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South Carolina

$190+ Cheap flights from Roanoke (ROA) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/19. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — CHS
Apr 15 — Apr 221
Wed 4/15
Wed 4/22
1 adult, Economy
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Cheap flight deals from Roanoke to South Carolina

Cheapest flights from Roanoke to South Carolina
Explore the most affordable flight options available from Roanoke to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.

This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:00 am
ROA
-
CHS
1 stop3h 57m
Delta
Fri 4/177:44 pm
CHS
-
ROA
1 stop4h 41m
Delta
Deal found 3/11$289
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:00 pm
ROA
-
CHS
1 stop3h 55m
American Airlines
Tue 3/3111:58 am
CHS
-
ROA
1 stop4h 35m
American Airlines
Deal found 3/12$299
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:00 am
ROA
-
CHS
1 stop3h 43m
Delta
Sun 8/236:30 am
CHS
-
ROA
1 stop4h 05m
Delta
Deal found 3/13$309
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:30 am
ROA
-
CHS
1 stop3h 55m
United Airlines
Sat 8/2910:00 am
CHS
-
ROA
1 stop4h 18m
United Airlines
Deal found 3/12$349
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2510:30 am
ROA
-
CHS
1 stop4h 24m
United Airlines
Mon 3/306:00 am
CHS
-
ROA
1 stop7h 29m
United Airlines
Deal found 3/10$359
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1912:58 pm
ROA
-
MYR
1 stop5h 02m
American Airlines
Sat 5/236:12 pm
MYR
-
ROA
1 stop5h 35m
American Airlines
Deal found 3/12$377
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:00 am
ROA
-
MYR
1 stop4h 29m
American Airlines
Mon 5/116:00 am
MYR
-
ROA
1 stop6h 33m
American Airlines
Deal found 3/11$382
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:00 am
ROA
-
MYR
1 stop3h 24m
American Airlines
Sun 4/195:00 am
MYR
-
ROA
1 stop3h 36m
American Airlines
Deal found 3/12$387
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 am
ROA
-
MYR
1 stop4h 09m
Delta
Sun 9/206:45 pm
MYR
-
ROA
1 stop5h 05m
Delta
Deal found 3/12$393
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:00 am
ROA
-
CLT
Nonstop1h 29m
American Airlines
Thu 6/259:20 am
CLT
-
ROA
Nonstop1h 25m
American Airlines
Deal found 3/11$399
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:00 am
ROA
-
MYR
1 stop5h 10m
American Airlines
Sun 9/206:31 pm
MYR
-
ROA
1 stop3h 02m
American Airlines
Deal found 3/12$402
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:38 pm
ROA
-
CLT
2 stops14h 50m
Multiple Airlines
Sun 5/107:58 pm
CLT
-
ROA
1 stop20h 06m
Multiple Airlines
Deal found 3/11$403

Find flight deals from Roanoke to South Carolina

Keep the following information in mind while searching for Roanoke to South Carolina flight deals. Data was last updated March 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$289
(Delta)

One-way from

$190
(Kiwi.com)

Popular in

August

Cheapest in

January

Average price

$379
Provider with most accurate pricing for Roanoke-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Roanoke-Myrtle Beach Intl flights.
Search Deals
From Roanoke to South Carolina
Search Deals
One-way flight from Roanoke to South Carolina
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($129 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Roanoke to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Fri 5/8

8:00 pm-11:59 pm

1 stop3h 59m

Charleston

Sat 5/16

8:17 pm-11:37 pm

1 stop3h 20m

$289

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Wed 4/8

6:00 am-9:57 am

1 stop3h 57m

Charleston

Fri 4/17

7:44 pm-12:25 am

1 stop4h 41m

$289

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Wed 8/26

10:30 am-2:25 pm

1 stop3h 55m

Charleston

Sat 8/29

7:52 pm-11:43 pm

1 stop3h 51m

$349

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Wed 3/25

10:30 am-2:54 pm

1 stop4h 24m

Charleston

Mon 3/30

6:00 am-1:29 pm

1 stop7h 29m

$359

RoanokeCharlotte

ROA - CLT

ROACLT

Roanoke

Sat 4/4

2:55 pm-6:52 pm

1 stop3h 57m

Charlotte Douglas

Sat 4/11

2:46 pm-7:10 pm

1 stop4h 24m

$406
Quickest round-trip

RoanokeCharlotte

ROA - CLT

ROACLT

Roanoke

Thu 4/16

6:00 am-7:25 am

Nonstop1h 25m

Charlotte Douglas

Mon 4/20

9:05 pm-10:26 pm

Nonstop1h 21m

$419

RoanokeCharlotte

ROA - CLT

ROACLT

Roanoke

Fri 4/10

7:59 pm-11:57 pm

1 stop3h 58m

Charlotte Douglas

Sun 4/12

6:00 am-9:49 am

1 stop3h 49m

$439

RoanokeCharlotte

ROA - CLT

ROACLT

Roanoke

Sat 4/11

7:59 pm-11:57 pm

1 stop3h 58m

Charlotte Douglas

Sun 4/12

6:00 am-9:49 am

1 stop3h 49m

$446

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Sat 3/28

7:51 pm-12:04 am

1 stop4h 13m

Myrtle Beach Intl

Mon 3/30

6:54 pm-12:19 am

1 stop5h 25m

$447

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Fri 5/8

6:45 am-12:17 pm

1 stop5h 32m

Charleston

Fri 5/15

6:00 am-9:57 am

1 stop3h 57m

$459

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Showing 1-10 of 53 resultsSorted by cheapest first
1
2
3
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6

Best time to book a flight from Roanoke to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to South Carolina

What is the cheapest month to book a flight from Roanoke to South Carolina?

Currently, January is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $144). Flying from Roanoke to South Carolina in December is currently the most expensive (average of $368). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Roanoke to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 16, 2026.
Read through reviews of airlines operating flights from Roanoke to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,466 reviews

Crew

7.9

Boarding

7.5

Entertainment

6.9

Comfort

7.2

Overall

7.1

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,466 reviews
American Airlines
7.1
Good
11,466 reviews

Crew

7.9

Boarding

7.5

Entertainment

6.9

Comfort

7.2

Overall

7.1

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Roanoke to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to South Carolina?

    If you book a flight to South Carolina from Roanoke, you will be flying from Roanoke, which is the city’s only airport. Roanoke (ROA) is located 4.2 mi from the center of Roanoke.

  • How long is the flight from Roanoke to South Carolina?

    American Airlines, Delta, and United Airlines can get you from Roanoke to South Carolina in just under 3h 55m. Your travel time can differ by up to 04m. The distance between Roanoke and South Carolina is about 306 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Roanoke to South Carolina?

    When deciding which route to take from Roanoke to South Carolina consider Roanoke - Charleston, Roanoke - Charlotte Douglas or Roanoke - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Roanoke to South Carolina that include hotel bookings?

    Yes. In addition to deals on Roanoke to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to South Carolina.

  • Can I find deals for business class flights from Roanoke to South Carolina?

    Yes. Cheapflights offers flight deals from Roanoke to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $144). Flying from Roanoke to South Carolina in December is currently the most expensive (average of $368). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Roanoke to South Carolina

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Top airline flying from Roanoke to South Carolina

Discover the top airline that operate flights from Roanoke to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$445FlexibilityNo cancel feeOn-time71%

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