HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Sicily

$779+ Cheap flights from Missouri to Sicily

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CTA
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Sicily with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Missouri to Sicily

Cheapest flights from Missouri to Sicily
Explore the most affordable flight options available from Missouri to Sicily. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Expedia deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/312:45 pmMCI - PMO
2 stops15h 15mMultiple Airlines
Wed 11/56:45 pmPMO - MCI
2 stops34h 05mMultiple Airlines
Deal found 10/30$1,571

Cheap flight deals from Missouri to Sicily

Keep the following information in mind while searching for Missouri to Sicily flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$779
(Lufthansa)

Popular in

April

Cheapest in

November

Average price

$996
Provider with most accurate pricing for Lambert-St Louis-Catania Fontanarossa flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Catania Fontanarossa flights.
Search Deals
From Missouri to Sicily
Search Deals
Highest demand for flights based on searches. 25% potential increase in price ($467 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 17% potential price decrease ($197 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Sicily that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Missouri to Sicily that are best for you.

Fly from

Missouri

Fly to

Sicily

Route

Depart

Return

Price

St. LouisCatania

STL - CTA

STLCTA

Lambert-St Louis

Fri 3/27

4:50 pm-11:15 am

1 stop12h 25m

Catania Fontanarossa

Tue 3/31

9:30 am-1:30 pm

1 stop35h 00m

$779

Kansas CityCatania

MCI - CTA

MCICTA

Kansas City

Fri 3/27

8:00 am-8:35 am

2 stops18h 35m

Catania Fontanarossa

Tue 3/31

7:20 pm-9:35 pm

2 stops33h 15m

$1,131

St. LouisCatania

STL - CTA

STLCTA

Lambert-St Louis

Thu 3/12

1:10 pm-11:15 am

2 stops40h 05m

Catania Fontanarossa

Fri 3/20

8:50 am-3:29 pm

2 stops36h 39m

$1,266

Kansas CityCatania

MCI - CTA

MCICTA

Kansas City

Fri 3/27

11:33 am-11:15 am

2 stops17h 42m

Catania Fontanarossa

Tue 3/31

9:35 am-10:29 pm

2 stops19h 54m

$1,292

Kansas CityPalermo

MCI - PMO

MCIPMO

Kansas City

Mon 11/3

12:45 pm-11:00 am

2 stops15h 15m

Palermo Punta Raisi

Wed 11/5

6:45 pm-9:50 pm

2 stops34h 05m

$1,571

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Best time to book a flight from Missouri to Sicily

Have a flexible travel schedule? Discover the best time to fly to Sicily from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Sicily

What is the cheapest time of day to fly from MO to SI?

Find hourly flight availability from Missouri to Sicily. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Missouri to Sicily is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 22% on airfare.

Reviews of airlines servicing Sicily

Get insights into the airlines that provide service to Sicily. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Sicily. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Missouri to Sicily, such as Delta and Lufthansa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,993 reviews
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Lufthansa
6.8
Okay
7,541 reviews
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Sicily. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Sicily?

    A quick flight from Missouri to Sicily can take about 12h 25m. Lufthansa provides one of the quickest options available for as low as $779. Airlines will cover a distance of 5353 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Missouri to Sicily that include hotel bookings?

    Yes. In addition to deals on Missouri to Sicily flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Sicily?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Sicily.

  • Can I find deals for business class flights from Missouri to Sicily?

    Yes. Cheapflights offers flight deals from Missouri to Sicily by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Sicily

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Leonardo da Vinci/Fiumicino flights
Newark to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Malpensa flights
Newark to Malpensa flights
LaGuardia to Leonardo da Vinci/Fiumicino flights
O'Hare Intl to Leonardo da Vinci/Fiumicino flights
Dallas/Fort Worth to Leonardo da Vinci/Fiumicino flights
Dulles Intl to Leonardo da Vinci/Fiumicino flights
Boston to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Linate flights
Los Angeles to Leonardo da Vinci/Fiumicino flights
Newark to Linate flights
LaGuardia to Malpensa flights
Miami to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Bergamo flights
Hobby to Leonardo da Vinci/Fiumicino flights
San Francisco to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Vicenza flights
Atlanta to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Ciampino flights
Newark to Bergamo flights
Newark to Vicenza flights
Philadelphia to Leonardo da Vinci/Fiumicino flights
Reagan-National to Leonardo da Vinci/Fiumicino flights
O'Hare Intl to Malpensa flights
Baltimore to Leonardo da Vinci/Fiumicino flights
Seattle to Leonardo da Vinci/Fiumicino flights
Midway to Leonardo da Vinci/Fiumicino flights
Ontario to Leonardo da Vinci/Fiumicino flights
Love Field to Leonardo da Vinci/Fiumicino flights
Santa Ana to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Florence flights
Los Angeles to Malpensa flights
Boston to Florence flights
Dulles Intl to Malpensa flights
San Francisco to Malpensa flights
Orlando to Leonardo da Vinci/Fiumicino flights
San Francisco to Linate flights
LaGuardia to Linate flights
O'Hare Intl to Linate flights
Los Angeles to Linate flights
George Bush Intcntl to Leonardo da Vinci/Fiumicino flights
Denver to Leonardo da Vinci/Fiumicino flights
Dulles Intl to Linate flights
John F Kennedy Intl to Naples flights
Newark to Florence flights
Reagan-National to Malpensa flights
Miami to Malpensa flights
Atlanta to Malpensa flights
Boston to Vicenza flights

Top 2 airlines flying from Missouri to Sicily

Discover the top 2 airlines that operate flights from Missouri to Sicily. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$806Average$1,314FlexibilityNo cancel feeOn-time76%
DeltaCheapest$1,008Average$1,257FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.