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Santo Domingo

$242+ Cheap flights from Panama City (PTY) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SDQ
Nov 1 — Nov 81
Sat 11/1
Sat 11/8
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santo Domingo Las Americas are usually found in January or February, booked 64 days in advance, depart on a Thursday or Wednesday and return on a Thursday

Cheap flight deals from Panama City to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 2, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$450
(Copa Airlines)

One-way from

$242
(Mytrip)

Popular in

December

Cheapest in

January

Average price

$446

Good round-trip deal

$449 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Santo Domingo Las Americas flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santo Domingo Las Americas flights.
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From Panama City Tocumen Intl to Santo Domingo Las Americas
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One-way flight from Panama City Tocumen Intl to Santo Domingo Las Americas
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Highest demand for flights based on searches. 0% potential increase in price ($0 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($3 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Santo Domingo Las Americas.
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Find flight deals from Panama City to Santo Domingo

Cheapest flights from Panama City to Santo Domingo
Explore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 2, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:55 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Wed 10/2211:57 amSDQ - PTY
Nonstop2h 32mCopa Airlines
Deal found 10/1$450
This Copa Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:55 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Thu 11/2011:55 amSDQ - PTY
Nonstop2h 37mCopa Airlines
Deal found 9/29$451
This Avianca deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/172:55 amPTY - SDQ
1 stop12h 55mAvianca
Tue 1/135:45 pmSDQ - PTY
1 stop16h 05mAvianca
Deal found 9/30$452
This Copa Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:26 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Tue 1/138:50 amSDQ - PTY
Nonstop2h 40mCopa Airlines
Deal found 10/2$453
This Copa Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/197:26 amPTY - SDQ
Nonstop2h 30mCopa Airlines
Tue 10/286:00 amSDQ - PTY
Nonstop2h 33mCopa Airlines
Deal found 10/1$461
This Copa Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/186:55 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Wed 11/58:55 amSDQ - PTY
Nonstop2h 35mCopa Airlines
Deal found 10/1$467
This Copa Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/110:55 pmPTY - SDQ
Nonstop2h 31mCopa Airlines
Wed 11/58:55 amSDQ - PTY
Nonstop2h 35mCopa Airlines
Deal found 9/29$469
This Avianca deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/133:25 amPTY - SDQ
1 stop12h 50mAvianca
Sat 10/1811:45 amSDQ - PTY
1 stop5h 45mAvianca
Deal found 9/30$471
This Avianca deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:45 amPTY - SDQ
1 stop6h 05mAvianca
Wed 11/55:45 pmSDQ - PTY
1 stop16h 05mAvianca
Deal found 9/30$473
This Priceline deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/35:55 pmPTY - SDQ
1 stop16h 30mAvianca
Tue 11/45:45 pmSDQ - PTY
1 stop16h 05mAvianca
Deal found 9/29$474
This Copa Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1712:44 pmPTY - SDQ
Nonstop2h 31mCopa Airlines
Fri 10/246:24 pmSDQ - PTY
Nonstop2h 31mCopa Airlines
Deal found 10/1$477
This Copa Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/276:55 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Fri 11/72:15 pmSDQ - PTY
Nonstop2h 35mCopa Airlines
Deal found 10/2$478

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 2, 2025.
Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

Fly from

Panama City

Fly to

Santo Domingo

Route

Depart

Return

Price

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Tue 10/21

12:44 pm-4:15 pm

Nonstop2h 31m

Santo Domingo Las Americas

Sat 10/25

11:57 am-1:29 pm

Nonstop2h 32m

$450

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Tue 10/14

12:44 pm-4:15 pm

Nonstop2h 31m

Santo Domingo Las Americas

Sat 10/25

11:57 am-1:29 pm

Nonstop2h 32m

$450

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Tue 10/14

12:44 pm-4:15 pm

Nonstop2h 31m

Santo Domingo Las Americas

Sat 10/18

11:57 am-1:29 pm

Nonstop2h 32m

$450

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 10/23

12:44 pm-4:15 pm

Nonstop2h 31m

Santo Domingo Las Americas

Wed 10/29

8:58 am-10:30 am

Nonstop2h 32m

$450

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 10/16

12:44 pm-4:15 pm

Nonstop2h 31m

Santo Domingo Las Americas

Mon 10/20

8:58 am-10:30 am

Nonstop2h 32m

$450

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 10/23

12:44 pm-4:15 pm

Nonstop2h 31m

Santo Domingo Las Americas

Sun 10/26

8:58 am-10:30 am

Nonstop2h 32m

$450

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Sat 10/25

11:13 pm-2:43 am

Nonstop2h 30m

Santo Domingo Las Americas

Fri 10/31

8:58 am-10:30 am

Nonstop2h 32m

$450

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Wed 10/29

6:55 pm-10:25 pm

Nonstop2h 30m

Santo Domingo Las Americas

Mon 11/3

11:55 am-1:32 pm

Nonstop2h 37m

$451

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 10/23

6:55 pm-10:25 pm

Nonstop2h 30m

Santo Domingo Las Americas

Thu 11/20

11:55 am-1:32 pm

Nonstop2h 37m

$451

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Mon 10/27

6:55 pm-10:25 pm

Nonstop2h 30m

Santo Domingo Las Americas

Mon 11/3

8:55 am-10:30 am

Nonstop2h 35m

$451

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/2

Showing 1-10 of 21 results
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Compare providers for flights from Panama City to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santo Domingo in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santo Domingo

How far ahead should I book a flight from Panama City to Santo Domingo?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santo Domingo. Price data was last updated on September 26, 2025.

The price you pay for your flight from Panama City to Santo Domingo may vary depending on when you book. For the best chance of a lower fare, look to book 19 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $362). Flying from Panama City to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SDQ?

Find hourly flight availability from Panama City to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 2, 2025.

One of the essential ways to save on airfare from Panama City to Santo Domingo is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 8% on airfare.

How much does it cost to fly round-trip from Panama City to Santo Domingo?

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated October 2, 2025.
Read through reviews of airlines operating flights from Panama City to Santo Domingo, such as Copa Airlines and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,542 reviews

Comfort

7.4

Entertainment

6.8

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,542 reviews
Copa Airlines
7.6
Good
1,542 reviews

Comfort

7.4

Entertainment

6.8

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,443 reviews
Copa Airlines
7.6
Good
1,542 reviews

Comfort

7.4

Entertainment

6.8

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santo Domingo?

    If you book a flight from Panama City to Santo Domingo, you will be flying from Tocumen Intl to Las Americas. Flights to Santo Domingo Las Americas (SDQ) from Panama City Tocumen Intl (PTY) take 2h 22m for a nonstop flight. There are 5 flights from Tocumen Intl to Santo Domingo per day from 2 airlines.

  • How popular is this Panama City to Santo Domingo flight route?

    The Panama City Tocumen Intl to Santo Domingo Las Americas flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Santo Domingo?

    A quick flight from Panama City to Santo Domingo can take about 2h 31m. Copa Airlines provides one of the quickest options available for as low as $450. There are 917 mi between Panama City and Santo Domingo. All flights are typically nonstop.

  • What are the cheapest airlines flying from Panama City to Santo Domingo round-trip?

    Cheapflights users have booked flights from Panama City to Santo Domingo round-trip from $292. Another airline that can offer you cheap pricing is Copa Airlines. These flights start at 31% lower than the current average price 3 months from now.

  • What are the most reliable airlines from Panama City to Santo Domingo?

    No one likes to see their flight delayed. When booking a flight from Panama City to Santo Domingo consider choosing KLM (97%), Air France (97%) or Turkish Airlines (96%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama City to Santo Domingo?

    Looking for the cheapest flight from Panama City to Santo Domingo? While on average our users pay $781, our data indicates the cheapest price to be $449. The most popular route (Panama City Tocumen Intl - Santo Domingo Las Americas), is priced around $446.

  • Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Panama City to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santo Domingo.

  • Can I find deals for business class flights from Panama City to Santo Domingo?

    Yes. Cheapflights offers flight deals from Panama City to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $362). Flying from Panama City to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Panama City to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Punta Cana flights
Panama City to Santiago de los Caballeros flights

Top 2 airlines flying from Panama City to Santo Domingo

Discover the top 2 airlines that operate flights from Panama City to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$292Average$345FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$394Average$447FlexibilityNo cancel feeOn-time70%

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