HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Sioux Falls

$359+ Cheap flights from Panama City, FL to Sioux Falls (ECP - FSD)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — FSD
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Sioux Falls with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Sioux Falls

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Sioux Falls (FSD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$371
(American Airlines)

Popular in

June

Cheapest in

August

Average price

$301
From Panama City NW Florida Beaches to Sioux Falls Joe Foss Field
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($138 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Panama City to Sioux Falls

Cheapest flights from Panama City to Sioux Falls
Explore the most affordable flight options available from Panama City to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/174:46 pmECP - FSD
1 stop6h 16mDelta
Sun 9/215:30 amFSD - ECP
1 stop4h 25mDelta
Deal found 9/8$359
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/23:52 pmECP - FSD
1 stop5h 27mAmerican Airlines
Mon 10/61:32 pmFSD - ECP
1 stop5h 12mAmerican Airlines
Deal found 9/10$371
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1712:01 pmECP - FSD
2 stops9h 22mAmerican Airlines
Sun 9/211:19 pmFSD - ECP
1 stop7h 49mAmerican Airlines
Deal found 9/8$570
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1711:09 amECP - FSD
2 stops9h 20mUnited Airlines
Sun 9/218:00 amFSD - ECP
2 stops8h 20mUnited Airlines
Deal found 9/8$777

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Panama City to Sioux Falls that are best for you.

Fly from

Panama City

Fly to

Sioux Falls

Route

Depart

Return

Price

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Thu 10/2

3:52 pm-9:19 pm

1 stop5h 27m

Sioux Falls Joe Foss Field

Mon 10/6

1:32 pm-6:44 pm

1 stop5h 12m

$371

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Panama City to Sioux Falls

Have a flexible travel schedule? Discover the best time to fly to Sioux Falls from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Sioux Falls

What is the cheapest month to book a flight from Panama City, Florida to Sioux Falls?

Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Sioux Falls (average of $334). Flying from Panama City, Florida to Sioux Falls in December is currently the most expensive (average of $446). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to FSD?

Find hourly flight availability from Panama City to Sioux Falls. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

One of the essential ways to save on airfare from Panama City, Florida to Sioux Falls is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 39% on airfare.

Reviews of airlines servicing Sioux Falls

Get insights into the airlines that provide service to Sioux Falls. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Sioux Falls. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Panama City to Sioux Falls. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Sioux Falls. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Sioux Falls?

    For as low as $371, American Airlines can have you in Sioux Falls from Panama City, Florida in 5h 27m. The distance from Panama City, Florida to Sioux Falls is about 1092 mi.

  • What are the cheapest airlines flying from Panama City, Florida to Sioux Falls round-trip?

    Our cheapest airline available from Panama City, Florida to Sioux Falls is Delta. Our recent data shows that you can find tickets from as low as $258 on this airline. An additional option worth looking into is American Airlines, starting at $258. Delta is 44% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Panama City to Sioux Falls that include hotel bookings?

    Yes. In addition to deals on Panama City to Sioux Falls flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Sioux Falls?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Sioux Falls.

  • Can I find deals for business class flights from Panama City to Sioux Falls?

    Yes. Cheapflights offers flight deals from Panama City to Sioux Falls by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Sioux Falls?

    Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Sioux Falls (average of $334). Flying from Panama City, Florida to Sioux Falls in December is currently the most expensive (average of $446). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Marshall

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Sioux Falls

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Rapid City flights
Tampa to Sioux Falls flights
Orlando to Sioux Falls flights
Tampa to Rapid City flights
Fort Lauderdale to Rapid City flights
Pensacola to Sioux Falls flights
West Palm Beach to Rapid City flights
West Palm Beach to Sioux Falls flights
Jacksonville to Sioux Falls flights
Miami to Rapid City flights
Tallahassee to Rapid City flights
Valparaiso to Sioux Falls flights
Miami to Sioux Falls flights
Fort Lauderdale to Sioux Falls flights
Fort Myers to Sioux Falls flights
Jacksonville to Rapid City flights
Fort Myers to Rapid City flights
Sarasota to Sioux Falls flights
Sarasota to Rapid City flights
Pensacola to Rapid City flights
Miami to Aberdeen flights
Melbourne to Sioux Falls flights
Daytona Beach to Rapid City flights
Valdosta to Rapid City flights
West Palm Beach to Aberdeen flights
Gainesville to Sioux Falls flights
Fort Lauderdale to Aberdeen flights
Valparaiso to Rapid City flights

Top 2 airlines flying from Panama City to Sioux Falls

Discover the top 2 airlines that operate flights from Panama City to Sioux Falls. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$258Average$371FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$508FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.