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Sao Paulo

$564+ Cheap flights from Iowa to Sao Paulo, Brazil (SAO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAO
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Iowa to Sao Paulo

Keep the following information in mind while searching for Iowa to Sao Paulo flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$1,100
(Delta)

One-way from

$564
(Copa Airlines)
Provider with most accurate pricing for Des Moines-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Sao Paulo (SAO) flights.
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From Iowa to Sao Paulo (SAO)
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One-way flight from Iowa to Sao Paulo (SAO)
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Find flight deals from Iowa to Sao Paulo

Cheapest flights from Iowa to Sao Paulo
Explore the most affordable flight options available from Iowa to Sao Paulo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/15:20 pmOMA - GRU
2 stops25h 30mCopa Airlines
Mon 11/35:25 amGRU - OMA
2 stops21h 05mCopa Airlines
Deal found 10/28$1,133
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1011:21 amDSM - GRU
1 stop17h 49mAmerican Airlines
Tue 12/1612:15 amGRU - DSM
1 stop26h 14mAmerican Airlines
Deal found 10/28$1,269
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/102:16 pmDSM - GRU
1 stop12h 24mMultiple Airlines
Wed 12/174:35 pmGRU - DSM
2 stops33h 01mMultiple Airlines
Deal found 10/30$1,272
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/108:00 amDSM - GRU
2 stops22h 30mUnited Airlines
Wed 12/1710:15 pmGRU - DSM
2 stops26h 25mUnited Airlines
Deal found 10/28$1,275
This Vliegwinkel deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Vliegwinkel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/52:16 pmDSM - GRU
1 stop16h 19mLATAM Airlines
Fri 12/1211:45 pmGRU - DSM
1 stop13h 53mLATAM Airlines
Deal found 10/28$1,328
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/102:16 pmDSM - GRU
1 stop16h 19mDelta
Wed 12/1711:45 pmGRU - DSM
1 stop13h 53mDelta
Deal found 10/28$1,340
This LATAM Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/102:16 pmDSM - GRU
3 stops20h 54mLATAM Airlines
Wed 12/177:35 amGRU - DSM
2 stops17h 59mLATAM Airlines
Deal found 10/28$1,348
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:50 pmDSM - GRU
2 stops35h 40mUnited Airlines
Sun 12/2110:15 pmGRU - DSM
2 stops22h 50mUnited Airlines
Deal found 10/30$1,358
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/111:27 amOMA - GRU
2 stops20h 53mUnited Airlines
Mon 11/39:45 pmGRU - OMA
1 stop15h 46mUnited Airlines
Deal found 10/28$1,605
This FlightHub deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/273:08 pmOMA - GRU
2 stops37h 02mLATAM Airlines
Fri 1/211:20 amGRU - OMA
2 stops33h 16mLATAM Airlines
Deal found 10/28$1,609
This Ovago deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:00 amOMA - GRU
1 stop23h 35mLATAM Airlines
Mon 1/57:45 pmGRU - OMA
2 stops31h 13mLATAM Airlines
Deal found 10/30$1,661
This Ovago deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:00 amOMA - GRU
1 stop19h 40mLATAM Airlines
Fri 1/210:40 amGRU - OMA
1 stop27h 14mLATAM Airlines
Deal found 10/30$1,702

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Sao Paulo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Iowa to Sao Paulo that are best for you.

Fly from

Iowa

Fly to

Sao Paulo

Route

Depart

Return

Price

MolineSao Paulo

MLI - GRU

MLIGRU

Moline Quad-City

Thu 4/2

5:55 am-5:40 am

1 stop21h 45m

Sao Paulo Guarulhos Intl

Mon 4/6

10:50 pm-4:26 pm

1 stop19h 36m

$1,100

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Mon 3/23

5:15 pm-9:35 am

1 stop14h 20m

Sao Paulo Guarulhos Intl

Wed 3/25

11:55 pm-10:28 pm

2 stops24h 33m

$1,100

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Mon 3/23

11:04 am-9:35 am

1 stop20h 31m

Sao Paulo Guarulhos Intl

Wed 3/25

11:45 pm-4:30 pm

1 stop18h 45m

$1,100

OmahaSao Paulo

OMA - GRU

OMAGRU

Omaha Eppley Airfield

Tue 3/24

11:05 am-5:45 am

2 stops16h 40m

Sao Paulo Guarulhos Intl

Fri 3/27

5:45 pm-10:40 am

2 stops18h 55m

$1,140

OmahaSao Paulo

OMA - GRU

OMAGRU

Omaha Eppley Airfield

Tue 3/24

6:30 pm-4:30 pm

2 stops20h 00m

Sao Paulo Guarulhos Intl

Fri 3/27

11:45 pm-3:15 pm

1 stop17h 30m

$1,140

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 2/15

6:49 pm-7:15 am

1 stop33h 26m

Sao Paulo Guarulhos Intl

Sun 2/22

9:45 pm-2:27 pm

1 stop19h 42m

$1,153

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 2/15

3:25 pm-8:10 am

1 stop13h 45m

Sao Paulo Guarulhos Intl

Sat 2/21

12:15 am-6:34 pm

2 stops21h 19m

$1,190

OmahaSao Paulo

OMA - GRU

OMAGRU

Omaha Eppley Airfield

Wed 1/14

5:18 pm-12:10 am

2 stops27h 52m

Sao Paulo Guarulhos Intl

Tue 1/20

5:25 am-11:07 pm

2 stops20h 42m

$1,248

OmahaSao Paulo

OMA - GRU

OMAGRU

Omaha Eppley Airfield

Wed 1/14

12:15 pm-5:40 am

1 stop14h 25m

Sao Paulo Guarulhos Intl

Tue 1/20

5:45 pm-10:13 am

2 stops19h 28m

$1,269

OmahaSao Paulo

OMA - GRU

OMAGRU

Omaha Eppley Airfield

Wed 1/14

4:12 pm-9:35 am

1 stop14h 23m

Sao Paulo Guarulhos Intl

Tue 1/20

9:15 pm-1:46 pm

1 stop19h 31m

$1,285

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 18 results
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Best time to book a flight from Iowa to Sao Paulo

Have a flexible travel schedule? Discover the best time to fly to Sao Paulo from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Sao Paulo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Sao Paulo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Sao Paulo?

    Departing from Iowa to Sao Paulo will take you 14h 20m. The distance between Iowa and Sao Paulo is about 5405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Iowa to Sao Paulo one-way?

    To fly one-way, consider booking your trip with Copa Airlines, which is currently one of the cheapest options available, starting at $564. American Airlines flights start at $657 while deals on Delta start at $658 one-way.

  • What are the most popular routes from Iowa to Sao Paulo?

    While some choose either Omaha Eppley Airfield - Sao Paulo Guarulhos Intl or Moline Quad-City - Sao Paulo Guarulhos Intl, Des Moines - Sao Paulo Guarulhos Intl is the most popular route from Iowa to Sao Paulo.

  • Can I find deals for flights from Iowa to Sao Paulo that include hotel bookings?

    Yes. In addition to deals on Iowa to Sao Paulo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Sao Paulo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Sao Paulo.

  • Can I find deals for business class flights from Iowa to Sao Paulo?

    Yes. Cheapflights offers flight deals from Iowa to Sao Paulo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Iowa to Sao Paulo

See prices for flight routes from nearby airports that may be better suited for you.
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