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South Carolina

$335+ Cheap flights from Odessa, TX to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/18. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — CHS
Jul 7 — Jul 141
Tue 7/7
Tue 7/14
1 adult, Economy
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Cheap flight deals from Odessa to South Carolina

Cheapest flights from Odessa to South Carolina
Explore the most affordable flight options available from Odessa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 7, 2026.

This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:00 am
MAF
-
CLT
1 stop4h 44m
American Airlines
Wed 7/156:00 pm
CLT
-
MAF
1 stop6h 59m
American Airlines
Deal found 6/2$412
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:40 pm
MAF
-
CLT
2 stops7h 35m
Southwest
Wed 7/811:50 am
CLT
-
MAF
2 stops7h 40m
Southwest
Deal found 6/3$438
This United Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:55 am
MAF
-
SAV
1 stop4h 45m
United Airlines
Wed 9/304:10 pm
SAV
-
MAF
1 stop6h 59m
United Airlines
Deal found 6/2$461
This United Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:40 pm
MAF
-
CLT
1 stop8h 46m
United Airlines
Wed 9/24:23 pm
CLT
-
MAF
1 stop6h 46m
United Airlines
Deal found 6/2$461
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/117:45 am
MAF
-
CLT
2 stops8h 35m
Southwest
Wed 7/154:20 pm
CLT
-
MAF
1 stop7h 55m
Southwest
Deal found 6/2$482
This United Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:00 am
MAF
-
MYR
2 stops9h 49m
United Airlines
Wed 11/181:00 pm
MYR
-
MAF
2 stops11h 30m
United Airlines
Deal found 6/2$487
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:46 pm
MAF
-
CLT
1 stop5h 13m
American Airlines
Tue 7/287:52 pm
CLT
-
MAF
1 stop5h 07m
American Airlines
Deal found 6/4$500
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:42 pm
MAF
-
SAV
1 stop7h 45m
American Airlines
Fri 6/197:44 pm
SAV
-
MAF
1 stop5h 15m
American Airlines
Deal found 6/2$507
This Southwest deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/192:40 pm
MAF
-
CLT
2 stops7h 35m
Southwest
Tue 6/234:20 pm
CLT
-
MAF
1 stop7h 50m
Southwest
Deal found 6/4$512
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/159:55 am
MAF
-
MYR
2 stops10h 20m
Southwest
Sat 7/253:00 pm
MYR
-
MAF
2 stops8h 35m
Southwest
Deal found 6/2$522
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:30 pm
MAF
-
SAV
1 stop6h 45m
United Airlines
Wed 11/1811:00 am
SAV
-
MAF
2 stops11h 24m
United Airlines
Deal found 6/6$522
This Southwest deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1911:30 am
MAF
-
SAV
2 stops8h 40m
Southwest
Tue 6/231:25 pm
SAV
-
MAF
2 stops10h 35m
Southwest
Deal found 6/4$528

Find flight deals from Odessa to South Carolina

Keep the following information in mind while searching for Odessa to South Carolina flight deals. Data was last updated June 7, 2026.

Round-trip from

$412
(American Airlines)

One-way from

$335
(Southwest)
From Odessa to South Carolina
Search Deals
One-way flight from Odessa to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 7, 2026.
Use the filters below to find and compare flights from Odessa to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 9/1

1:40 pm-11:26 pm

1 stop8h 46m

Charlotte Douglas

Wed 9/2

4:23 pm-10:09 pm

1 stop6h 46m

$461

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Thu 7/2

2:40 pm-8:35 pm

1 stop4h 55m

Charlotte Douglas

Wed 7/8

4:20 pm-11:15 pm

1 stop7h 55m

$477

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 7/11

7:45 am-5:20 pm

2 stops8h 35m

Charlotte Douglas

Wed 7/15

4:20 pm-11:15 pm

1 stop7h 55m

$482
Quickest round-trip

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Wed 7/22

6:46 pm-12:59 am

1 stop5h 13m

Charlotte Douglas

Tue 7/28

7:52 pm-11:59 pm

1 stop5h 07m

$500

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Tue 6/16

2:42 pm-11:27 pm

1 stop7h 45m

Savannah/Hilton Head

Fri 6/19

7:44 pm-11:59 pm

1 stop5h 15m

$507

MidlandMyrtle Beach

MAF - MYR

MAFMYR

Midland Intl

Wed 7/15

9:55 am-9:15 pm

2 stops10h 20m

Myrtle Beach Intl

Sat 7/25

3:00 pm-10:35 pm

2 stops8h 35m

$522

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Fri 6/19

11:30 am-7:20 pm

1 stop6h 50m

Savannah/Hilton Head

Tue 6/23

1:25 pm-11:10 pm

2 stops10h 45m

$553

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Fri 6/19

2:15 pm-9:55 pm

1 stop6h 40m

Savannah/Hilton Head

Tue 6/23

3:45 pm-9:57 pm

1 stop7h 12m

$583

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Fri 6/19

11:30 am-9:10 pm

2 stops8h 40m

Savannah/Hilton Head

Sat 6/20

11:30 am-10:30 pm

2 stops12h 00m

$610

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Thu 6/11

11:57 am-6:22 pm

1 stop5h 25m

Savannah/Hilton Head

Sat 6/13

3:45 pm-9:57 pm

1 stop7h 12m

$724

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/4

Showing 1-10 of 15 resultsSorted by cheapest first
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Best time to book a flight from Odessa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Odessa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Odessa to South Carolina?

    For as low as $507, United Airlines can have you in South Carolina from Odessa in 7h 45m. There are 1227 mi between Odessa and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Odessa to South Carolina?

    While some choose either Midland Intl - Charlotte Douglas or Midland Intl - Myrtle Beach Intl, Midland Intl - Savannah/Hilton Head is the most popular route from Odessa to South Carolina.

  • Can I find deals for flights from Odessa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Odessa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to South Carolina.

  • Can I find deals for business class flights from Odessa to South Carolina?

    Yes. Cheapflights offers flight deals from Odessa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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