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Santo Domingo

$106+ Cheap flights from Key Largo, FL to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/17. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SDQ
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Santo Domingo Las Americas are usually found in October or September, booked 84 days in advance, depart on a Wednesday or Thursday and return on a Friday

Find flight deals from Key Largo to Santo Domingo

Cheapest flights from Key Largo to Santo Domingo
Explore the most affordable flight options available from Key Largo to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This Expedia deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/76:25 pmMIA - SDQ
Nonstop2h 20mArajet
dom. 12/143:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/28$231
This Cheapflightsfares deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/86:25 pmMIA - SDQ
Nonstop2h 20mArajet
mar. 11/113:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/29$233
This CheapOair deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/46:25 pmMIA - SDQ
Nonstop2h 20mArajet
lun. 12/810:19 amSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/30$234
This CheapOair deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/136:25 pmMIA - SDQ
Nonstop2h 20mArajet
dom. 11/163:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/29$236
This FlightHub deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/17:25 pmMIA - SDQ
Nonstop2h 20mMultiple Airlines
vie. 12/266:04 pmSDQ - MIA
Nonstop2h 35mMultiple Airlines
Deal found 10/29$237
This Cheapflightsfares deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/71:09 pmMIA - SDQ
Nonstop2h 20mArajet
lun. 11/1010:19 amSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/28$238
This Expedia deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/116:25 pmMIA - SDQ
Nonstop2h 20mArajet
jue. 11/133:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/29$239
This Cheapflightsfares deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/312:09 pmMIA - SDQ
Nonstop2h 20mArajet
mié. 12/310:19 amSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/28$240
This Expedia deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/116:25 pmMIA - SDQ
Nonstop2h 20mArajet
jue. 12/183:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/28$241
This Cheapflightsfares deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/312:09 pmMIA - SDQ
Nonstop2h 20mArajet
mar. 12/23:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/28$242
This Arajet deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/66:25 pmMIA - SDQ
Nonstop2h 20mArajet
jue. 11/133:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/28$243
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/141:09 pmMIA - SDQ
Nonstop2h 20mArajet
jue. 11/203:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 10/29$245

Cheap flight deals from Key Largo to Santo Domingo

Keep the following information in mind while searching for Key Largo to Santo Domingo flight deals. Data was last updated octubre 30, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$231
(Expedia)

One-way from

$106
(Cheapflightsfares)

Popular in

December

Cheapest in

October

Average price

$260
Provider with most accurate pricing for Miami-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Santo Domingo Las Americas flights.
Search Deals
From Key Largo to Santo Domingo Las Americas
Search Deals
One-way flight from Key Largo to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($58 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Key Largo to Santo Domingo that are best for you.

Fly from

Key Largo

Fly to

Santo Domingo

Route

Depart

Return

Price

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

mar. 1/27

6:25 pm-9:45 pm

Nonstop2h 20m

Santo Domingo Las Americas

mar. 2/3

3:35 pm-4:55 pm

Nonstop2h 20m

$243

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

lun. 12/8

1:09 pm-4:29 pm

Nonstop2h 20m

Santo Domingo Las Americas

lun. 12/15

9:45 am-4:23 pm

1 stop7h 38m

$248

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

jue. 12/4

6:25 pm-9:45 pm

Nonstop2h 20m

Santo Domingo Las Americas

mié. 12/10

3:55 am-11:25 am

1 stop8h 30m

$248

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

dom. 12/7

3:02 pm-1:50 am

1 stop9h 48m

Santo Domingo Las Americas

dom. 12/14

3:35 pm-4:55 pm

Nonstop2h 20m

$248

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

dom. 11/30

3:02 pm-1:50 am

1 stop9h 48m

Santo Domingo Las Americas

dom. 12/7

3:35 pm-4:55 pm

Nonstop2h 20m

$250

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

sáb. 1/24

6:25 pm-9:45 pm

Nonstop2h 20m

Santo Domingo Las Americas

vie. 1/30

1:40 am-11:25 am

1 stop10h 45m

$250

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

mar. 1/13

6:25 pm-9:45 pm

Nonstop2h 20m

Santo Domingo Las Americas

mar. 1/20

6:10 am-12:27 pm

1 stop7h 17m

$252

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

vie. 11/28

4:18 pm-1:50 am

1 stop8h 32m

Santo Domingo Las Americas

mar. 12/2

3:35 pm-4:55 pm

Nonstop2h 20m

$255

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

mié. 12/10

4:18 pm-3:30 am

1 stop10h 12m

Santo Domingo Las Americas

mié. 12/17

10:19 am-11:39 am

Nonstop2h 20m

$260

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

mar. 1/27

6:25 pm-9:45 pm

Nonstop2h 20m

Santo Domingo Las Americas

mar. 2/3

6:10 am-12:27 pm

1 stop7h 17m

$260

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 21 results
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Best time to book a flight from Key Largo to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Santo Domingo

How far ahead should I book a flight from Key Largo to Santo Domingo?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Santo Domingo. Price data was last updated on October 24, 2025.

The best time to book flights from Key Largo to Santo Domingo is 84 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Key Largo to Santo Domingo?

Currently, April is the cheapest month in which you can book a flight from Key Largo to Santo Domingo (average of $123). Flying from Key Largo to Santo Domingo in December is currently the most expensive (average of $170). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SDQ?

Find hourly flight availability from Key Largo to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 30, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 26% on flights from Key Largo to Santo Domingo by exploring options for tickets in the evening.

What is the cheapest day to fly from Key Largo to Santo Domingo?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Santo Domingo. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Santo Domingo flight should consider departing on Thursday at noon when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated octubre 30, 2025.
Read reviews from past customers who have flown American Airlines, Spirit Airlines, and Frontier from Key Largo to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,035 reviews

Overall

7.2

Entertainment

6.9

Boarding

7.5

Food

6.4

Crew

8.0

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
11,035 reviews
American Airlines
7.2
Good
11,035 reviews

Overall

7.2

Entertainment

6.9

Boarding

7.5

Food

6.4

Crew

8.0

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
Spirit Airlines
6.3
Okay
8,115 reviews
American Airlines
7.2
Good
11,035 reviews

Overall

7.2

Entertainment

6.9

Boarding

7.5

Food

6.4

Crew

8.0

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
Frontier
5.8
Fair
3,123 reviews
American Airlines
7.2
Good
11,035 reviews

Overall

7.2

Entertainment

6.9

Boarding

7.5

Food

6.4

Crew

8.0

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Key Largo?

    Santo Domingo Las Americas (SDQ), located 17.5 mi from the city center, is the airport you fly into when you book flights from Key Largo to Santo Domingo. 9 airlines have flights to Las Americas from Key Largo on a regular basis. Booking flights from Key Largo to Santo Domingo Las Americas should not be difficult; the airport handles an average of 4 inbound flights from Key Largo per day.

  • How popular is this Key Largo to Santo Domingo flight route?

    This flight path from Key Largo to Santo Domingo Las Americas was viewed by 68 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Key Largo to Santo Domingo?

    Arajet can get you from Key Largo to Santo Domingo in just under 2h 20m. Your travel time will be generally consistent. Airlines will cover a distance of 848 mi. Generally, flights for this route are nonstop.

  • What are the most reliable airlines from Key Largo to Santo Domingo?

    The top 3 most reliable airlines when flying from Key Largo to Santo Domingo are Arajet (84%), American Airlines (77%) and Qatar Airways (76%).

  • What are the cheapest flights from Key Largo to Santo Domingo?

    On average you can expect to pay $221 for a flight from Key Largo to Santo Domingo. The cheapest flight overall is $106 while the most popular route, (Miami - Santo Domingo Las Americas) is currently priced at $220.

  • Can I find deals for flights from Key Largo to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Key Largo to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Santo Domingo.

  • Can I find deals for business class flights from Key Largo to Santo Domingo?

    Yes. Cheapflights offers flight deals from Key Largo to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Santo Domingo?

    Currently, April is the cheapest month in which you can book a flight from Key Largo to Santo Domingo (average of $123). Flying from Key Largo to Santo Domingo in December is currently the most expensive (average of $170). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top 8 airlines flying from Key Largo to Santo Domingo

Discover the top 8 airlines that operate flights from Key Largo to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$136Average$273FlexibilityNo cancel feeOn-time65%
FrontierCheapest$140Average$326FlexibilityNo cancel feeOn-time62%
Copa AirlinesCheapest$143Average$321FlexibilityNo cancel feeOn-time70%
ArajetCheapest$145Average$276FlexibilityNo cancel feeOn-timeN/A
JetBlueCheapest$187Average$366FlexibilityNo cancel feeOn-time62%
Sky HighCheapest$195Average$374FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$250Average$374FlexibilityNo cancel feeOn-time71%
Hahn AirCheapest$286Average$457FlexibilityNo cancel feeOn-timeN/A

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