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South Carolina

$56+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — CHS
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from Detroit to South Carolina

Cheapest flights from Detroit to South Carolina
Explore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This Mytrip deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:15 pmDTW - CLT
Nonstop1h 53mFrontier
Tue 12/303:07 pmCLT - DTW
1 stop18h 05mFrontier
Deal found 12/3$147
This Frontier deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:15 pmDTW - CLT
Nonstop1h 53mFrontier
Thu 1/19:24 amCLT - DTW
Nonstop1h 56mFrontier
Deal found 12/2$150
This Frontier deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:25 amDTW - CLT
1 stop10h 36mFrontier
Tue 12/309:24 amCLT - DTW
Nonstop1h 56mFrontier
Deal found 12/2$151
This Super.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:15 pmDTW - CLT
Nonstop1h 53mFrontier
Sun 12/289:24 amCLT - DTW
Nonstop1h 56mFrontier
Deal found 12/3$152
This Frontier deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1812:15 pmDTW - CLT
Nonstop1h 53mFrontier
Thu 12/259:24 amCLT - DTW
Nonstop1h 56mFrontier
Deal found 12/2$155
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:15 pmDTW - CLT
Nonstop1h 53mFrontier
Mon 12/299:43 pmCLT - DTW
1 stop22h 30mFrontier
Deal found 12/2$160
This Frontier deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:25 amDTW - CLT
1 stop10h 36mFrontier
Thu 1/19:24 amCLT - DTW
Nonstop1h 56mFrontier
Deal found 12/2$161
This Expedia deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3012:15 pmDTW - CLT
Nonstop1h 53mMultiple Airlines
Tue 1/69:38 pmCLT - DTW
1 stop11h 55mMultiple Airlines
Deal found 12/2$165
This Super.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:15 pmDTW - CLT
Nonstop1h 53mFrontier
Sun 12/289:24 amCLT - DTW
Nonstop1h 56mFrontier
Deal found 12/2$166
This Frontier deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1812:15 pmDTW - CLT
Nonstop1h 53mFrontier
Tue 12/309:24 amCLT - DTW
Nonstop1h 56mFrontier
Deal found 12/2$169
This Frontier deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:15 pmDTW - CLT
Nonstop1h 53mFrontier
Tue 12/309:24 amCLT - DTW
Nonstop1h 56mFrontier
Deal found 12/3$170
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:00 amDTW - MYR
1 stop11h 48mSpirit Airlines
Tue 2/101:07 pmMYR - DTW
1 stop10h 34mSpirit Airlines
Deal found 12/2$172

Find flight deals from Detroit to South Carolina

Keep the following information in mind while searching for Detroit to South Carolina flight deals. Data was last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$147
(Mytrip)

One-way from

$56
(Super.com)

Popular in

November

Cheapest in

August

Average price

$349

Good round-trip deal

$299 or less

Good one-way deal

$198 or less
Provider with most accurate pricing for Detroit (DTT)-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Myrtle Beach Intl flights.
Search Deals
From Detroit Metropolitan Wayne County to South Carolina
Search Deals
One-way flight from Detroit Metropolitan Wayne County to South Carolina
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($71 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to South Carolina.
Search Deals
Price to beat on a one-way flight from Detroit Metropolitan Wayne County to South Carolina.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South Carolina that are best for you.

Fly from

Detroit

Fly to

South Carolina

Route

Depart

Return

Price

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Sat 2/21

7:45 pm-9:32 pm

Nonstop1h 47m

Charlotte Douglas

Mon 2/23

6:59 pm-12:44 am

1 stop5h 45m

$149

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Mon 1/19

6:45 am-7:24 pm

1 stop12h 39m

Charlotte Douglas

Wed 1/21

6:01 pm-2:21 pm

1 stop20h 20m

$152

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 1/29

7:45 pm-9:32 pm

Nonstop1h 47m

Charlotte Douglas

Sun 2/1

9:30 am-11:26 am

Nonstop1h 56m

$169

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Fri 3/6

7:45 pm-9:32 pm

Nonstop1h 47m

Charlotte Douglas

Tue 3/10

9:29 am-11:22 am

Nonstop1h 53m

$169

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 1/8

7:45 pm-9:32 pm

Nonstop1h 47m

Charlotte Douglas

Sun 1/11

6:00 am-7:55 am

Nonstop1h 55m

$169

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 1/7

2:15 pm-4:05 pm

Nonstop1h 50m

Charlotte Douglas

Sun 1/11

6:00 am-7:55 am

Nonstop1h 55m

$169

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Fri 2/6

10:09 am-12:11 pm

Nonstop2h 02m

Charlotte Douglas

Tue 2/10

12:59 pm-2:47 pm

Nonstop1h 48m

$169

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Fri 1/16

7:45 pm-9:32 pm

Nonstop1h 47m

Charlotte Douglas

Mon 1/19

5:00 pm-6:53 pm

Nonstop1h 53m

$169

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Mon 12/22

6:25 am-5:01 pm

1 stop10h 36m

Charlotte Douglas

Mon 12/29

9:43 pm-8:13 pm

1 stop22h 30m

$174

DetroitMyrtle Beach

DTW - MYR

DTWMYR

Detroit Metropolitan Wayne County

Sat 2/21

6:00 am-5:10 pm

2 stops11h 10m

Myrtle Beach Intl

Wed 2/25

8:15 am-3:05 pm

2 stops6h 50m

$191

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 60 results
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Best time to book a flight from Detroit to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to South Carolina

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to South Carolina (average of $91). Flying from Detroit Metropolitan Wayne County Airport to South Carolina in December is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to SC?

Find hourly flight availability from Detroit to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

One of the essential ways to save on airfare from Detroit Metropolitan Wayne County Airport to South Carolina is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 16% on airfare.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Detroit to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Detroit Metropolitan Wayne County Airport to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Detroit Metropolitan Wayne County Airport to South Carolina

Explore weekly flight availability from Detroit to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 4, 2025.

The most flights from DTW to USSC are scheduled on a Wednesday (8 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 4, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Detroit Metropolitan Wayne County Airport to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,254 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Food

7.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,254 reviews
Southwest
8.0
Very good
4,254 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Food

7.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,011 reviews
Southwest
8.0
Very good
4,254 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Food

7.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,045 reviews
Southwest
8.0
Very good
4,254 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Food

7.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,161 reviews
Southwest
8.0
Very good
4,254 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Food

7.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Detroit to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to South Carolina?

    If you book a flight to South Carolina from Detroit, you will be flying from Detroit Metropolitan Wayne County, which is the city’s only airport. Detroit Metropolitan Wayne County (DTW) is located 17.3 mi from the center of Detroit.

  • How long is the flight from Detroit Metropolitan Wayne County Airport to South Carolina?

    Delta, Southwest, and American Airlines can get you from Detroit Metropolitan Wayne County Airport to South Carolina in just under 1h 47m. Your travel time can differ by up to 9h 23m. The distance from Detroit Metropolitan Wayne County Airport to South Carolina is about 500 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Detroit Metropolitan Wayne County Airport to South Carolina one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $36. American Airlines flights start at $79 while deals on Delta start at $138 one-way.

  • What are the most popular routes from Detroit Metropolitan Wayne County Airport to South Carolina?

    When deciding which route to take from Detroit Metropolitan Wayne County Airport to South Carolina consider Detroit Metropolitan Wayne County - Charlotte Douglas, Detroit Metropolitan Wayne County - Charleston or Detroit Metropolitan Wayne County - Myrtle Beach Intl as they are the most popular.

  • What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to South Carolina?

    The top 3 most reliable airlines when flying from Detroit Metropolitan Wayne County Airport to South Carolina are Air France (96%), WestJet (92%) and Delta (89%).

  • What are the cheapest flights from Detroit Metropolitan Wayne County Airport to South Carolina?

    Looking for the cheapest flight from Detroit Metropolitan Wayne County Airport to South Carolina? While on average our users pay $289, our data indicates the cheapest price to be $55. The most popular route (Detroit Metropolitan Wayne County - Charlotte Douglas), is priced around $136.

  • Can I find deals for flights from Detroit to South Carolina that include hotel bookings?

    Yes. In addition to deals on Detroit to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to South Carolina.

  • Can I find deals for business class flights from Detroit to South Carolina?

    Yes. Cheapflights offers flight deals from Detroit to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to South Carolina (average of $91). Flying from Detroit Metropolitan Wayne County Airport to South Carolina in December is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Detroit to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Detroit to South Carolina

Discover the top 4 airlines that operate flights from Detroit to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$76Average$170FlexibilityNo cancel feeOn-time65%
DeltaCheapest$159Average$379FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$198Average$342FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$231Average$363FlexibilityNo cancel feeOn-time63%

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