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$294+ Cheap flights from Panama City, FL to Sioux Falls (ECP - FSD)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/13. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — FSD
feb. 25 — mar. 41
mié. 2/25
mié. 3/4
1 adult, Economy
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Cheap flight deals from Panama City to Sioux Falls

Cheapest flights from Panama City to Sioux Falls
Explore the most affordable flight options available from Panama City to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 26, 2026.

This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/133:00 pm
ECP
-
FSD
1 stop8h 03m
American Airlines
lun. 2/165:44 am
FSD
-
ECP
1 stop6h 24m
American Airlines
Deal found 1/24$294
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/172:19 pm
ECP
-
FSD
1 stop7h 30m
United Airlines
mar. 4/217:39 am
FSD
-
ECP
1 stop5h 44m
United Airlines
Deal found 1/25$359
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/62:10 pm
ECP
-
FSD
1 stop7h 52m
United Airlines
jue. 3/127:43 am
FSD
-
ECP
1 stop5h 31m
United Airlines
Deal found 1/26$477
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/610:36 am
ECP
-
FSD
2 stops8h 34m
American Airlines
jue. 3/127:42 pm
FSD
-
ECP
1 stop18h 42m
American Airlines
Deal found 1/26$511
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/51:10 pm
ECP
-
FSD
2 stops10h 34m
United Airlines
vie. 2/63:11 pm
FSD
-
ECP
2 stops25h 01m
United Airlines
Deal found 1/26$833

Find flight deals from Panama City to Sioux Falls

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Sioux Falls (FSD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated enero 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$294
(American Airlines)
Provider with most accurate pricing for Panama City NW Florida Beaches-Sioux Falls Joe Foss Field flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Sioux Falls Joe Foss Field flights.
Search Deals
From Panama City NW Florida Beaches to Sioux Falls Joe Foss Field
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 26, 2026.
Use the filters below to find and compare flights from Panama City to Sioux Falls that are best for you.

Fly from

Panama City

Fly to

Sioux Falls

Route

Depart

Return

Price

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

vie. 2/13

7:19 am-7:10 pm

2 stops11h 51m

Sioux Falls Joe Foss Field

lun. 2/16

1:26 pm-9:22 pm

1 stop7h 56m

$299

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

vie. 4/17

2:19 pm-9:49 pm

1 stop7h 30m

Sioux Falls Joe Foss Field

mar. 4/21

7:39 am-1:23 pm

1 stop5h 44m

$359

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

vie. 3/6

2:10 pm-10:02 pm

1 stop7h 52m

Sioux Falls Joe Foss Field

jue. 3/12

7:43 am-1:14 pm

1 stop5h 31m

$477

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

vie. 3/6

10:36 am-7:10 pm

2 stops8h 34m

Sioux Falls Joe Foss Field

jue. 3/12

7:42 pm-2:24 pm

1 stop18h 42m

$511

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

jue. 2/5

1:10 pm-11:44 pm

2 stops10h 34m

Sioux Falls Joe Foss Field

vie. 2/6

3:11 pm-4:12 pm

2 stops25h 01m

$833

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

jue. 2/5

7:02 am-12:53 pm

1 stop5h 51m

Sioux Falls Joe Foss Field

vie. 2/6

1:23 pm-9:19 pm

1 stop7h 56m

$849

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

dom. 3/1

1:18 pm-7:10 pm

1 stop5h 52m

$450

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

dom. 3/1

6:30 am-8:39 pm

3 stops14h 09m

$594

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Compare providers for flights from Panama City to Sioux Falls

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Sioux Falls in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Sioux Falls flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Sioux Falls flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Sioux Falls flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Sioux Falls flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Sioux Falls flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Sioux Falls

Have a flexible travel schedule? Discover the best time to fly to Sioux Falls from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Sioux Falls

What is the cheapest month to book a flight from Panama City, Florida to Sioux Falls?

Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to Sioux Falls (average of $250). Flying from Panama City, Florida to Sioux Falls in August is currently the most expensive (average of $571). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Sioux Falls. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Sioux Falls?

    For as low as $359, American Airlines can have you in Sioux Falls from Panama City, Florida in 7h 30m. The distance from Panama City, Florida to Sioux Falls is about 1092 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Panama City to Sioux Falls that include hotel bookings?

    Yes. In addition to deals on Panama City to Sioux Falls flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Sioux Falls?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Sioux Falls.

  • Can I find deals for business class flights from Panama City to Sioux Falls?

    Yes. Cheapflights offers flight deals from Panama City to Sioux Falls by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Sioux Falls?

    Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to Sioux Falls (average of $250). Flying from Panama City, Florida to Sioux Falls in August is currently the most expensive (average of $571). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Marshall

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