$53+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Detroit to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to South Carolina
Keep the following information in mind while searching for Detroit to South Carolina flight deals. Data was last updated January 20, 2026.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $116 (Cheapflightsfares) |
One-way from | $53 (Expedia) |
Popular in | December |
Cheapest in | August |
Average price | $242 |
Good round-trip deal | $300 or less |
Good one-way deal | $234 or less |
Find flight deals from Detroit to South Carolina
Cheapest flights from Detroit to South CarolinaExplore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.
Explore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Booking.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Orbitz deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Thu 2/26
2:15 pm-4:05 pm
Nonstop1h 50m
Charlotte Douglas
Wed 3/4
9:30 am-11:24 am
Nonstop1h 54m
DetroitCharleston
DTW - CHS
DTWCHS
Detroit Metropolitan Wayne County
Tue 2/17
6:02 pm-3:55 pm
2 stops21h 53m
Charleston
Tue 2/24
5:00 pm-12:09 am
1 stop7h 09m
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Sat 2/14
7:45 pm-9:42 pm
Nonstop1h 57m
Charlotte Douglas
Wed 2/18
8:22 am-10:17 am
Nonstop1h 55m
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Sat 2/14
7:45 pm-9:32 pm
Nonstop1h 47m
Charlotte Douglas
Tue 2/17
5:00 pm-6:51 pm
Nonstop1h 51m
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Thu 2/19
6:20 am-11:00 am
1 stop4h 40m
Charlotte Douglas
Mon 2/23
6:00 am-7:52 am
Nonstop1h 52m
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Sat 2/14
2:15 pm-4:05 pm
Nonstop1h 50m
Charlotte Douglas
Wed 2/18
5:00 pm-6:51 pm
Nonstop1h 51m
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Tue 2/10
6:17 pm-8:26 pm
Nonstop2h 09m
Charlotte Douglas
Mon 2/16
10:50 pm-12:38 am
Nonstop1h 48m
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Thu 2/12
10:06 am-12:08 pm
Nonstop2h 02m
Charlotte Douglas
Mon 2/16
9:30 am-11:24 am
Nonstop1h 54m
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Sat 2/14
7:45 pm-9:32 pm
Nonstop1h 47m
Charlotte Douglas
Mon 2/16
6:00 am-7:52 am
Nonstop1h 52m
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Wed 2/18
6:20 am-11:00 am
1 stop4h 40m
Charlotte Douglas
Sun 2/22
6:00 am-7:52 am
Nonstop1h 52m
Best time to book a flight from Detroit to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Detroit with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to South Carolina
What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?
Currently, May is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to South Carolina (average of $90). Flying from Detroit Metropolitan Wayne County Airport to South Carolina in December is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DTW to SC?
Find hourly flight availability from Detroit to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 20, 2026.
One of the essential ways to save on airfare from Detroit Metropolitan Wayne County Airport to South Carolina is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 29% on airfare.
What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Detroit to South Carolina. Price data was last updated on January 17, 2026.
Travelers seeking maximum savings on their Detroit Metropolitan Wayne County Airport to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Weekly flight availability from Detroit Metropolitan Wayne County Airport to South Carolina
Explore weekly flight availability from Detroit to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 20, 2026.
The most flights from DTW to USSC are scheduled on a Monday (7 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (1 on average).
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 20, 2026.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Detroit Metropolitan Wayne County Airport to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
Overall
Crew
Entertainment
Food
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Overall
Crew
Entertainment
Food
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Overall
Crew
Entertainment
Food
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Overall
Crew
Entertainment
Food
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Overall
Crew
Entertainment
Food
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Detroit to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Detroit to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Detroit to South Carolina
Discover the top 4 airlines that operate flights from Detroit to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$64 | Average$159 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$158 | Average$388 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$339 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$207 | Average$344 | FlexibilityNo cancel fee | On-time63% |