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South Carolina

$109+ Cheap flights from Key West (EYW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Key West to South Carolina

Keep the following information in mind while searching for Key West to South Carolina flight deals. Data was last updated September 15, 2025.

Round-trip from

$230
(Kiwi.com)

One-way from

$109
(Kiwi.com)
From Key West to South Carolina
Search Deals
One-way flight from Key West to South Carolina
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Find flight deals from Key West to South Carolina

Cheapest flights from Key West to South Carolina
Explore the most affordable flight options available from Key West to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2912:32 pmEYW - CLT
1 stop6h 33mMultiple Airlines
Fri 10/312:38 pmCLT - EYW
1 stop21h 29mMultiple Airlines
Deal found 9/14$230
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2210:47 amEYW - CHS
1 stop3h 42mBreeze Airways
Mon 12/19:23 pmCHS - EYW
1 stop13h 42mBreeze Airways
Deal found 9/14$249
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:59 amEYW - CLT
1 stop26h 22mMultiple Airlines
Tue 12/96:25 amCLT - EYW
2 stops27h 42mMultiple Airlines
Deal found 9/13$257
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/258:55 amEYW - CLT
1 stop23h 15mMultiple Airlines
Tue 9/304:08 pmCLT - EYW
2 stops40h 07mMultiple Airlines
Deal found 9/13$259
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2912:32 pmEYW - CHS
2 stops34h 11mMultiple Airlines
Fri 10/39:23 pmCHS - EYW
1 stop12h 44mMultiple Airlines
Deal found 9/14$260
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/68:55 amEYW - CLT
1 stop7h 00mMultiple Airlines
Tue 11/1111:00 amCLT - EYW
2 stops23h 07mMultiple Airlines
Deal found 9/13$281
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/68:06 amEYW - CLT
Nonstop2h 19mAmerican Airlines
Tue 11/117:33 pmCLT - EYW
Nonstop2h 15mAmerican Airlines
Deal found 9/13$305
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/298:47 amEYW - CHS
1 stop23h 50mBreeze Airways
Fri 10/39:23 pmCHS - EYW
1 stop12h 44mBreeze Airways
Deal found 9/14$321
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:40 amEYW - CLT
1 stop6h 02mDelta
Tue 11/117:55 amCLT - EYW
1 stop6h 08mDelta
Deal found 9/13$325
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2210:47 amEYW - CHS
2 stops23h 58mMultiple Airlines
Mon 12/19:23 pmCHS - EYW
1 stop13h 42mMultiple Airlines
Deal found 9/14$343
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2812:29 pmEYW - CLT
2 stops48h 24mMultiple Airlines
Thu 10/27:16 pmCLT - EYW
1 stop12h 59mMultiple Airlines
Deal found 9/13$352
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:17 pmEYW - SAV
1 stop5h 26mDelta
Tue 11/118:00 amSAV - EYW
1 stop6h 03mDelta
Deal found 9/12$373

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Key West

Fly to

South Carolina

Route

Depart

Return

Price

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Mon 9/29

12:32 pm-7:05 pm

1 stop6h 33m

Charlotte Douglas

Fri 10/3

12:38 pm-10:07 am

1 stop21h 29m

$230

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Sat 11/22

10:47 am-2:29 pm

1 stop3h 42m

Charleston

Mon 12/1

9:23 pm-11:05 am

1 stop13h 42m

$249

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 12/4

10:59 am-1:21 pm

1 stop26h 22m

Charlotte Douglas

Tue 12/9

6:25 am-10:07 am

2 stops27h 42m

$257

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Mon 9/29

12:32 pm-10:43 pm

2 stops34h 11m

Charleston

Fri 10/3

9:23 pm-10:07 am

1 stop12h 44m

$260

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 11/6

8:55 am-3:55 pm

1 stop7h 00m

Charlotte Douglas

Tue 11/11

11:00 am-10:07 am

2 stops23h 07m

$281

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 11/6

8:06 am-10:25 am

Nonstop2h 19m

Charlotte Douglas

Tue 11/11

7:33 pm-9:48 pm

Nonstop2h 15m

$305

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Mon 9/29

8:47 am-8:37 am

1 stop23h 50m

Charleston

Fri 10/3

9:23 pm-10:07 am

1 stop12h 44m

$321

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 12/4

3:01 pm-9:25 pm

1 stop6h 24m

Charlotte Douglas

Tue 12/9

9:50 am-2:06 pm

1 stop4h 16m

$325

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 11/6

7:40 am-1:42 pm

1 stop6h 02m

Charlotte Douglas

Tue 11/11

7:55 am-2:03 pm

1 stop6h 08m

$325

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Sat 11/22

10:47 am-10:45 am

2 stops23h 58m

Charleston

Mon 12/1

9:23 pm-11:05 am

1 stop13h 42m

$343

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 54 results
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Best time to book a flight from Key West to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to South Carolina

What is the cheapest time of day to fly from EYW to SC?

Find hourly flight availability from Key West to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Key West to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 15, 2025.
Read through reviews of airlines operating flights from Key West to South Carolina, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,956 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,956 reviews
Delta
8.0
Very good
7,956 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,956 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key West to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Key West to South Carolina?

    For a flight from Key West to South Carolina, you will be flying from Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from Key West to South Carolina?

    A quick flight from Key West to South Carolina can take about 2h 19m. Breeze Airways provides one of the quickest options available for as low as $305. There are 738 mi between Key West and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Key West to South Carolina one-way?

    To fly one-way, consider booking your trip with Breeze Airways, which is currently one of the cheapest options available, starting at $119. American Airlines flights start at $149 while deals on Spirit Airlines start at $193 one-way.

  • What are the most popular routes from Key West to South Carolina?

    When deciding which route to take from Key West to South Carolina consider Key West - Charlotte Douglas, Key West - Charleston or Key West - Savannah/Hilton Head as they are the most popular.

  • Can I find deals for flights from Key West to South Carolina that include hotel bookings?

    Yes. In addition to deals on Key West to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to South Carolina.

  • Can I find deals for business class flights from Key West to South Carolina?

    Yes. Cheapflights offers flight deals from Key West to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Key West to South Carolina (average of $217). Flying from Key West to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key West to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Key West to South Carolina

Discover the top 2 airlines that operate flights from Key West to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$313FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$293Average$588FlexibilityNo cancel feeOn-time71%

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