HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$49+ Cheap flights from Detroit (DTT) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/4. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — CHS
Feb 6 — Feb 131
Fri 2/6
Fri 2/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Detroit to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Detroit to South Carolina

Keep the following information in mind while searching for Detroit to South Carolina flight deals. Data was last updated January 7, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$107
(Mytrip)

One-way from

$49
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$238

Good round-trip deal

$300 or less

Good one-way deal

$304 or less
Provider with most accurate pricing for Detroit (DTT)-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Myrtle Beach Intl flights.
Search Deals
From Detroit (DTT) to South Carolina
Search Deals
One-way flight from Detroit (DTT) to South Carolina
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($78 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Detroit (DTT) to South Carolina.
Search Deals
Price to beat on a one-way flight from Detroit (DTT) to South Carolina.
Search Deals

Find flight deals from Detroit to South Carolina

Cheapest flights from Detroit to South Carolina
Explore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.

This Mytrip deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/225:00 amDTW - CHS
1 stop11h 10mSpirit Airlines
Mon 1/265:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/7$107
This Mytrip deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/285:00 amDTW - MYR
1 stop9h 42mSpirit Airlines
Wed 2/1110:00 amMYR - DTW
1 stop14h 19mSpirit Airlines
Deal found 1/6$112
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2110:08 pmDTW - CHS
1 stop18h 02mSpirit Airlines
Sun 1/255:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/6$112
This Mytrip deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/35:00 amDTW - MYR
1 stop9h 42mSpirit Airlines
Tue 2/1010:00 amMYR - DTW
1 stop11h 03mSpirit Airlines
Deal found 1/6$113
This Trip.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/315:00 amDTW - MYR
1 stop9h 42mSpirit Airlines
Sat 2/710:00 amMYR - DTW
1 stop14h 19mSpirit Airlines
Deal found 1/6$118
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/610:08 pmDTW - CHS
1 stop18h 02mSpirit Airlines
Mon 2/95:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/6$120
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/235:00 amDTW - CHS
1 stop11h 10mSpirit Airlines
Sun 1/255:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/7$121
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/285:00 amDTW - MYR
1 stop9h 42mSpirit Airlines
Tue 3/310:09 amMYR - DTW
1 stop14h 00mSpirit Airlines
Deal found 1/7$123
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2110:08 pmDTW - CHS
1 stop18h 02mSpirit Airlines
Mon 1/265:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/7$123
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/285:00 amDTW - MYR
1 stop9h 42mSpirit Airlines
Sat 2/2811:57 amMYR - DTW
1 stop12h 12mSpirit Airlines
Deal found 1/7$124
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/235:00 amDTW - CHS
1 stop11h 10mSpirit Airlines
Fri 1/305:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/6$126
This Kiwi.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3110:08 pmDTW - CHS
1 stop18h 02mSpirit Airlines
Mon 2/25:05 pmCHS - DTW
1 stop7h 14mSpirit Airlines
Deal found 1/4$129

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Detroit to South Carolina that are best for you.

Fly from

Detroit

Fly to

South Carolina

Route

Depart

Return

Price

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 2/5

2:15 pm-4:05 pm

Nonstop1h 50m

Charlotte Douglas

Mon 2/9

5:25 am-11:01 am

1 stop5h 36m

$149

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 2/4

2:15 pm-4:05 pm

Nonstop1h 50m

Charlotte Douglas

Wed 2/11

12:59 pm-2:47 pm

Nonstop1h 48m

$149

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 1/28

8:15 am-1:38 pm

1 stop5h 23m

Charlotte Douglas

Wed 2/4

12:59 pm-2:47 pm

Nonstop1h 48m

$159

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 1/28

7:45 pm-9:32 pm

Nonstop1h 47m

Charlotte Douglas

Mon 2/2

12:59 pm-2:47 pm

Nonstop1h 48m

$159

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 1/29

12:21 pm-6:10 pm

1 stop5h 49m

Charlotte Douglas

Thu 2/5

9:30 am-11:26 am

Nonstop1h 56m

$159

DetroitSavannah

DTW - SAV

DTWSAV

Detroit Metropolitan Wayne County

Fri 2/6

2:36 pm-11:25 pm

2 stops8h 49m

Savannah/Hilton Head

Sun 2/8

1:17 pm-12:19 am

1 stop11h 02m

$175

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 3/4

5:09 am-1:43 pm

1 stop8h 34m

Charlotte Douglas

Sun 3/8

9:36 pm-1:41 am

1 stop28h 05m

$178

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 2/5

7:45 pm-9:32 pm

Nonstop1h 47m

Charlotte Douglas

Sun 2/8

5:25 am-9:30 am

1 stop4h 05m

$179

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Sun 2/1

7:45 pm-9:32 pm

Nonstop1h 47m

Charlotte Douglas

Thu 2/26

5:25 am-9:30 am

1 stop4h 05m

$189

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 1/29

7:45 pm-9:32 pm

Nonstop1h 47m

Charlotte Douglas

Sun 2/1

6:00 am-7:52 am

Nonstop1h 52m

$189

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/6

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Detroit to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit to South Carolina

What is the cheapest month to book a flight from Detroit to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Detroit to South Carolina (average of $89). Flying from Detroit to South Carolina in December is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTT to SC?

Find hourly flight availability from Detroit to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 7, 2026.

When flying from Detroit to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 31% versus a flight at noon.

What is the cheapest day to fly from Detroit to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Detroit to South Carolina. Price data was last updated on January 3, 2026.

Travelers seeking maximum savings on their Detroit to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Detroit to South Carolina

Explore weekly flight availability from Detroit to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 7, 2026.

The most flights from DTT to USSC are scheduled on a Monday (6 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (2 on average).

How much does it cost to fly round-trip from Detroit to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 7, 2026.
Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Detroit to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,249 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,249 reviews
Southwest
8.0
Very good
4,249 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,021 reviews
Southwest
8.0
Very good
4,249 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,090 reviews
Southwest
8.0
Very good
4,249 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,283 reviews
Southwest
8.0
Very good
4,249 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Detroit to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to South Carolina?

    Most people fly from Detroit All airports (DTT) if they book a flight from Detroit to South Carolina. Detroit All airports is conveniently located just 0.6 mi from Detroit’s city center.

  • How long is the flight from Detroit to South Carolina?

    There are many flights that can get you from Detroit to South Carolina in 1h 50m. Fly via Delta, United Airlines, or American Airlines to get the fastest option. There are 500 mi between Detroit and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Detroit to South Carolina one-way?

    $36 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $79 and $138, respectively.

  • What are the most popular routes from Detroit to South Carolina?

    The most popular route from Detroit to South Carolina is Detroit Metropolitan Wayne County - Charlotte Douglas. You may also consider Detroit Metropolitan Wayne County - Charleston or Detroit Metropolitan Wayne County - Savannah/Hilton Head.

  • What are the most reliable airlines from Detroit to South Carolina?

    The top 3 most reliable airlines when flying from Detroit to South Carolina are SkyWest Airlines (100%), Republic Airways (85%) and WestJet (80%).

  • What are the cheapest flights from Detroit to South Carolina?

    Looking for the cheapest flight from Detroit to South Carolina? While on average our users pay $357, our data indicates the cheapest price to be $198. The most popular route (Detroit Metropolitan Wayne County - Charlotte Douglas), is priced around $100.

  • Can I find deals for flights from Detroit to South Carolina that include hotel bookings?

    Yes. In addition to deals on Detroit to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to South Carolina.

  • Can I find deals for business class flights from Detroit to South Carolina?

    Yes. Cheapflights offers flight deals from Detroit to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Detroit to South Carolina (average of $89). Flying from Detroit to South Carolina in December is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Detroit to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Las Vegas flights
O'Hare Intl to Dallas/Fort Worth flights
O'Hare Intl to Sky Harbor Intl flights
Detroit to Orlando flights
Detroit to Fort Lauderdale flights
O'Hare Intl to Tampa flights
O'Hare Intl to Los Angeles flights
O'Hare Intl to Atlanta flights
O'Hare Intl to Orlando flights
O'Hare Intl to Miami flights
O'Hare Intl to Fort Lauderdale flights
O'Hare Intl to John F Kennedy Intl flights
Detroit to Miami flights
O'Hare Intl to Denver flights
O'Hare Intl to San Francisco flights
Detroit to Sky Harbor Intl flights
O'Hare Intl to Fort Myers flights
O'Hare Intl to LaGuardia flights
Detroit to Dallas/Fort Worth flights
Midway to Las Vegas flights
Detroit to Tampa flights
O'Hare Intl to Newark flights
O'Hare Intl to Seattle flights
Detroit to Los Angeles flights
Detroit to Las Vegas flights
Midway to Atlanta flights
O'Hare Intl to Santa Ana flights
Midway to Los Angeles flights
Midway to Orlando flights
O'Hare Intl to San Diego flights
O'Hare Intl to Salt Lake City flights
O'Hare Intl to Honolulu flights
Midway to Dallas/Fort Worth flights
O'Hare Intl to West Palm Beach flights
Detroit to Fort Myers flights
O'Hare Intl to New Orleans flights
Midway to Sky Harbor Intl flights
Midway to Miami flights
Midway to Fort Lauderdale flights
O'Hare Intl to Baltimore flights
O'Hare Intl to Sarasota flights
O'Hare Intl to Austin flights
Midway to Newark flights
Detroit to Sarasota flights
O'Hare Intl to Ontario flights
Detroit to John F Kennedy Intl flights
Midway to LaGuardia flights
O'Hare Intl to Palm Springs flights
Detroit to Denver flights
Midway to Fort Myers flights

Top 4 airlines flying from Detroit to South Carolina

Discover the top 4 airlines that operate flights from Detroit to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$76Average$170FlexibilityNo cancel feeOn-time65%
DeltaCheapest$159Average$394FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$197Average$343FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$207Average$356FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.