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South Carolina

$91+ Cheap flights from Key West (EYW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Cheap flight deals from Key West to South Carolina

Keep the following information in mind while searching for Key West to South Carolina flight deals. Data was last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$222
(Kiwi.com)

One-way from

$91
(Kiwi.com)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
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From Key West to South Carolina
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One-way flight from Key West to South Carolina
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Find flight deals from Key West to South Carolina

Cheapest flights from Key West to South Carolina
Explore the most affordable flight options available from Key West to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:59 amEYW - CLT
1 stop21h 40mMultiple Airlines
Mon 11/178:58 pmCLT - EYW
1 stop14h 07mMultiple Airlines
Deal found 10/29$222
This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:20 pmEYW - CLT
1 stop11h 39mSpirit Airlines
Sun 12/77:00 amCLT - EYW
1 stop4h 20mSpirit Airlines
Deal found 10/26$224
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/263:55 pmEYW - CLT
1 stop24h 55mMultiple Airlines
Wed 12/33:56 pmCLT - EYW
1 stop23h 48mMultiple Airlines
Deal found 10/29$229
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1111:45 amEYW - CLT
2 stops21h 17mMultiple Airlines
Sat 11/157:59 pmCLT - EYW
1 stop12h 16mMultiple Airlines
Deal found 10/27$259
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/612:15 pmEYW - CHS
1 stop10h 27mMultiple Airlines
Mon 11/109:23 pmCHS - EYW
1 stop13h 42mMultiple Airlines
Deal found 10/28$265
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/610:59 amEYW - CHS
2 stops45h 34mBreeze Airways
Mon 11/109:23 pmCHS - EYW
1 stop13h 42mBreeze Airways
Deal found 10/28$266
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:55 amEYW - SAV
2 stops22h 38mMultiple Airlines
Mon 11/179:24 amSAV - EYW
1 stop9h 01mMultiple Airlines
Deal found 10/29$267
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/267:53 pmEYW - CHS
1 stop4h 10mAmerican Airlines
Wed 12/35:38 pmCHS - EYW
1 stop4h 08mAmerican Airlines
Deal found 10/27$297
This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:20 pmEYW - CLT
3 stops23h 44mMultiple Airlines
Sun 12/712:59 pmCLT - EYW
3 stops24h 40mMultiple Airlines
Deal found 10/26$384
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:00 amEYW - CLT
Nonstop2h 19mAmerican Airlines
Sun 12/77:30 pmCLT - EYW
Nonstop2h 15mAmerican Airlines
Deal found 10/26$389
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/151:57 pmEYW - SAV
1 stop5h 47mAmerican Airlines
Fri 11/218:14 pmSAV - EYW
1 stop3h 36mAmerican Airlines
Deal found 10/26$407
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/132:58 pmEYW - SAV
1 stop4h 16mDelta
Mon 11/1710:42 amSAV - EYW
1 stop6h 41mDelta
Deal found 10/29$447

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Key West

Fly to

South Carolina

Route

Depart

Return

Price

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 11/13

10:59 am-8:39 am

1 stop21h 40m

Charlotte Douglas

Mon 11/17

8:58 pm-11:05 am

1 stop14h 07m

$222

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 12/4

12:20 pm-11:59 pm

1 stop11h 39m

Charlotte Douglas

Sun 12/7

7:00 am-11:20 am

1 stop4h 20m

$224

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Wed 11/26

3:55 pm-4:50 pm

1 stop24h 55m

Charlotte Douglas

Wed 12/3

3:56 pm-3:44 pm

1 stop23h 48m

$229

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Tue 11/11

11:45 am-9:02 am

2 stops21h 17m

Charlotte Douglas

Sat 11/15

7:59 pm-8:15 am

1 stop12h 16m

$259

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Thu 11/13

8:55 am-7:33 am

2 stops22h 38m

Savannah/Hilton Head

Mon 11/17

9:24 am-6:25 pm

1 stop9h 01m

$267

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Wed 11/26

7:53 pm-12:03 am

1 stop4h 10m

Charleston

Wed 12/3

5:38 pm-9:46 pm

1 stop4h 08m

$297

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 1/15

9:46 am-8:03 am

1 stop22h 17m

Charlotte Douglas

Mon 1/19

9:53 pm-1:30 pm

2 stops15h 37m

$322

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 12/4

12:20 pm-12:04 pm

3 stops23h 44m

Charlotte Douglas

Sun 12/7

12:59 pm-1:39 pm

3 stops24h 40m

$384

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 1/15

7:08 am-9:25 am

Nonstop2h 17m

Charlotte Douglas

Mon 1/19

7:30 pm-9:47 pm

Nonstop2h 17m

$387

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 12/4

8:00 am-10:19 am

Nonstop2h 19m

Charlotte Douglas

Sun 12/7

7:30 pm-9:45 pm

Nonstop2h 15m

$389

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 37 results
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Best time to book a flight from Key West to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to South Carolina

What is the cheapest time of day to fly from EYW to SC?

Find hourly flight availability from Key West to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 29, 2025.

When flying from Key West to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 24% versus a flight at noon.

How much does it cost to fly round-trip from Key West to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 29, 2025.
Read through reviews of airlines operating flights from Key West to South Carolina, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,992 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,992 reviews
Delta
7.9
Good
7,992 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,992 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key West to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Key West to South Carolina?

    For a flight from Key West to South Carolina, you will be flying from Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from Key West to South Carolina?

    A quick flight from Key West to South Carolina can take about 4h 10m. Spirit Airlines provides one of the quickest options available for as low as $297. There are 585 mi between Key West and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Key West to South Carolina?

    When deciding which route to take from Key West to South Carolina consider Key West - Charlotte Douglas, Key West - Charleston or Key West - Savannah/Hilton Head as they are the most popular.

  • Can I find deals for flights from Key West to South Carolina that include hotel bookings?

    Yes. In addition to deals on Key West to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to South Carolina.

  • Can I find deals for business class flights from Key West to South Carolina?

    Yes. Cheapflights offers flight deals from Key West to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Key West to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Key West to South Carolina

Discover the top 2 airlines that operate flights from Key West to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$313FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$387Average$658FlexibilityNo cancel feeOn-time71%

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