$170+ Cheap flights from Odessa, TX to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — CHS
Oct 13 — Oct 201
Round-trip
1 adult, Economy
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Find cheap flights from Odessa to South Carolina with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Odessa to South Carolina
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Cheapest flights from Odessa to South CarolinaExplore the most affordable flight options available from Odessa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
Explore the most affordable flight options available from Odessa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:30 am -
2 stops7h 05m
Mon 11/23:35 pm -
2 stops9h 30m
Deal found 9/9![Southwest logo]()
$414
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:23 pm -
1 stop5h 36m
Sat 10/31:05 pm -
1 stop4h 37m
Deal found 9/10![American Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
1 stop4h 57m
Wed 11/114:18 pm -
1 stop6h 57m
Deal found 9/10![United Airlines logo]()
$429
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:40 am -
1 stop5h 55m
Wed 10/281:15 pm -
1 stop7h 40m
Deal found 9/13![Southwest logo]()
$437
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:00 am -
2 stops11h 11m
Wed 11/1811:27 am -
2 stops11h 31m
Deal found 9/10![United Airlines logo]()
$456
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2512:55 pm -
2 stops8h 00m
Sat 10/311:35 am -
2 stops10h 10m
Deal found 9/10![Southwest logo]()
$499
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:23 pm -
1 stop5h 36m
Tue 9/295:05 pm -
1 stop5h 14m
Deal found 9/10![American Airlines logo]()
$517
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2512:55 pm -
2 stops8h 00m
Tue 9/2912:35 pm -
1 stop6h 05m
Deal found 9/10![Southwest logo]()
$568
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/121:30 pm -
1 stop6h 45m
Wed 9/164:23 pm -
1 stop6h 46m
Deal found 9/10![United Airlines logo]()
$691
Best flights from Odessa to South CarolinaDiscover carefully curated flight deals from Odessa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
Discover carefully curated flight deals from Odessa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:30 am -
2 stops7h 05m
Mon 11/23:35 pm -
2 stops9h 30m
Deal found 9/9![Southwest logo]()
$414
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:23 pm -
1 stop5h 36m
Sat 10/31:05 pm -
1 stop4h 37m
Deal found 9/10![American Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
1 stop4h 57m
Wed 11/114:18 pm -
1 stop6h 57m
Deal found 9/10![United Airlines logo]()
$429
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:40 am -
1 stop5h 55m
Wed 10/281:15 pm -
1 stop7h 40m
Deal found 9/13![Southwest logo]()
$437
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:00 am -
2 stops11h 11m
Wed 11/1811:27 am -
2 stops11h 31m
Deal found 9/10![United Airlines logo]()
$456
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2512:55 pm -
2 stops8h 00m
Sat 10/311:35 am -
2 stops10h 10m
Deal found 9/10![Southwest logo]()
$499
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2512:55 pm -
2 stops8h 00m
Tue 9/2912:35 pm -
1 stop6h 05m
Deal found 9/10![Southwest logo]()
$568
Last-minute flights from Odessa to South CarolinaDiscover last-minute flight deals from Odessa to South Carolina. Data last updated September 13, 2026 and is based on user searches.
Discover last-minute flight deals from Odessa to South Carolina. Data last updated September 13, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/121:30 pm -
1 stop6h 45m
Wed 9/164:23 pm -
1 stop6h 46m
Deal found 9/10![United Airlines logo]()
$691
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:23 pm -
1 stop5h 36m
Sat 10/31:05 pm -
1 stop4h 37m
Deal found 9/10![American Airlines logo]()
$428
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2512:55 pm -
2 stops8h 00m
Sat 10/311:35 am -
2 stops10h 10m
Deal found 9/10![Southwest logo]()
$499
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:23 pm -
1 stop5h 36m
Tue 9/295:05 pm -
1 stop5h 14m
Deal found 9/10![American Airlines logo]()
$517
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2512:55 pm -
2 stops8h 00m
Tue 9/2912:35 pm -
1 stop6h 05m
Deal found 9/10![Southwest logo]()
$568
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:40 am -
1 stop5h 55m
Wed 10/281:15 pm -
1 stop7h 40m
Deal found 9/13![Southwest logo]()
$437
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:30 am -
2 stops7h 05m
Mon 11/23:35 pm -
2 stops9h 30m
Deal found 9/9![Southwest logo]()
$414
One-way flights from Odessa to South CarolinaSearch for one-way flight options from Odessa to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
Search for one-way flight options from Odessa to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/92:25 pm -
1 stop6h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![United Airlines logo]()
$170
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
1 stop5h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![American Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/108:55 am -
2 stops7h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Southwest logo]()
$224
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1311:56 am -
2 stops11h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![United Airlines logo]()
$234
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:23 pm -
1 stop5h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$259
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/292:23 pm -
1 stop7h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2912:25 pm -
2 stops8h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Southwest logo]()
$274
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2512:55 pm -
2 stops8h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Southwest logo]()
$310
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:00 am -
1 stop8h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![United Airlines logo]()
$328
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/198:20 am -
2 stops9h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Southwest logo]()
$333
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/122:16 pm -
1 stop6h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![American Airlines logo]()
$424
Find flight deals from Odessa to South Carolina
Keep the following information in mind while searching for Odessa to South Carolina flight deals. Data was last updated September 13, 2026.
Round-trip from | $414 (Southwest) |
|---|---|
One-way from | $170 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Odessa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
Use the filters below to find and compare flights from Odessa to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MidlandCharlotte
MAF Midland Intl - CLT Charlotte Douglas
MAFCLT
Midland Intl
Sat 1/9
2:25 pm-9:52 pm
1 stop6h 27m
Charlotte Douglas
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$170
Quickest round-trip
MidlandCharlotte
MAF Midland Intl - CLT Charlotte Douglas
MAFCLT
Midland Intl
Tue 10/13
6:00 am-12:12 pm
1 stop5h 12m
Charlotte Douglas
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
MidlandCharlotte
MAF Midland Intl - CLT Charlotte Douglas
MAFCLT
Midland Intl
Sun 1/10
5:00 am-12:07 pm
1 stop6h 07m
Charlotte Douglas
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
MidlandCharlotte
MAF Midland Intl - CLT Charlotte Douglas
MAFCLT
Midland Intl
Sun 1/10
8:55 am-5:10 pm
2 stops7h 15m
Charlotte Douglas
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$224
MidlandCharlotte
MAF Midland Intl - CLT Charlotte Douglas
MAFCLT
Midland Intl
Tue 10/13
11:56 am-11:59 pm
2 stops11h 03m
Charlotte Douglas
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$234
MidlandCharlotte
MAF Midland Intl - CLT Charlotte Douglas
MAFCLT
Midland Intl
Tue 10/13
8:35 am-6:10 pm
2 stops8h 35m
Charlotte Douglas
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$234
MidlandCharlotte
MAF Midland Intl - CLT Charlotte Douglas
MAFCLT
Midland Intl
Fri 9/25
5:23 pm-11:59 pm
1 stop5h 36m
Charlotte Douglas
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$259
MidlandCharlotte
MAF Midland Intl - CLT Charlotte Douglas
MAFCLT
Midland Intl
Tue 9/29
2:23 pm-10:33 pm
1 stop7h 10m
Charlotte Douglas
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$269
MidlandCharlotte
MAF Midland Intl - CLT Charlotte Douglas
MAFCLT
Midland Intl
Wed 9/30
12:20 pm-9:15 pm
2 stops7h 55m
Charlotte Douglas
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$274
MidlandCharlotte
MAF Midland Intl - CLT Charlotte Douglas
MAFCLT
Midland Intl
Tue 9/29
12:25 pm-9:30 pm
2 stops8h 05m
Charlotte Douglas
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$274
Showing 1-10 of 18 resultsSorted by cheapest first
Best time to book a flight from Odessa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Odessa with our price prediction graph.
MAF-CLT
MAF-SAV
MAF-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Odessa to South Carolina
OD3-USSC
MAF-CLT
MAF-SAV
MAF-MYR
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 13, 2026.
Read reviews from past customers who have flown Southwest and American Airlines from Odessa to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Related info for your journey
Find useful and relevant information for your journey from Odessa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Odessa to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Odessa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Odessa and South Carolina flights
Browse other Odessa and South Carolina flight options. Last updated on September 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Odessa after your stay in South Carolina
Top 2 airlines flying from Odessa to South Carolina
Discover the top 2 airlines that operate flights from Odessa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$372 | Average$390 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$540 | Average$817 | FlexibilityNo cancel fee | On-time71% |