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South Carolina

$54+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/2. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — CHS
Mar 10 — Mar 171
Tue 3/10
Tue 3/17
1 adult, Economy
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Cheap flight deals from Detroit to South Carolina

Cheapest flights from Detroit to South Carolina
Explore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 8, 2026.

This Mytrip deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:09 am
DTW
-
CHS
1 stop10h 56m
Spirit Airlines
Mon 3/95:00 pm
CHS
-
DTW
1 stop14h 49m
Spirit Airlines
Deal found 2/5$113
This Kiwi.com deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/810:59 pm
DTW
-
CHS
1 stop17h 06m
Spirit Airlines
Tue 3/105:00 pm
CHS
-
DTW
1 stop7h 09m
Spirit Airlines
Deal found 2/5$124
This CheapOair deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:09 am
DTW
-
CHS
1 stop10h 56m
Spirit Airlines
Tue 3/105:00 pm
CHS
-
DTW
1 stop14h 49m
Spirit Airlines
Deal found 2/5$126
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/149:53 pm
DTW
-
CHS
1 stop10h 47m
Spirit Airlines
Fri 4/173:35 pm
CHS
-
DTW
1 stop24h 50m
Spirit Airlines
Deal found 2/6$129
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2811:15 am
DTW
-
CHS
1 stop21h 25m
Spirit Airlines
Sat 5/23:35 pm
CHS
-
DTW
1 stop8h 55m
Spirit Airlines
Deal found 2/7$132
This Cheapflightsfares deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:06 pm
DTW
-
MYR
1 stop6h 33m
Spirit Airlines
Tue 3/33:59 pm
MYR
-
DTW
1 stop5h 55m
Spirit Airlines
Deal found 2/5$133
This Mytrip deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:09 am
DTW
-
CHS
1 stop10h 56m
Spirit Airlines
Wed 2/255:00 pm
CHS
-
DTW
1 stop14h 49m
Spirit Airlines
Deal found 2/5$133
This CheapOair deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/610:59 pm
DTW
-
CHS
1 stop17h 06m
Spirit Airlines
Mon 3/95:00 pm
CHS
-
DTW
1 stop14h 49m
Spirit Airlines
Deal found 2/5$134
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:09 am
DTW
-
CHS
1 stop10h 56m
Spirit Airlines
Tue 3/1712:04 pm
CHS
-
DTW
1 stop20h 42m
Spirit Airlines
Deal found 2/7$135
This Mytrip deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:09 am
DTW
-
CHS
1 stop10h 56m
Spirit Airlines
Wed 3/1812:04 pm
CHS
-
DTW
1 stop8h 44m
Spirit Airlines
Deal found 2/6$136
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/271:45 pm
DTW
-
CHS
1 stop24h 55m
Spirit Airlines
Wed 5/69:35 am
CHS
-
DTW
1 stop6h 50m
Spirit Airlines
Deal found 2/7$138
This CheapOair deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2112:06 pm
DTW
-
CLT
1 stop8h 06m
Multiple Airlines
Mon 2/234:45 pm
CLT
-
DTW
Nonstop1h 58m
Multiple Airlines
Deal found 2/5$141

Find flight deals from Detroit to South Carolina

Keep the following information in mind while searching for Detroit to South Carolina flight deals. Data was last updated February 8, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$113
(Mytrip)

One-way from

$54
(Frontier)

Popular in

December

Cheapest in

August

Average price

$256

Good round-trip deal

$339 or less

Good one-way deal

$208 or less
Provider with most accurate pricing for Detroit (DTT)-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Myrtle Beach Intl flights.
Search Deals
From Detroit Metropolitan Wayne County to South Carolina
Search Deals
One-way flight from Detroit Metropolitan Wayne County to South Carolina
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($75 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to South Carolina.
Search Deals
Price to beat on a one-way flight from Detroit Metropolitan Wayne County to South Carolina.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South Carolina that are best for you.

Fly from

Detroit

Fly to

South Carolina

Route

Depart

Return

Price

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Tue 4/14

9:53 pm-8:40 am

1 stop10h 47m

Charleston

Fri 4/17

3:35 pm-4:25 pm

1 stop24h 50m

$132

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Tue 4/28

11:15 am-8:40 am

1 stop21h 25m

Charleston

Sat 5/2

3:35 pm-12:30 am

1 stop8h 55m

$132

DetroitSavannah

DTW - SAV

DTWSAV

Detroit Metropolitan Wayne County

Thu 3/12

11:34 am-3:55 pm

1 stop4h 21m

Savannah/Hilton Head

Mon 3/16

4:50 pm-8:46 am

1 stop15h 56m

$142

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Fri 3/13

6:56 pm-8:47 pm

Nonstop1h 51m

Charlotte Douglas

Sat 3/28

3:12 pm-8:48 pm

1 stop5h 36m

$157

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Tue 3/10

10:59 pm-10:17 am

2 stops11h 18m

Charlotte Douglas

Tue 3/17

9:18 am-3:50 pm

1 stop6h 32m

$165

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Tue 4/28

5:09 pm-8:40 am

2 stops15h 31m

Charleston

Sat 5/2

3:35 pm-12:30 am

1 stop8h 55m

$166

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Wed 3/11

5:09 am-4:05 pm

1 stop10h 56m

Charleston

Thu 3/12

12:04 pm-8:46 am

1 stop20h 42m

$167

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Sat 2/28

2:15 pm-4:05 pm

Nonstop1h 50m

Charlotte Douglas

Sun 3/1

6:00 am-7:52 am

Nonstop1h 52m

$189

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 2/26

7:05 am-9:07 am

Nonstop2h 02m

Charlotte Douglas

Sun 3/1

6:00 am-7:52 am

Nonstop1h 52m

$189

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Tue 2/24

10:06 am-12:08 pm

Nonstop2h 02m

Charlotte Douglas

Sat 2/28

1:11 pm-3:03 pm

Nonstop1h 52m

$194

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/7

Showing 1-10 of 60 results
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Best time to book a flight from Detroit to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to South Carolina

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to South Carolina (average of $91). Flying from Detroit Metropolitan Wayne County Airport to South Carolina in December is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to SC?

Find hourly flight availability from Detroit to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 8, 2026.

One of the essential ways to save on airfare from Detroit Metropolitan Wayne County Airport to South Carolina is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 25% on airfare.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Detroit to South Carolina. Price data was last updated on January 31, 2026.

Travelers seeking maximum savings on their Detroit Metropolitan Wayne County Airport to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 8, 2026.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Detroit Metropolitan Wayne County Airport to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,280 reviews

Boarding

8.1

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,280 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.1

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,172 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.1

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,249 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.1

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,430 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.1

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Detroit to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to South Carolina?

    If you book a flight to South Carolina from Detroit, you will be flying from Detroit Metropolitan Wayne County, which is the city’s only airport. Detroit Metropolitan Wayne County (DTW) is located 17.3 mi from the center of Detroit.

  • How long is the flight from Detroit Metropolitan Wayne County Airport to South Carolina?

    Spirit Airlines, Delta, and American Airlines can get you from Detroit Metropolitan Wayne County Airport to South Carolina in just under 1h 50m. Your travel time can differ by up to 8h 57m. The distance from Detroit Metropolitan Wayne County Airport to South Carolina is about 500 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Detroit Metropolitan Wayne County Airport to South Carolina one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $92. American Airlines flights start at $130 while deals on Frontier start at $132 one-way.

  • What are the most popular routes from Detroit Metropolitan Wayne County Airport to South Carolina?

    When deciding which route to take from Detroit Metropolitan Wayne County Airport to South Carolina consider Detroit Metropolitan Wayne County - Charlotte Douglas, Detroit Metropolitan Wayne County - Myrtle Beach Intl or Detroit Metropolitan Wayne County - Charleston as they are the most popular.

  • What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to South Carolina?

    The top 3 most reliable airlines when flying from Detroit Metropolitan Wayne County Airport to South Carolina are Republic Airways (81%), WestJet (63%) and Korean Air (63%).

  • What are the cheapest flights from Detroit Metropolitan Wayne County Airport to South Carolina?

    Looking for the cheapest flight from Detroit Metropolitan Wayne County Airport to South Carolina? While on average our users pay $351, our data indicates the cheapest price to be $158. The most popular route (Detroit Metropolitan Wayne County - Charlotte Douglas), is priced around $117.

  • Can I find deals for flights from Detroit to South Carolina that include hotel bookings?

    Yes. In addition to deals on Detroit to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to South Carolina.

  • Can I find deals for business class flights from Detroit to South Carolina?

    Yes. Cheapflights offers flight deals from Detroit to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to South Carolina (average of $91). Flying from Detroit Metropolitan Wayne County Airport to South Carolina in December is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Detroit to South Carolina

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Top 4 airlines flying from Detroit to South Carolina

Discover the top 4 airlines that operate flights from Detroit to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$64Average$160FlexibilityNo cancel feeOn-time65%
DeltaCheapest$158Average$387FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$198Average$340FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$207Average$346FlexibilityNo cancel feeOn-time63%

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