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South Carolina

$212+ Cheap flights from Odessa, TX to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — CHS
Aug 22 — Aug 291
Sat 8/22
Sat 8/29
1 adult, Economy
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Cheap flight deals from Odessa to South Carolina

Cheapest flights from Odessa to South Carolina
Explore the most affordable flight options available from Odessa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.

This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:00 am
MAF
-
CLT
1 stop6h 12m
American Airlines
Mon 8/245:45 am
CLT
-
MAF
1 stop5h 01m
American Airlines
Deal found 7/20$375
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1812:25 pm
MAF
-
CLT
2 stops8h 00m
Southwest
Mon 8/245:00 pm
CLT
-
MAF
1 stop6h 10m
Southwest
Deal found 7/20$380
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/112:13 pm
MAF
-
SAV
1 stop6h 46m
United Airlines
Thu 8/137:05 am
SAV
-
MAF
1 stop7h 27m
United Airlines
Deal found 7/21$423
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:00 am
MAF
-
CLT
1 stop4h 54m
United Airlines
Sat 8/225:04 pm
CLT
-
MAF
1 stop5h 47m
United Airlines
Deal found 7/21$423
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/512:20 pm
MAF
-
CLT
2 stops8h 05m
Southwest
Tue 8/116:50 am
CLT
-
MAF
2 stops7h 50m
Southwest
Deal found 7/21$435
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/48:00 am
MAF
-
CLT
2 stops8h 50m
Southwest
Sun 9/612:30 pm
CLT
-
MAF
1 stop10h 35m
Southwest
Deal found 7/21$446
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/59:37 am
MAF
-
CLT
2 stops9h 45m
United Airlines
Tue 8/114:23 pm
CLT
-
MAF
1 stop6h 46m
United Airlines
Deal found 7/21$450
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:40 am
MAF
-
CLT
1 stop6h 36m
United Airlines
Sat 8/295:04 pm
CLT
-
MAF
1 stop7h 40m
United Airlines
Deal found 7/19$465
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:00 am
MAF
-
SAV
1 stop6h 45m
United Airlines
Thu 10/297:00 am
SAV
-
MAF
1 stop7h 36m
United Airlines
Deal found 7/22$475
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:00 am
MAF
-
SAV
1 stop5h 52m
American Airlines
Sun 8/97:00 am
SAV
-
MAF
1 stop5h 19m
American Airlines
Deal found 7/20$507
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:00 am
MAF
-
MYR
2 stops8h 33m
United Airlines
Tue 12/1511:25 am
MYR
-
MAF
2 stops13h 05m
United Airlines
Deal found 7/19$514
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2110:40 am
MAF
-
MYR
2 stops10h 10m
Southwest
Sat 11/2810:10 am
MYR
-
MAF
2 stops13h 55m
Southwest
Deal found 7/21$590

Find flight deals from Odessa to South Carolina

Keep the following information in mind while searching for Odessa to South Carolina flight deals. Data was last updated July 23, 2026.

Round-trip from

$375
(American Airlines)

One-way from

$212
(United Airlines)
From Odessa to South Carolina
Search Deals
One-way flight from Odessa to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Odessa to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 8/18

5:00 am-12:12 pm

1 stop6h 12m

Charlotte Douglas

Mon 8/24

5:45 am-9:46 am

1 stop5h 01m

$375

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 8/18

12:25 pm-9:10 pm

2 stops7h 45m

Charlotte Douglas

Mon 8/24

11:50 am-5:45 pm

2 stops6h 55m

$385

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Tue 8/11

2:13 pm-9:59 pm

1 stop6h 46m

Savannah/Hilton Head

Thu 8/13

7:05 am-1:32 pm

1 stop7h 27m

$423
Quickest round-trip

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 8/18

5:00 am-10:54 am

1 stop4h 54m

Charlotte Douglas

Sat 8/22

5:04 pm-9:51 pm

1 stop5h 47m

$423

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Wed 8/5

12:20 pm-9:25 pm

2 stops8h 05m

Charlotte Douglas

Tue 8/11

6:50 am-1:40 pm

2 stops7h 50m

$435

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Fri 9/4

8:00 am-5:50 pm

2 stops8h 50m

Charlotte Douglas

Sun 9/6

12:30 pm-10:05 pm

1 stop10h 35m

$446

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Sun 10/25

5:00 am-12:45 pm

1 stop6h 45m

Savannah/Hilton Head

Thu 10/29

7:00 am-1:36 pm

1 stop7h 36m

$475

MidlandMyrtle Beach

MAF - MYR

MAFMYR

Midland Intl

Mon 12/14

5:00 am-2:33 pm

2 stops8h 33m

Myrtle Beach Intl

Tue 12/15

11:25 am-11:30 pm

2 stops13h 05m

$514

MidlandMyrtle Beach

MAF - MYR

MAFMYR

Midland Intl

Wed 8/5

8:00 am-3:37 pm

1 stop6h 37m

Myrtle Beach Intl

Sun 8/9

5:00 am-1:51 pm

2 stops9h 51m

$830

MidlandMyrtle Beach

MAF - MYR

MAFMYR

Midland Intl

Mon 8/3

5:00 am-2:19 pm

2 stops8h 19m

Myrtle Beach Intl

Fri 8/7

10:34 am-4:15 pm

2 stops30h 41m

$857

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/22

Showing 1-10 of 17 resultsSorted by cheapest first
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Best time to book a flight from Odessa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to South Carolina

No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Odessa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Odessa to South Carolina?

    For as low as $375, American Airlines can have you in South Carolina from Odessa in 6h 12m. There are 1241 mi between Odessa and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Odessa to South Carolina?

    While some choose either Midland Intl - Myrtle Beach Intl or Midland Intl - Savannah/Hilton Head, Midland Intl - Charlotte Douglas is the most popular route from Odessa to South Carolina.

  • Can I find deals for flights from Odessa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Odessa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to South Carolina.

  • Can I find deals for business class flights from Odessa to South Carolina?

    Yes. Cheapflights offers flight deals from Odessa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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