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$432+ Cheap flights from Des Moines (DSM) to Sao Paulo, Brazil (SAO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAO
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Des Moines to Sao Paulo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Sao Paulo (SAO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$837
(Mytrip)

One-way from

$432
(Kiwi.com)

Popular in

June

Cheapest in

March

Average price

$1,178
From Des Moines to Sao Paulo (SAO)
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One-way flight from Des Moines to Sao Paulo (SAO)
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Highest demand for flights based on searches. 23% potential increase in price ($350 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($111 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Sao Paulo

Cheapest flights from Des Moines to Sao Paulo
Explore the most affordable flight options available from Des Moines to Sao Paulo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/268:47 pmDSM - GRU
3 stops41h 28mMultiple Airlines
Sun 11/24:10 amGRU - DSM
3 stops37h 40mMultiple Airlines
Deal found 9/11$837
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/276:39 pmDSM - GRU
1 stop12h 56mMultiple Airlines
Mon 11/35:25 amGRU - DSM
2 stops55h 40mMultiple Airlines
Deal found 9/11$1,133
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/255:15 pmDSM - GRU
1 stop14h 20mMultiple Airlines
Sat 11/15:25 amGRU - DSM
2 stops31h 26mMultiple Airlines
Deal found 9/10$1,208

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Sao Paulo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Des Moines to Sao Paulo that are best for you.

Fly from

Des Moines

Fly to

Sao Paulo

Route

Depart

Return

Price

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 10/26

8:47 pm-4:15 pm

3 stops41h 28m

Sao Paulo Guarulhos Intl

Sun 11/2

4:10 am-2:50 pm

3 stops37h 40m

$837

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sat 10/25

5:15 pm-9:35 am

1 stop14h 20m

Sao Paulo Guarulhos Intl

Sat 11/1

5:25 am-10:51 am

2 stops31h 26m

$1,208

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Mon 10/27

1:05 pm-9:00 am

2 stops17h 55m

Sao Paulo Guarulhos Intl

Mon 11/3

9:30 pm-12:14 pm

2 stops17h 44m

$1,260

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Mon 10/27

8:02 am-7:15 am

1 stop21h 13m

Sao Paulo Guarulhos Intl

Mon 11/3

9:45 pm-10:30 am

1 stop15h 45m

$1,270

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Mon 10/27

3:48 pm-8:10 am

1 stop14h 22m

Sao Paulo Guarulhos Intl

Sun 11/2

12:15 am-11:33 pm

1 stop26h 18m

$1,271

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Thu 11/20

9:19 am-8:00 pm

3 stops31h 41m

$432

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Thu 11/20

6:05 am-9:30 am

1 stop24h 25m

$658

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sat 10/25

8:00 am-12:15 am

2 stops38h 15m

$661

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sat 10/25

9:30 am-8:10 am

1 stop20h 40m

$698

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from Des Moines to Sao Paulo

Have a flexible travel schedule? Discover the best time to fly to Sao Paulo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Sao Paulo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Sao Paulo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Sao Paulo?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Sao Paulo from Des Moines. Booking flights from Des Moines (DSM) to Sao Paulo should be relatively easy as there are 0 daily outbound flights to Sao Paulo from 0 different airlines.

  • What are the cheapest airlines to fly from Des Moines to Sao Paulo one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $658. Copa Airlines flights start at $661 while deals on American Airlines start at $698 one-way.

  • Can I find deals for flights from Des Moines to Sao Paulo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Sao Paulo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Sao Paulo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Sao Paulo.

  • Can I find deals for business class flights from Des Moines to Sao Paulo?

    Yes. Cheapflights offers flight deals from Des Moines to Sao Paulo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Sao Paulo?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Sao Paulo (average of $677). Flying from Des Moines to Sao Paulo in December is currently the most expensive (average of $1,209). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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