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Sicily

$488+ Cheap flights from Missouri to Sicily

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — CTA
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Missouri to Sicily

Best flights from Missouri to Sicily
Discover carefully curated flight deals from Missouri to Sicily that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 18, 2025.

This FlightHub deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:55 pmSTL - CTA
2 stops39h 40mLufthansa
Thu 2/2610:15 amCTA - STL
2 stops44h 50mLufthansa
Deal found 12/17$488
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2112:37 pmMCI - PMO
2 stops16h 03mUnited Airlines
Sat 2/286:10 amPMO - MCI
2 stops18h 22mUnited Airlines
Deal found 12/16$715
This Air Canada deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:20 pmSTL - CTA
2 stops22h 10mMultiple Airlines
Wed 5/206:00 amCTA - STL
2 stops37h 06mMultiple Airlines
Deal found 12/17$815
This KLM deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:00 pmSTL - CTA
1 stop31h 55mKLM
Wed 5/208:45 pmCTA - STL
2 stops27h 04mKLM
Deal found 12/17$817
This KAYAK deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1912:37 pmMCI - PMO
2 stops15h 43mLufthansa
Fri 2/2712:10 pmPMO - MCI
2 stops16h 49mLufthansa
Deal found 12/16$498
This Air Canada deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1811:25 amSTL - CTA
3 stops20h 15mAir Canada
Thu 2/2610:15 amCTA - STL
3 stops19h 44mAir Canada
Deal found 12/17$1,020
This Expedia deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/314:49 pmSTL - CTA
2 stops17h 31mLufthansa
Sat 2/711:30 amCTA - STL
2 stops19h 29mLufthansa
Deal found 12/17$499
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/189:59 amMCI - CTA
1 stop14h 56mDelta
Tue 5/269:55 amCTA - MCI
2 stops19h 30mDelta
Deal found 12/16$1,144
This FlightHub deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2011:32 amMCI - PMO
2 stops16h 53mLufthansa
Sun 3/16:25 pmPMO - MCI
2 stops34h 34mLufthansa
Deal found 12/16$504
This Lufthansa deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2111:27 amMCI - PMO
2 stops17h 13mLufthansa
Sat 2/2812:10 pmPMO - MCI
2 stops16h 49mLufthansa
Deal found 12/16$512
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:10 amMCI - PMO
2 stops19h 30mUnited Airlines
Thu 2/266:10 amPMO - MCI
2 stops20h 56mUnited Airlines
Deal found 12/16$715
This KAYAK deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/2211:32 amMCI - PMO
2 stops17h 08mLufthansa
Sun 3/16:10 amPMO - MCI
2 stops18h 23mLufthansa
Deal found 12/16$515
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1911:32 amMCI - PMO
2 stops17h 08mUnited Airlines
Thu 2/266:10 amPMO - MCI
2 stops20h 56mUnited Airlines
Deal found 12/16$715
This KAYAK deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2312:37 pmMCI - PMO
2 stops16h 03mLufthansa
Sun 3/16:10 amPMO - MCI
2 stops22h 49mLufthansa
Deal found 12/16$515
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:00 amMCI - PMO
2 stops20h 40mUnited Airlines
Sun 3/16:10 amPMO - MCI
2 stops20h 32mUnited Airlines
Deal found 12/16$715
This Air Canada deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/184:05 pmSTL - CTA
2 stops15h 35mMultiple Airlines
Thu 2/2610:15 amCTA - STL
3 stops19h 44mMultiple Airlines
Deal found 12/17$940
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/45:45 pmMCI - PMO
2 stops34h 55mUnited Airlines
Sun 2/86:10 amPMO - MCI
2 stops20h 46mUnited Airlines
Deal found 12/16$722
This KLM deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:42 pmMCI - CTA
2 stops18h 48mKLM
Tue 5/269:55 amCTA - MCI
2 stops21h 00mKLM
Deal found 12/16$982
This KLM deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:42 pmMCI - CTA
2 stops18h 48mMultiple Airlines
Tue 5/269:55 amCTA - MCI
2 stops19h 57mMultiple Airlines
Deal found 12/16$982
This KAYAK deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2312:37 pmMCI - PMO
2 stops16h 03mLufthansa
Tue 3/36:10 amPMO - MCI
2 stops20h 56mLufthansa
Deal found 12/16$615
This Air Canada deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/44:05 pmSTL - CTA
2 stops15h 35mAir Canada
Sun 2/810:05 amCTA - STL
2 stops36h 24mAir Canada
Deal found 12/16$1,155
This KAYAK deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:27 pmMCI - PMO
2 stops34h 13mLufthansa
Mon 3/212:25 pmPMO - MCI
2 stops40h 34mLufthansa
Deal found 12/16$730
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3111:22 amSTL - CTA
2 stops16h 33mUnited Airlines
Fri 2/136:00 amCTA - STL
2 stops21h 23mUnited Airlines
Deal found 12/16$1,392
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3111:22 amSTL - CTA
2 stops16h 33mUnited Airlines
Thu 2/196:00 amCTA - STL
2 stops40h 29mUnited Airlines
Deal found 12/16$1,393
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/511:22 amSTL - CTA
2 stops16h 33mUnited Airlines
Thu 2/196:00 amCTA - STL
2 stops40h 29mUnited Airlines
Deal found 12/16$1,393

Find flight deals from Missouri to Sicily

Keep the following information in mind while searching for Missouri to Sicily flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$483
(FlightHub)
Provider with most accurate pricing for Lambert-St Louis-Catania Fontanarossa flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Catania Fontanarossa flights.
Search Deals
From Missouri to Sicily
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Sicily that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Missouri to Sicily that are best for you.

Fly from

Missouri

Fly to

Sicily

Route

Depart

Return

Price

St. LouisCatania

STL - CTA

STLCTA

Lambert-St Louis

Wed 2/18

6:55 pm-5:35 pm

2 stops39h 40m

Catania Fontanarossa

Thu 2/26

10:15 am-12:05 am

2 stops44h 50m

$488

Kansas CityPalermo

MCI - PMO

MCIPMO

Kansas City

Thu 2/19

12:37 pm-11:20 am

2 stops15h 43m

Palermo Punta Raisi

Fri 2/27

12:10 pm-9:59 pm

2 stops16h 49m

$498

St. LouisCatania

STL - CTA

STLCTA

Lambert-St Louis

Sat 1/31

4:49 pm-5:20 pm

2 stops17h 31m

Catania Fontanarossa

Sat 2/7

11:30 am-11:59 pm

2 stops19h 29m

$499

Kansas CityPalermo

MCI - PMO

MCIPMO

Kansas City

Fri 2/20

11:32 am-11:25 am

2 stops16h 53m

Palermo Punta Raisi

Sun 3/1

6:25 pm-9:59 pm

2 stops34h 34m

$504

Kansas CityPalermo

MCI - PMO

MCIPMO

Kansas City

Sat 2/21

11:27 am-11:40 am

2 stops17h 13m

Palermo Punta Raisi

Sat 2/28

12:10 pm-9:59 pm

2 stops16h 49m

$512

Kansas CityPalermo

MCI - PMO

MCIPMO

Kansas City

Sun 2/22

11:32 am-11:40 am

2 stops17h 08m

Palermo Punta Raisi

Sun 3/1

6:10 am-5:33 pm

2 stops18h 23m

$515

Kansas CityPalermo

MCI - PMO

MCIPMO

Kansas City

Mon 2/23

12:37 pm-11:40 am

2 stops16h 03m

Palermo Punta Raisi

Sun 3/1

6:10 am-9:59 pm

2 stops22h 49m

$515

Kansas CityPalermo

MCI - PMO

MCIPMO

Kansas City

Mon 2/23

12:37 pm-11:40 am

2 stops16h 03m

Palermo Punta Raisi

Tue 3/3

6:10 am-8:06 pm

2 stops20h 56m

$615

Kansas CityPalermo

MCI - PMO

MCIPMO

Kansas City

Sat 2/21

12:37 pm-11:40 am

2 stops16h 03m

Palermo Punta Raisi

Sat 2/28

6:10 am-5:32 pm

2 stops18h 22m

$715

Kansas CityPalermo

MCI - PMO

MCIPMO

Kansas City

Fri 2/20

9:10 am-11:40 am

2 stops19h 30m

Palermo Punta Raisi

Thu 2/26

6:10 am-8:06 pm

2 stops20h 56m

$715

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 26 results
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Best time to book a flight from Missouri to Sicily

Have a flexible travel schedule? Discover the best time to fly to Sicily from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Sicily

What is the cheapest time of day to fly from MO to SI?

Find hourly flight availability from Missouri to Sicily. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

One of the essential ways to save on airfare from Missouri to Sicily is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 22% on airfare.

Reviews of airlines servicing Sicily

Get insights into the airlines that provide service to Sicily. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Sicily. Reviews last updated December 18, 2025.
Read through reviews of airlines operating flights from Missouri to Sicily, such as Delta and Lufthansa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,006 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,006 reviews
Delta
7.9
Good
8,006 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Lufthansa
6.8
Okay
7,634 reviews
Delta
7.9
Good
8,006 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Sicily. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Sicily?

    A quick flight from Missouri to Sicily can take about 31h 55m. Lufthansa provides one of the quickest options available for as low as $817. Airlines will cover a distance of 5353 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Missouri to Sicily that include hotel bookings?

    Yes. In addition to deals on Missouri to Sicily flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Sicily?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Sicily.

  • Can I find deals for business class flights from Missouri to Sicily?

    Yes. Cheapflights offers flight deals from Missouri to Sicily by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Missouri to Sicily

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Missouri to Sicily

Discover the top 2 airlines that operate flights from Missouri to Sicily. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$806Average$1,321FlexibilityNo cancel feeOn-time76%
DeltaCheapest$1,008Average$1,342FlexibilityNo cancel feeOn-timeN/A

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