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$170+ Cheap flights from Panama City, FL to Sioux Falls (ECP - FSD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — FSD
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Panama City to Sioux Falls

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Sioux Falls (FSD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$259
(Delta)

One-way from

$170
(Delta)

Popular in

June

Cheapest in

August

Average price

$521
From Panama City NW Florida Beaches to Sioux Falls Joe Foss Field
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One-way flight from Panama City NW Florida Beaches to Sioux Falls Joe Foss Field
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Highest demand for flights based on searches. 22% potential increase in price ($137 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($31 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Panama City to Sioux Falls

Cheapest flights from Panama City to Sioux Falls
Explore the most affordable flight options available from Panama City to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/224:49 pmECP - FSD
1 stop6h 17mDelta
Tue 8/265:27 amFSD - ECP
1 stop5h 07mDelta
Deal found 7/29$259
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2212:06 pmECP - FSD
2 stops8h 57mAmerican Airlines
Mon 8/257:01 amFSD - ECP
2 stops10h 29mAmerican Airlines
Deal found 7/29$284
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/116:30 amECP - FSD
2 stops11h 44mUnited Airlines
Fri 8/159:15 amFSD - ECP
2 stops12h 45mUnited Airlines
Deal found 7/27$572

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Panama City to Sioux Falls that are best for you.

Fly from

Panama City

Fly to

Sioux Falls

Route

Depart

Return

Price

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Fri 8/22

4:49 pm-11:06 pm

1 stop6h 17m

Sioux Falls Joe Foss Field

Tue 8/26

5:27 am-10:34 am

1 stop5h 07m

$259

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Fri 8/22

12:06 pm-9:03 pm

2 stops8h 57m

Sioux Falls Joe Foss Field

Mon 8/25

7:01 am-5:30 pm

2 stops10h 29m

$284

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Mon 8/11

6:30 am-6:14 pm

2 stops11h 44m

Sioux Falls Joe Foss Field

Fri 8/15

9:15 am-10:00 pm

2 stops12h 45m

$572

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Mon 9/15

4:46 pm-11:02 pm

1 stop6h 16m

$170

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Mon 9/15

12:01 pm-11:57 pm

2 stops11h 56m

$244

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Sat 10/18

1:55 pm-10:22 pm

1 stop8h 27m

$275

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Panama City to Sioux Falls

Have a flexible travel schedule? Discover the best time to fly to Sioux Falls from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Sioux Falls

What is the cheapest month to book a flight from Panama City, Florida to Sioux Falls?

Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Sioux Falls (average of $334). Flying from Panama City, Florida to Sioux Falls in December is currently the most expensive (average of $446). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to FSD?

Find hourly flight availability from Panama City to Sioux Falls. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

One of the essential ways to save on airfare from Panama City, Florida to Sioux Falls is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 39% on airfare.

Reviews of airlines servicing Sioux Falls

Get insights into the airlines that provide service to Sioux Falls. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Sioux Falls. Reviews last updated July 29, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Panama City to Sioux Falls. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,979 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Sioux Falls. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City, Florida to Sioux Falls round-trip?

    Our cheapest airline available from Panama City, Florida to Sioux Falls is Delta. Our recent data shows that you can find tickets from as low as $259 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $284 and $572 round-trip. Delta is 43% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City, Florida to Sioux Falls one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $170. American Airlines flights start at $244 while deals on United Airlines start at $275 one-way.

  • Can I find deals for flights from Panama City to Sioux Falls that include hotel bookings?

    Yes. In addition to deals on Panama City to Sioux Falls flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Sioux Falls?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Sioux Falls.

  • Can I find deals for business class flights from Panama City to Sioux Falls?

    Yes. Cheapflights offers flight deals from Panama City to Sioux Falls by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Sioux Falls?

    Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Sioux Falls (average of $334). Flying from Panama City, Florida to Sioux Falls in December is currently the most expensive (average of $446). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 2 airlines flying from Panama City to Sioux Falls

Discover the top 2 airlines that operate flights from Panama City to Sioux Falls. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$258Average$334FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$385Average$560FlexibilityNo cancel feeOn-time71%

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