HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$89+ Cheap flights from Key West (EYW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key West to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Key West to South Carolina

Cheapest flights from Key West to South Carolina
Explore the most affordable flight options available from Key West to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/129:46 am
EYW
-
CHS
1 stop22h 57m
Breeze Airways
Mon 2/168:28 pm
CHS
-
EYW
1 stop15h 53m
Breeze Airways
Deal found 1/28$213
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/129:46 am
EYW
-
CHS
1 stop22h 57m
Multiple Airlines
Mon 2/166:35 pm
CHS
-
EYW
2 stops17h 46m
Multiple Airlines
Deal found 1/28$217
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/129:46 am
EYW
-
CLT
1 stop4h 57m
Multiple Airlines
Mon 2/165:55 am
CLT
-
EYW
1 stop7h 35m
Multiple Airlines
Deal found 1/27$221
This Breeze Airways deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1111:51 am
EYW
-
CHS
1 stop20h 47m
Breeze Airways
Sat 3/145:16 pm
CHS
-
EYW
1 stop22h 26m
Breeze Airways
Deal found 1/26$225
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:25 pm
EYW
-
CLT
1 stop18h 01m
Multiple Airlines
Sun 5/317:18 pm
CLT
-
EYW
1 stop18h 43m
Multiple Airlines
Deal found 1/27$257
This Travelocity deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:25 pm
EYW
-
CLT
1 stop10h 15m
Spirit Airlines
Mon 6/16:00 am
CLT
-
EYW
1 stop7h 30m
Spirit Airlines
Deal found 1/27$259
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/301:06 pm
EYW
-
CLT
1 stop27h 48m
Multiple Airlines
Sun 2/19:59 pm
CLT
-
EYW
1 stop14h 27m
Multiple Airlines
Deal found 1/28$263
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/202:25 pm
EYW
-
SAV
1 stop8h 54m
Multiple Airlines
Mon 2/232:03 pm
SAV
-
EYW
2 stops22h 18m
Multiple Airlines
Deal found 1/27$267
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/12:25 pm
EYW
-
CHS
1 stop27h 15m
Multiple Airlines
Fri 3/65:00 pm
CHS
-
EYW
2 stops39h 06m
Multiple Airlines
Deal found 1/28$267
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2910:06 am
EYW
-
CLT
1 stop7h 53m
Multiple Airlines
Mon 2/27:43 pm
CLT
-
EYW
2 stops38h 26m
Multiple Airlines
Deal found 1/26$280
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1712:15 pm
EYW
-
CLT
1 stop20h 11m
Multiple Airlines
Sun 5/317:18 pm
CLT
-
EYW
1 stop18h 43m
Multiple Airlines
Deal found 1/27$301
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:25 pm
EYW
-
CLT
1 stop18h 01m
Multiple Airlines
Tue 6/28:55 am
CLT
-
EYW
2 stops31h 22m
Multiple Airlines
Deal found 1/27$308

Find flight deals from Key West to South Carolina

Keep the following information in mind while searching for Key West to South Carolina flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$213
(Kiwi.com)

One-way from

$89
(Kiwi.com)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
Search Deals
From Key West to South Carolina
Search Deals
One-way flight from Key West to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Key West

Fly to

South Carolina

Route

Depart

Return

Price

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 2/12

9:46 am-8:43 am

1 stop22h 57m

Charleston

Mon 2/16

8:28 pm-12:21 pm

1 stop15h 53m

$213

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 2/12

9:46 am-8:43 am

1 stop22h 57m

Charleston

Mon 2/16

6:35 pm-12:21 pm

2 stops17h 46m

$217

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 2/12

9:46 am-2:43 pm

1 stop4h 57m

Charlotte Douglas

Mon 2/16

5:55 am-1:30 pm

1 stop7h 35m

$221

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Wed 3/11

11:51 am-8:38 am

1 stop20h 47m

Charleston

Sat 3/14

5:16 pm-3:42 pm

1 stop22h 26m

$225

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Mon 5/18

2:25 pm-8:26 am

1 stop18h 01m

Charlotte Douglas

Sun 5/31

7:18 pm-2:01 pm

1 stop18h 43m

$257

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Mon 5/18

2:25 pm-12:40 am

1 stop10h 15m

Charlotte Douglas

Mon 6/1

6:00 am-1:30 pm

1 stop7h 30m

$259

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Fri 2/20

2:25 pm-11:19 pm

1 stop8h 54m

Savannah/Hilton Head

Mon 2/23

2:03 pm-12:21 pm

2 stops22h 18m

$267

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Sun 3/1

2:25 pm-5:40 pm

1 stop27h 15m

Charleston

Fri 3/6

5:00 pm-8:06 am

2 stops39h 06m

$267

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Sun 5/17

12:15 pm-8:26 am

1 stop20h 11m

Charlotte Douglas

Sun 5/31

7:18 pm-2:01 pm

1 stop18h 43m

$301

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Mon 5/18

2:25 pm-8:26 am

1 stop18h 01m

Charlotte Douglas

Tue 6/2

8:55 am-4:17 pm

2 stops31h 22m

$308

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 38 results
1
2
3
4

Best time to book a flight from Key West to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Key West to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Key West to South Carolina?

    For a flight from Key West to South Carolina, you will be flying from Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from Key West to South Carolina?

    A quick flight from Key West to South Carolina can take about 8h 07m. Breeze Airways provides one of the quickest options available for as low as $384. There are 609 mi between Key West and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Key West to South Carolina?

    When deciding which route to take from Key West to South Carolina consider Key West - Charlotte Douglas, Key West - Savannah/Hilton Head or Key West - Charleston as they are the most popular.

  • Can I find deals for flights from Key West to South Carolina that include hotel bookings?

    Yes. In addition to deals on Key West to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to South Carolina.

  • Can I find deals for business class flights from Key West to South Carolina?

    Yes. Cheapflights offers flight deals from Key West to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key West to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to John F Kennedy Intl flights
Miami to John F Kennedy Intl flights
Fort Lauderdale to Newark flights
Fort Lauderdale to LaGuardia flights
Orlando to John F Kennedy Intl flights
Orlando to Las Vegas flights
Miami to LaGuardia flights
Miami to Newark flights
Fort Lauderdale to Las Vegas flights
Tampa to John F Kennedy Intl flights
Orlando to Los Angeles flights
West Palm Beach to Newark flights
Tampa to LaGuardia flights
Orlando to Newark flights
Orlando to LaGuardia flights
Tampa to Newark flights
Orlando to Denver flights
Miami to Denver flights
West Palm Beach to John F Kennedy Intl flights
Orlando to Seattle flights
Tampa to Seattle flights
Tampa to Las Vegas flights
Miami to Las Vegas flights
Orlando to Dulles Intl flights
Miami to Los Angeles flights
Fort Lauderdale to Atlanta flights
Fort Lauderdale to Denver flights
Miami to Dulles Intl flights
Tampa to Denver flights
West Palm Beach to LaGuardia flights
Tampa to Atlanta flights
Orlando to Dallas/Fort Worth flights
Tampa to Boston flights
Miami to Atlanta flights
Jacksonville to John F Kennedy Intl flights
Tampa to Los Angeles flights
Orlando to Reagan-National flights
Jacksonville to Newark flights
Tampa to Dallas/Fort Worth flights
West Palm Beach to Atlanta flights
Fort Lauderdale to Los Angeles flights
Fort Lauderdale to Dulles Intl flights
Orlando to San Francisco flights
Tampa to Sky Harbor Intl flights
Orlando to Baltimore flights
Orlando to Sky Harbor Intl flights
Miami to Baltimore flights
Orlando to Boston flights
Tampa to Dulles Intl flights
Fort Myers to John F Kennedy Intl flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.