$415+ Cheap flights from Amarillo (AMA) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
AMA — CHS
May 17 — May 241
Round-trip
1 adult, Economy
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Find cheap flights from Amarillo to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Amarillo to South Carolina
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Best
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Cheapest flights from Amarillo to South CarolinaExplore the most affordable flight options available from Amarillo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2026.
Explore the most affordable flight options available from Amarillo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2026.
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:00 am
AMA
- CAE
1 stop4h 58m
American Airlines
Sat 5/237:21 pm
CAE
- AMA
1 stop5h 38m
American Airlines
Deal found 4/16![American Airlines logo]()
$415
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:17 pm
AMA
- CHS
1 stop5h 39m
American Airlines
Thu 7/97:21 pm
CHS
- AMA
1 stop5h 38m
American Airlines
Deal found 4/15![American Airlines logo]()
$447
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:00 am
AMA
- CHS
1 stop6h 11m
United Airlines
Wed 5/65:07 pm
CHS
- AMA
1 stop6h 27m
United Airlines
Deal found 4/13![United Airlines logo]()
$457
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:23 am
AMA
- CHS
1 stop6h 03m
American Airlines
Sat 11/73:16 pm
CHS
- AMA
1 stop8h 04m
American Airlines
Deal found 4/16![American Airlines logo]()
$467
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/33:18 pm
AMA
- CHS
1 stop5h 57m
United Airlines
Thu 7/910:00 am
CHS
- AMA
2 stops13h 30m
United Airlines
Deal found 4/15![United Airlines logo]()
$470
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/224:17 pm
AMA
- CAE
1 stop6h 16m
American Airlines
Sun 5/247:21 pm
CAE
- AMA
1 stop5h 38m
American Airlines
Deal found 4/16![American Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:00 am
AMA
- CAE
1 stop5h 58m
American Airlines
Mon 5/184:15 pm
CAE
- AMA
1 stop7h 28m
American Airlines
Deal found 4/13![American Airlines logo]()
$721
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:17 pm
AMA
- CAE
1 stop6h 16m
American Airlines
Wed 5/271:53 pm
CAE
- AMA
1 stop5h 43m
American Airlines
Deal found 4/14![American Airlines logo]()
$762
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:18 pm
AMA
- CAE
2 stops21h 28m
United Airlines
Wed 5/2710:31 am
CAE
- AMA
2 stops12h 59m
United Airlines
Deal found 4/14![United Airlines logo]()
$783
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
AMA
- CAE
1 stop4h 58m
American Airlines
Mon 5/184:15 pm
CAE
- AMA
1 stop7h 28m
American Airlines
Deal found 4/13![American Airlines logo]()
$811
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
AMA
- CAE
1 stop4h 58m
American Airlines
Thu 5/144:15 pm
CAE
- AMA
1 stop6h 27m
American Airlines
Deal found 4/13![American Airlines logo]()
$817
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:15 pm
AMA
- CAE
2 stops17h 44m
United Airlines
Mon 5/187:38 pm
CAE
- AMA
2 stops16h 46m
United Airlines
Deal found 4/13![United Airlines logo]()
$842
Best flights from Amarillo to South CarolinaDiscover carefully curated flight deals from Amarillo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2026.
Discover carefully curated flight deals from Amarillo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2026.
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:00 am
AMA
- CAE
1 stop5h 58m
American Airlines
Sat 5/234:09 pm
CAE
- AMA
2 stops8h 50m
American Airlines
Deal found 4/16![American Airlines logo]()
$420
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:00 am
AMA
- CHS
1 stop6h 11m
United Airlines
Wed 5/65:07 pm
CHS
- AMA
1 stop6h 27m
United Airlines
Deal found 4/13![United Airlines logo]()
$457
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:17 pm
AMA
- CHS
1 stop5h 39m
American Airlines
Thu 7/97:21 pm
CHS
- AMA
1 stop5h 38m
American Airlines
Deal found 4/15![American Airlines logo]()
$447
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/33:18 pm
AMA
- CHS
1 stop5h 57m
United Airlines
Thu 7/910:00 am
CHS
- AMA
2 stops13h 30m
United Airlines
Deal found 4/15![United Airlines logo]()
$470
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/23:05 pm
AMA
- CHS
1 stop5h 54m
United Airlines
Wed 5/68:00 am
CHS
- AMA
1 stop9h 32m
United Airlines
Deal found 4/17![United Airlines logo]()
$567
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/224:17 pm
AMA
- CAE
1 stop6h 16m
American Airlines
Sun 5/247:21 pm
CAE
- AMA
1 stop5h 38m
American Airlines
Deal found 4/16![American Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:00 am
AMA
- CAE
1 stop5h 58m
American Airlines
Mon 5/184:15 pm
CAE
- AMA
1 stop7h 28m
American Airlines
Deal found 4/13![American Airlines logo]()
$721
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:15 pm
AMA
- CAE
2 stops17h 44m
United Airlines
Mon 5/187:38 pm
CAE
- AMA
2 stops16h 46m
United Airlines
Deal found 4/13![United Airlines logo]()
$842
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:00 am
AMA
- CAE
1 stop5h 58m
American Airlines
Sun 5/35:00 am
CAE
- AMA
2 stops8h 35m
American Airlines
Deal found 4/14![American Airlines logo]()
$864
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:06 pm
AMA
- CAE
2 stops20h 53m
United Airlines
Thu 5/147:38 pm
CAE
- AMA
2 stops27h 56m
United Airlines
Deal found 4/13![United Airlines logo]()
$936
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:20 pm
AMA
- CAE
2 stops15h 25m
United Airlines
Sun 5/2410:31 am
CAE
- AMA
2 stops25h 50m
United Airlines
Deal found 4/16![United Airlines logo]()
$943
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:00 am
AMA
- CAE
3 stops11h 21m
United Airlines
Sun 5/36:30 am
CAE
- AMA
3 stops11h 02m
United Airlines
Deal found 4/14![United Airlines logo]()
$1,152
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/239:00 am
AMA
- CAE
2 stops11h 26m
United Airlines
Wed 5/276:25 am
CAE
- AMA
3 stops11h 16m
United Airlines
Deal found 4/14![United Airlines logo]()
$1,181
Last-minute flights from Amarillo to South CarolinaDiscover last-minute flight deals from Amarillo to South Carolina. Data last updated April 17, 2026 and is based on user searches.
Discover last-minute flight deals from Amarillo to South Carolina. Data last updated April 17, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/23:05 pm
AMA
- CHS
1 stop5h 54m
United Airlines
Wed 5/68:00 am
CHS
- AMA
1 stop9h 32m
United Airlines
Deal found 4/17![United Airlines logo]()
$567
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:30 am
AMA
- CHS
2 stops9h 45m
Southwest
Wed 5/67:40 am
CHS
- AMA
2 stops10h 15m
Southwest
Deal found 4/17![Southwest logo]()
$577
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:00 am
AMA
- CHS
1 stop6h 11m
United Airlines
Wed 5/65:07 pm
CHS
- AMA
1 stop6h 27m
United Airlines
Deal found 4/13![United Airlines logo]()
$457
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
AMA
- CAE
1 stop4h 58m
American Airlines
Mon 5/184:15 pm
CAE
- AMA
1 stop7h 28m
American Airlines
Deal found 4/13![American Airlines logo]()
$811
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
AMA
- CAE
1 stop4h 58m
American Airlines
Thu 5/144:15 pm
CAE
- AMA
1 stop6h 27m
American Airlines
Deal found 4/13![American Airlines logo]()
$817
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:15 pm
AMA
- CAE
2 stops17h 44m
United Airlines
Mon 5/187:38 pm
CAE
- AMA
2 stops16h 46m
United Airlines
Deal found 4/13![United Airlines logo]()
$842
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:00 am
AMA
- CAE
1 stop5h 58m
American Airlines
Mon 5/184:15 pm
CAE
- AMA
1 stop7h 28m
American Airlines
Deal found 4/13![American Airlines logo]()
$721
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:00 am
AMA
- CAE
1 stop4h 58m
American Airlines
Sat 5/237:21 pm
CAE
- AMA
1 stop5h 38m
American Airlines
Deal found 4/16![American Airlines logo]()
$415
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/224:17 pm
AMA
- CAE
1 stop6h 16m
American Airlines
Sun 5/247:21 pm
CAE
- AMA
1 stop5h 38m
American Airlines
Deal found 4/16![American Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:17 pm
AMA
- CAE
1 stop6h 16m
American Airlines
Wed 5/271:53 pm
CAE
- AMA
1 stop5h 43m
American Airlines
Deal found 4/14![American Airlines logo]()
$762
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:18 pm
AMA
- CAE
2 stops21h 28m
United Airlines
Wed 5/2710:31 am
CAE
- AMA
2 stops12h 59m
United Airlines
Deal found 4/14![United Airlines logo]()
$783
Find flight deals from Amarillo to South Carolina
Keep the following information in mind while searching for Amarillo to South Carolina flight deals. Data was last updated April 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $415 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Amarillo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2026.
Use the filters below to find and compare flights from Amarillo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
AmarilloColumbia
AMA - CAE
AMACAE
Amarillo
Sat 5/16
5:00 am-11:58 am
1 stop5h 58m
Columbia Metropolitan
Sat 5/23
4:09 pm-11:59 pm
2 stops8h 50m
$420
Quickest round-trip
AmarilloCharleston
AMA - CHS
AMACHS
Amarillo
Fri 7/3
4:17 pm-10:56 pm
1 stop5h 39m
Charleston
Thu 7/9
7:21 pm-11:59 pm
1 stop5h 38m
$447
AmarilloCharleston
AMA - CHS
AMACHS
Amarillo
Tue 5/5
9:00 am-4:11 pm
1 stop6h 11m
Charleston
Wed 5/6
5:07 pm-10:34 pm
1 stop6h 27m
$457
AmarilloCharleston
AMA - CHS
AMACHS
Amarillo
Fri 7/3
3:18 pm-10:15 pm
1 stop5h 57m
Charleston
Thu 7/9
10:00 am-10:30 pm
2 stops13h 30m
$470
AmarilloCharleston
AMA - CHS
AMACHS
Amarillo
Sat 5/2
3:05 pm-9:59 pm
1 stop5h 54m
Charleston
Wed 5/6
8:00 am-4:32 pm
1 stop9h 32m
$567
AmarilloColumbia
AMA - CAE
AMACAE
Amarillo
Fri 5/22
4:17 pm-11:33 pm
1 stop6h 16m
Columbia Metropolitan
Sun 5/24
7:21 pm-11:59 pm
1 stop5h 38m
$702
AmarilloColumbia
AMA - CAE
AMACAE
Amarillo
Mon 5/11
5:00 am-11:58 am
1 stop5h 58m
Columbia Metropolitan
Mon 5/18
4:15 pm-10:43 pm
1 stop7h 28m
$721
AmarilloColumbia
AMA - CAE
AMACAE
Amarillo
Thu 5/7
3:15 pm-9:59 am
2 stops17h 44m
Columbia Metropolitan
Mon 5/18
7:38 pm-11:24 am
2 stops16h 46m
$842
AmarilloColumbia
AMA - CAE
AMACAE
Amarillo
Wed 4/29
5:00 am-11:58 am
1 stop5h 58m
Columbia Metropolitan
Sun 5/3
5:00 am-12:35 pm
2 stops8h 35m
$864
AmarilloColumbia
AMA - CAE
AMACAE
Amarillo
Thu 5/7
12:06 pm-9:59 am
2 stops20h 53m
Columbia Metropolitan
Thu 5/14
7:38 pm-10:34 pm
2 stops27h 56m
$936
Showing 1-10 of 13 resultsSorted by cheapest first
Best time to book a flight from Amarillo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Amarillo with our price prediction graph.
AMA-CAE
AMA-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Amarillo to South Carolina
AMA-USSC
AMA-CAE
AMA-CHS
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 17, 2026.
Read through reviews of airlines operating flights from Amarillo to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.9
Food
6.4
Overall
7.1
Comfort
7.2
Boarding
7.5
Crew
7.9
Reviews
1 / 20
6.0
Goodsheila,Mar 2025
DFW - MSP
Entertainment
6.9
Food
6.4
Overall
7.1
Comfort
7.2
Boarding
7.5
Crew
7.9
Reviews
1 / 20
6.0
Goodsheila,Mar 2025
DFW - MSP
Related info for your journey
Find useful and relevant information for your journey from Amarillo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Amarillo to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Amarillo to South Carolina by cabin class
Find flights from Amarillo to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Amarillo and South Carolina flights
Browse other Amarillo and South Carolina flight options. Last updated on April 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Amarillo to South Carolina flights
Consider these flights traveling from Amarillo to South Carolina.
Top airline flying from Amarillo to South Carolina
Discover the top airline that operate flights from Amarillo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$370 | Average$557 | FlexibilityNo cancel fee | On-time71% |