HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santo Domingo

$247+ Cheap flights from Panama City (PTY) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SDQ
Dec 18 — Dec 251
Thu 12/18
Thu 12/25
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Santo Domingo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santo Domingo Las Americas are usually found in March or January, booked 55 days in advance, depart on a Saturday or Tuesday and return on a Thursday

Cheap flight deals from Panama City to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$452
(Priceline)

One-way from

$247
(Avianca)

Popular in

December

Cheapest in

March

Average price

$452

Good round-trip deal

$452 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santo Domingo Las Americas flights.
Search Deals
From Panama City Tocumen Intl to Santo Domingo Las Americas
Search Deals
One-way flight from Panama City Tocumen Intl to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($12 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($3 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Santo Domingo Las Americas.
Search Deals

Find flight deals from Panama City to Santo Domingo

Cheapest flights from Panama City to Santo Domingo
Explore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 18, 2025.

This Priceline deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/212:55 amPTY - SDQ
1 stop12h 55mAvianca
Tue 11/255:45 pmSDQ - PTY
1 stop16h 05mAvianca
Deal found 11/16$452
This Copa Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/297:26 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Sat 1/38:50 amSDQ - PTY
Nonstop2h 40mCopa Airlines
Deal found 11/17$453
This Copa Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:10 amPTY - SDQ
Nonstop2h 30mCopa Airlines
Mon 1/58:50 amSDQ - PTY
Nonstop2h 40mCopa Airlines
Deal found 11/17$463
This Copa Airlines deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:26 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Mon 1/512:40 pmSDQ - PTY
Nonstop2h 35mCopa Airlines
Deal found 11/15$469
This Priceline deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/29:45 amPTY - SDQ
1 stop6h 05mAvianca
Sat 1/1712:20 pmSDQ - PTY
1 stop5h 35mAvianca
Deal found 11/17$474
This Copa Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:10 amPTY - SDQ
Nonstop2h 30mCopa Airlines
Fri 1/237:05 pmSDQ - PTY
Nonstop2h 35mCopa Airlines
Deal found 11/17$479
This Copa Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:10 amPTY - SDQ
Nonstop2h 30mCopa Airlines
Mon 2/236:39 pmSDQ - PTY
Nonstop2h 35mCopa Airlines
Deal found 11/17$490
This Copa Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/287:26 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Thu 2/511:57 amSDQ - PTY
Nonstop2h 35mCopa Airlines
Deal found 11/18$495
This Priceline deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/132:55 amPTY - SDQ
1 stop12h 55mAvianca
Sun 2/15:45 pmSDQ - PTY
1 stop8h 15mAvianca
Deal found 11/17$498
This Copa Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/217:26 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Sat 1/3112:40 pmSDQ - PTY
Nonstop2h 35mCopa Airlines
Deal found 11/16$504
This Copa Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/189:42 amPTY - SDQ
Nonstop2h 30mCopa Airlines
Tue 1/138:50 amSDQ - PTY
Nonstop2h 40mCopa Airlines
Deal found 11/18$506
This Copa Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:26 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Sat 1/32:11 pmSDQ - PTY
Nonstop2h 36mCopa Airlines
Deal found 11/17$517

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 18, 2025.
Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

Fly from

Panama City

Fly to

Santo Domingo

Route

Depart

Return

Price

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Fri 11/21

2:55 am-4:50 pm

1 stop12h 55m

Santo Domingo Las Americas

Tue 11/25

5:45 pm-8:50 am

1 stop16h 05m

$452

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Fri 1/2

8:10 am-11:32 am

Nonstop2h 22m

Santo Domingo Las Americas

Mon 1/5

8:50 am-10:30 am

Nonstop2h 40m

$453

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Mon 1/26

10:55 pm-2:17 am

Nonstop2h 22m

Santo Domingo Las Americas

Mon 2/2

8:50 am-10:30 am

Nonstop2h 40m

$453

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Wed 1/7

10:55 pm-2:17 am

Nonstop2h 22m

Santo Domingo Las Americas

Mon 1/12

8:50 am-10:30 am

Nonstop2h 40m

$453

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Fri 1/23

9:42 am-1:09 pm

Nonstop2h 27m

Santo Domingo Las Americas

Mon 2/2

11:57 am-1:32 pm

Nonstop2h 35m

$453

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 12/4

12:44 pm-4:15 pm

Nonstop2h 31m

Santo Domingo Las Americas

Wed 12/10

8:55 am-10:30 am

Nonstop2h 35m

$453

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Mon 1/5

10:55 pm-2:17 am

Nonstop2h 22m

Santo Domingo Las Americas

Mon 3/2

6:39 pm-8:14 pm

Nonstop2h 35m

$453

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Sat 12/27

7:26 pm-10:56 pm

Nonstop2h 30m

Santo Domingo Las Americas

Tue 1/6

6:00 am-7:42 am

Nonstop2h 42m

$453

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Mon 12/22

10:55 pm-2:26 am

Nonstop2h 31m

Santo Domingo Las Americas

Sun 2/22

6:39 pm-8:14 pm

Nonstop2h 35m

$453

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Fri 2/13

7:10 pm-10:39 pm

Nonstop2h 29m

Santo Domingo Las Americas

Tue 2/17

8:50 am-10:30 am

Nonstop2h 40m

$453

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/18

Showing 1-10 of 16 results
1
2

Compare providers for flights from Panama City to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santo Domingo in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Santo Domingo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Santo Domingo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santo Domingo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santo Domingo

How far ahead should I book a flight from Panama City to Santo Domingo?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santo Domingo. Price data was last updated on November 14, 2025.

The price you pay for your flight from Panama City to Santo Domingo may vary depending on when you book. For the best chance of a lower fare, look to book 55 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santo Domingo?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $235). Flying from Panama City to Santo Domingo in December is currently the most expensive (average of $378). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SDQ?

Find hourly flight availability from Panama City to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 18, 2025.

When flying from Panama City to Santo Domingo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated November 18, 2025.
Read through reviews of airlines operating flights from Panama City to Santo Domingo, such as Copa Airlines and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,566 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.6

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,566 reviews
Copa Airlines
7.6
Good
1,566 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.6

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,475 reviews
Copa Airlines
7.6
Good
1,566 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.6

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santo Domingo?

    If you book a flight from Panama City to Santo Domingo, you will be flying from Tocumen Intl to Las Americas. Flights to Santo Domingo Las Americas (SDQ) from Panama City Tocumen Intl (PTY) take 2h 22m for a nonstop flight. There are 5 flights from Tocumen Intl to Santo Domingo per day from 2 airlines.

  • How popular is this Panama City to Santo Domingo flight route?

    The Panama City Tocumen Intl to Santo Domingo Las Americas flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Santo Domingo?

    A quick flight from Panama City to Santo Domingo can take about 2h 22m. Avianca provides one of the quickest options available for as low as $453. There are 917 mi between Panama City and Santo Domingo. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City to Santo Domingo round-trip?

    Cheapflights users have booked flights from Panama City to Santo Domingo round-trip from $292. Another airline that can offer you cheap pricing is Copa Airlines. These flights start at 32% lower than the current average price 3 months from now.

  • What are the most reliable airlines from Panama City to Santo Domingo?

    No one likes to see their flight delayed. When booking a flight from Panama City to Santo Domingo consider choosing Air France (89%), KLM (89%) or Turkish Airlines (88%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama City to Santo Domingo?

    Looking for the cheapest flight from Panama City to Santo Domingo? While on average our users pay $782, our data indicates the cheapest price to be $302. The most popular route (Panama City Tocumen Intl - Santo Domingo Las Americas), is priced around $453.

  • Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Panama City to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santo Domingo.

  • Can I find deals for business class flights from Panama City to Santo Domingo?

    Yes. Cheapflights offers flight deals from Panama City to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santo Domingo?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $235). Flying from Panama City to Santo Domingo in December is currently the most expensive (average of $378). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Punta Cana flights
Panama City to Santiago de los Caballeros flights

Top 2 airlines flying from Panama City to Santo Domingo

Discover the top 2 airlines that operate flights from Panama City to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$292Average$345FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$395Average$451FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.