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South Carolina

$161+ Cheap flights from Melbourne, FL (MLB) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
MLB — CHS
Apr 16 — Apr 231
Thu 4/16
Thu 4/23
1 adult, Economy
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Cheap flight deals from Melbourne to South Carolina

Cheapest flights from Melbourne to South Carolina
Explore the most affordable flight options available from Melbourne to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.

This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
MLB
-
GSP
1 stop4h 20m
Delta
Sun 5/37:59 pm
GSP
-
MLB
1 stop3h 51m
Delta
Deal found 3/17$329
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2011:54 am
MLB
-
CLT
Nonstop1h 57m
American Airlines
Sat 5/234:36 pm
CLT
-
MLB
Nonstop2h 01m
American Airlines
Deal found 3/14$351
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/295:55 am
MLB
-
GSP
1 stop3h 30m
Delta
Sat 1/25:05 pm
GSP
-
MLB
1 stop5h 37m
Delta
Deal found 3/16$357
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/265:55 am
MLB
-
GSP
1 stop3h 30m
Delta
Mon 1/45:40 am
GSP
-
MLB
1 stop4h 54m
Delta
Deal found 3/16$367
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:35 pm
MLB
-
CLT
Nonstop1h 59m
American Airlines
Sun 5/249:10 am
CLT
-
MLB
Nonstop2h 01m
American Airlines
Deal found 3/16$371
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:22 am
MLB
-
CLT
Nonstop1h 58m
American Airlines
Mon 4/273:15 pm
CLT
-
MLB
Nonstop1h 50m
American Airlines
Deal found 3/13$375
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1711:20 am
MLB
-
SAV
1 stop6h 28m
Delta
Sun 6/215:30 am
SAV
-
MLB
1 stop5h 04m
Delta
Deal found 3/15$377
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:18 pm
MLB
-
CHS
1 stop3h 38m
Delta
Fri 6/55:15 am
CHS
-
MLB
1 stop5h 10m
Delta
Deal found 3/16$377
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:43 pm
MLB
-
CAE
1 stop5h 13m
Delta
Sat 4/254:01 pm
CAE
-
MLB
1 stop5h 38m
Delta
Deal found 3/16$385
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:28 pm
MLB
-
CAE
1 stop4h 31m
Delta
Mon 4/275:47 pm
CAE
-
MLB
1 stop6h 03m
Delta
Deal found 3/14$387
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:46 am
MLB
-
GSP
1 stop3h 18m
Delta
Mon 5/187:42 pm
GSP
-
MLB
1 stop4h 04m
Delta
Deal found 3/16$387
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/295:55 am
MLB
-
GSP
1 stop3h 30m
Delta
Sun 1/35:40 am
GSP
-
MLB
1 stop4h 54m
Delta
Deal found 3/16$393

Find flight deals from Melbourne to South Carolina

Keep the following information in mind while searching for Melbourne to South Carolina flight deals. Data was last updated March 17, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$329
(Delta)

One-way from

$161
(Kiwi.com)

Popular in

February

Cheapest in

July

Average price

$183
Provider with most accurate pricing for Orlando (ORL)-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Orlando (ORL)-Myrtle Beach Intl flights.
Search Deals
From Melbourne to South Carolina
Search Deals
One-way flight from Melbourne to South Carolina
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($18 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Melbourne to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Melbourne to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MelbourneGreenville

MLB - GSP

MLBGSP

Melbourne

Tue 4/28

6:00 am-10:20 am

1 stop4h 20m

Greenville

Sun 5/3

7:59 pm-11:50 pm

1 stop3h 51m

$329
Quickest round-trip

MelbourneCharlotte

MLB - CLT

MLBCLT

Melbourne

Thu 8/6

8:21 am-10:10 am

Nonstop1h 49m

Charlotte Douglas

Tue 8/11

11:25 am-1:18 pm

Nonstop1h 53m

$375

MelbourneCharlotte

MLB - CLT

MLBCLT

Melbourne

Fri 5/8

6:22 am-8:20 am

Nonstop1h 58m

Charlotte Douglas

Sat 5/9

10:30 pm-12:14 am

Nonstop1h 44m

$375

MelbourneSavannah

MLB - SAV

MLBSAV

Melbourne

Wed 6/17

11:20 am-5:48 pm

1 stop6h 28m

Savannah/Hilton Head

Sun 6/21

5:30 am-10:34 am

1 stop5h 04m

$377

MelbourneCharleston

MLB - CHS

MLBCHS

Melbourne

Wed 5/27

7:18 pm-11:59 pm

1 stop4h 41m

Charleston

Sat 6/13

5:55 pm-10:46 pm

1 stop4h 51m

$377

MelbourneColumbia

MLB - CAE

MLBCAE

Melbourne

Thu 4/23

12:28 pm-4:59 pm

1 stop4h 31m

Columbia Metropolitan

Mon 4/27

5:47 pm-11:50 pm

1 stop6h 03m

$387

MelbourneGreenville

MLB - GSP

MLBGSP

Melbourne

Fri 5/29

2:39 pm-8:13 pm

1 stop5h 34m

Greenville

Mon 6/1

7:42 pm-11:46 pm

1 stop4h 04m

$387

MelbourneGreenville

MLB - GSP

MLBGSP

Melbourne

Thu 5/14

7:18 pm-11:43 pm

1 stop4h 25m

Greenville

Mon 5/18

7:42 pm-11:46 pm

1 stop4h 04m

$387

MelbourneGreenville

MLB - GSP

MLBGSP

Melbourne

Fri 5/29

7:18 pm-11:43 pm

1 stop4h 25m

Greenville

Sun 5/31

6:45 am-10:25 am

1 stop3h 40m

$387

MelbourneGreenville

MLB - GSP

MLBGSP

Melbourne

Tue 3/31

6:00 am-11:05 am

1 stop5h 05m

Greenville

Sat 4/4

5:38 pm-9:41 pm

1 stop4h 03m

$403

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/12

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Melbourne to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Melbourne with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Melbourne to South Carolina

What is the cheapest month to book a flight from Melbourne, Florida to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Melbourne, Florida to South Carolina (average of $46). Flying from Melbourne, Florida to South Carolina in February is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 17, 2026.
Read through reviews of airlines operating flights from Melbourne to South Carolina, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,288 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,288 reviews
Delta
7.9
Good
8,288 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.1
Good
11,468 reviews
Delta
7.9
Good
8,288 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Melbourne to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Melbourne to South Carolina?

    Located just 2.7 mi from the city center, Melbourne (MLB) is the airport most travelers will use when flying to South Carolina from Melbourne.

  • How long is the flight from Melbourne, Florida to South Carolina?

    A quick flight from Melbourne, Florida to South Carolina can take about 1h 49m. Delta provides one of the quickest options available for as low as $375. There are 492 mi between Melbourne, Florida and South Carolina. This flight may include one or multiple stops.

  • What are the most popular routes from Melbourne, Florida to South Carolina?

    While some choose either Melbourne - Charlotte Douglas or Melbourne - Greenville, Melbourne - Columbia Metropolitan is the most popular route from Melbourne, Florida to South Carolina.

  • Can I find deals for flights from Melbourne to South Carolina that include hotel bookings?

    Yes. In addition to deals on Melbourne to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Melbourne to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Melbourne to South Carolina.

  • Can I find deals for business class flights from Melbourne to South Carolina?

    Yes. Cheapflights offers flight deals from Melbourne to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Melbourne, Florida to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Melbourne, Florida to South Carolina (average of $46). Flying from Melbourne, Florida to South Carolina in February is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Melbourne to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Melbourne to South Carolina

Discover the top 2 airlines that operate flights from Melbourne to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$276Average$406FlexibilityNo cancel feeOn-time71%
DeltaCheapest$297Average$336FlexibilityNo cancel feeOn-timeN/A

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