In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

What are the most popular routes from Odessa to South Carolina?

While some choose either Midland Intl - Savannah/Hilton Head or Midland Intl - Myrtle Beach Intl, Midland Intl - Charlotte Douglas is the most popular route from Odessa to South Carolina.

What is the cheapest time of day to fly from OD3 to SC?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Odessa to South Carolina as you normally would.

Can I find deals for flights from Odessa to South Carolina that include hotel bookings?

Yes. In addition to deals on Odessa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Odessa to South Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to South Carolina.

Can I find deals for business class flights from Odessa to South Carolina?

Yes. Cheapflights offers flight deals from Odessa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Find Cheap Flights from Odessa to South Carolina

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Reviews of airlines servicing South Carolina

Read reviews from past customers who have flown Southwest and American Airlines from Odessa to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,224 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Southwest

7.9

Good

4,224 reviews

Southwest

7.9

Good

4,224 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

American Airlines

7.0

Good

12,193 reviews

Southwest

7.9

Good

4,224 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Related info for your journey

What are the most popular routes from Odessa to South Carolina?
While some choose either Midland Intl - Savannah/Hilton Head or Midland Intl - Myrtle Beach Intl, Midland Intl - Charlotte Douglas is the most popular route from Odessa to South Carolina.
Can I find deals for flights from Odessa to South Carolina that include hotel bookings?
Yes. In addition to deals on Odessa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Odessa to South Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to South Carolina.
Can I find deals for business class flights from Odessa to South Carolina?
Yes. Cheapflights offers flight deals from Odessa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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Top 2 airlines flying from Odessa to South Carolina

Airline	Cheapest	Average	Flexibility	On-time
Southwest	Cheapest$372	Average$390	FlexibilityNo cancel fee	On-time63%
American Airlines	Cheapest$540	Average$817	FlexibilityNo cancel fee	On-time71%

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Find cheap flights from Odessa to South Carolina with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Reviews of airlines servicing South Carolina

Read reviews from past customers who have flown Southwest and American Airlines from Odessa to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What are the most popular routes from Odessa to South Carolina?

Can I find deals for flights from Odessa to South Carolina that include hotel bookings?

How can I find direct flights from Odessa to South Carolina?

Can I find deals for business class flights from Odessa to South Carolina?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Odessa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Complete your trip

Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Odessa to South Carolina by cabin class

Find flights from Odessa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Odessa and South Carolina flights

Browse other Odessa and South Carolina flight options. Last updated on October 25, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Find a return flight route from South Carolina

Find the right flight back to Odessa after your stay in South Carolina

Top 2 airlines flying from Odessa to South Carolina

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Book with Flexibility

Travel Smart

Cheap flights from Odessa, TX to South Carolina

Find cheap flights from Odessa to South Carolina with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Reviews of airlines servicing South Carolina

Read reviews from past customers who have flown Southwest and American Airlines from Odessa to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What are the most popular routes from Odessa to South Carolina?

Can I find deals for flights from Odessa to South Carolina that include hotel bookings?

How can I find direct flights from Odessa to South Carolina?

Can I find deals for business class flights from Odessa to South Carolina?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Odessa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Complete your trip

Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Odessa to South Carolina by cabin class

Find flights from Odessa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Odessa and South Carolina flights

Browse other Odessa and South Carolina flight options. Last updated on October 25, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Find a return flight route from South Carolina

Find the right flight back to Odessa after your stay in South Carolina

Top 2 airlines flying from Odessa to South Carolina

100% Free

Book with Flexibility

Travel Smart