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$53+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — CHS
Feb 5 — Feb 121
Thu 2/5
Thu 2/12
1 adult, Economy
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Cheap flight deals from Detroit to South Carolina

Keep the following information in mind while searching for Detroit to South Carolina flight deals. Data was last updated January 6, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$118
(Mytrip)

One-way from

$53
(Booking.com)

Popular in

December

Cheapest in

August

Average price

$238

Good round-trip deal

$300 or less

Good one-way deal

$304 or less
Provider with most accurate pricing for Detroit (DTT)-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Detroit (DTT)-Myrtle Beach Intl flights.
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From Detroit Metropolitan Wayne County to South Carolina
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One-way flight from Detroit Metropolitan Wayne County to South Carolina
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Highest demand for flights based on searches. 23% potential increase in price ($78 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to South Carolina.
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Price to beat on a one-way flight from Detroit Metropolitan Wayne County to South Carolina.
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Find flight deals from Detroit to South Carolina

Cheapest flights from Detroit to South Carolina
Explore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

This Mytrip deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/226:00 amDTW - CHS
1 stop10h 10mSpirit Airlines
Mon 1/265:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/4$118
This Kiwi.com deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3110:08 pmDTW - CHS
1 stop18h 02mSpirit Airlines
Sat 2/75:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/3$126
This Kiwi.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3110:08 pmDTW - CHS
1 stop18h 02mSpirit Airlines
Mon 2/25:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/4$129
This Mytrip deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/235:00 amDTW - SAV
1 stop7h 22mSpirit Airlines
Fri 1/301:17 pmSAV - DTW
1 stop11h 02mSpirit Airlines
Deal found 1/5$132
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/235:00 amDTW - CHS
1 stop11h 10mSpirit Airlines
Fri 1/305:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/6$132
This Kiwi.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/175:09 amDTW - CHS
1 stop10h 46mSpirit Airlines
Sat 2/215:00 pmCHS - DTW
1 stop7h 09mSpirit Airlines
Deal found 1/4$133
This Kiwi.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:00 amDTW - CHS
1 stop9h 55mSpirit Airlines
Mon 2/235:00 pmCHS - DTW
1 stop7h 09mSpirit Airlines
Deal found 1/4$134
This Mytrip deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/15:00 amDTW - SAV
1 stop7h 22mSpirit Airlines
Fri 2/61:17 pmSAV - DTW
1 stop11h 02mSpirit Airlines
Deal found 1/5$135
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/127:14 amDTW - CLT
Nonstop1h 57mAmerican Airlines
Sat 2/141:06 pmCLT - DTW
Nonstop1h 51mAmerican Airlines
Deal found 1/6$139
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/65:00 amDTW - SAV
1 stop7h 22mSpirit Airlines
Mon 2/91:17 pmSAV - DTW
1 stop21h 39mSpirit Airlines
Deal found 1/6$140
This Delta deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/57:05 amDTW - CLT
Nonstop2h 02mDelta
Mon 2/912:59 pmCLT - DTW
Nonstop1h 48mDelta
Deal found 1/5$140
This Kiwi.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/35:00 amDTW - MYR
1 stop9h 42mSpirit Airlines
Tue 2/1010:00 amMYR - DTW
1 stop14h 19mSpirit Airlines
Deal found 1/4$141

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 6, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South Carolina that are best for you.

Fly from

Detroit

Fly to

South Carolina

Route

Depart

Return

Price

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Sat 2/14

2:15 pm-4:05 pm

Nonstop1h 50m

Charlotte Douglas

Tue 2/17

5:25 am-9:30 am

1 stop4h 05m

$149

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 1/29

7:45 pm-9:32 pm

Nonstop1h 47m

Charlotte Douglas

Thu 2/5

9:30 am-11:26 am

Nonstop1h 56m

$149

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Tue 2/10

5:15 am-10:50 am

1 stop5h 35m

Charlotte Douglas

Wed 2/18

5:00 pm-6:51 pm

Nonstop1h 51m

$149

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Tue 1/27

7:05 am-9:07 am

Nonstop2h 02m

Charlotte Douglas

Wed 2/4

5:25 am-11:01 am

1 stop5h 36m

$159

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 2/5

2:15 pm-8:38 pm

1 stop6h 23m

Charlotte Douglas

Mon 2/9

6:59 pm-11:42 pm

1 stop4h 43m

$159

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 1/29

2:15 pm-4:05 pm

Nonstop1h 50m

Charlotte Douglas

Sat 1/31

6:00 am-7:52 am

Nonstop1h 52m

$159

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 1/28

8:15 am-1:38 pm

1 stop5h 23m

Charlotte Douglas

Wed 2/4

12:59 pm-2:47 pm

Nonstop1h 48m

$159

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 2/5

10:09 am-12:11 pm

Nonstop2h 02m

Charlotte Douglas

Sun 2/8

6:00 am-7:52 am

Nonstop1h 52m

$169

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Fri 2/20

10:06 am-12:08 pm

Nonstop2h 02m

Charlotte Douglas

Sat 2/21

5:00 pm-6:51 pm

Nonstop1h 51m

$169

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Fri 2/20

5:09 am-2:17 pm

1 stop9h 08m

Charlotte Douglas

Sun 2/22

10:50 am-10:05 am

1 stop23h 15m

$170

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/6

Showing 1-10 of 60 results
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Best time to book a flight from Detroit to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to South Carolina

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to South Carolina (average of $89). Flying from Detroit Metropolitan Wayne County Airport to South Carolina in December is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to SC?

Find hourly flight availability from Detroit to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 6, 2026.

One of the essential ways to save on airfare from Detroit Metropolitan Wayne County Airport to South Carolina is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 31% on airfare.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Detroit to South Carolina. Price data was last updated on January 3, 2026.

Travelers seeking maximum savings on their Detroit Metropolitan Wayne County Airport to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Detroit Metropolitan Wayne County Airport to South Carolina

Explore weekly flight availability from Detroit to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 6, 2026.

The most flights from DTW to USSC are scheduled on a Monday (6 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 6, 2026.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Detroit Metropolitan Wayne County Airport to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,247 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,247 reviews
Southwest
8.0
Very good
4,247 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,017 reviews
Southwest
8.0
Very good
4,247 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,083 reviews
Southwest
8.0
Very good
4,247 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,272 reviews
Southwest
8.0
Very good
4,247 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Detroit to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to South Carolina?

    If you book a flight to South Carolina from Detroit, you will be flying from Detroit Metropolitan Wayne County, which is the city’s only airport. Detroit Metropolitan Wayne County (DTW) is located 17.3 mi from the center of Detroit.

  • How long is the flight from Detroit Metropolitan Wayne County Airport to South Carolina?

    Spirit Airlines, Delta, and American Airlines can get you from Detroit Metropolitan Wayne County Airport to South Carolina in just under 1h 50m. Your travel time can differ by up to 8h 20m. The distance from Detroit Metropolitan Wayne County Airport to South Carolina is about 500 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Detroit Metropolitan Wayne County Airport to South Carolina one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $36. American Airlines flights start at $79 while deals on Delta start at $138 one-way.

  • What are the most popular routes from Detroit Metropolitan Wayne County Airport to South Carolina?

    When deciding which route to take from Detroit Metropolitan Wayne County Airport to South Carolina consider Detroit Metropolitan Wayne County - Charlotte Douglas, Detroit Metropolitan Wayne County - Charleston or Detroit Metropolitan Wayne County - Myrtle Beach Intl as they are the most popular.

  • What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to South Carolina?

    The top 3 most reliable airlines when flying from Detroit Metropolitan Wayne County Airport to South Carolina are SkyWest Airlines (100%), Republic Airways (85%) and WestJet (80%).

  • What are the cheapest flights from Detroit Metropolitan Wayne County Airport to South Carolina?

    Looking for the cheapest flight from Detroit Metropolitan Wayne County Airport to South Carolina? While on average our users pay $357, our data indicates the cheapest price to be $198. The most popular route (Detroit Metropolitan Wayne County - Charlotte Douglas), is priced around $101.

  • Can I find deals for flights from Detroit to South Carolina that include hotel bookings?

    Yes. In addition to deals on Detroit to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to South Carolina.

  • Can I find deals for business class flights from Detroit to South Carolina?

    Yes. Cheapflights offers flight deals from Detroit to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to South Carolina (average of $89). Flying from Detroit Metropolitan Wayne County Airport to South Carolina in December is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Detroit to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Detroit to South Carolina

Discover the top 4 airlines that operate flights from Detroit to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$76Average$170FlexibilityNo cancel feeOn-time65%
DeltaCheapest$159Average$394FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$197Average$343FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$207Average$356FlexibilityNo cancel feeOn-time63%

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