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$173+ Cheap flights from Cape Cod and the Islands to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.
ACK — CHS
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Cape Cod and the Islands to South Carolina

Keep the following information in mind while searching for Cape Cod and the Islands to South Carolina flight deals. Data was last updated September 16, 2025.

Round-trip from

$435
(JetBlue)

One-way from

$173
(Expedia)

Popular in

April

Cheapest in

February

Average price

$194
From Cape Cod and the Islands to South Carolina
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One-way flight from Cape Cod and the Islands to South Carolina
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Cape Cod and the Islands to South Carolina

Cheapest flights from Cape Cod and the Islands to South Carolina
Explore the most affordable flight options available from Cape Cod and the Islands to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This JetBlue deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2910:16 amHYA - CHS
1 stop7h 29mJetBlue
Wed 10/11:02 pmCHS - HYA
1 stop4h 36mJetBlue
Deal found 9/16$515
This JetBlue deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:48 amHYA - CHS
1 stop5h 19mJetBlue
Fri 9/261:02 pmCHS - HYA
1 stop4h 36mJetBlue
Deal found 9/16$645
This JetBlue deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/96:45 amPVC - CHS
1 stop5h 20mJetBlue
Sun 10/127:00 amCHS - PVC
1 stop4h 24mJetBlue
Deal found 9/14$700
This JetBlue deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1010:55 amPVC - CHS
1 stop5h 19mJetBlue
Sun 10/127:00 amCHS - PVC
1 stop4h 24mJetBlue
Deal found 9/14$850
This JetBlue deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/96:45 amPVC - CHS
1 stop5h 20mJetBlue
Mon 10/137:00 amCHS - PVC
1 stop4h 24mJetBlue
Deal found 9/14$890
This JetBlue deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:50 amACK - CHS
1 stop5h 17mJetBlue
Sun 10/57:00 amCHS - ACK
1 stop6h 21mJetBlue
Deal found 9/16$909
This JetBlue deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:43 amMVY - SAV
1 stop6h 32mJetBlue
Mon 10/204:10 pmSAV - MVY
1 stop4h 35mJetBlue
Deal found 9/14$1,004
This JetBlue deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1012:00 pmPVC - CHS
1 stop4h 14mJetBlue
Mon 10/137:00 amCHS - PVC
1 stop4h 24mJetBlue
Deal found 9/14$1,040
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:00 pmACK - CHS
1 stop20h 19mMultiple Airlines
Sun 10/52:59 pmCHS - ACK
2 stops29h 01mMultiple Airlines
Deal found 9/16$1,429

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cape Cod and the Islands to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Cape Cod and the Islands to South Carolina that are best for you.

Fly from

Cape Cod and the Islands

Fly to

South Carolina

Route

Depart

Return

Price

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Sat 2/28

4:09 pm-8:44 pm

1 stop4h 35m

Charleston

Tue 3/3

9:30 am-2:00 pm

1 stop4h 30m

$435

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Mon 9/29

10:16 am-5:45 pm

1 stop7h 29m

Charleston

Wed 10/1

1:02 pm-5:38 pm

1 stop4h 36m

$515

ProvincetownCharleston

PVC - CHS

PVCCHS

Provincetown

Thu 10/9

6:45 am-12:05 pm

1 stop5h 20m

Charleston

Sun 10/12

7:00 am-11:24 am

1 stop4h 24m

$700

ProvincetownCharleston

PVC - CHS

PVCCHS

Provincetown

Fri 10/10

10:55 am-4:14 pm

1 stop5h 19m

Charleston

Sun 10/12

7:00 am-11:24 am

1 stop4h 24m

$850

ProvincetownCharleston

PVC - CHS

PVCCHS

Provincetown

Thu 10/9

6:45 am-12:05 pm

1 stop5h 20m

Charleston

Mon 10/13

7:00 am-11:24 am

1 stop4h 24m

$890

NantucketCharleston

ACK - CHS

ACKCHS

Nantucket Memorial

Wed 10/1

6:50 am-12:07 pm

1 stop5h 17m

Charleston

Sun 10/5

7:00 am-1:21 pm

1 stop6h 21m

$909

West TisburySavannah

MVY - SAV

MVYSAV

West Tisbury Martha's Vineyard

Fri 10/17

8:43 am-3:15 pm

1 stop6h 32m

Savannah/Hilton Head

Mon 10/20

4:10 pm-8:45 pm

1 stop4h 35m

$1,004

ProvincetownCharleston

PVC - CHS

PVCCHS

Provincetown

Fri 10/10

12:00 pm-4:14 pm

1 stop4h 14m

Charleston

Mon 10/13

7:00 am-11:24 am

1 stop4h 24m

$1,040

NantucketCharleston

ACK - CHS

ACKCHS

Nantucket Memorial

Wed 10/1

6:00 pm-2:19 pm

1 stop20h 19m

Charleston

Sun 10/5

2:59 pm-8:00 pm

2 stops29h 01m

$1,429

NantucketCharleston

ACK - CHS

ACKCHS

Nantucket Memorial

Sat 10/11

4:11 pm-8:54 am

2 stops16h 43m

$173

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 27 results
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Best time to book a flight from Cape Cod and the Islands to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Cape Cod and the Islands with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cape Cod and the Islands to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Cape Cod and the Islands to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Cape Cod and the Islands to South Carolina?

    JetBlue can get you from Cape Cod and the Islands to South Carolina in just under 4h 35m. Your travel time can differ by up to . The distance between Cape Cod and the Islands and South Carolina is about 808 mi.

  • Can I find deals for flights from Cape Cod and the Islands to South Carolina that include hotel bookings?

    Yes. In addition to deals on Cape Cod and the Islands to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cape Cod and the Islands to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cape Cod and the Islands to South Carolina.

  • Can I find deals for business class flights from Cape Cod and the Islands to South Carolina?

    Yes. Cheapflights offers flight deals from Cape Cod and the Islands to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cape Cod and the Islands to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Cape Cod and the Islands to South Carolina (average of $217). Flying from Cape Cod and the Islands to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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