mon 10/125:28 pm
STL
- MDT
1 stop5h 15m
Delta
Deal found 7/24![Delta logo]()
$359
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am
MDT
- STL
1 stop5h 20m
American Airlines
Fri 9/1811:01 am
STL
- MDT
1 stop6h 12m
American Airlines
Deal found 7/22![American Airlines logo]()
$360
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:38 pm
MDT
- STL
1 stop4h 54m
American Airlines
Wed 8/55:42 pm
STL
- MDT
1 stop4h 21m
American Airlines
Deal found 7/22![American Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:30 am
MDT
- STL
1 stop5h 02m
United Airlines
Tue 11/31:08 pm
STL
- MDT
1 stop4h 49m
United Airlines
Deal found 7/23![United Airlines logo]()
$371
Best flights from Harrisburg to St. LouisDiscover carefully curated flight deals from Harrisburg to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 27, 2026.
Discover carefully curated flight deals from Harrisburg to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 27, 2026.
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:00 am
MDT
- STL
1 stop4h 20m
Delta
Mon 9/75:23 pm
STL
- MDT
1 stop5h 20m
Delta
Deal found 7/23![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/122:17 pm
MDT
- STL
1 stop6h 43m
United Airlines
Tue 9/1512:59 pm
STL
- MDT
1 stop7h 02m
United Airlines
Deal found 7/25![United Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:30 am
MDT
- STL
1 stop5h 02m
United Airlines
Tue 11/31:08 pm
STL
- MDT
1 stop4h 49m
United Airlines
Deal found 7/24![United Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:52 pm
MDT
- STL
1 stop5h 19m
United Airlines
Mon 8/313:32 pm
STL
- MDT
1 stop4h 21m
United Airlines
Deal found 7/25![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:58 pm
MDT
- STL
1 stop6h 58m
Delta
Sat 11/286:00 pm
STL
- MDT
1 stop4h 12m
Delta
Deal found 7/25![Delta logo]()
$550
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:15 am
MDT
- STL
2 stops10h 23m
United Airlines
Mon 9/78:00 am
STL
- MDT
1 stop4h 32m
United Airlines
Deal found 7/22![United Airlines logo]()
$542
Last-minute flights from Harrisburg to St. LouisDiscover last-minute flight deals from Harrisburg to St. Louis. Data last updated July 27, 2026 and is based on user searches.
Discover last-minute flight deals from Harrisburg to St. Louis. Data last updated July 27, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/257:15 pm
MDT
- STL
1 stop6h 00m
American Airlines
Wed 7/295:48 pm
STL
- MDT
1 stop4h 22m
American Airlines
Deal found 7/22![American Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:38 pm
MDT
- STL
1 stop4h 54m
American Airlines
Wed 8/55:42 pm
STL
- MDT
1 stop4h 21m
American Airlines
Deal found 7/22![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/307:45 pm
MDT
- STL
1 stop5h 31m
American Airlines
Sun 8/25:48 pm
STL
- MDT
1 stop4h 22m
American Airlines
Deal found 7/22![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:45 pm
MDT
- STL
1 stop5h 31m
American Airlines
Fri 8/76:00 am
STL
- MDT
1 stop6h 58m
American Airlines
Deal found 7/24![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/57:34 pm
MDT
- STL
1 stop5h 00m
American Airlines
Sat 8/155:42 pm
STL
- MDT
1 stop4h 21m
American Airlines
Deal found 7/22![American Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:24 pm
MDT
- STL
1 stop5h 57m
Delta
Sat 8/86:09 pm
STL
- MDT
1 stop4h 12m
Delta
Deal found 7/23![Delta logo]()
$378
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:55 pm
MDT
- STL
1 stop6h 34m
United Airlines
Thu 8/139:30 am
STL
- MDT
1 stop6h 22m
United Airlines
Deal found 7/22![United Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:55 pm
MDT
- STL
1 stop4h 31m
United Airlines
Mon 8/103:22 pm
STL
- MDT
1 stop5h 07m
United Airlines
Deal found 7/23![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:34 pm
MDT
- STL
1 stop5h 00m
American Airlines
Tue 8/256:00 am
STL
- MDT
1 stop5h 45m
American Airlines
Deal found 7/26![American Airlines logo]()
$310
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2810:40 am
MDT
- STL
1 stop5h 58m
United Airlines
Sun 8/3010:53 am
STL
- MDT
1 stop4h 59m
United Airlines
Deal found 7/26![United Airlines logo]()
$319
One-way flights from Harrisburg to St. LouisSearch for one-way flight options from Harrisburg to St. Louis. Find affordable one-way fares based on user searches. Data last updated July 27, 2026.
Search for one-way flight options from Harrisburg to St. Louis. Find affordable one-way fares based on user searches. Data last updated July 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2410:56 am
MDT
- STL
2 stops30h 35m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$220
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/147:31 pm
MDT
- STL
1 stop13h 53m
American Airlines
Deal found 7/22![American Airlines logo]()
$227
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:31 pm
MDT
- STL
1 stop5h 43m
American Airlines
Deal found 7/24![American Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/147:13 pm
MDT
- STL
3 stops47h 24m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$305
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/147:59 pm
MDT
- STL
2 stops20h 32m
United Airlines
Deal found 7/22![United Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/15:55 pm
MDT
- STL
1 stop4h 31m
United Airlines
Deal found 7/23![United Airlines logo]()
$349
Find flight deals from Harrisburg to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $310 (American Airlines) |
One-way from | $220 (Kiwi.com) |
Popular in | March |
Cheapest in | January |
Average price | $379 |
Cheapflights Fare Finder
Customize your flight search to find flights from Harrisburg to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Thu 9/3
6:00 am-9:20 am
1 stop4h 20m
Lambert-St Louis
Mon 9/7
5:23 pm-11:43 pm
1 stop5h 20m
$319
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Sat 9/12
2:17 pm-8:00 pm
1 stop6h 43m
Lambert-St Louis
Tue 9/15
12:59 pm-9:01 pm
1 stop7h 02m
$381
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Sat 10/31
6:30 am-10:32 am
1 stop5h 02m
Lambert-St Louis
Tue 11/3
1:08 pm-6:57 pm
1 stop4h 49m
$381
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Fri 8/28
2:52 pm-7:11 pm
1 stop5h 19m
Lambert-St Louis
Mon 8/31
3:32 pm-8:53 pm
1 stop4h 21m
$399
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Thu 9/3
6:15 am-3:38 pm
2 stops10h 23m
Lambert-St Louis
Mon 9/7
8:00 am-1:32 pm
1 stop4h 32m
$542
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Wed 11/25
5:58 pm-11:56 pm
1 stop6h 58m
Lambert-St Louis
Sat 11/28
6:00 pm-11:12 pm
1 stop4h 12m
$550
Cheapest one-way
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Mon 8/24
10:56 am-4:31 pm
2 stops30h 35m
$220
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Fri 8/14
7:31 pm-8:24 am
1 stop13h 53m
$227
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Fri 8/14
7:13 pm-5:37 pm
3 stops47h 24m
$305
HarrisburgSt. Louis
MDT - STL
MDTSTL
Harrisburg
Fri 8/14
7:59 pm-3:31 pm
2 stops20h 32m
$308
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Harrisburg to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to St. Louis in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Harrisburg-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Harrisburg-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Harrisburg to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Harrisburg with our price prediction graph.
MDT-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Harrisburg to St. Louis
What is the cheapest month to book a flight from Harrisburg to St. Louis?
Currently, January is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $304). Flying from Harrisburg to St. Louis in March is currently the most expensive (average of $520). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Harrisburg to St. Louis?
Airfare is typical for this route at the moment.
Harrisburg to St. Louis flights typically cost between $290 and $348 in August.The cheapest round-trip price found within the last 5 days was $310 on American Airlines (Aug 18-Aug 25).
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated July 27, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Harrisburg to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Entertainment
7.8
Comfort
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Entertainment
7.8
Comfort
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Entertainment
7.8
Comfort
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Entertainment
7.8
Comfort
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Harrisburg to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Farmington
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Harrisburg and St. Louis flights
Browse other Harrisburg and St. Louis flight options. Last updated on July 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 27, 2026.
Top 3 airlines flying from Harrisburg to St. Louis
Discover the top 3 airlines that operate flights from Harrisburg to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$432 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$379 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$251 | Average$363 | FlexibilityNo cancel fee | On-timeN/A |