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$564+ Cheap flights from Des Moines (DSM) to Sao Paulo, Brazil (SAO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAO
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Des Moines to Sao Paulo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Sao Paulo (SAO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$993
(Mytrip)

One-way from

$564
(Copa Airlines)
Provider with most accurate pricing for Des Moines-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Sao Paulo (SAO) flights.
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From Des Moines to Sao Paulo (SAO)
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One-way flight from Des Moines to Sao Paulo (SAO)
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Find flight deals from Des Moines to Sao Paulo

Cheapest flights from Des Moines to Sao Paulo
Explore the most affordable flight options available from Des Moines to Sao Paulo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/268:40 amDSM - GRU
2 stops21h 20mMultiple Airlines
Wed 12/35:25 pmGRU - DSM
3 stops31h 56mMultiple Airlines
Deal found 10/27$993
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:30 pmDSM - GRU
1 stop32h 10mDelta
Thu 1/1511:45 pmGRU - DSM
1 stop19h 44mDelta
Deal found 10/27$1,189
This KAYAK deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/162:16 pmDSM - GRU
2 stops19h 29mLATAM Airlines
Mon 1/124:30 pmGRU - DSM
2 stops21h 11mLATAM Airlines
Deal found 10/26$1,192
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/162:16 pmDSM - GRU
2 stops19h 29mDelta
Mon 1/125:45 pmGRU - DSM
2 stops19h 56mDelta
Deal found 10/26$1,200
This LATAM Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:15 pmDSM - GRU
2 stops27h 45mLATAM Airlines
Tue 1/138:15 amGRU - DSM
2 stops29h 26mLATAM Airlines
Deal found 10/27$1,203
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:30 pmDSM - GRU
1 stop32h 10mDelta
Wed 1/1412:55 pmGRU - DSM
2 stops24h 46mDelta
Deal found 10/27$1,216
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:15 amDSM - GRU
2 stops20h 25mDelta
Wed 1/1411:45 pmGRU - DSM
1 stop25h 46mDelta
Deal found 10/27$1,232
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:30 pmDSM - GRU
1 stop32h 10mDelta
Thu 1/1511:45 pmGRU - DSM
1 stop25h 46mDelta
Deal found 10/27$1,239

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Sao Paulo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Des Moines to Sao Paulo that are best for you.

Fly from

Des Moines

Fly to

Sao Paulo

Route

Depart

Return

Price

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Thu 3/12

5:15 pm-9:35 am

1 stop14h 20m

Sao Paulo Guarulhos Intl

Sun 4/12

11:45 pm-10:16 am

2 stops36h 31m

$1,065

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Mon 2/16

11:26 am-8:10 am

1 stop17h 44m

Sao Paulo Guarulhos Intl

Sun 2/22

12:15 am-11:59 pm

1 stop26h 44m

$1,087

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Mon 3/23

5:45 am-5:40 am

1 stop21h 55m

Sao Paulo Guarulhos Intl

Wed 3/25

10:40 am-10:28 pm

1 stop13h 48m

$1,100

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Mon 3/23

11:04 am-5:45 am

2 stops16h 41m

Sao Paulo Guarulhos Intl

Wed 3/25

11:45 pm-4:30 pm

1 stop18h 45m

$1,100

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Wed 12/24

7:30 am-9:55 am

1 stop23h 25m

Sao Paulo Guarulhos Intl

Thu 1/15

11:45 pm-10:41 am

1 stop13h 56m

$1,189

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Thu 12/25

6:15 am-5:40 am

2 stops20h 25m

Sao Paulo Guarulhos Intl

Wed 1/14

12:55 pm-10:41 am

2 stops24h 46m

$1,205

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Wed 12/3

8:00 am-6:30 am

2 stops19h 30m

$564

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Wed 12/3

6:00 am-8:05 am

1 stop23h 05m

$657

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Wed 12/3

2:16 pm-2:10 pm

3 stops20h 54m

$666

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Compare providers for flights from Des Moines to Sao Paulo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Sao Paulo in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Sao Paulo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Sao Paulo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Sao Paulo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Sao Paulo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Sao Paulo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Sao Paulo

Have a flexible travel schedule? Discover the best time to fly to Sao Paulo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Sao Paulo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Sao Paulo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Sao Paulo?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Sao Paulo from Des Moines. Booking flights from Des Moines (DSM) to Sao Paulo should be relatively easy as there are 0 daily outbound flights to Sao Paulo from 0 different airlines.

  • How long is the flight from Des Moines to Sao Paulo?

    For as low as $1,065, LATAM Airlines can have you in Sao Paulo from Des Moines in 14h 20m. Airlines will cover a distance of 5405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to Sao Paulo one-way?

    To fly one-way, consider booking your trip with Copa Airlines, which is currently one of the cheapest options available, starting at $564. American Airlines flights start at $657 while deals on LATAM Airlines start at $666 one-way.

  • Can I find deals for flights from Des Moines to Sao Paulo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Sao Paulo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Sao Paulo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Sao Paulo.

  • Can I find deals for business class flights from Des Moines to Sao Paulo?

    Yes. Cheapflights offers flight deals from Des Moines to Sao Paulo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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