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South Carolina

$112+ Cheap flights from Roanoke (ROA) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — CHS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Roanoke to South Carolina

Keep the following information in mind while searching for Roanoke to South Carolina flight deals. Data was last updated September 11, 2025.

Round-trip from

$229
(American Airlines)

One-way from

$112
(Kiwi.com)
From Roanoke to South Carolina
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One-way flight from Roanoke to South Carolina
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Find flight deals from Roanoke to South Carolina

Cheapest flights from Roanoke to South Carolina
Explore the most affordable flight options available from Roanoke to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:00 amROA - CHS
1 stop4h 26mAmerican Airlines
Sat 11/19:01 amCHS - ROA
1 stop5h 39mAmerican Airlines
Deal found 9/10$229
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1412:50 pmROA - CHS
1 stop3h 54mAmerican Airlines
Mon 11/176:10 amCHS - ROA
1 stop3h 35mAmerican Airlines
Deal found 9/9$284
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/239:20 pmROA - CLT
1 stop15h 00mMultiple Airlines
Sun 10/2610:06 pmCLT - ROA
1 stop22h 37mMultiple Airlines
Deal found 9/11$287
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/179:54 pmROA - CLT
1 stop15h 58mMultiple Airlines
Wed 10/222:14 pmCLT - ROA
2 stops30h 16mMultiple Airlines
Deal found 9/10$292
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/166:45 amROA - MYR
1 stop7h 57mUnited Airlines
Sat 9/202:47 pmMYR - ROA
1 stop3h 57mUnited Airlines
Deal found 9/9$299
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:45 amROA - CHS
1 stop7h 22mUnited Airlines
Mon 9/2910:17 amCHS - ROA
1 stop3h 47mUnited Airlines
Deal found 9/10$299
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/179:51 amROA - CLT
Nonstop1h 25mAmerican Airlines
Wed 10/221:06 pmCLT - ROA
Nonstop1h 16mAmerican Airlines
Deal found 9/10$303
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:06 pmROA - CHS
1 stop3h 52mAmerican Airlines
Sun 11/167:53 pmCHS - ROA
1 stop4h 12mAmerican Airlines
Deal found 9/9$314
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:00 amROA - MYR
1 stop3h 48mDelta
Tue 12/92:41 pmMYR - ROA
1 stop4h 39mDelta
Deal found 9/10$317
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:30 pmROA - CLT
1 stop4h 29mUnited Airlines
Wed 10/2210:34 amCLT - ROA
1 stop3h 30mUnited Airlines
Deal found 9/10$318
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/128:20 amROA - MYR
2 stops6h 26mAmerican Airlines
Sun 11/168:07 pmMYR - ROA
1 stop3h 58mAmerican Airlines
Deal found 9/11$322
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/248:30 amROA - CLT
Nonstop1h 33mAmerican Airlines
Mon 10/274:37 pmCLT - ROA
Nonstop1h 18mAmerican Airlines
Deal found 9/9$323

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Roanoke to South Carolina that are best for you.

Fly from

Roanoke

Fly to

South Carolina

Route

Depart

Return

Price

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Thu 10/30

6:00 am-10:26 am

1 stop4h 26m

Charleston

Sat 11/1

9:01 am-2:40 pm

1 stop5h 39m

$229

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Sat 11/15

3:50 pm-9:47 pm

1 stop5h 57m

Charleston

Thu 11/20

8:17 pm-12:21 am

1 stop4h 04m

$229

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Fri 11/14

12:50 pm-4:44 pm

1 stop3h 54m

Charleston

Mon 11/17

6:10 am-9:45 am

1 stop3h 35m

$284

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Tue 9/16

6:45 am-2:42 pm

1 stop7h 57m

Myrtle Beach Intl

Sat 9/20

2:47 pm-6:44 pm

1 stop3h 57m

$299

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Thu 9/25

6:45 am-2:07 pm

1 stop7h 22m

Charleston

Mon 9/29

10:17 am-2:04 pm

1 stop3h 47m

$299

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Thu 11/13

8:06 pm-11:58 pm

1 stop3h 52m

Charleston

Sun 11/16

7:53 pm-12:05 am

1 stop4h 12m

$314

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Sat 12/6

6:00 am-9:48 am

1 stop3h 48m

Myrtle Beach Intl

Tue 12/9

6:56 pm-12:20 am

1 stop5h 24m

$317

RoanokeCharlotte

ROA - CLT

ROACLT

Roanoke

Fri 10/17

7:30 pm-11:59 pm

1 stop4h 29m

Charlotte Douglas

Wed 10/22

10:34 am-2:04 pm

1 stop3h 30m

$318

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Wed 11/12

8:20 am-2:46 pm

2 stops6h 26m

Myrtle Beach Intl

Sun 11/16

8:07 pm-12:05 am

1 stop3h 58m

$322

RoanokeCharlotte

ROA - CLT

ROACLT

Roanoke

Fri 10/10

5:00 am-6:32 am

Nonstop1h 32m

Charlotte Douglas

Sun 10/12

7:30 am-8:48 am

Nonstop1h 18m

$323

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 44 results
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Best time to book a flight from Roanoke to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to South Carolina

What is the cheapest month to book a flight from Roanoke to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $217). Flying from Roanoke to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ROA to SC?

Find hourly flight availability from Roanoke to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Roanoke to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Roanoke to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Overall

7.2

Entertainment

6.9

Food

6.4

Crew

8.0

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Overall

7.2

Entertainment

6.9

Food

6.4

Crew

8.0

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Roanoke to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to South Carolina?

    If you book a flight to South Carolina from Roanoke, you will be flying from Roanoke, which is the city’s only airport. Roanoke (ROA) is located 4.2 mi from the center of Roanoke.

  • How long is the flight from Roanoke to South Carolina?

    American Airlines, Delta, and United Airlines can get you from Roanoke to South Carolina in just under 4h 26m. Your travel time can differ by up to 3h 31m. The distance between Roanoke and South Carolina is about 306 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Roanoke to South Carolina one-way?

    $186 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $280 and $363, respectively.

  • What are the most popular routes from Roanoke to South Carolina?

    When deciding which route to take from Roanoke to South Carolina consider Roanoke - Myrtle Beach Intl, Roanoke - Charlotte Douglas or Roanoke - Charleston as they are the most popular.

  • Can I find deals for flights from Roanoke to South Carolina that include hotel bookings?

    Yes. In addition to deals on Roanoke to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to South Carolina.

  • Can I find deals for business class flights from Roanoke to South Carolina?

    Yes. Cheapflights offers flight deals from Roanoke to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $217). Flying from Roanoke to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Roanoke to South Carolina

Discover the top airline that operate flights from Roanoke to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$404FlexibilityNo cancel feeOn-time71%

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