How long is the flight from Harrisburg to St. Louis?

Departing from Harrisburg to St. Louis will take you 4h 29m. Harrisburg and St. Louis are separated by a distance of 731 mi. This flight may include one or multiple stops.

What are the cheapest airlines flying from Harrisburg to St. Louis round-trip?

American Airlines, at $248, was found to be the cheapest airline from Harrisburg to St. Louis.Alternate airlines to your destination round-trip include United Airlines and Delta. American Airlines is currently priced 28% below the average price you’ll pay for this route.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the most popular airlines that fly from Harrisburg to St. Louis?

The most popular airlines flying from Harrisburg to St. Louis are American Airlines, Delta and United Airlines. Something to consider prior to booking your flight.

What is the cheapest time of day to fly from MDT to STL?

When flying from Harrisburg to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Most accurate provider : When it comes to deals on Harrisburg-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Harrisburg-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Harrisburg-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Harrisburg-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Harrisburg to St. Louis that include hotel bookings?

Yes. In addition to deals on Harrisburg to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Harrisburg to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to St. Louis.

Can I find deals for business class flights from Harrisburg to St. Louis?

Yes. Cheapflights offers flight deals from Harrisburg to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$90+ Flights from Harrisburg to St. Louis

Q: How much does it cost to fly round-trip from Harrisburg to St. Louis?

Airfare is below average for this route at the moment. Harrisburg to St. Louis flights typically cost between $328 and $480 in January. The cheapest round-trip price found within the last 3 days was $145 on Frontier (Jan 17-Jan 24).

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Cheap flight deals from Harrisburg to St. Louis

Cheapest flights from Harrisburg to St. Louis
Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Fri 12/263:00 pmMDT - STL

1 stop5h 22mUnited Airlines

Mon 12/2911:05 amSTL - MDT

1 stop4h 28mUnited Airlines

Deal found 12/24

$369

Fri 12/261:34 pmMDT - STL

2 stops9h 42mDelta

Mon 12/2911:59 amSTL - MDT

2 stops10h 03mDelta

Deal found 12/24

$1,756

Best flights from Harrisburg to St. Louis
Discover carefully curated flight deals from Harrisburg to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 28, 2025.

Sat 1/172:31 pmMDT - STL

1 stop9h 03mFrontier

Sat 1/2412:12 pmSTL - MDT

1 stop6h 18mFrontier

Deal found 12/26

$145

Sat 1/171:45 pmMDT - STL

1 stop6h 42mDelta

Tue 1/205:04 pmSTL - MDT

1 stop5h 22mDelta

Deal found 12/26

$260

Tue 2/2412:52 pmMDT - STL

1 stop7h 05mAmerican Airlines

Thu 3/56:00 amSTL - MDT

1 stop4h 33mAmerican Airlines

Deal found 12/27

$260

Sun 1/186:10 amMDT - STL

1 stop4h 29mDelta

Sat 1/247:10 amSTL - MDT

1 stop5h 06mDelta

Deal found 12/26

$260

Wed 1/285:47 amMDT - STL

1 stop4h 53mAmerican Airlines

Thu 2/266:33 pmSTL - MDT

1 stop4h 14mAmerican Airlines

Deal found 12/27

$260

Sun 1/186:10 amMDT - STL

1 stop4h 29mDelta

Sun 1/259:59 amSTL - MDT

1 stop6h 08mDelta

Deal found 12/26

$260

Sat 1/176:10 amMDT - STL

1 stop4h 29mDelta

Thu 1/2210:19 amSTL - MDT

1 stop4h 36mDelta

Deal found 12/26

$260

Wed 1/146:10 amMDT - STL

1 stop4h 29mDelta

Thu 1/2212:00 pmSTL - MDT

1 stop4h 07mDelta

Deal found 12/26

$269

Wed 1/146:10 amMDT - STL

1 stop4h 29mDelta

Wed 1/215:56 pmSTL - MDT

1 stop4h 00mDelta

Deal found 12/26

$269

Thu 1/156:02 pmMDT - STL

1 stop6h 37mDelta

Thu 1/2212:00 pmSTL - MDT

1 stop4h 07mDelta

Deal found 12/26

$269

Wed 1/146:02 pmMDT - STL

1 stop6h 37mDelta

Sun 1/2510:19 amSTL - MDT

1 stop4h 36mDelta

Deal found 12/26

$269

Thu 1/156:02 pmMDT - STL

1 stop6h 37mDelta

Wed 1/216:00 amSTL - MDT

1 stop4h 37mDelta

Deal found 12/26

$269

Last-minute flights from Harrisburg to St. Louis
Discover last-minute flight deals from Harrisburg to St. Louis. Data last updated December 28, 2025 and is based on user searches.

Fri 12/263:00 pmMDT - STL

1 stop5h 22mUnited Airlines

Mon 12/2911:05 amSTL - MDT

1 stop4h 28mUnited Airlines

Deal found 12/24

$369

Tue 1/63:10 pmMDT - STL

1 stop5h 17mUnited Airlines

Sat 1/101:15 pmSTL - MDT

1 stop6h 50mUnited Airlines

Deal found 12/25

$339

Mon 1/125:05 pmMDT - STL

1 stop4h 38mDelta

Fri 1/236:00 amSTL - MDT

1 stop4h 37mDelta

Deal found 12/26

$294

Fri 1/165:05 pmMDT - STL

1 stop4h 38mDelta

Sun 1/259:59 amSTL - MDT

1 stop6h 08mDelta

Deal found 12/26

$269

Sat 1/172:31 pmMDT - STL

1 stop9h 03mFrontier

Sat 1/2412:12 pmSTL - MDT

1 stop6h 18mFrontier

Deal found 12/26

$145

Sat 1/171:45 pmMDT - STL

1 stop6h 42mDelta

Sun 1/256:00 amSTL - MDT

1 stop4h 37mDelta

Deal found 12/26

$260

Sat 1/171:45 pmMDT - STL

1 stop6h 42mDelta

Fri 1/236:00 amSTL - MDT

1 stop4h 37mDelta

Deal found 12/26

$285

Sun 1/186:10 amMDT - STL

1 stop4h 29mDelta

Tue 1/209:59 amSTL - MDT

1 stop6h 08mDelta

Deal found 12/26

$497

Tue 1/206:30 amMDT - STL

1 stop6h 59mUnited Airlines

Fri 1/2312:44 pmSTL - MDT

1 stop19h 51mUnited Airlines

Deal found 12/24

$473

Wed 1/286:30 amMDT - STL

1 stop5h 32mUnited Airlines

Thu 2/266:25 amSTL - MDT

2 stops11h 15mUnited Airlines

Deal found 12/27

$490

One-way flights from Harrisburg to St. Louis
Search for one-way flight options from Harrisburg to St. Louis. Find affordable one-way fares based on user searches. Data last updated December 28, 2025.

Fri 1/3011:27 amMDT - STL

1 stop13h 06mFrontier

Deal found 12/26

$90

Sat 1/248:25 pmMDT - STL

1 stop28h 08mFrontier

Deal found 12/26

$171

Wed 12/314:28 pmMDT - STL

2 stops27h 08mMultiple Airlines

Deal found 12/26

$177

Fri 1/3011:27 amMDT - STL

3 stops20h 24mMultiple Airlines

Deal found 12/26

$179

Sun 1/115:51 pmMDT - STL

3 stops49h 45mMultiple Airlines

Deal found 12/26

$202

Sat 1/248:25 pmMDT - STL

2 stops35h 26mMultiple Airlines

Deal found 12/26

$207

Mon 1/264:35 pmMDT - STL

1 stop5h 08mDelta

Deal found 12/26

$237

Find flight deals from Harrisburg to St. Louis

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$145 (Frontier)
One-way from	$90 (Kiwi.com)
Popular in	December
Cheapest in	February
Average price	$451

Provider with most accurate pricing for Harrisburg-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Harrisburg-Lambert-St Louis flights.

Search Deals

From Harrisburg to Lambert-St Louis

Search Deals

One-way flight from Harrisburg to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 13% potential increase in price ($54 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sat 1/17

2:31 pm-10:34 pm

1 stop9h 03m

Lambert-St Louis

Sat 1/24

12:12 pm-7:30 pm

1 stop6h 18m

$145

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sat 1/17

1:45 pm-7:27 pm

1 stop6h 42m

Lambert-St Louis

Tue 1/20

5:04 pm-11:26 pm

1 stop5h 22m

$260

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Tue 2/24

12:52 pm-6:57 pm

1 stop7h 05m

Lambert-St Louis

Thu 3/5

6:00 am-11:33 am

1 stop4h 33m

$260

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sun 1/18

6:10 am-9:39 am

1 stop4h 29m

Lambert-St Louis

Sat 1/24

7:10 am-1:16 pm

1 stop5h 06m

$260

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Wed 1/28

5:47 am-9:40 am

1 stop4h 53m

Lambert-St Louis

Thu 2/26

6:33 pm-11:47 pm

1 stop4h 14m

$260

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sun 1/18

6:10 am-9:39 am

1 stop4h 29m

Lambert-St Louis

Sun 1/25

9:59 am-5:07 pm

1 stop6h 08m

$260

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sat 1/17

6:10 am-9:39 am

1 stop4h 29m

Lambert-St Louis

Thu 1/22

10:19 am-3:55 pm

1 stop4h 36m

$260

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Wed 1/14

6:10 am-9:39 am

1 stop4h 29m

Lambert-St Louis

Thu 1/22

12:00 pm-5:07 pm

1 stop4h 07m

$269

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Wed 1/14

6:10 am-9:39 am

1 stop4h 29m

Lambert-St Louis

Wed 1/21

5:56 pm-10:56 pm

1 stop4h 00m

$269

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Thu 1/15

6:02 pm-11:39 pm

1 stop6h 37m

Lambert-St Louis

Thu 1/22

12:00 pm-5:07 pm

1 stop4h 07m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/26

Showing 1-10 of 20 results

Compare providers for flights from Harrisburg to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to St. Louis in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Harrisburg-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Harrisburg-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Harrisburg-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Harrisburg-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Harrisburg with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to St. Louis

What is the cheapest month to book a flight from Harrisburg to St. Louis?

Currently, September is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $109). Flying from Harrisburg to St. Louis in June is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Harrisburg to St. Louis?

Reviews of airlines servicing St. Louis

Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

8,019 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

United Airlines

7.4

Good

9,113 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

American Airlines

7.2

Good

11,072 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

How long is the flight from Harrisburg to St. Louis?
Departing from Harrisburg to St. Louis will take you 4h 29m. Harrisburg and St. Louis are separated by a distance of 731 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Harrisburg to St. Louis round-trip?
American Airlines, at $248, was found to be the cheapest airline from Harrisburg to St. Louis.Alternate airlines to your destination round-trip include United Airlines and Delta. American Airlines is currently priced 28% below the average price you’ll pay for this route.
Can I find deals for flights from Harrisburg to St. Louis that include hotel bookings?
Yes. In addition to deals on Harrisburg to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Harrisburg to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to St. Louis.
Can I find deals for business class flights from Harrisburg to St. Louis?
Yes. Cheapflights offers flight deals from Harrisburg to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Harrisburg to St. Louis?
Currently, September is the cheapest month in which you can book a flight from Harrisburg to St. Louis (average of $109). Flying from Harrisburg to St. Louis in June is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip

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Other flights to St. Louis

Top 3 airlines flying from Harrisburg to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$248	Average$353	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$248	Average$342	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$248	Average$323	FlexibilityNo cancel fee	On-timeN/A

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$90+ Cheap flights from Harrisburg to St. Louis (MDT - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/30. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Harrisburg to St. Louis with Cheapflights

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2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Harrisburg to St. Louis

Cheapest flights from Harrisburg to St. LouisExplore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Find flight deals from Harrisburg to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.

Compare providers for flights from Harrisburg to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to St. Louis in December.

Best time to book a flight from Harrisburg to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Harrisburg with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to St. Louis

What is the cheapest month to book a flight from Harrisburg to St. Louis?

How much does it cost to fly round-trip from Harrisburg to St. Louis?

Reviews of airlines servicing St. Louis

Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Harrisburg to St. Louis?

What are the cheapest airlines flying from Harrisburg to St. Louis round-trip?

Can I find deals for flights from Harrisburg to St. Louis that include hotel bookings?

How can I find direct flights from Harrisburg to St. Louis?

Can I find deals for business class flights from Harrisburg to St. Louis?

What is the cheapest month to book a flight from Harrisburg to St. Louis?

Traveling to a place near St. Louis?

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Top 3 airlines flying from Harrisburg to St. Louis

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Cheapest flights from Harrisburg to St. Louis
Explore the most affordable flight options available from Harrisburg to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.