How popular is this Panama City to Santo Domingo flight route?

The Panama City Tocumen Intl to Santo Domingo Las Americas flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines flying from Panama City to Santo Domingo round-trip?

Cheapflights users have booked flights from Panama City to Santo Domingo round-trip from $294. Other airlines that can offer you cheap pricing are Copa Airlines, from $429, and United Airlines, from $2,262. These flights start at 28% lower than the current average price 3 months from now.

What are the cheapest airlines to fly from Panama City to Santo Domingo one-way?

To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $162. Copa Airlines flights start at $474 while deals on United Airlines start at $1,589 one-way.

What is the cheapest day to fly from Panama City to Santo Domingo?

Travelers seeking maximum savings on their Panama City to Santo Domingo flight should consider departing on Thursday afternoons when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What are the cheapest flights from Panama City to Santo Domingo?

Looking for the cheapest flight from Panama City to Santo Domingo? While on average our users pay $428, our data indicates the cheapest price to be $202. The most popular route (Panama City Tocumen Intl - Santo Domingo Las Americas), is priced around $356.

What are the most reliable airlines from Panama City to Santo Domingo?

No one likes to see their flight delayed. When booking a flight from Panama City to Santo Domingo consider choosing Copa Airlines (93%), KLM (91%) or Air France (91%) as they are the most reliable in getting you off to your destination on time.

What is the cheapest day to fly round-trip from Panama City to Santo Domingo?

Leaving on a Wednesday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 11% on the overall cost on flights from Panama City to Santo Domingo.

How far in advance should I book a flight from Panama City to Santo Domingo?

Find a great deal and save up to 51% by booking at least 56 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Panama City to Santo Domingo within the next two weeks, with the cheapest ticket starting at $500.

What is the cheapest month to fly from Panama City to Santo Domingo?

The best pricing can be found in the month of July. Prices to Santo Domingo from Panama City average $411. You can even find prices in July for less than $411, as users have found deals to Santo Domingo from as low as $293. The month of June appears to be one of the more expensive times to travel to Santo Domingo from Panama City. Flying in the targeted month can save you up to 4%.

What airports do I use to fly from Panama City to Santo Domingo?

If you book a flight from Panama City to Santo Domingo, you will be flying from Tocumen Intl to Las Americas. Flights to Santo Domingo Las Americas (SDQ) from Panama City Tocumen Intl (PTY) take 2h 31m for a nonstop flight. There are 8 flights from Tocumen Intl to Santo Domingo per day from 2 airlines.

Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?

Yes. In addition to deals on Panama City to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Santo Domingo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santo Domingo.

Can I find deals for business class flights from Panama City to Santo Domingo?

Yes. Cheapflights offers flight deals from Panama City to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$162+ Flights from Panama City to Santo Domingo

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santo Domingo Las Americas are usually found in July or August, booked 62 days in advance, depart on a Thursday or Tuesday and return on a Thursday

Cheap flight deals from Panama City to Santo Domingo

Round-trip from	$294 (Priceline)
One-way from	$162 (FlightHub)
Popular in	June
Cheapest in	July
Average price	$428
Good round-trip deal	$374 or less

From Panama City Tocumen Intl to Santo Domingo Las Americas

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One-way flight from Panama City Tocumen Intl to Santo Domingo Las Americas

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High demand for flights, 1% potential price rise

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Cheapest flight prices on average. 0% potential price decrease ($2 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Price to beat on a round-trip flight from Panama City Tocumen Intl to Santo Domingo Las Americas.

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Find flight deals from Panama City to Santo Domingo

Cheapest flights from Panama City to Santo Domingo
Explore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

mié. 6/1110:05 pmPTY - SDQ

1 stop11h 45mAvianca

dom. 6/156:10 pmSDQ - PTY

1 stop7h 00mAvianca

Deal found 6/11

$294

jue. 10/95:25 pmPTY - SDQ

2 stops20h 25mMultiple Airlines

jue. 10/2311:45 amSDQ - PTY

1 stop13h 25mMultiple Airlines

Deal found 6/11

$391

mié. 7/309:37 amPTY - SDQ

Nonstop2h 33mCopa Airlines

sáb. 8/238:55 amSDQ - PTY

Nonstop2h 35mCopa Airlines

Deal found 6/10

$429

Best flights from Panama City to Santo Domingo
Discover carefully curated flight deals from Panama City to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated junio 12, 2025.

lun. 6/1610:05 pmPTY - SDQ

1 stop11h 45mAvianca

sáb. 6/2111:45 amSDQ - PTY

1 stop5h 45mAvianca

Deal found 6/11

$294

lun. 8/45:25 pmPTY - SDQ

1 stop16h 25mMultiple Airlines

lun. 8/186:32 pmSDQ - PTY

2 stops30h 38mMultiple Airlines

Deal found 6/11

$427

jue. 7/36:55 pmPTY - SDQ

Nonstop2h 32mCopa Airlines

jue. 7/1011:54 amSDQ - PTY

Nonstop2h 35mCopa Airlines

Deal found 6/11

$429

mié. 7/309:13 amPTY - SDQ

2 stops15h 37mUnited Airlines

sáb. 8/93:20 pmSDQ - PTY

2 stops15h 53mUnited Airlines

Deal found 6/10

$2,262

lun. 8/112:05 pmPTY - SDQ

2 stops26h 55mDelta

lun. 8/181:59 pmSDQ - PTY

2 stops23h 51mDelta

Deal found 6/10

$5,822

Last-minute flights from Panama City to Santo Domingo
Discover last-minute flight deals from Panama City to Santo Domingo. Data last updated junio 12, 2025 and is based on user searches.

jue. 6/123:20 amPTY - SDQ

1 stop12h 55mAvianca

lun. 6/1611:45 amSDQ - PTY

1 stop14h 00mAvianca

Deal found 6/12

$294

vie. 6/133:30 pmPTY - SDQ

2 stops33h 20mUnited Airlines

mié. 6/183:20 pmSDQ - PTY

2 stops25h 52mUnited Airlines

Deal found 6/10

$1,863

lun. 6/168:10 pmPTY - SDQ

2 stops27h 42mMultiple Airlines

sáb. 6/216:10 pmSDQ - PTY

1 stop7h 00mMultiple Airlines

Deal found 6/11

$432

mar. 6/179:55 amPTY - SDQ

1 stop6h 20mAvianca

jue. 6/1911:45 amSDQ - PTY

1 stop10h 25mAvianca

Deal found 6/12

$294

mar. 6/172:23 pmPTY - SDQ

2 stops21h 05mDelta

jue. 6/197:44 pmSDQ - PTY

2 stops18h 24mDelta

Deal found 6/10

$6,204

jue. 6/196:55 pmPTY - SDQ

Nonstop2h 32mCopa Airlines

dom. 6/222:05 pmSDQ - PTY

Nonstop2h 37mCopa Airlines

Deal found 6/10

$514

sáb. 6/2110:05 pmPTY - SDQ

2 stops14h 35mMultiple Airlines

dom. 6/296:10 pmSDQ - PTY

1 stop7h 00mMultiple Airlines

Deal found 6/10

$456

mié. 7/3012:44 pmPTY - SDQ

Nonstop2h 33mCopa Airlines

vie. 8/811:54 amSDQ - PTY

Nonstop2h 35mCopa Airlines

Deal found 6/10

$429

mié. 7/302:28 pmPTY - SDQ

2 stops21h 07mDelta

sáb. 8/231:59 pmSDQ - PTY

2 stops23h 51mDelta

Deal found 6/10

$5,990

One-way flights from Panama City to Santo Domingo
Search for one-way flight options from Panama City to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated junio 12, 2025.

jue. 6/263:20 amPTY - SDQ

1 stop12h 55mAvianca

Deal found 6/10

$162

lun. 6/303:25 amPTY - SDQ

2 stops20h 27mMultiple Airlines

Deal found 6/11

$283

vie. 6/206:55 pmPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 6/9

$474

mar. 7/110:55 pmPTY - SDQ

1 stop12h 00mUnited Airlines

Deal found 6/11

$1,589

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

lun. 6/16

3:25 am-10:50 am

1 stop6h 25m

Santo Domingo Las Americas

jue. 6/19

6:10 pm-12:10 am

1 stop7h 00m

$294

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

lun. 8/4

5:25 pm-10:50 am

1 stop16h 25m

Santo Domingo Las Americas

lun. 8/18

6:32 pm-12:10 am

2 stops30h 38m

$427

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

mié. 7/30

12:44 pm-4:17 pm

Nonstop2h 33m

Santo Domingo Las Americas

vie. 8/8

11:54 am-1:29 pm

Nonstop2h 35m

$429

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

jue. 7/24

7:55 am-1:50 am

2 stops16h 55m

Santo Domingo Las Americas

lun. 7/28

1:10 pm-6:37 pm

2 stops30h 27m

$1,915

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

lun. 8/11

2:05 pm-6:00 pm

2 stops26h 55m

Santo Domingo Las Americas

lun. 8/18

1:59 pm-12:50 pm

2 stops23h 51m

$5,822

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

jue. 6/26

3:20 am-5:15 pm

1 stop12h 55m

$162

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

lun. 6/30

3:25 am-12:52 am

2 stops20h 27m

$283

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

vie. 6/20

6:55 pm-10:27 pm

Nonstop2h 32m

$474

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

mar. 7/1

7:55 am-1:50 am

2 stops16h 55m

$1,589

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Panama City to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santo Domingo

How far ahead should I book a flight from Panama City to Santo Domingo?

The price you pay for your flight from Panama City to Santo Domingo may vary depending on when you book. For the best chance of a lower fare, look to book 62 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $362). Flying from Panama City to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SDQ?

One of the essential ways to save on airfare from Panama City to Santo Domingo is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 1% on airfare.

Weekly flight availability from Panama City to Santo Domingo

The most flights from PTY to SDQ are scheduled on a Monday (10 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (5 on average).

Rainfall in Santo Domingo by month

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

Temperature in Santo Domingo by month

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

Reviews of airlines servicing Santo Domingo

Get a feel of what it's like to fly with Delta, Copa Airlines and United Airlines from Panama City to Santo Domingo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Sep 2023

LGA - SYR

No A/C bad landing by pilot kinda scary. Not because of weather

Delta

8.0

Very good

7,946 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Sep 2023

LGA - SYR

No A/C bad landing by pilot kinda scary. Not because of weather

Copa Airlines

7.5

Good

1,451 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Sep 2023

LGA - SYR

No A/C bad landing by pilot kinda scary. Not because of weather

United Airlines

7.4

Good

8,790 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Sep 2023

LGA - SYR

No A/C bad landing by pilot kinda scary. Not because of weather

Avianca

6.7

Okay

2,345 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Sep 2023

LGA - SYR

No A/C bad landing by pilot kinda scary. Not because of weather

Related info for your journey

What airports do I use to fly from Panama City to Santo Domingo?
If you book a flight from Panama City to Santo Domingo, you will be flying from Tocumen Intl to Las Americas. Flights to Santo Domingo Las Americas (SDQ) from Panama City Tocumen Intl (PTY) take 2h 31m for a nonstop flight. There are 8 flights from Tocumen Intl to Santo Domingo per day from 2 airlines.
How popular is this Panama City to Santo Domingo flight route?
The Panama City Tocumen Intl to Santo Domingo Las Americas flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines flying from Panama City to Santo Domingo round-trip?
Cheapflights users have booked flights from Panama City to Santo Domingo round-trip from $294. Other airlines that can offer you cheap pricing are Copa Airlines, from $429, and United Airlines, from $2,262. These flights start at 28% lower than the current average price 3 months from now.
What are the cheapest airlines to fly from Panama City to Santo Domingo one-way?
To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $162. Copa Airlines flights start at $474 while deals on United Airlines start at $1,589 one-way.
What are the most reliable airlines from Panama City to Santo Domingo?
No one likes to see their flight delayed. When booking a flight from Panama City to Santo Domingo consider choosing Copa Airlines (93%), KLM (91%) or Air France (91%) as they are the most reliable in getting you off to your destination on time.
What are the cheapest flights from Panama City to Santo Domingo?
Looking for the cheapest flight from Panama City to Santo Domingo? While on average our users pay $428, our data indicates the cheapest price to be $202. The most popular route (Panama City Tocumen Intl - Santo Domingo Las Americas), is priced around $356.
Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?
Yes. In addition to deals on Panama City to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Santo Domingo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santo Domingo.
Can I find deals for business class flights from Panama City to Santo Domingo?
Yes. Cheapflights offers flight deals from Panama City to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Santo Domingo?
Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $362). Flying from Panama City to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Panama City to Santo Domingo

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$288	Average$348	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$372	Average$417	FlexibilityNo cancel fee	On-time70%

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$162+ Cheap flights from Panama City (PTY) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/26. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Santo Domingo with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santo Domingo Las Americas are usually found in July or August, booked 62 days in advance, depart on a Thursday or Tuesday and return on a Thursday

Cheap flight deals from Panama City to Santo Domingo

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Find flight deals from Panama City to Santo Domingo

Cheapest flights from Panama City to Santo DomingoExplore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

Explore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

Best time to book a flight from Panama City to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santo Domingo

How far ahead should I book a flight from Panama City to Santo Domingo?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santo Domingo. Price data was last updated on June 9, 2025.

What is the cheapest month to book a flight from Panama City to Santo Domingo?

What is the cheapest time of day to fly from PTY to SDQ?

Find hourly flight availability from Panama City to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

Weekly flight availability from Panama City to Santo Domingo

Rainfall in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average rainfall totals by month.

Temperature in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average temperature totals by month.

Reviews of airlines servicing Santo Domingo

Get a feel of what it's like to fly with Delta, Copa Airlines and United Airlines from Panama City to Santo Domingo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Panama City to Santo Domingo?

How popular is this Panama City to Santo Domingo flight route?

What are the cheapest airlines flying from Panama City to Santo Domingo round-trip?

What are the cheapest airlines to fly from Panama City to Santo Domingo one-way?

What are the most reliable airlines from Panama City to Santo Domingo?

What are the cheapest flights from Panama City to Santo Domingo?

Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?

How can I find direct flights from Panama City to Santo Domingo?

Can I find deals for business class flights from Panama City to Santo Domingo?

What is the cheapest month to book a flight from Panama City to Santo Domingo?

Traveling to a place near Panama City?

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Alternative routes for Panama City to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Panama City to Santo Domingo

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Travel Smart

Cheapest flights from Panama City to Santo Domingo
Explore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.