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South Carolina

$214+ Cheap flights from Odessa, TX to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — CHS
May 22 — May 291
Fri 5/22
Fri 5/29
1 adult, Economy
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Cheap flight deals from Odessa to South Carolina

Cheapest flights from Odessa to South Carolina
Explore the most affordable flight options available from Odessa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.

This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:30 am
MAF
-
SAV
1 stop6h 27m
United Airlines
Wed 8/263:39 pm
SAV
-
MAF
1 stop6h 48m
United Airlines
Deal found 4/20$365
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:00 am
MAF
-
MYR
2 stops8h 15m
United Airlines
Wed 8/2610:00 am
MYR
-
MAF
2 stops12h 27m
United Airlines
Deal found 4/20$387
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:35 am
MAF
-
CLT
1 stop6h 00m
Southwest
Tue 10/131:05 pm
CLT
-
MAF
1 stop7h 35m
Southwest
Deal found 4/19$427
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:35 am
MAF
-
CLT
2 stops7h 10m
Southwest
Sun 5/312:50 pm
CLT
-
MAF
2 stops10h 20m
Southwest
Deal found 4/20$437
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/810:35 am
MAF
-
CLT
1 stop7h 00m
Southwest
Mon 10/121:20 pm
CLT
-
MAF
2 stops7h 20m
Southwest
Deal found 4/18$452
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:15 pm
MAF
-
CLT
2 stops7h 50m
Southwest
Mon 7/64:00 pm
CLT
-
MAF
2 stops8h 05m
Southwest
Deal found 4/19$457
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:00 am
MAF
-
MYR
1 stop6h 37m
American Airlines
Tue 8/254:23 pm
MYR
-
MAF
1 stop6h 01m
American Airlines
Deal found 4/18$492
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:00 am
MAF
-
CLT
1 stop6h 40m
Southwest
Sat 5/96:10 am
CLT
-
MAF
1 stop6h 25m
Southwest
Deal found 4/20$507
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:00 am
MAF
-
MYR
2 stops12h 03m
United Airlines
Wed 6/103:08 pm
MYR
-
MAF
2 stops9h 36m
United Airlines
Deal found 4/16$508
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:13 pm
MAF
-
CLT
1 stop6h 26m
United Airlines
Sat 5/96:30 am
CLT
-
MAF
1 stop8h 02m
United Airlines
Deal found 4/18$532
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:00 am
MAF
-
MYR
2 stops8h 15m
United Airlines
Tue 8/253:21 pm
MYR
-
MAF
2 stops9h 16m
United Airlines
Deal found 4/18$558
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:00 am
MAF
-
MYR
2 stops8h 18m
United Airlines
Sat 5/911:30 am
MYR
-
MAF
2 stops11h 16m
United Airlines
Deal found 4/20$667

Find flight deals from Odessa to South Carolina

Keep the following information in mind while searching for Odessa to South Carolina flight deals. Data was last updated April 22, 2026.

Round-trip from

$365
(United Airlines)

One-way from

$214
(American Airlines)
From Odessa to South Carolina
Search Deals
One-way flight from Odessa to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Odessa to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Tue 8/25

7:30 am-2:57 pm

1 stop6h 27m

Savannah/Hilton Head

Wed 8/26

3:39 pm-9:27 pm

1 stop6h 48m

$365

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Thu 6/25

1:30 pm-11:15 pm

2 stops8h 45m

Charlotte Douglas

Thu 7/2

6:35 am-12:55 pm

2 stops7h 20m

$437

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Thu 10/8

10:35 am-6:35 pm

1 stop7h 00m

Charlotte Douglas

Mon 10/12

1:20 pm-7:40 pm

2 stops7h 20m

$452

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 6/30

1:15 pm-10:05 pm

2 stops7h 50m

Charlotte Douglas

Mon 7/6

4:00 pm-11:05 pm

2 stops8h 05m

$457

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Thu 5/28

9:50 am-7:50 pm

1 stop9h 00m

Charlotte Douglas

Sun 5/31

2:50 pm-11:30 pm

1 stop9h 40m

$504
Quickest round-trip

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 5/5

11:00 am-6:40 pm

1 stop6h 40m

Charlotte Douglas

Sat 5/9

6:10 am-11:35 am

1 stop6h 25m

$507

MidlandMyrtle Beach

MAF - MYR

MAFMYR

Midland Intl

Tue 6/9

5:00 am-6:03 pm

2 stops12h 03m

Myrtle Beach Intl

Wed 6/10

3:08 pm-11:44 pm

2 stops9h 36m

$508

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 5/5

7:20 am-3:15 pm

1 stop6h 55m

Charlotte Douglas

Sat 5/9

6:30 am-1:32 pm

1 stop8h 02m

$532

MidlandMyrtle Beach

MAF - MYR

MAFMYR

Midland Intl

Tue 5/5

5:00 am-2:18 pm

2 stops8h 18m

Myrtle Beach Intl

Sat 5/9

11:30 am-9:46 pm

2 stops11h 16m

$667

MidlandMyrtle Beach

MAF - MYR

MAFMYR

Midland Intl

Fri 5/15

12:46 pm-11:57 pm

2 stops10h 11m

Myrtle Beach Intl

Tue 5/19

4:47 pm-9:42 am

1 stop17h 55m

$1,368

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/19

Showing 1-10 of 14 resultsSorted by cheapest first
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Best time to book a flight from Odessa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Odessa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Odessa to South Carolina?

    For as low as $365, United Airlines can have you in South Carolina from Odessa in 6h 27m. There are 1227 mi between Odessa and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Odessa to South Carolina?

    While some choose either Midland Intl - Myrtle Beach Intl or Midland Intl - Savannah/Hilton Head, Midland Intl - Charlotte Douglas is the most popular route from Odessa to South Carolina.

  • Can I find deals for flights from Odessa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Odessa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to South Carolina.

  • Can I find deals for business class flights from Odessa to South Carolina?

    Yes. Cheapflights offers flight deals from Odessa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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