HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Padre Island

Cheap flights from Knoxville (TYS) to South Padre Island, TX

TYS — MFE
Nov 22 — Nov 291
Sat 11/22
Sat 11/29
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to South Padre Island with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to South Padre Island

Keep the following information in mind while searching for Knoxville to South Padre Island flight deals. Data was last updated October 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars
Provider with most accurate pricing for Knoxville McGhee Tyson-Brownsville South Padre Is. Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Brownsville South Padre Is. Intl flights.
Search Deals

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South Padre Island

What is the cheapest time of day to fly from TYS to SO9?

Find hourly flight availability from Knoxville to South Padre Island. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

It’s typically best to fly out from Knoxville to South Padre Island in the evening. Doing so could potentially save you 40% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing South Padre Island

Get insights into the airlines that provide service to South Padre Island. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Padre Island. Reviews last updated October 23, 2025.
Read reviews from past customers who have flown American Airlines from Knoxville to South Padre Island. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,033 reviews

Entertainment

6.9

Food

6.4

Comfort

7.2

Overall

7.2

Crew

8.0

Boarding

7.5

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2025

PIT - DFW

Due to gate changes,we nearly missed our flight. The gate agent reassigned our seats and would NOT give us our assigned seats,but she did honor that same request to the man who arrived after us. Her rudeness and difficulty was not appropriate.
American Airlines
7.2
Good
11,033 reviews
American Airlines
7.2
Good
11,033 reviews

Entertainment

6.9

Food

6.4

Comfort

7.2

Overall

7.2

Crew

8.0

Boarding

7.5

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2025

PIT - DFW

Due to gate changes,we nearly missed our flight. The gate agent reassigned our seats and would NOT give us our assigned seats,but she did honor that same request to the man who arrived after us. Her rudeness and difficulty was not appropriate.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South Padre Island. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South Padre Island?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to South Padre Island. On average, McGhee Tyson has 0 outbound flights to South Padre Island per day from 1 airline. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • Can I find deals for flights from Knoxville to South Padre Island that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Padre Island flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Padre Island?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Padre Island.

  • Can I find deals for business class flights from Knoxville to South Padre Island?

    Yes. Cheapflights offers flight deals from Knoxville to South Padre Island by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to South Padre Island

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Dallas/Fort Worth flights
Memphis to Dallas/Fort Worth flights
Memphis to Hobby flights
Nashville to Hobby flights
Memphis to George Bush Intcntl flights
Nashville to George Bush Intcntl flights
Nashville to Austin flights
Chattanooga to Dallas/Fort Worth flights
Knoxville to Hobby flights
Knoxville to Dallas/Fort Worth flights
Knoxville to George Bush Intcntl flights
Nashville to Love Field flights
Memphis to Austin flights
Memphis to Love Field flights
Nashville to San Antonio flights
Chattanooga to Love Field flights
Chattanooga to Hobby flights
Blountville to Dallas/Fort Worth flights
Knoxville to Love Field flights
Knoxville to Austin flights
Knoxville to San Antonio flights
Memphis to San Antonio flights
Nashville to El Paso flights
Chattanooga to George Bush Intcntl flights
Chattanooga to Austin flights
Nashville to McAllen flights
Chattanooga to San Antonio flights
Memphis to El Paso flights
Nashville to Brownsville flights
Blountville to Love Field flights
Blountville to Hobby flights
Blountville to George Bush Intcntl flights
Nashville to Harlingen flights
Nashville to Corpus Christi flights
Knoxville to El Paso flights
Nashville to Amarillo flights
Blountville to Austin flights
Nashville to Lubbock flights
Chattanooga to El Paso flights
Blountville to San Antonio flights
Knoxville to McAllen flights
Memphis to Lubbock flights
Blountville to El Paso flights
Memphis to McAllen flights
Nashville to Abilene flights
Nashville to Tyler flights
Nashville to Killeen flights
Nashville to Waco flights
Nashville to Wichita Falls flights
Blountville to Corpus Christi flights

Top airline flying from Knoxville to South Padre Island

Discover the top airline that operate flights from Knoxville to South Padre Island. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$419FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.