HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

$186+ Cheap flights from Harrisburg to St. Louis (MDT - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — STL
feb. 20 — feb. 271
vie. 2/20
vie. 2/27
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Harrisburg to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Harrisburg to St. Louis

Cheapest flights from Harrisburg to St. Louis
Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 21, 2026.

This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/266:00 am
MDT
-
STL
1 stop5h 03m
American Airlines
mié. 3/42:00 pm
STL
-
MDT
1 stop7h 14m
American Airlines
Deal found 1/19$260
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/56:30 am
MDT
-
STL
1 stop6h 59m
United Airlines
dom. 2/88:05 am
STL
-
MDT
1 stop5h 10m
United Airlines
Deal found 1/20$269
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/186:00 am
MDT
-
STL
1 stop4h 40m
American Airlines
dom. 2/2210:37 am
STL
-
MDT
1 stop6h 13m
American Airlines
Deal found 1/21$290
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/196:10 am
MDT
-
STL
1 stop4h 36m
Delta
mar. 3/2412:04 pm
STL
-
MDT
1 stop4h 22m
Delta
Deal found 1/20$295
This Booking.com deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/1210:13 pm
MDT
-
STL
1 stop26h 06m
Frontier
lun. 3/168:10 pm
STL
-
MDT
1 stop20h 48m
Frontier
Deal found 1/21$301
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 1/236:02 pm
MDT
-
STL
1 stop6h 35m
Delta
vie. 1/305:56 pm
STL
-
MDT
1 stop4h 00m
Delta
Deal found 1/21$319
This United Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 1/313:10 pm
MDT
-
STL
1 stop5h 17m
United Airlines
mié. 2/410:10 am
STL
-
MDT
1 stop5h 24m
United Airlines
Deal found 1/18$339
This Kiwi.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/134:07 pm
MDT
-
STL
2 stops32h 52m
Multiple Airlines
lun. 2/233:49 pm
STL
-
MDT
1 stop17h 43m
Multiple Airlines
Deal found 1/19$348
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 1/226:30 am
MDT
-
STL
1 stop5h 32m
United Airlines
dom. 1/258:05 am
STL
-
MDT
1 stop5h 10m
United Airlines
Deal found 1/21$369
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/2710:46 am
MDT
-
STL
1 stop14h 41m
Multiple Airlines
jue. 3/59:50 am
STL
-
MDT
2 stops28h 26m
Multiple Airlines
Deal found 1/20$371
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/166:00 am
MDT
-
STL
1 stop5h 03m
American Airlines
lun. 2/239:37 am
STL
-
MDT
1 stop7h 13m
American Airlines
Deal found 1/19$379
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 1/225:30 pm
MDT
-
STL
1 stop6h 28m
United Airlines
jue. 1/296:30 am
STL
-
MDT
1 stop6h 45m
United Airlines
Deal found 1/20$389

Find flight deals from Harrisburg to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated enero 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$260
(American Airlines)

One-way from

$186
(Flightnetwork)

Popular in

December

Cheapest in

February

Average price

$316
Provider with most accurate pricing for Harrisburg-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Lambert-St Louis flights.
Search Deals
From Harrisburg to Lambert-St Louis
Search Deals
One-way flight from Harrisburg to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($48 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 21, 2026.
Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.

Fly from

Harrisburg

Fly to

St. Louis

Route

Depart

Return

Price

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

vie. 2/27

6:00 am-10:03 am

1 stop5h 03m

Lambert-St Louis

mié. 3/4

9:37 am-5:50 pm

1 stop7h 13m

$260

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

jue. 2/5

6:10 am-9:34 am

1 stop4h 24m

Lambert-St Louis

lun. 2/9

5:56 pm-11:00 pm

1 stop4h 04m

$269

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

jue. 2/5

6:30 am-12:29 pm

1 stop6h 59m

Lambert-St Louis

dom. 2/8

8:30 am-1:51 pm

1 stop4h 21m

$269

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

vie. 2/13

7:35 pm-10:52 pm

1 stop4h 17m

Lambert-St Louis

lun. 2/23

9:15 am-4:16 pm

1 stop6h 01m

$269

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

vie. 2/13

5:55 pm-11:36 pm

1 stop6h 41m

Lambert-St Louis

vie. 2/20

5:50 pm-11:00 pm

1 stop4h 10m

$269

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

mié. 2/18

6:00 am-9:40 am

1 stop4h 40m

Lambert-St Louis

dom. 2/22

10:37 am-5:50 pm

1 stop6h 13m

$290

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

jue. 3/19

6:10 am-9:46 am

1 stop4h 36m

Lambert-St Louis

mar. 3/24

12:04 pm-5:26 pm

1 stop4h 22m

$295

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

jue. 3/12

10:13 pm-11:19 pm

1 stop26h 06m

Lambert-St Louis

lun. 3/16

8:10 pm-5:58 pm

1 stop20h 48m

$301

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

sáb. 1/31

6:30 am-12:29 pm

1 stop6h 59m

Lambert-St Louis

mié. 2/4

11:20 am-4:34 pm

1 stop4h 14m

$339

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

dom. 6/14

6:25 pm-11:38 pm

1 stop6h 13m

$237

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 16 results
1
2

Compare providers for flights from Harrisburg to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to St. Louis in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-St. Louis flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to St. Louis

What is the cheapest month to book a flight from Harrisburg to St. Louis?

Currently, September is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $109). Flying from Harrisburg to St. Louis in June is currently the most expensive (average of $263). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated enero 21, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,088 reviews

Crew

8.5

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,088 reviews
Delta
7.9
Good
8,088 reviews

Crew

8.5

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,191 reviews
Delta
7.9
Good
8,088 reviews

Crew

8.5

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,174 reviews
Delta
7.9
Good
8,088 reviews

Crew

8.5

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to St. Louis?

    Departing from Harrisburg to St. Louis will take you 4h 24m. Harrisburg and St. Louis are separated by a distance of 731 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Harrisburg to St. Louis round-trip?

    American Airlines, at $248, was found to be the cheapest airline from Harrisburg to St. Louis.Alternate airlines to your destination round-trip include United Airlines and Delta. American Airlines is currently priced 27% below the average price you’ll pay for this route.

  • Can I find deals for flights from Harrisburg to St. Louis that include hotel bookings?

    Yes. In addition to deals on Harrisburg to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to St. Louis.

  • Can I find deals for business class flights from Harrisburg to St. Louis?

    Yes. Cheapflights offers flight deals from Harrisburg to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to St. Louis?

    Currently, September is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $109). Flying from Harrisburg to St. Louis in June is currently the most expensive (average of $263). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Harrisburg to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Newark to St. Louis flights
LaGuardia to St. Louis flights
Dulles Intl to Kansas City flights
John F Kennedy Intl to Kansas City flights
John F Kennedy Intl to St. Louis flights
LaGuardia to Kansas City flights
Dulles Intl to St. Louis flights
Newark to Kansas City flights
Reagan-National to Kansas City flights
Philadelphia to St. Louis flights
Philadelphia to Kansas City flights
Reagan-National to St. Louis flights
Philadelphia to Springfield flights
Pittsburgh to St. Louis flights
Dulles Intl to Springfield flights
John F Kennedy Intl to Springfield flights
Newark to Springfield flights
Pittsburgh to Kansas City flights
LaGuardia to Springfield flights
Harrisburg to Kansas City flights
Reagan-National to Springfield flights
Harrisburg to Springfield flights
Allentown to Kansas City flights
Allentown to Springfield flights
State College to St. Louis flights
Dulles Intl to Columbia flights
John F Kennedy Intl to Columbia flights
Reagan-National to Columbia flights
Allentown to St. Louis flights
Newark to Columbia flights
Pittsburgh to Springfield flights
Scranton to Kansas City flights
LaGuardia to Columbia flights
Philadelphia to Columbia flights
Philadelphia to Joplin flights
State College to Kansas City flights
Elmira to St. Louis flights
Newark to Joplin flights
Dulles Intl to Joplin flights
LaGuardia to Joplin flights
Scranton to St. Louis flights
Harrisburg to Joplin flights
Allentown to Columbia flights
State College to Springfield flights
Allentown to Joplin flights
Scranton to Springfield flights
Newark to Quincy flights
Pittsburgh to Joplin flights

Top 3 airlines flying from Harrisburg to St. Louis

Discover the top 3 airlines that operate flights from Harrisburg to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$348FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$320FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$323FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.