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$271+ Cheap flights from Panama City, FL to Sioux Falls (ECP - FSD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/6. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — FSD
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Find flight deals from Panama City to Sioux Falls

Cheapest flights from Panama City to Sioux Falls
Explore the most affordable flight options available from Panama City to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/115:00 pmECP - FSD
1 stop6h 09mDelta
Tue 11/185:05 amFSD - ECP
1 stop5h 21mDelta
Deal found 10/28$274
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:22 pmECP - FSD
1 stop5h 47mAmerican Airlines
Sun 11/161:03 pmFSD - ECP
1 stop8h 12mAmerican Airlines
Deal found 10/28$289
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/315:00 pmECP - FSD
1 stop5h 56mDelta
Sat 11/155:05 amFSD - ECP
1 stop5h 21mDelta
Deal found 10/28$316
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:31 amECP - FSD
1 stop6h 14mAmerican Airlines
Wed 11/126:30 amFSD - ECP
1 stop8h 19mAmerican Airlines
Deal found 10/28$329
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:47 amECP - FSD
1 stop5h 49mAmerican Airlines
Sat 12/61:09 pmFSD - ECP
1 stop6h 02mAmerican Airlines
Deal found 10/26$347
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/285:00 pmECP - FSD
1 stop5h 56mDelta
Sat 11/155:05 amFSD - ECP
1 stop5h 21mDelta
Deal found 10/28$349
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:32 amECP - FSD
1 stop6h 15mAmerican Airlines
Sun 11/25:30 amFSD - ECP
1 stop5h 58mAmerican Airlines
Deal found 10/27$351

Cheap flight deals from Panama City to Sioux Falls

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Sioux Falls (FSD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$274
(Delta)

Popular in

June

Cheapest in

August
Provider with most accurate pricing for Panama City NW Florida Beaches-Sioux Falls Joe Foss Field flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Sioux Falls Joe Foss Field flights.
Search Deals
From Panama City NW Florida Beaches to Sioux Falls Joe Foss Field
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($122 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($33 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Panama City to Sioux Falls that are best for you.

Fly from

Panama City

Fly to

Sioux Falls

Route

Depart

Return

Price

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Tue 11/11

5:00 pm-11:09 pm

1 stop6h 09m

Sioux Falls Joe Foss Field

Tue 11/18

1:30 pm-10:37 pm

2 stops9h 07m

$279

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Tue 11/11

6:47 am-12:21 pm

1 stop5h 34m

Sioux Falls Joe Foss Field

Tue 11/18

5:30 am-4:44 pm

2 stops11h 14m

$279

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Thu 11/13

3:22 pm-9:09 pm

1 stop5h 47m

Sioux Falls Joe Foss Field

Sun 11/16

1:03 pm-9:15 pm

1 stop8h 12m

$289

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Thu 11/13

5:09 pm-11:09 pm

1 stop6h 00m

Sioux Falls Joe Foss Field

Sun 11/16

5:05 am-10:26 am

1 stop5h 21m

$334

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Thu 4/16

6:55 am-12:19 pm

1 stop5h 24m

Sioux Falls Joe Foss Field

Mon 4/20

1:33 pm-8:22 pm

1 stop6h 49m

$339

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Tue 12/2

6:47 am-12:36 pm

1 stop5h 49m

Sioux Falls Joe Foss Field

Sat 12/6

1:09 pm-7:11 pm

1 stop6h 02m

$347

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Tue 1/6

5:14 pm-11:14 pm

1 stop6h 00m

$271

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Mon 1/5

5:14 pm-11:14 pm

1 stop6h 00m

$271

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Tue 1/6

12:03 pm-9:30 pm

2 stops9h 27m

$276

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Thu 11/13

12:58 pm-9:09 pm

1 stop8h 11m

$338

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 12 results
1
2

Compare providers for flights from Panama City to Sioux Falls

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Sioux Falls in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Sioux Falls flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-Sioux Falls flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Sioux Falls flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Sioux Falls flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Sioux Falls flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Sioux Falls

Have a flexible travel schedule? Discover the best time to fly to Sioux Falls from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Sioux Falls

What is the cheapest month to book a flight from Panama City, Florida to Sioux Falls?

Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to Sioux Falls (average of $250). Flying from Panama City, Florida to Sioux Falls in November is currently the most expensive (average of $395). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to FSD?

Find hourly flight availability from Panama City to Sioux Falls. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

One of the essential ways to save on airfare from Panama City, Florida to Sioux Falls is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 38% on airfare.

Reviews of airlines servicing Sioux Falls

Get insights into the airlines that provide service to Sioux Falls. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Sioux Falls. Reviews last updated October 28, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Panama City to Sioux Falls. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Sioux Falls. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Sioux Falls?

    For as low as $279, Delta can have you in Sioux Falls from Panama City, Florida in 5h 34m. The distance from Panama City, Florida to Sioux Falls is about 1092 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City, Florida to Sioux Falls round-trip?

    Our cheapest airline available from Panama City, Florida to Sioux Falls is Delta. Our recent data shows that you can find tickets from as low as $258 on this airline. An additional option worth looking into is American Airlines, starting at $258. Delta is 45% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Panama City to Sioux Falls that include hotel bookings?

    Yes. In addition to deals on Panama City to Sioux Falls flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Sioux Falls?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Sioux Falls.

  • Can I find deals for business class flights from Panama City to Sioux Falls?

    Yes. Cheapflights offers flight deals from Panama City to Sioux Falls by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Sioux Falls?

    Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to Sioux Falls (average of $250). Flying from Panama City, Florida to Sioux Falls in November is currently the most expensive (average of $395). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Marshall

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Top 2 airlines flying from Panama City to Sioux Falls

Discover the top 2 airlines that operate flights from Panama City to Sioux Falls. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$258Average$371FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$508FlexibilityNo cancel feeOn-time71%

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