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South Carolina

$243+ Cheap flights from Columbia, MO (COU) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
COU — CHS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Columbia to South Carolina

Cheapest flights from Columbia to South Carolina
Explore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/273:16 pm
COU
-
CLT
1 stop5h 07m
United Airlines
Tue 7/710:40 am
CLT
-
COU
1 stop4h 49m
United Airlines
Deal found 1/28$258
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2111:15 am
COU
-
CLT
1 stop4h 54m
United Airlines
Tue 2/2411:23 am
CLT
-
COU
2 stops11h 10m
United Airlines
Deal found 1/28$264
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/248:00 am
COU
-
CLT
2 stops9h 55m
United Airlines
Tue 3/311:23 am
CLT
-
COU
2 stops11h 10m
United Airlines
Deal found 1/26$269
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2511:15 am
COU
-
CLT
1 stop5h 07m
United Airlines
Sat 3/2810:26 am
CLT
-
COU
1 stop4h 40m
United Airlines
Deal found 1/27$293
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2011:15 am
COU
-
CHS
2 stops11h 29m
United Airlines
Tue 2/2410:20 am
CHS
-
COU
1 stop5h 08m
United Airlines
Deal found 1/28$299
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/311:17 am
COU
-
CLT
1 stop5h 07m
United Airlines
Sat 2/710:44 am
CLT
-
COU
1 stop4h 51m
United Airlines
Deal found 1/26$328
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/48:10 am
COU
-
CHS
1 stop4h 52m
United Airlines
Sat 2/710:30 am
CHS
-
COU
1 stop7h 49m
United Airlines
Deal found 1/27$328
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/58:09 am
COU
-
CHS
2 stops8h 50m
United Airlines
Sun 2/86:00 am
CHS
-
COU
2 stops9h 35m
United Airlines
Deal found 1/27$365
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2711:15 am
COU
-
CLT
1 stop5h 07m
United Airlines
Thu 4/96:15 am
CLT
-
COU
1 stop5h 40m
United Airlines
Deal found 1/28$372
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/277:00 am
COU
-
CLT
Nonstop2h 15m
American Airlines
Tue 7/79:22 pm
CLT
-
COU
Nonstop2h 15m
American Airlines
Deal found 1/28$373
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/2711:17 am
COU
-
CHS
1 stop7h 45m
United Airlines
Sat 1/3110:30 am
CHS
-
COU
1 stop5h 05m
United Airlines
Deal found 1/26$428
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1911:15 am
COU
-
CHS
1 stop5h 49m
United Airlines
Mon 3/238:15 am
CHS
-
COU
1 stop6h 51m
United Airlines
Deal found 1/28$453

Find flight deals from Columbia to South Carolina

Keep the following information in mind while searching for Columbia to South Carolina flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$258
(United Airlines)

One-way from

$243
(United Airlines)
Provider with most accurate pricing for Columbia Regional-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Myrtle Beach Intl flights.
Search Deals
From Columbia Regional to South Carolina
Search Deals
One-way flight from Columbia Regional to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Columbia to South Carolina that are best for you.

Fly from

Columbia

Fly to

South Carolina

Route

Depart

Return

Price

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Tue 2/24

3:10 pm-9:01 pm

1 stop4h 51m

Charlotte Douglas

Tue 3/3

10:30 am-2:28 pm

1 stop4h 58m

$258

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 6/27

3:16 pm-9:23 pm

1 stop5h 07m

Charlotte Douglas

Tue 7/7

10:40 am-2:29 pm

1 stop4h 49m

$258

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 7/15

3:16 pm-9:23 pm

1 stop5h 07m

Charlotte Douglas

Sat 7/18

5:28 pm-9:10 pm

1 stop4h 42m

$258

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 2/21

3:10 pm-9:03 pm

1 stop4h 53m

Charlotte Douglas

Tue 2/24

6:00 am-10:33 am

1 stop5h 33m

$258

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Thu 6/4

11:23 am-11:56 pm

2 stops11h 33m

Charlotte Douglas

Sat 7/4

5:28 pm-9:10 pm

1 stop4h 42m

$264

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 3/25

11:15 am-5:22 pm

1 stop5h 07m

Charlotte Douglas

Sat 3/28

10:26 am-2:06 pm

1 stop4h 40m

$293

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Fri 2/20

11:15 am-11:44 pm

2 stops11h 29m

Charleston

Tue 2/24

10:20 am-2:28 pm

1 stop5h 08m

$299

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Thu 3/19

11:15 am-6:04 pm

1 stop5h 49m

Charleston

Mon 3/23

8:15 am-2:06 pm

1 stop6h 51m

$453

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Wed 2/11

8:09 am-2:02 pm

1 stop4h 53m

Charleston

Sun 2/15

1:11 pm-10:33 am

1 stop22h 22m

$522

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Sun 3/22

6:30 pm-11:46 am

1 stop16h 16m

Myrtle Beach Intl

Wed 3/25

5:19 pm-10:36 pm

1 stop6h 17m

$524

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/29

Showing 1-10 of 28 results
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Best time to book a flight from Columbia to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to South Carolina
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 29, 2026.
See what other customers who have flown with American Airlines from Columbia to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,206 reviews

Boarding

7.5

Comfort

7.2

Crew

8.0

Entertainment

6.9

Overall

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,206 reviews
American Airlines
7.2
Good
11,206 reviews

Boarding

7.5

Comfort

7.2

Crew

8.0

Entertainment

6.9

Overall

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Columbia to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to South Carolina?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to South Carolina.

  • How long is the flight from Columbia, Missouri to South Carolina?

    Departing from Columbia, Missouri to South Carolina will take you 4h 51m. There are 669 mi between Columbia, Missouri and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Columbia, Missouri to South Carolina?

    When deciding which route to take from Columbia, Missouri to South Carolina consider Columbia Regional - Charlotte Douglas, Columbia Regional - Charleston or Columbia Regional - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Columbia to South Carolina that include hotel bookings?

    Yes. In addition to deals on Columbia to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to South Carolina.

  • Can I find deals for business class flights from Columbia to South Carolina?

    Yes. Cheapflights offers flight deals from Columbia to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Columbia to South Carolina

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Top airline flying from Columbia to South Carolina

Discover the top airline that operate flights from Columbia to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$410Average$488FlexibilityNo cancel feeOn-time71%

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