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South Carolina

$73+ Cheap flights from Key West (EYW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/3. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Apr 21 — Apr 281
Tue 4/21
Tue 4/28
1 adult, Economy
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Cheap flight deals from Key West to South Carolina

Cheapest flights from Key West to South Carolina
Explore the most affordable flight options available from Key West to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/24:22 pm
EYW
-
CHS
1 stop5h 37m
Breeze Airways
Mon 4/68:28 pm
CHS
-
EYW
1 stop15h 53m
Breeze Airways
Deal found 3/17$133
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/39:49 am
EYW
-
CHS
1 stop12h 04m
Breeze Airways
Mon 4/68:28 pm
CHS
-
EYW
1 stop15h 53m
Breeze Airways
Deal found 3/17$143
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/39:49 am
EYW
-
CHS
1 stop12h 04m
Breeze Airways
Tue 4/73:01 pm
CHS
-
EYW
1 stop20h 10m
Breeze Airways
Deal found 3/17$168
This Breeze Airways deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/24:22 pm
EYW
-
CHS
1 stop5h 37m
Breeze Airways
Tue 4/73:01 pm
CHS
-
EYW
1 stop20h 10m
Breeze Airways
Deal found 3/17$169
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:51 am
EYW
-
CHS
1 stop20h 47m
Breeze Airways
Tue 4/143:01 pm
CHS
-
EYW
1 stop20h 10m
Breeze Airways
Deal found 3/21$183
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:51 am
EYW
-
CHS
1 stop20h 47m
Breeze Airways
Sun 4/128:59 pm
CHS
-
EYW
1 stop12h 10m
Breeze Airways
Deal found 3/21$195
This Breeze Airways deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/811:46 am
EYW
-
CHS
1 stop3h 42m
Breeze Airways
Wed 7/158:56 pm
CHS
-
EYW
1 stop22h 20m
Breeze Airways
Deal found 3/19$197
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:51 am
EYW
-
CHS
1 stop20h 47m
Breeze Airways
Mon 4/138:28 pm
CHS
-
EYW
1 stop15h 53m
Breeze Airways
Deal found 3/21$200
This Breeze Airways deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:56 pm
EYW
-
CHS
1 stop18h 48m
Breeze Airways
Sun 8/92:53 pm
CHS
-
EYW
1 stop20h 34m
Breeze Airways
Deal found 3/17$222
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2911:46 am
EYW
-
CHS
1 stop3h 42m
Breeze Airways
Sat 8/18:56 pm
CHS
-
EYW
1 stop22h 20m
Breeze Airways
Deal found 3/19$224
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/812:25 pm
EYW
-
CLT
1 stop12h 13m
Multiple Airlines
Sun 4/124:33 pm
CLT
-
EYW
1 stop19h 53m
Multiple Airlines
Deal found 3/18$225
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:46 am
EYW
-
CLT
1 stop7h 00m
Multiple Airlines
Mon 4/69:00 pm
CLT
-
EYW
2 stops15h 21m
Multiple Airlines
Deal found 3/18$232

Find flight deals from Key West to South Carolina

Keep the following information in mind while searching for Key West to South Carolina flight deals. Data was last updated March 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$133
(Kiwi.com)

One-way from

$73
(Kiwi.com)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
Search Deals
From Key West to South Carolina
Search Deals
One-way flight from Key West to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 4/2

4:22 pm-9:59 pm

1 stop5h 37m

Charleston

Tue 4/7

3:01 pm-11:11 am

1 stop20h 10m

$169

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 4/3

9:49 am-9:53 pm

1 stop12h 04m

Charleston

Tue 4/7

3:01 pm-11:11 am

1 stop20h 10m

$181

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Wed 7/8

11:46 am-3:28 pm

1 stop3h 42m

Charleston

Wed 7/15

8:56 pm-7:16 pm

1 stop22h 20m

$197

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Wed 4/8

11:51 am-8:38 am

1 stop20h 47m

Charleston

Mon 4/13

8:28 pm-12:21 pm

1 stop15h 53m

$200

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 8/6

7:56 pm-2:44 pm

1 stop18h 48m

Charleston

Sun 8/9

2:53 pm-11:27 am

1 stop20h 34m

$222

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Wed 4/8

12:25 pm-12:38 am

1 stop12h 13m

Charlotte Douglas

Sun 4/12

4:33 pm-12:26 pm

1 stop19h 53m

$225

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 4/10

9:49 am-9:53 pm

1 stop12h 04m

Charleston

Mon 4/13

8:28 pm-12:21 pm

1 stop15h 53m

$253

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 4/9

9:46 am-8:43 am

1 stop22h 57m

Charleston

Tue 4/14

3:01 pm-11:11 am

1 stop20h 10m

$279

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 4/9

4:22 pm-9:59 pm

1 stop5h 37m

Charleston

Sun 4/12

8:59 pm-9:09 am

1 stop12h 10m

$286

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Fri 5/1

2:30 pm-10:48 pm

1 stop8h 18m

Savannah/Hilton Head

Mon 5/4

7:30 am-4:58 pm

1 stop9h 28m

$298

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/19

Showing 1-10 of 49 resultsSorted by cheapest first
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Best time to book a flight from Key West to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Key West to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Key West to South Carolina?

    For a flight from Key West to South Carolina, you will be flying from Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from Key West to South Carolina?

    A quick flight from Key West to South Carolina can take about 4h. Breeze Airways provides one of the quickest options available for as low as $407. There are 609 mi between Key West and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Key West to South Carolina?

    When deciding which route to take from Key West to South Carolina consider Key West - Charlotte Douglas, Key West - Charleston or Key West - Savannah/Hilton Head as they are the most popular.

  • Can I find deals for flights from Key West to South Carolina that include hotel bookings?

    Yes. In addition to deals on Key West to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to South Carolina.

  • Can I find deals for business class flights from Key West to South Carolina?

    Yes. Cheapflights offers flight deals from Key West to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Key West to South Carolina

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