$84+ Cheap flights from Buffalo to St. Louis (BUF - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — STL
Apr 11 — Apr 181
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Buffalo to St. LouisExplore the most affordable flight options available from Buffalo to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.
Explore the most affordable flight options available from Buffalo to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:56 pm
BUF
- STL
1 stop21h 30m
Frontier
Wed 5/68:13 pm
STL
- BUF
1 stop15h 00m
Frontier
Deal found 3/7![Frontier logo]()
$182
This CheapOair deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/229:47 pm
BUF
- STL
1 stop26h 32m
Frontier
Thu 3/268:02 am
STL
- BUF
1 stop25h 47m
Frontier
Deal found 3/7![Frontier logo]()
$261
This CheapOair deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/111:55 am
BUF
- STL
1 stop13h 02m
Frontier
Wed 6/34:44 pm
STL
- BUF
1 stop18h 32m
Frontier
Deal found 3/9![Frontier logo]()
$267
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/293:10 pm
BUF
- STL
2 stops7h 50m
Southwest
Wed 5/610:25 am
STL
- BUF
2 stops6h 50m
Southwest
Deal found 3/7![Southwest logo]()
$287
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/254:10 pm
BUF
- STL
1 stop6h 55m
Southwest
Mon 4/275:40 am
STL
- BUF
1 stop3h 35m
Southwest
Deal found 3/7![Southwest logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/301:00 pm
BUF
- STL
1 stop22h 32m
Frontier
Wed 4/18:16 pm
STL
- BUF
2 stops15h 01m
Frontier
Deal found 3/9![Frontier logo]()
$297
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:00 pm
BUF
- STL
1 stop4h 52m
United Airlines
Sat 4/48:21 am
STL
- BUF
1 stop3h 51m
United Airlines
Deal found 3/8![United Airlines logo]()
$318
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
BUF
- STL
1 stop6h 47m
American Airlines
Sun 5/35:51 am
STL
- BUF
1 stop4h 01m
American Airlines
Deal found 3/9![American Airlines logo]()
$334
Best flights from Buffalo to St. LouisDiscover carefully curated flight deals from Buffalo to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 12, 2026.
Discover carefully curated flight deals from Buffalo to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 12, 2026.
This CheapOair deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/229:47 pm
BUF
- STL
1 stop26h 32m
Frontier
Thu 3/268:02 am
STL
- BUF
1 stop25h 47m
Frontier
Deal found 3/7![Frontier logo]()
$261
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/274:00 pm
BUF
- STL
1 stop4h 45m
Southwest
Tue 4/285:35 am
STL
- BUF
1 stop3h 45m
Southwest
Deal found 3/7![Southwest logo]()
$289
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:00 am
BUF
- STL
1 stop6h 11m
United Airlines
Tue 6/1610:20 am
STL
- BUF
1 stop5h 26m
United Airlines
Deal found 3/7![United Airlines logo]()
$342
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/254:10 pm
BUF
- STL
1 stop6h 55m
Southwest
Mon 4/275:40 am
STL
- BUF
1 stop3h 35m
Southwest
Deal found 3/7![Southwest logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/301:00 pm
BUF
- STL
1 stop22h 32m
Frontier
Wed 4/18:16 pm
STL
- BUF
2 stops15h 01m
Frontier
Deal found 3/9![Frontier logo]()
$297
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:00 pm
BUF
- STL
1 stop3h 45m
Southwest
Wed 6/31:45 pm
STL
- BUF
2 stops7h 30m
Southwest
Deal found 3/9![Southwest logo]()
$294
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:55 pm
BUF
- STL
1 stop4h 18m
United Airlines
Tue 5/59:21 am
STL
- BUF
1 stop6h 33m
United Airlines
Deal found 3/11![United Airlines logo]()
$359
This CheapOair deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/511:55 am
BUF
- STL
1 stop13h 02m
Frontier
Sun 6/74:44 pm
STL
- BUF
1 stop18h 32m
Frontier
Deal found 3/10![Frontier logo]()
$362
Last-minute flights from Buffalo to St. LouisDiscover last-minute flight deals from Buffalo to St. Louis. Data last updated March 12, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to St. Louis. Data last updated March 12, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/229:47 pm
BUF
- STL
1 stop26h 32m
Frontier
Thu 3/268:02 am
STL
- BUF
1 stop25h 47m
Frontier
Deal found 3/7![Frontier logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/301:00 pm
BUF
- STL
1 stop22h 32m
Frontier
Wed 4/18:16 pm
STL
- BUF
2 stops15h 01m
Frontier
Deal found 3/9![Frontier logo]()
$297
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:00 pm
BUF
- STL
1 stop4h 52m
United Airlines
Sat 4/48:21 am
STL
- BUF
1 stop3h 51m
United Airlines
Deal found 3/8![United Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/254:10 pm
BUF
- STL
1 stop6h 55m
Southwest
Mon 4/275:40 am
STL
- BUF
1 stop3h 35m
Southwest
Deal found 3/7![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/274:00 pm
BUF
- STL
2 stops8h 15m
Southwest
Tue 4/282:30 pm
STL
- BUF
2 stops6h 45m
Southwest
Deal found 3/7![Southwest logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:56 pm
BUF
- STL
1 stop21h 30m
Frontier
Wed 5/68:13 pm
STL
- BUF
1 stop15h 00m
Frontier
Deal found 3/7![Frontier logo]()
$182
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/293:10 pm
BUF
- STL
2 stops7h 50m
Southwest
Wed 5/610:25 am
STL
- BUF
2 stops6h 50m
Southwest
Deal found 3/7![Southwest logo]()
$287
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
BUF
- STL
1 stop6h 47m
American Airlines
Sun 5/35:51 am
STL
- BUF
1 stop4h 01m
American Airlines
Deal found 3/9![American Airlines logo]()
$334
One-way flights from Buffalo to St. LouisSearch for one-way flight options from Buffalo to St. Louis. Find affordable one-way fares based on user searches. Data last updated March 12, 2026.
Search for one-way flight options from Buffalo to St. Louis. Find affordable one-way fares based on user searches. Data last updated March 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:08 pm
BUF
- STL
1 stop22h 22m
Frontier
Deal found 3/7![Frontier logo]()
$84
This Frontier deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1511:25 am
BUF
- STL
1 stop12h 54m
Frontier
Deal found 3/9![Frontier logo]()
$141
This Trip.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:18 pm
BUF
- STL
1 stop19h 32m
Frontier
Deal found 3/10![Frontier logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/301:00 pm
BUF
- STL
1 stop22h 32m
Frontier
Deal found 3/8![Frontier logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:08 pm
BUF
- STL
3 stops31h 04m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$158
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:27 am
BUF
- STL
1 stop5h 13m
American Airlines
Deal found 3/9![American Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/11:02 pm
BUF
- STL
1 stop29h 32m
Frontier
Deal found 3/11![Frontier logo]()
$164
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:55 am
BUF
- STL
1 stop6h 55m
Southwest
Deal found 3/10![Southwest logo]()
$173
This deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:50 pm
BUF
- STL
1 stop4h 23m
United Airlines
Deal found 3/9![United Airlines logo]()
$174
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:00 pm
BUF
- STL
1 stop6h 56m
American Airlines
Deal found 3/11![American Airlines logo]()
$184
Find flight deals from Buffalo to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $182 (Kiwi.com) |
One-way from | $84 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $575 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from Buffalo to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloSt. Louis
BUF - STL
BUFSTL
Buffalo
Sun 3/22
9:47 pm-11:19 pm
1 stop26h 32m
Lambert-St Louis
Thu 3/26
8:02 am-10:49 am
1 stop25h 47m
$261
Quickest round-trip
BuffaloSt. Louis
BUF - STL
BUFSTL
Buffalo
Mon 4/27
4:00 pm-7:45 pm
1 stop4h 45m
Lambert-St Louis
Tue 4/28
5:35 am-10:20 am
1 stop3h 45m
$289
BuffaloSt. Louis
BUF - STL
BUFSTL
Buffalo
Sat 4/25
4:10 pm-10:05 pm
1 stop6h 55m
Lambert-St Louis
Mon 4/27
5:40 am-10:15 am
1 stop3h 35m
$289
BuffaloSt. Louis
BUF - STL
BUFSTL
Buffalo
Mon 6/1
8:00 pm-10:45 pm
1 stop3h 45m
Lambert-St Louis
Wed 6/3
1:45 pm-10:15 pm
2 stops7h 30m
$294
BuffaloSt. Louis
BUF - STL
BUFSTL
Buffalo
Mon 3/30
1:00 pm-10:32 am
1 stop22h 32m
Lambert-St Louis
Wed 4/1
8:16 pm-12:17 pm
2 stops15h 01m
$297
BuffaloSt. Louis
BUF - STL
BUFSTL
Buffalo
Thu 6/11
7:00 am-12:11 pm
1 stop6h 11m
Lambert-St Louis
Tue 6/16
10:20 am-4:46 pm
1 stop5h 26m
$342
BuffaloSt. Louis
BUF - STL
BUFSTL
Buffalo
Mon 5/4
5:55 pm-9:13 pm
1 stop4h 18m
Lambert-St Louis
Tue 5/5
9:21 am-4:54 pm
1 stop6h 33m
$359
BuffaloSt. Louis
BUF - STL
BUFSTL
Buffalo
Fri 6/5
11:55 am-11:57 pm
1 stop13h 02m
Lambert-St Louis
Sun 6/7
4:44 pm-12:16 pm
1 stop18h 32m
$362
Cheapest one-way
BuffaloSt. Louis
BUF - STL
BUFSTL
Buffalo
Wed 5/6
1:08 pm-10:30 am
1 stop22h 22m
$84
BuffaloSt. Louis
BUF - STL
BUFSTL
Buffalo
Fri 5/15
11:25 am-11:19 pm
1 stop12h 54m
$141
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Buffalo to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to St. Louis in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Buffalo-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Buffalo with our price prediction graph.
BUF-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to St. Louis
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated March 12, 2026.
Read through reviews of airlines operating flights from Buffalo to St. Louis, such as Southwest,Delta, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
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Buffalo and St. Louis flights
Browse other Buffalo and St. Louis flight options. Last updated on March 12, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on March 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 12, 2026.
Top 3 airlines flying from Buffalo to St. Louis
Discover the top 3 airlines that operate flights from Buffalo to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$164 | Average$341 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$236 | Average$371 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$317 | Average$442 | FlexibilityNo cancel fee | On-time63% |