To save up to 20% on this flight, we recommend booking at least 25 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Des Moines to Sioux Falls from $420 1-2 weeks out and tickets from $449 for flights departing within the next 72 hours.
Our data shows that August tends to be the cheapest month to fly to Sioux Falls from Des Moines. Users have commonly found prices around $374 for the month, but tickets can be as low as $133. Due to multiple factors, prepare for potentially higher prices in October.