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$353+ Cheap flights from Amarillo (AMA) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.
AMA — CHS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Amarillo to South Carolina

Cheapest flights from Amarillo to South Carolina
Explore the most affordable flight options available from Amarillo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:47 pm
AMA
-
CAE
1 stop5h 48m
American Airlines
Sat 5/94:15 pm
CAE
-
AMA
1 stop7h 28m
American Airlines
Deal found 1/27$353
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1312:10 pm
AMA
-
CHS
2 stops8h 30m
Southwest
Tue 3/1710:50 am
CHS
-
AMA
2 stops12h 15m
Southwest
Deal found 1/27$495
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/149:05 am
AMA
-
CHS
1 stop6h 05m
United Airlines
Wed 2/185:10 pm
CHS
-
AMA
1 stop5h 58m
United Airlines
Deal found 1/27$529
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:15 am
AMA
-
CAE
1 stop6h 13m
American Airlines
Sun 3/227:44 pm
CAE
-
AMA
1 stop5h 15m
American Airlines
Deal found 1/27$572
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/307:30 am
AMA
-
CAE
2 stops10h 25m
United Airlines
Mon 2/29:10 am
CAE
-
AMA
2 stops13h 49m
United Airlines
Deal found 1/27$625
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2012:30 pm
AMA
-
CAE
1 stop5h 44m
American Airlines
Sun 3/227:44 pm
CAE
-
AMA
1 stop5h 15m
American Airlines
Deal found 1/27$649
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/35:35 pm
AMA
-
CAE
2 stops29h 09m
United Airlines
Sat 2/710:10 am
CAE
-
AMA
2 stops12h 49m
United Airlines
Deal found 1/27$658
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:30 pm
AMA
-
CHS
2 stops23h 34m
United Airlines
Tue 3/175:06 pm
CHS
-
AMA
1 stop6h 32m
United Airlines
Deal found 1/28$683
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:30 pm
AMA
-
CHS
2 stops23h 34m
United Airlines
Wed 3/185:06 pm
CHS
-
AMA
1 stop6h 32m
United Airlines
Deal found 1/28$684
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/209:00 am
AMA
-
CAE
2 stops33h 01m
United Airlines
Sun 3/227:39 pm
CAE
-
AMA
2 stops27h 59m
United Airlines
Deal found 1/28$720

Find flight deals from Amarillo to South Carolina

Keep the following information in mind while searching for Amarillo to South Carolina flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$353
(American Airlines)
Provider with most accurate pricing for Amarillo-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Amarillo-Myrtle Beach Intl flights.
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From Amarillo to South Carolina
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Amarillo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Amarillo to South Carolina that are best for you.

Fly from

Amarillo

Fly to

South Carolina

Route

Depart

Return

Price

AmarilloColumbia

AMA - CAE

AMACAE

Amarillo

Sat 5/2

4:47 pm-11:35 pm

1 stop5h 48m

Columbia Metropolitan

Sat 5/9

4:15 pm-10:43 pm

1 stop7h 28m

$353

AmarilloCharleston

AMA - CHS

AMACHS

Amarillo

Sat 2/14

9:05 am-4:10 pm

1 stop6h 05m

Charleston

Wed 2/18

5:10 pm-10:08 pm

1 stop5h 58m

$529

AmarilloCharleston

AMA - CHS

AMACHS

Amarillo

Fri 3/13

12:10 pm-9:40 pm

2 stops8h 30m

Charleston

Tue 3/17

12:50 pm-10:05 pm

1 stop10h 15m

$564

AmarilloColumbia

AMA - CAE

AMACAE

Amarillo

Wed 3/18

7:15 am-2:28 pm

1 stop6h 13m

Columbia Metropolitan

Sun 3/22

7:44 pm-11:59 pm

1 stop5h 15m

$572

AmarilloColumbia

AMA - CAE

AMACAE

Amarillo

Fri 3/20

12:30 pm-7:14 pm

1 stop5h 44m

Columbia Metropolitan

Sun 3/22

7:44 pm-11:59 pm

1 stop5h 15m

$649

AmarilloCharleston

AMA - CHS

AMACHS

Amarillo

Fri 3/13

5:30 pm-6:04 pm

2 stops23h 34m

Charleston

Wed 3/18

5:06 pm-10:38 pm

1 stop6h 32m

$684

AmarilloColumbia

AMA - CAE

AMACAE

Amarillo

Fri 3/20

9:00 am-7:01 pm

2 stops33h 01m

Columbia Metropolitan

Sun 3/22

7:39 pm-10:38 pm

2 stops27h 59m

$720

AmarilloColumbia

AMA - CAE

AMACAE

Amarillo

Wed 3/18

3:10 pm-7:01 pm

2 stops26h 51m

Columbia Metropolitan

Sun 3/22

7:39 pm-11:29 am

2 stops16h 50m

$831

AmarilloColumbia

AMA - CAE

AMACAE

Amarillo

Sat 5/2

8:00 am-8:56 pm

3 stops11h 56m

Columbia Metropolitan

Sat 5/9

10:34 am-9:31 pm

2 stops11h 57m

$851

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Best time to book a flight from Amarillo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Amarillo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Amarillo to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Amarillo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Amarillo to South Carolina?

    Most people fly from Amarillo (AMA) if they book a flight from Amarillo to South Carolina. Amarillo is conveniently located just 6.9 mi from Amarillo’s city center.

  • How long is the flight from Amarillo to South Carolina?

    A quick flight from Amarillo to South Carolina can take about 5h 48m. American Airlines provides one of the quickest options available for as low as $353. The distance between Amarillo and South Carolina is about 1171 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Amarillo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Amarillo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Amarillo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Amarillo to South Carolina.

  • Can I find deals for business class flights from Amarillo to South Carolina?

    Yes. Cheapflights offers flight deals from Amarillo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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