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Santo Domingo

$248+ Cheap flights from Panama City (PTY) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/5. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SDQ
Mar 21 — Mar 281
Sat 3/21
Sat 3/28
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santo Domingo Las Americas are usually found in April or March, booked 75 days in advance, depart on a Thursday or Tuesday and return on a Thursday

Cheap flight deals from Panama City to Santo Domingo

Cheapest flights from Panama City to Santo Domingo
Explore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 19, 2026.

This Avianca deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Wed 3/185:45 pm
SDQ
-
PTY
1 stop16h 05m
Avianca
Deal found 2/18$452
This Avianca deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/13:05 am
PTY
-
SDQ
1 stop7h 45m
Avianca
Sun 4/512:45 pm
SDQ
-
PTY
1 stop13h 20m
Avianca
Deal found 2/19$453
This Copa Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/19:42 am
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Fri 5/16:39 pm
SDQ
-
PTY
Nonstop2h 35m
Copa Airlines
Deal found 2/18$474
This Copa Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:26 pm
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Fri 4/38:43 am
SDQ
-
PTY
Nonstop2h 37m
Copa Airlines
Deal found 2/16$485
This Avianca deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/275:50 pm
PTY
-
SDQ
1 stop16h 35m
Avianca
Tue 3/3112:45 pm
SDQ
-
PTY
1 stop13h 20m
Avianca
Deal found 2/16$490
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/232:55 am
PTY
-
SDQ
1 stop7h 30m
Avianca
Sat 2/2812:20 pm
SDQ
-
PTY
1 stop5h 35m
Avianca
Deal found 2/19$491
This Avianca deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Tue 3/35:45 pm
SDQ
-
PTY
1 stop8h 15m
Avianca
Deal found 2/19$504
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/229:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Sat 2/285:45 pm
SDQ
-
PTY
1 stop8h 15m
Avianca
Deal found 2/19$513
This Avianca deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Fri 2/275:45 pm
SDQ
-
PTY
1 stop7h 55m
Avianca
Deal found 2/19$525
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:55 am
PTY
-
SDQ
2 stops12h 34m
Multiple Airlines
Sat 3/75:53 pm
SDQ
-
PTY
1 stop13h 40m
Multiple Airlines
Deal found 2/16$528
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:25 am
PTY
-
SDQ
1 stop12h 20m
Multiple Airlines
Sat 3/145:53 pm
SDQ
-
PTY
2 stops32h 07m
Multiple Airlines
Deal found 2/19$530
This Avianca deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Thu 2/2612:20 pm
SDQ
-
PTY
1 stop5h 35m
Avianca
Deal found 2/19$541

Find flight deals from Panama City to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$452
(Avianca)

One-way from

$248
(Avianca)

Popular in

December

Cheapest in

April

Average price

$452

Good round-trip deal

$473 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santo Domingo Las Americas flights.
Search Deals
From Panama City Tocumen Intl to Santo Domingo Las Americas
Search Deals
One-way flight from Panama City Tocumen Intl to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($16 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($2 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Santo Domingo Las Americas.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

Fly from

Panama City

Fly to

Santo Domingo

Route

Depart

Return

Price

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Wed 4/1

7:26 pm-10:47 pm

Nonstop2h 21m

Santo Domingo Las Americas

Thu 4/30

2:12 pm-3:49 pm

Nonstop2h 37m

$474

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 4/9

7:24 am-10:54 am

Nonstop2h 30m

Santo Domingo Las Americas

Tue 4/14

12:38 pm-2:15 pm

Nonstop2h 37m

$474

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Sat 3/14

7:10 pm-10:40 pm

Nonstop2h 30m

Santo Domingo Las Americas

Tue 3/17

6:00 am-7:44 am

Nonstop2h 44m

$474

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 3/5

12:44 pm-4:14 pm

Nonstop2h 30m

Santo Domingo Las Americas

Tue 3/31

2:12 pm-3:49 pm

Nonstop2h 37m

$474

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 7/2

9:42 am-1:13 pm

Nonstop2h 31m

Santo Domingo Las Americas

Wed 7/22

12:43 pm-2:15 pm

Nonstop2h 32m

$474

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 3/5

9:45 am-4:50 pm

1 stop6h 05m

$248

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 4/2

10:10 am-5:55 pm

1 stop6h 45m

$248

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Mon 8/10

3:05 am-11:50 am

1 stop7h 45m

$248

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Fri 2/27

2:55 am-11:25 am

1 stop7h 30m

$248

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Mon 4/13

10:10 am-5:55 pm

1 stop6h 45m

$248

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/17

Showing 1-10 of 15 results
1
2
  • Most accurate provider: When it comes to deals on Panama City-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santo Domingo

How far ahead should I book a flight from Panama City to Santo Domingo?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santo Domingo. Price data was last updated on February 13, 2026.

The price you pay for your flight from Panama City to Santo Domingo may vary depending on when you book. For the best chance of a lower fare, look to book 75 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santo Domingo?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $193). Flying from Panama City to Santo Domingo in October is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SDQ?

Find hourly flight availability from Panama City to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 19, 2026.

One of the essential ways to save on airfare from Panama City to Santo Domingo is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 7% on airfare.

How much does it cost to fly round-trip from Panama City to Santo Domingo?

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated February 19, 2026.
Read through reviews of airlines operating flights from Panama City to Santo Domingo, such as Copa Airlines and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,552 reviews

Boarding

7.8

Crew

8.1

Comfort

7.4

Entertainment

6.8

Food

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.5
Good
1,552 reviews
Copa Airlines
7.5
Good
1,552 reviews

Boarding

7.8

Crew

8.1

Comfort

7.4

Entertainment

6.8

Food

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.6
Okay
2,497 reviews
Copa Airlines
7.5
Good
1,552 reviews

Boarding

7.8

Crew

8.1

Comfort

7.4

Entertainment

6.8

Food

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santo Domingo?

    If you book a flight from Panama City to Santo Domingo, you will be flying from Tocumen Intl to Las Americas. Flights to Santo Domingo Las Americas (SDQ) from Panama City Tocumen Intl (PTY) take 2h 21m for a nonstop flight. There are 5 flights from Tocumen Intl to Santo Domingo per day from 2 airlines.

  • How popular is this Panama City to Santo Domingo flight route?

    The Panama City Tocumen Intl to Santo Domingo Las Americas flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Santo Domingo?

    A quick flight from Panama City to Santo Domingo can take about 2h 21m. Copa Airlines provides one of the quickest options available for as low as $474. There are 917 mi between Panama City and Santo Domingo. All flights are typically nonstop.

  • What are the cheapest airlines flying from Panama City to Santo Domingo round-trip?

    Cheapflights users have booked flights from Panama City to Santo Domingo round-trip from $289. Another airline that can offer you cheap pricing is Copa Airlines. These flights start at 34% lower than the current average price 3 months from now.

  • What are the most reliable airlines from Panama City to Santo Domingo?

    No one likes to see their flight delayed. When booking a flight from Panama City to Santo Domingo consider choosing KLM (96%), Air France (96%) or Turkish Airlines (96%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama City to Santo Domingo?

    Looking for the cheapest flight from Panama City to Santo Domingo? While on average our users pay $793, our data indicates the cheapest price to be $473. The most popular route (Panama City Tocumen Intl - Santo Domingo Las Americas), is priced around $458.

  • Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Panama City to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santo Domingo.

  • Can I find deals for business class flights from Panama City to Santo Domingo?

    Yes. Cheapflights offers flight deals from Panama City to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santo Domingo?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $193). Flying from Panama City to Santo Domingo in October is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Punta Cana flights
Panama City to Santiago de los Caballeros flights

Top 2 airlines flying from Panama City to Santo Domingo

Discover the top 2 airlines that operate flights from Panama City to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$289Average$345FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$395Average$452FlexibilityNo cancel feeOn-time70%

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