HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$122+ Cheap flights from Cape Cod and the Islands to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/12. Fares are subject to change and may not be available on all flights or dates of travel.
ACK — CHS
Jun 21 — Jun 281
Sat 6/21
Sat 6/28
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Cape Cod and the Islands to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Cape Cod and the Islands to South Carolina

Keep the following information in mind while searching for Cape Cod and the Islands to South Carolina flight deals. Data was last updated June 16, 2025.

Round-trip from

$206
(American Airlines)

One-way from

$122
(American Airlines)

Popular in

April

Cheapest in

February

Average price

$190
From Cape Cod and the Islands to South Carolina
Search Deals
One-way flight from Cape Cod and the Islands to South Carolina
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($33 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Cape Cod and the Islands to South Carolina

Cheapest flights from Cape Cod and the Islands to South Carolina
Explore the most affordable flight options available from Cape Cod and the Islands to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2025.

This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/254:27 pmACK - CHS
1 stop5h 03mAmerican Airlines
Tue 7/296:00 amCHS - ACK
1 stop5h 44mAmerican Airlines
Deal found 6/14$206
This JetBlue deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1910:16 amMVY - SAV
1 stop5h 47mJetBlue
Sun 7/279:55 amSAV - MVY
1 stop6h 06mJetBlue
Deal found 6/15$222
This JetBlue deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1611:23 amMVY - CHS
1 stop6h 41mJetBlue
Thu 7/1711:00 amCHS - MVY
1 stop5h 01mJetBlue
Deal found 6/16$243
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2812:12 pmHYA - CHS
1 stop5h 32mAmerican Airlines
Tue 7/17:45 amCHS - HYA
1 stop4h 03mAmerican Airlines
Deal found 6/16$316
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/222:13 pmMVY - CHS
1 stop7h 09mDelta
Mon 8/257:00 amCHS - MVY
1 stop6h 33mDelta
Deal found 6/14$328
This JetBlue deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/86:48 amHYA - CHS
1 stop5h 36mJetBlue
Wed 7/911:00 amCHS - HYA
1 stop5h 10mJetBlue
Deal found 6/15$423
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2612:15 pmACK - CLT
2 stops9h 09mAmerican Airlines
Mon 6/309:21 amCLT - ACK
1 stop7h 35mAmerican Airlines
Deal found 6/14$456
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/264:10 pmACK - CLT
2 stops7h 47mUnited Airlines
Mon 6/306:00 amCLT - ACK
2 stops9h 10mUnited Airlines
Deal found 6/15$469
This JetBlue Airways deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/2910:36 amHYA - CHS
1 stop24h 44mMultiple Airlines
Thu 7/38:45 pmCHS - HYA
1 stop23h 42mMultiple Airlines
Deal found 6/14$525
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/183:22 pmMVY - MYR
2 stops8h 37mDelta
Mon 7/216:00 amMYR - MVY
2 stops7h 33mDelta
Deal found 6/14$588
This JetBlue deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2812:00 pmPVC - CHS
1 stop7h 50mJetBlue
Mon 7/71:19 pmCHS - PVC
1 stop4h 07mJetBlue
Deal found 6/15$757
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/296:10 pmMVY - CLT
1 stop12h 25mAmerican Airlines
Thu 7/310:33 pmCLT - MVY
1 stop13h 07mAmerican Airlines
Deal found 6/14$820

Cheapflights Fare Finder

Customize your flight search to find flights from Cape Cod and the Islands to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
Use the filters below to find and compare flights from Cape Cod and the Islands to South Carolina that are best for you.

Fly from

Cape Cod and the Islands

Fly to

South Carolina

Route

Depart

Return

Price

NantucketCharleston

ACK - CHS

ACKCHS

Nantucket Memorial

Fri 7/25

4:27 pm-9:30 pm

1 stop5h 03m

Charleston

Tue 7/29

6:00 am-11:44 am

1 stop5h 44m

$206

West TisburySavannah

MVY - SAV

MVYSAV

West Tisbury Martha's Vineyard

Sat 7/19

10:16 am-4:03 pm

1 stop5h 47m

Savannah/Hilton Head

Sun 7/27

9:55 am-4:01 pm

1 stop6h 06m

$222

West TisburyCharleston

MVY - CHS

MVYCHS

West Tisbury Martha's Vineyard

Wed 7/16

11:23 am-6:04 pm

1 stop6h 41m

Charleston

Thu 7/17

11:00 am-4:01 pm

1 stop5h 01m

$243

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Sat 6/28

12:12 pm-5:44 pm

1 stop5h 32m

Charleston

Tue 7/1

7:45 am-11:48 am

1 stop4h 03m

$316

West TisburyCharleston

MVY - CHS

MVYCHS

West Tisbury Martha's Vineyard

Fri 8/22

2:13 pm-9:22 pm

1 stop7h 09m

Charleston

Mon 8/25

7:00 am-1:33 pm

1 stop6h 33m

$328

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Tue 7/8

6:48 am-12:24 pm

1 stop5h 36m

Charleston

Wed 7/9

11:00 am-4:10 pm

1 stop5h 10m

$423

NantucketCharlotte

ACK - CLT

ACKCLT

Nantucket Memorial

Thu 6/26

12:15 pm-9:24 pm

2 stops9h 09m

Charlotte Douglas

Mon 6/30

9:21 am-4:56 pm

1 stop7h 35m

$456

NantucketCharlotte

ACK - CLT

ACKCLT

Nantucket Memorial

Thu 6/26

4:10 pm-11:57 pm

2 stops7h 47m

Charlotte Douglas

Mon 6/30

6:00 am-3:10 pm

2 stops9h 10m

$469

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Sun 6/29

10:36 am-11:20 am

1 stop24h 44m

Charleston

Thu 7/3

8:45 pm-8:27 pm

1 stop23h 42m

$525

West TisburyMyrtle Beach

MVY - MYR

MVYMYR

West Tisbury Martha's Vineyard

Fri 7/18

3:22 pm-11:59 pm

2 stops8h 37m

Myrtle Beach Intl

Mon 7/21

6:00 am-1:33 pm

2 stops7h 33m

$588

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/14

Showing 1-10 of 31 results
1
2
3
4

Best time to book a flight from Cape Cod and the Islands to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Cape Cod and the Islands with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cape Cod and the Islands to South Carolina

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 16, 2025.
To help decide which airline to fly from Cape Cod and the Islands to South Carolina, see what other customers have to say about Delta, United Airlines and JetBlue. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,963 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,963 reviews
Delta
8.0
Very good
7,963 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,801 reviews
Delta
8.0
Very good
7,963 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
JetBlue
7.3
Good
2,922 reviews
Delta
8.0
Very good
7,963 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,963 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Cape Cod and the Islands to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Cape Cod and the Islands to South Carolina one-way?

    $122 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and JetBlue, with prices starting from $137 and $269, respectively.

  • Can I find deals for flights from Cape Cod and the Islands to South Carolina that include hotel bookings?

    Yes. In addition to deals on Cape Cod and the Islands to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cape Cod and the Islands to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cape Cod and the Islands to South Carolina.

  • Can I find deals for business class flights from Cape Cod and the Islands to South Carolina?

    Yes. Cheapflights offers flight deals from Cape Cod and the Islands to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cape Cod and the Islands to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Cape Cod and the Islands to South Carolina (average of $217). Flying from Cape Cod and the Islands to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Cape Cod and the Islands to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Boston to O'Hare Intl flights
Boston to Los Angeles flights
Boston to Las Vegas flights
Boston to Miami flights
Boston to Seattle flights
Boston to Orlando flights
Boston to San Francisco flights
Boston to Denver flights
Boston to Reagan-National flights
Boston to Fort Lauderdale flights
Boston to Dallas/Fort Worth flights
Boston to Atlanta flights
Boston to Newark flights
Boston to Hobby flights
Hartford to Orlando flights
Boston to Baltimore flights
Boston to Charlotte flights
Boston to Nashville flights
Boston to LaGuardia flights
Boston to Dulles Intl flights
Boston to Philadelphia flights
Boston to Minneapolis flights
Boston to Charleston flights
Boston to George Bush Intcntl flights
Boston to Salt Lake City flights
Boston to Tampa flights
Boston to Portland flights
Boston to Honolulu flights
Hartford to O'Hare Intl flights
Boston to John F Kennedy Intl flights
Boston to San Diego flights
Hartford to Denver flights
Boston to Sky Harbor Intl flights
Boston to Raleigh flights
Boston to Detroit flights
Hartford to Los Angeles flights
Boston to Midway flights
Hartford to Tampa flights
Boston to Bozeman flights
Boston to Austin flights
Boston to New Orleans flights
Hartford to Las Vegas flights
Hartford to Atlanta flights
Boston to Pittsburgh flights
Boston to Cleveland flights
Boston to Cincinnati flights
Boston to Ontario flights
Boston to West Palm Beach flights
Boston to Milwaukee flights
Hartford to Fort Lauderdale flights

Top airline flying from Cape Cod and the Islands to South Carolina

Discover the top airline that operate flights from Cape Cod and the Islands to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$263Average$300FlexibilityNo cancel feeOn-time62%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.