$72+ Cheap flights from Detroit (DTT) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/22. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — CHS
Sep 5 — Sep 121
Round-trip
1 adult, Economy
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Find cheap flights from Detroit to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Detroit to South CarolinaExplore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 6, 2026.
Explore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:18 am -
1 stop7h 37m
Wed 9/912:23 pm -
1 stop11h 04m
Deal found 8/5![Multiple Airlines logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:23 pm -
2 stops17h 04m
Tue 9/1512:29 pm -
1 stop10h 58m
Deal found 8/2![Multiple Airlines logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/204:23 pm -
1 stop22h 05m
Fri 9/252:18 pm -
1 stop9h 09m
Deal found 8/5![Multiple Airlines logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:23 pm -
1 stop24h 51m
Mon 9/217:03 pm -
1 stop15h 40m
Deal found 8/5![Multiple Airlines logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:28 am -
1 stop25h 56m
Fri 10/28:58 pm -
1 stop15h 38m
Deal found 8/5![Multiple Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:28 am -
1 stop25h 56m
Wed 9/306:00 am -
2 stops17h 27m
Deal found 8/5![Multiple Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:23 pm -
1 stop20h 37m
Wed 9/2312:23 pm -
1 stop11h 04m
Deal found 8/1![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:23 pm -
1 stop20h 37m
Sat 9/1212:23 pm -
1 stop11h 04m
Deal found 8/1![Multiple Airlines logo]()
$177
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:23 pm -
1 stop20h 37m
Wed 9/3012:23 pm -
1 stop11h 04m
Deal found 8/3![Multiple Airlines logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/148:57 pm -
1 stop11h 41m
Thu 9/174:43 pm -
1 stop6h 44m
Deal found 8/3![Multiple Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:28 am -
1 stop25h 56m
Sat 9/266:00 am -
1 stop6h 36m
Deal found 8/6![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/148:57 pm -
1 stop11h 41m
Fri 9/188:58 pm -
1 stop12h 49m
Deal found 8/3![Multiple Airlines logo]()
$185
Best flights from Detroit to South CarolinaDiscover carefully curated flight deals from Detroit to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 6, 2026.
Discover carefully curated flight deals from Detroit to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 6, 2026.
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:41 am -
Nonstop1h 57m
Fri 9/115:45 pm -
1 stop7h 09m
Deal found 8/5![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:35 am -
2 stops7h 50m
Sat 9/55:15 pm -
1 stop3h 50m
Deal found 8/1![Southwest logo]()
$312
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:20 am -
1 stop4h 01m
Thu 10/155:37 pm -
1 stop6h 22m
Deal found 8/1![United Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:21 am -
2 stops6h 20m
Wed 9/165:10 am -
1 stop5h 05m
Deal found 8/2![American Airlines logo]()
$410
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:45 am -
Nonstop1h 57m
Thu 11/1211:22 am -
Nonstop2h 01m
Deal found 8/1![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:34 am -
1 stop6h 29m
Sat 9/263:00 pm -
1 stop7h 15m
Deal found 8/3![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:35 pm -
1 stop3h 50m
Mon 10/193:55 pm -
1 stop7h 05m
Deal found 8/4![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:20 am -
1 stop4h 03m
Sat 9/196:49 pm -
Nonstop2h 11m
Deal found 8/6![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:00 am -
1 stop5h 59m
Mon 9/141:50 pm -
1 stop8h 19m
Deal found 8/1![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2612:55 pm -
2 stops8h 30m
Mon 8/316:35 am -
2 stops8h 35m
Deal found 8/2![Southwest logo]()
$339
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:40 am -
Nonstop1h 56m
Wed 10/147:01 pm -
1 stop5h 57m
Deal found 8/5![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:35 am -
1 stop6h 30m
Sun 9/62:58 pm -
1 stop5h 31m
Deal found 8/5![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/52:50 pm -
1 stop4h 35m
Sun 9/69:10 am -
1 stop4h 05m
Deal found 8/2![Southwest logo]()
$341
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am -
1 stop4h 37m
Sat 9/2612:50 pm -
2 stops9h 08m
Deal found 8/3![American Airlines logo]()
$416
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:20 pm -
1 stop4h 08m
Fri 9/2511:34 am -
Nonstop1h 54m
Deal found 8/6![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:30 am -
2 stops6h 51m
Tue 9/86:25 am -
1 stop5h 02m
Deal found 8/5![United Airlines logo]()
$324
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:20 pm -
2 stops8h 30m
Sat 8/296:30 am -
2 stops14h 30m
Deal found 8/3![Southwest logo]()
$345
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:05 pm -
1 stop5h 23m
Wed 9/3011:34 am -
Nonstop1h 54m
Deal found 8/1![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:30 am -
2 stops6h 56m
Sat 10/35:37 pm -
1 stop6h 22m
Deal found 8/1![United Airlines logo]()
$331
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/303:10 pm -
1 stop4h 25m
Fri 2/56:30 am -
1 stop6h 25m
Deal found 8/5![Southwest logo]()
$348
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:25 pm -
1 stop4h 58m
Sun 10/255:40 am -
1 stop4h 47m
Deal found 8/4![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:43 pm -
1 stop4h 16m
Wed 9/91:43 pm -
1 stop3h 47m
Deal found 8/3![American Airlines logo]()
$491
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:25 am -
1 stop5h 49m
Sun 10/115:40 am -
1 stop4h 47m
Deal found 8/4![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:10 am -
2 stops10h 30m
Mon 11/27:25 pm -
1 stop4h 30m
Deal found 8/4![Southwest logo]()
$351
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/144:26 pm -
1 stop5h 02m
Fri 8/216:25 am -
1 stop5h 02m
Deal found 8/2![United Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:20 am -
1 stop6h 54m
Tue 9/86:00 am -
1 stop4h 20m
Deal found 8/4![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/288:55 am -
2 stops7h 30m
Mon 8/311:05 pm -
2 stops7h 45m
Deal found 8/4![Southwest logo]()
$358
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:43 pm -
1 stop4h 16m
Tue 8/183:22 pm -
1 stop7h 08m
Deal found 8/1![American Airlines logo]()
$551
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/129:15 am -
1 stop4h 48m
Wed 8/192:58 pm -
1 stop5h 31m
Deal found 8/1![United Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/311:20 pm -
2 stops8h 30m
Mon 9/76:35 am -
2 stops8h 35m
Deal found 8/3![Southwest logo]()
$358
Last-minute flights from Detroit to South CarolinaDiscover last-minute flight deals from Detroit to South Carolina. Data last updated August 6, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to South Carolina. Data last updated August 6, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:18 am -
1 stop7h 37m
Wed 9/912:23 pm -
1 stop11h 04m
Deal found 8/5![Multiple Airlines logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:23 pm -
2 stops17h 04m
Tue 9/1512:29 pm -
1 stop10h 58m
Deal found 8/2![Multiple Airlines logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:23 pm -
1 stop20h 37m
Sat 9/1212:23 pm -
1 stop11h 04m
Deal found 8/1![Multiple Airlines logo]()
$177
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:23 pm -
1 stop24h 51m
Mon 9/217:03 pm -
1 stop15h 40m
Deal found 8/5![Multiple Airlines logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/148:57 pm -
1 stop11h 41m
Thu 9/174:43 pm -
1 stop6h 44m
Deal found 8/3![Multiple Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/148:57 pm -
1 stop11h 41m
Fri 9/188:58 pm -
1 stop12h 49m
Deal found 8/3![Multiple Airlines logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:23 pm -
1 stop20h 37m
Wed 9/2312:23 pm -
1 stop11h 04m
Deal found 8/1![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/204:23 pm -
1 stop22h 05m
Fri 9/252:18 pm -
1 stop9h 09m
Deal found 8/5![Multiple Airlines logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:28 am -
1 stop25h 56m
Wed 9/306:00 am -
2 stops17h 27m
Deal found 8/5![Multiple Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:28 am -
1 stop25h 56m
Sat 9/266:00 am -
1 stop6h 36m
Deal found 8/6![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:23 pm -
1 stop20h 37m
Wed 9/3012:23 pm -
1 stop11h 04m
Deal found 8/3![Multiple Airlines logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:28 am -
1 stop25h 56m
Fri 10/28:58 pm -
1 stop15h 38m
Deal found 8/5![Multiple Airlines logo]()
$170
One-way flights from Detroit to South CarolinaSearch for one-way flight options from Detroit to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 6, 2026.
Search for one-way flight options from Detroit to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:28 am -
1 stop25h 56m
Deal found 8/5![Multiple Airlines logo]()
$72
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:18 am -
1 stop7h 37m
Deal found 8/3![Multiple Airlines logo]()
$74
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/294:23 pm -
1 stop23h 52m
Deal found 8/1![Multiple Airlines logo]()
$75
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1111:00 am -
1 stop9h 59m
Deal found 8/4![Multiple Airlines logo]()
$78
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:23 pm -
2 stops17h 04m
Deal found 8/4![Multiple Airlines logo]()
$78
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/44:23 pm -
1 stop21h 37m
Deal found 8/4![Multiple Airlines logo]()
$80
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:23 pm -
1 stop24h 51m
Deal found 8/3![Multiple Airlines logo]()
$81
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:18 am -
1 stop21h 39m
Deal found 8/2![Multiple Airlines logo]()
$82
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:28 am -
1 stop25h 56m
Deal found 8/3![Multiple Airlines logo]()
$87
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/611:28 am -
1 stop24h 16m
Deal found 8/5![Multiple Airlines logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:31 pm -
1 stop19h 56m
Deal found 8/4![Multiple Airlines logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:23 pm -
1 stop23h 40m
Deal found 8/5![Multiple Airlines logo]()
$91
Find flight deals from Detroit to South Carolina
Keep the following information in mind while searching for Detroit to South Carolina flight deals. Data was last updated August 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $143 (Kiwi.com) |
One-way from | $72 (Kiwi.com) |
Popular in | March |
Cheapest in | October |
Average price | $318 |
Good round-trip deal | $299 or less |
Good one-way deal | $333 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from Detroit to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitMyrtle Beach
DTW Detroit Metropolitan Wayne County - MYR Myrtle Beach Intl
DTWMYR
Detroit Metropolitan Wayne County
Sun 9/6
8:41 am-10:38 am
Nonstop1h 57m
Myrtle Beach Intl
Fri 9/11
5:45 pm-12:54 am
1 stop7h 09m
$309
Quickest round-trip
DetroitMyrtle Beach
DTW Detroit Metropolitan Wayne County - MYR Myrtle Beach Intl
DTWMYR
Detroit Metropolitan Wayne County
Mon 10/12
8:45 am-10:42 am
Nonstop1h 57m
Myrtle Beach Intl
Thu 11/12
11:22 am-1:23 pm
Nonstop2h 01m
$309
DetroitCharleston
DTW Detroit Metropolitan Wayne County - CHS Charleston
DTWCHS
Detroit Metropolitan Wayne County
Sat 9/12
7:20 am-11:23 am
1 stop4h 03m
Charleston
Sat 9/19
6:49 pm-9:00 pm
Nonstop2h 11m
$309
DetroitCharlotte
DTW Detroit Metropolitan Wayne County - CLT Charlotte Douglas
DTWCLT
Detroit Metropolitan Wayne County
Sat 8/29
6:35 am-2:25 pm
2 stops7h 50m
Charlotte Douglas
Sat 9/5
5:15 pm-9:05 pm
1 stop3h 50m
$312
DetroitMyrtle Beach
DTW Detroit Metropolitan Wayne County - MYR Myrtle Beach Intl
DTWMYR
Detroit Metropolitan Wayne County
Wed 9/30
8:40 am-10:36 am
Nonstop1h 56m
Myrtle Beach Intl
Wed 10/14
7:01 pm-12:58 am
1 stop5h 57m
$314
DetroitMyrtle Beach
DTW Detroit Metropolitan Wayne County - MYR Myrtle Beach Intl
DTWMYR
Detroit Metropolitan Wayne County
Fri 9/18
7:20 pm-11:28 pm
1 stop4h 08m
Myrtle Beach Intl
Fri 9/25
11:34 am-1:28 pm
Nonstop1h 54m
$314
DetroitMyrtle Beach
DTW Detroit Metropolitan Wayne County - MYR Myrtle Beach Intl
DTWMYR
Detroit Metropolitan Wayne County
Fri 9/25
6:05 pm-11:28 pm
1 stop5h 23m
Myrtle Beach Intl
Wed 9/30
11:34 am-1:28 pm
Nonstop1h 54m
$314
DetroitColumbia
DTW Detroit Metropolitan Wayne County - CAE Columbia Metropolitan
DTWCAE
Detroit Metropolitan Wayne County
Tue 9/15
10:20 am-2:21 pm
1 stop4h 01m
Columbia Metropolitan
Thu 10/15
5:37 pm-11:59 pm
1 stop6h 22m
$319
DetroitHilton Head Island
DTW Detroit Metropolitan Wayne County - HHH Hilton Head Island
DTWHHH
Detroit Metropolitan Wayne County
Wed 9/23
7:34 am-2:03 pm
1 stop6h 29m
Hilton Head Island
Sat 9/26
3:00 pm-10:15 pm
1 stop7h 15m
$319
DetroitHilton Head Island
DTW Detroit Metropolitan Wayne County - HHH Hilton Head Island
DTWHHH
Detroit Metropolitan Wayne County
Fri 9/11
7:00 am-12:59 pm
1 stop5h 59m
Hilton Head Island
Mon 9/14
1:50 pm-10:09 pm
1 stop8h 19m
$319
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Detroit to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Detroit with our price prediction graph.
DTW-CHS
DTW-CLT
DTW-HHH
DTW-CAE
DTW-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to South Carolina
DTT-USSC
DTW-CHS
DTW-CLT
DTW-HHH
DTW-CAE
What is the cheapest month to book a flight from Detroit to South Carolina?
Currently, October is the cheapest month in which you can book a flight from Detroit to South Carolina (average of $327). Flying from Detroit to South Carolina in March is currently the most expensive (average of $457). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DTT to SC?
Find hourly flight availability from Detroit to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 6, 2026.
When flying from Detroit to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 17% versus a flight in the morning.
Weekly flight availability from Detroit to South Carolina
Explore weekly flight availability from Detroit to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 6, 2026.
The most flights from DTT to USSC are scheduled on a Wednesday (9 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).
How much does it cost to fly round-trip from Detroit to South Carolina?
Airfare is typical for this route at the moment.
Detroit to South Carolina flights typically cost between $131 and $514 in September.The cheapest round-trip price found within the last 5 days was $170 on Multiple Airlines (Sep 29-Oct 2).
How far ahead should I book a flight from Detroit to South Carolina?
The best time to book flights from Detroit to South Carolina is 86 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest day to fly from Detroit to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Detroit to South Carolina. Price data was last updated on August 1, 2026.
Travelers seeking maximum savings on their Detroit to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 6, 2026.
Read reviews from past customers who have flown Southwest,Delta, andAmerican Airlines from Detroit to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
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Alternative routes for Detroit to South Carolina
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Complete your trip
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Detroit and South Carolina flights
Browse other Detroit and South Carolina flight options. Last updated on August 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Detroit to South Carolina flights
Consider these flights traveling from Detroit to South Carolina.
Top 4 airlines flying from Detroit to South Carolina
Discover the top 4 airlines that operate flights from Detroit to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$440 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$230 | Average$408 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$233 | Average$391 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$283 | Average$338 | FlexibilityNo cancel fee | On-time69% |