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South Carolina

$64+ Cheap flights from Key West (EYW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Key West to South Carolina

Cheapest flights from Key West to South Carolina
Explore the most affordable flight options available from Key West to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2510:59 amEYW - CHS
1 stop3h 29mMultiple Airlines
Sun 12/2810:18 pmCHS - EYW
1 stop15h 12mMultiple Airlines
Deal found 12/10$204
This Expedia deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:30 pmEYW - CLT
1 stop6h 03mSpirit Airlines
Fri 1/29:00 amCLT - EYW
1 stop4h 30mSpirit Airlines
Deal found 12/9$220
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:30 pmEYW - CLT
1 stop6h 03mMultiple Airlines
Fri 1/210:38 pmCLT - EYW
2 stops33h 37mMultiple Airlines
Deal found 12/9$262
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/262:30 pmEYW - SAV
1 stop8h 18mMultiple Airlines
Tue 12/302:30 pmSAV - EYW
1 stop23h 00mMultiple Airlines
Deal found 12/11$263
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/148:55 amEYW - CLT
1 stop24h 42mMultiple Airlines
Thu 1/19:34 pmCLT - EYW
1 stop14h 56mMultiple Airlines
Deal found 12/10$283
This Breeze Airways deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2510:59 amEYW - CHS
1 stop3h 29mBreeze Airways
Sat 12/279:09 pmCHS - EYW
1 stop13h 10mBreeze Airways
Deal found 12/10$303
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/118:55 amEYW - CLT
1 stop11h 05mMultiple Airlines
Fri 12/1210:38 pmCLT - EYW
2 stops33h 37mMultiple Airlines
Deal found 12/10$347
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2510:59 amEYW - CHS
1 stop3h 29mMultiple Airlines
Sat 12/275:20 pmCHS - EYW
2 stops39h 57mMultiple Airlines
Deal found 12/10$359
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/148:55 amEYW - CLT
1 stop11h 05mMultiple Airlines
Sun 12/1410:33 pmCLT - EYW
1 stop9h 42mMultiple Airlines
Deal found 12/10$378
This Breeze Airways deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2310:59 amEYW - CHS
1 stop3h 44mBreeze Airways
Tue 12/309:08 pmCHS - EYW
1 stop9h 59mBreeze Airways
Deal found 12/10$415
This Mytrip deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1412:20 pmEYW - CLT
1 stop11h 39mSpirit Airlines
Thu 1/19:34 pmCLT - EYW
2 stops15h 56mSpirit Airlines
Deal found 12/10$439
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2311:47 amEYW - SAV
1 stop4h 39mDelta
Thu 12/255:30 amSAV - EYW
1 stop5h 22mDelta
Deal found 12/11$524

Find flight deals from Key West to South Carolina

Keep the following information in mind while searching for Key West to South Carolina flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$187
(Kiwi.com)

One-way from

$64
(Breeze Airways)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
Search Deals
From Key West to South Carolina
Search Deals
One-way flight from Key West to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Key West

Fly to

South Carolina

Route

Depart

Return

Price

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Wed 1/7

2:30 pm-8:33 pm

1 stop6h 03m

Charlotte Douglas

Sun 1/11

8:46 pm-12:26 pm

1 stop15h 40m

$187

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Wed 12/31

2:30 pm-8:33 pm

1 stop6h 03m

Charlotte Douglas

Fri 1/2

9:00 am-1:30 pm

1 stop4h 30m

$220

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Fri 2/6

2:25 pm-11:25 pm

1 stop9h 00m

Savannah/Hilton Head

Mon 2/9

7:00 am-1:30 pm

1 stop6h 30m

$229

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 2/13

1:06 pm-9:00 am

1 stop19h 54m

Charlotte Douglas

Mon 2/16

2:43 pm-12:21 pm

1 stop21h 38m

$244

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Fri 12/26

2:30 pm-10:48 pm

1 stop8h 18m

Savannah/Hilton Head

Tue 12/30

2:30 pm-1:30 pm

1 stop23h 00m

$263

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 12/25

10:59 am-2:28 pm

1 stop3h 29m

Charleston

Sun 12/28

10:18 pm-8:39 am

2 stops34h 21m

$264

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 12/25

10:59 am-2:28 pm

1 stop3h 29m

Charleston

Sat 12/27

9:09 pm-10:19 am

1 stop13h 10m

$303

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Sun 12/14

8:55 am-9:37 am

1 stop24h 42m

Charlotte Douglas

Thu 1/1

9:38 pm-12:30 pm

2 stops14h 52m

$316

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 1/16

9:49 am-1:22 pm

1 stop3h 33m

Charleston

Sun 1/18

3:01 pm-12:26 pm

1 stop21h 25m

$326

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Wed 1/7

2:30 pm-2:20 pm

3 stops23h 50m

Charlotte Douglas

Sun 1/11

9:07 pm-1:30 pm

3 stops16h 23m

$337

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 38 results
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Best time to book a flight from Key West to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to South Carolina

What is the cheapest time of day to fly from EYW to SC?

Find hourly flight availability from Key West to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

When flying from Key West to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 26% versus a flight at noon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 12, 2025.
Read through reviews of airlines operating flights from Key West to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,050 reviews

Food

6.5

Comfort

7.2

Crew

8.0

Entertainment

6.9

Overall

7.2

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
11,050 reviews
American Airlines
7.2
Good
11,050 reviews

Food

6.5

Comfort

7.2

Crew

8.0

Entertainment

6.9

Overall

7.2

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Key West to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Key West to South Carolina?

    For a flight from Key West to South Carolina, you will be flying from Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from Key West to South Carolina?

    A quick flight from Key West to South Carolina can take about 3h 29m. Spirit Airlines provides one of the quickest options available for as low as $303. There are 585 mi between Key West and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Key West to South Carolina?

    When deciding which route to take from Key West to South Carolina consider Key West - Charlotte Douglas, Key West - Savannah/Hilton Head or Key West - Charleston as they are the most popular.

  • Can I find deals for flights from Key West to South Carolina that include hotel bookings?

    Yes. In addition to deals on Key West to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to South Carolina.

  • Can I find deals for business class flights from Key West to South Carolina?

    Yes. Cheapflights offers flight deals from Key West to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Key West to South Carolina

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Top airline flying from Key West to South Carolina

Discover the top airline that operate flights from Key West to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$387Average$658FlexibilityNo cancel feeOn-time71%

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