South Carolina

$266+ Cheap flights from South Dakota to South Carolina

FSD — CHS
Dec 3 — Dec 101
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Cheap flight deals from South Dakota to South Carolina

Cheapest flights from South Dakota to South Carolina

Mon 11/165:34 pm -
1 stop17h 57m
Thu 11/1910:13 pm -
1 stop20h 35m
Deal found 10/30$266
Tue 12/18:27 am -
1 stop4h 50m
Tue 12/82:04 pm -
1 stop7h 04m
Deal found 11/1$341
Sun 11/295:41 pm -
1 stop26h 20m
Sun 12/610:15 pm -
1 stop13h 00m
Deal found 10/30$345
Wed 12/26:00 am -
1 stop6h 17m
Wed 12/92:05 pm -
1 stop7h 51m
Deal found 10/31$349
Thu 12/33:19 pm -
1 stop5h 48m
Thu 12/107:00 am -
1 stop6h 24m
Deal found 11/2$349
Sat 12/51:04 pm -
2 stops9h 04m
Tue 12/86:02 am -
2 stops9h 47m
Deal found 10/30$351
Fri 12/48:00 am -
1 stop5h 12m
Tue 12/85:34 pm -
1 stop6h 08m
Deal found 11/1$359
Tue 12/13:17 pm -
2 stops7h 38m
Tue 12/83:28 pm -
2 stops10h 18m
Deal found 11/1$365
Fri 12/42:40 pm -
2 stops7h 07m
Tue 12/88:14 am -
2 stops9h 39m
Deal found 11/1$369
Sat 11/2111:29 am -
2 stops10h 30m
Thu 11/266:00 am -
2 stops11h 54m
Deal found 10/31$369
Tue 11/177:00 am -
1 stop8h 07m
Sat 11/216:27 pm -
1 stop7h 28m
Deal found 10/30$374
Wed 11/186:11 am -
1 stop6h 28m
Wed 12/163:38 pm -
1 stop7h 54m
Deal found 10/29$394

Find flight deals from South Dakota to South Carolina

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$266
(Kiwi.com)

Popular in

November

Cheapest in

August

Average price

$778
Provider with most accurate pricing for Sioux Falls Joe Foss Field-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Sioux Falls Joe Foss Field-Myrtle Beach Intl flights.
From South Dakota to South Carolina
Highest demand for flights based on searches. 25% potential increase in price ($191 potential increase over avg. RT price).
Cheapest flight prices on average. 4% potential price decrease ($24 potential savings vs. average RT price).
Average for round-trip flights in November 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from South Dakota to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Sioux FallsCharleston

FSD Sioux Falls Joe Foss Field - CHS Charleston

FSDCHS

Sioux Falls Joe Foss Field

Tue 12/1

8:27 am-2:17 pm

1 stop4h 50m

Charleston

Tue 12/8

2:04 pm-8:08 pm

1 stop7h 04m

$341

Sioux FallsCharleston

FSD Sioux Falls Joe Foss Field - CHS Charleston

FSDCHS

Sioux Falls Joe Foss Field

Sun 11/29

5:41 pm-9:01 pm

1 stop26h 20m

Charleston

Sun 12/6

10:15 pm-10:15 am

1 stop13h 00m

$345

Sioux FallsCharleston

FSD Sioux Falls Joe Foss Field - CHS Charleston

FSDCHS

Sioux Falls Joe Foss Field

Sat 12/5

11:01 am-7:22 pm

2 stops7h 21m

Charleston

Tue 12/8

3:14 pm-7:14 pm

1 stop5h 00m

$346

Sioux FallsCharleston

FSD Sioux Falls Joe Foss Field - CHS Charleston

FSDCHS

Sioux Falls Joe Foss Field

Fri 1/22

4:15 pm-11:41 pm

1 stop6h 26m

Charleston

Fri 1/29

7:24 am-12:07 pm

1 stop5h 43m

$349

Sioux FallsCharleston

FSD Sioux Falls Joe Foss Field - CHS Charleston

FSDCHS

Sioux Falls Joe Foss Field

Fri 1/22

7:30 am-1:46 pm

1 stop5h 16m

Charleston

Fri 1/29

10:14 am-6:38 pm

2 stops9h 24m

$354

Rapid CityGreenville

RAP Rapid City - GSP Greenville

RAPGSP

Rapid City

Fri 12/4

8:00 am-3:12 pm

1 stop5h 12m

Greenville

Tue 12/8

5:34 pm-9:42 pm

1 stop6h 08m

$359

Sioux FallsCharleston

FSD Sioux Falls Joe Foss Field - CHS Charleston

FSDCHS

Sioux Falls Joe Foss Field

Fri 1/22

12:51 pm-12:02 am

2 stops10h 11m

Charleston

Fri 1/29

1:05 pm-7:24 pm

2 stops7h 19m

$359

Rapid CityCharleston

RAP Rapid City - CHS Charleston

RAPCHS

Rapid City

Sat 4/10

6:55 am-4:36 pm

1 stop7h 41m

Charleston

Sat 4/17

5:30 am-11:12 am

2 stops7h 42m

$364

Rapid CityCharleston

RAP Rapid City - CHS Charleston

RAPCHS

Rapid City

Tue 1/12

5:00 am-4:00 pm

2 stops9h 00m

Charleston

Sun 1/24

2:42 pm-9:38 pm

2 stops8h 56m

$369
Quickest round-trip

Sioux FallsCharleston

FSD Sioux Falls Joe Foss Field - CHS Charleston

FSDCHS

Sioux Falls Joe Foss Field

Mon 11/23

7:39 am-1:56 pm

1 stop5h 17m

Charleston

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$374

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/1

Showing 1-10 of 34 resultsSorted by cheapest first
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Best time to book a flight from South Dakota to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from South Dakota with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from South Dakota to South Carolina

No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from South Dakota to South Carolina. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.8

Comfort

7.8

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.8

Comfort

7.8

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.8

Comfort

7.8

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.8

Comfort

7.8

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Related info for your journey

  • How long is the flight from South Dakota to South Carolina?

    For as low as $341, Delta can have you in South Carolina from South Dakota in 4h 50m. South Dakota and South Carolina are separated by a distance of 1164 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from South Dakota to South Carolina that include hotel bookings?

    Yes. In addition to deals on South Dakota to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Dakota to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Dakota to South Carolina.

  • Can I find deals for business class flights from South Dakota to South Carolina?

    Yes. Cheapflights offers flight deals from South Dakota to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Dakota to South Carolina

Top 3 airlines flying from South Dakota to South Carolina

AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$258Average$409FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$264Average$490FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$308Average$527FlexibilityNo cancel feeOn-time71%

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