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South Carolina

$185+ Cheap flights from Roanoke (ROA) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/6. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — CHS
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Roanoke to South Carolina

Cheapest flights from Roanoke to South Carolina
Explore the most affordable flight options available from Roanoke to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/116:00 am
ROA
-
MYR
1 stop3h 46m
Delta
Sun 2/156:00 am
MYR
-
ROA
1 stop4h 30m
Delta
Deal found 1/27$249
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/97:51 pm
ROA
-
CHS
1 stop4h 25m
Delta
Wed 3/186:30 am
CHS
-
ROA
1 stop3h 57m
Delta
Deal found 1/26$249
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/248:15 am
ROA
-
CHS
2 stops6h 47m
American Airlines
Tue 3/36:10 pm
CHS
-
ROA
1 stop4h 49m
American Airlines
Deal found 1/27$254
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/61:56 pm
ROA
-
MYR
1 stop4h 53m
American Airlines
Thu 2/126:00 am
MYR
-
ROA
1 stop4h 37m
American Airlines
Deal found 1/27$259
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/26:00 am
ROA
-
CHS
1 stop3h 42m
Delta
Sat 8/85:55 pm
CHS
-
ROA
1 stop5h 55m
Delta
Deal found 1/28$259
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/137:51 pm
ROA
-
CHS
1 stop4h 25m
Delta
Mon 3/167:58 pm
CHS
-
ROA
1 stop4h 06m
Delta
Deal found 1/26$274
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/137:51 pm
ROA
-
CHS
1 stop4h 25m
Delta
Tue 3/175:27 am
CHS
-
ROA
1 stop5h 00m
Delta
Deal found 1/26$299
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:00 am
ROA
-
CHS
1 stop5h 24m
Delta
Wed 3/1810:32 am
CHS
-
ROA
2 stops12h 27m
Delta
Deal found 1/26$302
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/273:47 pm
ROA
-
CHS
1 stop3h 31m
Delta
Tue 2/35:25 am
CHS
-
ROA
1 stop5h 14m
Delta
Deal found 1/26$309
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2910:15 am
ROA
-
CHS
1 stop4h 33m
United Airlines
Sat 1/312:58 pm
CHS
-
ROA
1 stop4h 33m
United Airlines
Deal found 1/26$319
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/147:51 pm
ROA
-
CHS
2 stops16h 13m
Delta
Mon 3/167:58 pm
CHS
-
ROA
1 stop4h 06m
Delta
Deal found 1/26$322
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/137:51 pm
ROA
-
CHS
1 stop4h 25m
Delta
Wed 3/1810:32 am
CHS
-
ROA
2 stops12h 27m
Delta
Deal found 1/26$327

Find flight deals from Roanoke to South Carolina

Keep the following information in mind while searching for Roanoke to South Carolina flight deals. Data was last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Delta)

One-way from

$185
(Kiwi.com)

Popular in

August

Cheapest in

January

Average price

$144
Provider with most accurate pricing for Roanoke-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Roanoke-Myrtle Beach Intl flights.
Search Deals
From Roanoke to South Carolina
Search Deals
One-way flight from Roanoke to South Carolina
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($114 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Roanoke to South Carolina that are best for you.

Fly from

Roanoke

Fly to

South Carolina

Route

Depart

Return

Price

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Wed 2/11

6:00 am-9:46 am

1 stop3h 46m

Myrtle Beach Intl

Sun 2/15

6:00 am-10:30 am

1 stop4h 30m

$249

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Tue 2/24

2:47 pm-7:00 pm

1 stop4h 13m

Charleston

Tue 3/3

2:48 pm-8:07 pm

1 stop5h 19m

$249

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Sat 3/14

7:51 pm-11:55 pm

1 stop4h 04m

Charleston

Wed 3/18

5:27 am-10:27 am

1 stop5h 00m

$249

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Sat 3/14

7:51 pm-11:55 pm

1 stop4h 04m

Charleston

Mon 3/16

7:58 pm-12:04 am

1 stop4h 06m

$249

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Wed 3/11

6:00 am-9:44 am

1 stop3h 44m

Charleston

Mon 3/16

7:58 pm-12:04 am

1 stop4h 06m

$249

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Fri 5/1

7:43 pm-12:22 am

1 stop4h 39m

Charleston

Mon 5/4

7:44 pm-12:25 am

1 stop4h 41m

$249

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Mon 3/9

7:51 pm-12:16 am

1 stop4h 25m

Charleston

Tue 3/17

5:27 am-10:27 am

1 stop5h 00m

$274

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Tue 3/10

6:00 am-9:44 am

1 stop3h 44m

Charleston

Tue 3/17

5:27 am-10:27 am

1 stop5h 00m

$274

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Fri 3/13

7:51 pm-12:16 am

1 stop4h 25m

Charleston

Mon 3/16

7:58 pm-12:04 am

1 stop4h 06m

$274

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Sat 3/14

7:51 pm-11:55 pm

1 stop4h 04m

Charleston

Tue 3/17

5:27 am-10:27 am

1 stop5h 00m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 36 results
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Best time to book a flight from Roanoke to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to South Carolina

What is the cheapest month to book a flight from Roanoke to South Carolina?

Currently, January is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $144). Flying from Roanoke to South Carolina in December is currently the most expensive (average of $368). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Roanoke to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 28, 2026.
Read through reviews of airlines operating flights from Roanoke to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,201 reviews

Overall

7.2

Food

6.4

Comfort

7.2

Crew

8.0

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,201 reviews
American Airlines
7.2
Good
11,201 reviews

Overall

7.2

Food

6.4

Comfort

7.2

Crew

8.0

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to South Carolina?

    If you book a flight to South Carolina from Roanoke, you will be flying from Roanoke, which is the city’s only airport. Roanoke (ROA) is located 4.2 mi from the center of Roanoke.

  • How long is the flight from Roanoke to South Carolina?

    Delta, United Airlines, and American Airlines can get you from Roanoke to South Carolina in just under 3h 40m. Your travel time can differ by up to 33m. The distance between Roanoke and South Carolina is about 258 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Roanoke to South Carolina?

    When deciding which route to take from Roanoke to South Carolina consider Roanoke - Charlotte Douglas, Roanoke - Charleston or Roanoke - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Roanoke to South Carolina that include hotel bookings?

    Yes. In addition to deals on Roanoke to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to South Carolina.

  • Can I find deals for business class flights from Roanoke to South Carolina?

    Yes. Cheapflights offers flight deals from Roanoke to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $144). Flying from Roanoke to South Carolina in December is currently the most expensive (average of $368). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Roanoke to South Carolina

Discover the top airline that operate flights from Roanoke to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$448FlexibilityNo cancel feeOn-time71%

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