HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$122+ Cheap flights from Roanoke (ROA) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — CHS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Roanoke to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Roanoke to South Carolina

Cheapest flights from Roanoke to South Carolina
Explore the most affordable flight options available from Roanoke to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:03 pmROA - MYR
1 stop3h 47mDelta
Sun 1/46:59 pmMYR - ROA
1 stop5h 09mDelta
Deal found 12/11$274
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:00 amROA - MYR
1 stop3h 20mAmerican Airlines
Wed 1/712:05 pmMYR - ROA
1 stop3h 00mAmerican Airlines
Deal found 12/11$297
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:03 pmROA - MYR
1 stop3h 47mDelta
Wed 3/186:58 pmMYR - ROA
1 stop5h 06mDelta
Deal found 12/11$298
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:03 pmROA - MYR
1 stop3h 47mDelta
Thu 3/126:58 pmMYR - ROA
1 stop5h 06mDelta
Deal found 12/11$308
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:55 pmROA - MYR
1 stop21h 42mMultiple Airlines
Wed 1/76:00 amMYR - ROA
2 stops32h 55mMultiple Airlines
Deal found 12/11$314
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:00 amROA - MYR
1 stop3h 20mAmerican Airlines
Mon 1/57:46 pmMYR - ROA
1 stop3h 53mAmerican Airlines
Deal found 12/11$334
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:08 amROA - CLT
Nonstop1h 28mAmerican Airlines
Thu 12/251:10 pmCLT - ROA
Nonstop1h 12mAmerican Airlines
Deal found 12/10$338
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:15 amROA - CHS
1 stop4h 09mUnited Airlines
Tue 12/307:45 pmCHS - ROA
1 stop3h 45mUnited Airlines
Deal found 12/10$339
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:08 amROA - CLT
Nonstop1h 28mAmerican Airlines
Thu 12/251:10 pmCLT - ROA
Nonstop1h 12mAmerican Airlines
Deal found 12/10$343
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:03 pmROA - MYR
1 stop3h 47mDelta
Fri 1/26:00 amMYR - ROA
1 stop4h 37mDelta
Deal found 12/11$348
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:00 amROA - CLT
Nonstop1h 34mAmerican Airlines
Sat 12/2710:25 pmCLT - ROA
Nonstop1h 14mAmerican Airlines
Deal found 12/10$348
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1910:32 amROA - CHS
1 stop4h 50mUnited Airlines
Tue 12/2310:00 amCHS - ROA
1 stop4h 16mUnited Airlines
Deal found 12/11$359

Find flight deals from Roanoke to South Carolina

Keep the following information in mind while searching for Roanoke to South Carolina flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$193
(American Airlines)

One-way from

$122
(Kiwi.com)

Popular in

August

Cheapest in

February

Average price

$368
Provider with most accurate pricing for Roanoke-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Roanoke-Myrtle Beach Intl flights.
Search Deals
From Roanoke to South Carolina
Search Deals
One-way flight from Roanoke to South Carolina
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($93 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Roanoke to South Carolina that are best for you.

Fly from

Roanoke

Fly to

South Carolina

Route

Depart

Return

Price

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Sun 1/4

6:00 am-12:31 pm

1 stop6h 31m

Myrtle Beach Intl

Tue 3/17

6:58 pm-12:04 am

1 stop5h 06m

$259

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Wed 12/31

6:00 am-10:24 am

1 stop4h 24m

Myrtle Beach Intl

Tue 3/17

6:58 pm-12:04 am

1 stop5h 06m

$274

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Wed 12/31

6:00 am-10:24 am

1 stop4h 24m

Myrtle Beach Intl

Sun 1/4

6:59 pm-12:08 am

1 stop5h 09m

$274

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Tue 12/30

7:03 pm-10:50 pm

1 stop3h 47m

Myrtle Beach Intl

Sun 1/4

6:59 pm-12:08 am

1 stop5h 09m

$274

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Sun 1/4

6:00 am-12:31 pm

1 stop6h 31m

Myrtle Beach Intl

Wed 3/18

6:58 pm-12:04 am

1 stop5h 06m

$283

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Sun 1/4

6:00 am-12:31 pm

1 stop6h 31m

Myrtle Beach Intl

Thu 3/12

6:58 pm-12:04 am

1 stop5h 06m

$293

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Tue 12/30

7:03 pm-10:50 pm

1 stop3h 47m

Myrtle Beach Intl

Wed 3/18

6:58 pm-12:04 am

1 stop5h 06m

$298

RoanokeCharlotte

ROA - CLT

ROACLT

Roanoke

Tue 2/17

2:50 pm-4:12 pm

Nonstop1h 22m

Charlotte Douglas

Sun 2/22

8:05 pm-9:26 pm

Nonstop1h 21m

$303

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Fri 1/2

7:03 pm-10:50 pm

1 stop3h 47m

Myrtle Beach Intl

Sun 1/4

6:59 pm-12:08 am

1 stop5h 09m

$303

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Fri 1/2

6:00 am-12:31 pm

1 stop6h 31m

Myrtle Beach Intl

Tue 3/17

6:58 pm-12:04 am

1 stop5h 06m

$303

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 37 results
1
2
3
4

Best time to book a flight from Roanoke to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to South Carolina

What is the cheapest month to book a flight from Roanoke to South Carolina?

Currently, July is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $207). Flying from Roanoke to South Carolina in December is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ROA to SC?

Find hourly flight availability from Roanoke to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s optimal to fly from Roanoke to South Carolina in the afternoon. By choosing this option you can save up to 32% on the cost of your flight, compared to a flight at noon.

How much does it cost to fly round-trip from Roanoke to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 12, 2025.
Read through reviews of airlines operating flights from Roanoke to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,050 reviews

Boarding

7.5

Overall

7.2

Comfort

7.2

Crew

8.0

Food

6.5

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,050 reviews
American Airlines
7.2
Good
11,050 reviews

Boarding

7.5

Overall

7.2

Comfort

7.2

Crew

8.0

Food

6.5

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Roanoke to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to South Carolina?

    If you book a flight to South Carolina from Roanoke, you will be flying from Roanoke, which is the city’s only airport. Roanoke (ROA) is located 4.2 mi from the center of Roanoke.

  • How long is the flight from Roanoke to South Carolina?

    Delta, American Airlines, and United Airlines can get you from Roanoke to South Carolina in just under 1h 22m. Your travel time can differ by up to 5h 09m. The distance between Roanoke and South Carolina is about 155 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Roanoke to South Carolina?

    When deciding which route to take from Roanoke to South Carolina consider Roanoke - Charlotte Douglas, Roanoke - Charleston or Roanoke - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Roanoke to South Carolina that include hotel bookings?

    Yes. In addition to deals on Roanoke to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to South Carolina.

  • Can I find deals for business class flights from Roanoke to South Carolina?

    Yes. Cheapflights offers flight deals from Roanoke to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to South Carolina?

    Currently, July is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $207). Flying from Roanoke to South Carolina in December is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Roanoke to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Dulles Intl to Miami flights
Reagan-National to Miami flights
Dulles Intl to Las Vegas flights
Dulles Intl to Dallas/Fort Worth flights
Dulles Intl to Orlando flights
Reagan-National to Los Angeles flights
Dulles Intl to Los Angeles flights
Dulles Intl to Fort Lauderdale flights
Reagan-National to Fort Lauderdale flights
Reagan-National to Orlando flights
Reagan-National to Las Vegas flights
Dulles Intl to Tampa flights
Dulles Intl to Atlanta flights
Reagan-National to Dallas/Fort Worth flights
Raleigh to LaGuardia flights
Dulles Intl to Sky Harbor Intl flights
Raleigh to John F Kennedy Intl flights
Dulles Intl to Seattle flights
Reagan-National to Seattle flights
Dulles Intl to Hobby flights
Raleigh to Miami flights
Dulles Intl to Denver flights
Reagan-National to Atlanta flights
Dulles Intl to O'Hare Intl flights
Reagan-National to O'Hare Intl flights
Reagan-National to Hobby flights
Dulles Intl to New Orleans flights
Dulles Intl to Salt Lake City flights
Reagan-National to New Orleans flights
Dulles Intl to Portland flights
Dulles Intl to John F Kennedy Intl flights
Dulles Intl to San Francisco flights
Reagan-National to John F Kennedy Intl flights
Reagan-National to Salt Lake City flights
Raleigh to Newark flights
Dulles Intl to George Bush Intcntl flights
Reagan-National to San Francisco flights
Reagan-National to Sky Harbor Intl flights
Raleigh to Dallas/Fort Worth flights
Reagan-National to Tampa flights
Reagan-National to LaGuardia flights
Raleigh to Orlando flights
Raleigh to Fort Lauderdale flights
Raleigh to Las Vegas flights
Reagan-National to West Palm Beach flights
Dulles Intl to Honolulu flights
Reagan-National to George Bush Intcntl flights
Reagan-National to Denver flights
Dulles Intl to Boston flights
Dulles Intl to West Palm Beach flights

Top airline flying from Roanoke to South Carolina

Discover the top airline that operate flights from Roanoke to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$443FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.