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Santo Domingo

$112+ Cheap flights from Key Largo, FL to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/29. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SDQ
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Santo Domingo Las Americas are usually found in October or September, booked 84 days in advance, depart on a Wednesday or Tuesday and return on a Friday

Cheap flight deals from Key Largo to Santo Domingo

Cheapest flights from Key Largo to Santo Domingo
Explore the most affordable flight options available from Key Largo to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Super.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/285:30 amMIA - SDQ
1 stop8h 48mFrontier
Wed 12/316:04 pmSDQ - MIA
Nonstop2h 35mFrontier
Deal found 12/13$243
This Priceline deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2711:05 pmMIA - SDQ
1 stop19h 22mFrontier
Wed 12/316:04 pmSDQ - MIA
Nonstop2h 35mFrontier
Deal found 12/13$247
This Frontier deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/291:25 pmMIA - SDQ
Nonstop2h 24mFrontier
Mon 12/298:42 pmSDQ - MIA
1 stop10h 18mFrontier
Deal found 12/14$249
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:33 pmMIA - SDQ
1 stop7h 57mMultiple Airlines
Wed 12/316:04 pmSDQ - MIA
Nonstop2h 35mMultiple Airlines
Deal found 12/15$250
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:25 pmMIA - SDQ
Nonstop2h 20mMultiple Airlines
Wed 12/316:04 pmSDQ - MIA
Nonstop2h 35mMultiple Airlines
Deal found 12/14$251
This Frontier deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:25 pmMIA - SDQ
Nonstop2h 24mFrontier
Fri 1/93:02 pmSDQ - MIA
Nonstop2h 37mFrontier
Deal found 12/13$264
This Expedia deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:25 pmMIA - SDQ
Nonstop2h 20mMultiple Airlines
Wed 12/316:04 pmSDQ - MIA
Nonstop2h 35mMultiple Airlines
Deal found 12/13$265
This Frontier deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2811:05 pmMIA - SDQ
1 stop9h 21mFrontier
Mon 12/296:04 pmSDQ - MIA
Nonstop2h 35mFrontier
Deal found 12/15$266
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:53 pmMIA - SDQ
1 stop7h 32mMultiple Airlines
Wed 12/246:04 pmSDQ - MIA
Nonstop2h 35mMultiple Airlines
Deal found 12/12$272
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:53 pmMIA - SDQ
1 stop7h 32mMultiple Airlines
Fri 12/196:04 pmSDQ - MIA
Nonstop2h 35mMultiple Airlines
Deal found 12/15$276
This Frontier deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/291:25 pmMIA - SDQ
Nonstop2h 24mFrontier
Tue 12/304:34 pmSDQ - MIA
1 stop9h 13mFrontier
Deal found 12/14$280

Find flight deals from Key Largo to Santo Domingo

Keep the following information in mind while searching for Key Largo to Santo Domingo flight deals. Data was last updated December 15, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$239
(Booking.com)

One-way from

$112
(Super.com)

Popular in

December

Cheapest in

October

Average price

$446
Provider with most accurate pricing for Miami-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Santo Domingo Las Americas flights.
Search Deals
From Key Largo to Santo Domingo Las Americas
Search Deals
One-way flight from Key Largo to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($33 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Key Largo to Santo Domingo that are best for you.

Fly from

Key Largo

Fly to

Santo Domingo

Route

Depart

Return

Price

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

Fri 1/23

4:18 pm-1:50 am

1 stop8h 32m

Santo Domingo Las Americas

Sun 2/8

5:10 pm-6:30 pm

Nonstop2h 20m

$244

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

Fri 1/30

4:18 pm-1:50 am

1 stop8h 32m

Santo Domingo Las Americas

Mon 2/2

10:19 am-11:39 am

Nonstop2h 20m

$244

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

Mon 2/2

5:53 pm-2:25 am

1 stop7h 32m

Santo Domingo Las Americas

Mon 2/9

10:19 am-11:39 am

Nonstop2h 20m

$244

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

Fri 1/16

1:09 pm-4:29 pm

Nonstop2h 20m

Santo Domingo Las Americas

Sat 1/17

2:00 am-1:32 pm

1 stop12h 32m

$252

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

Wed 1/14

1:09 pm-4:29 pm

Nonstop2h 20m

Santo Domingo Las Americas

Sat 1/17

2:00 am-1:32 pm

1 stop12h 32m

$252

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

Tue 2/24

6:25 pm-9:45 pm

Nonstop2h 20m

Santo Domingo Las Americas

Tue 3/3

6:10 am-12:27 pm

1 stop7h 17m

$253

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

Wed 2/18

1:09 pm-4:29 pm

Nonstop2h 20m

Santo Domingo Las Americas

Wed 2/25

9:45 am-2:48 pm

1 stop6h 03m

$253

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

Thu 1/29

12:55 pm-9:40 pm

1 stop7h 45m

Santo Domingo Las Americas

Sun 2/1

5:10 pm-6:30 pm

Nonstop2h 20m

$257

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

Sun 2/22

3:02 pm-1:50 am

1 stop9h 48m

Santo Domingo Las Americas

Sun 3/1

5:10 pm-6:30 pm

Nonstop2h 20m

$257

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

Sat 3/7

12:55 pm-9:40 pm

1 stop7h 45m

Santo Domingo Las Americas

Fri 3/13

1:40 am-12:25 pm

1 stop10h 45m

$263

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 23 results
1
2
3

Best time to book a flight from Key Largo to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Santo Domingo

How far ahead should I book a flight from Key Largo to Santo Domingo?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Santo Domingo. Price data was last updated on December 12, 2025.

The best time to book flights from Key Largo to Santo Domingo is 84 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Key Largo to Santo Domingo?

Currently, April is the cheapest month in which you can book a flight from Key Largo to Santo Domingo (average of $123). Flying from Key Largo to Santo Domingo in December is currently the most expensive (average of $176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SDQ?

Find hourly flight availability from Key Largo to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 23% on flights from Key Largo to Santo Domingo by exploring options for tickets in the evening.

What is the cheapest day to fly from Key Largo to Santo Domingo?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Santo Domingo. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Santo Domingo flight should consider departing on Thursday at noon when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Santo Domingo

Explore weekly flight availability from Key Largo to Santo Domingo. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 15, 2025.

The most flights from KE9 to SDQ are scheduled on a Monday (10 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (1 on average).

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated December 15, 2025.
Read reviews from past customers who have flown American Airlines, Spirit Airlines, and Frontier from Key Largo to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,048 reviews

Crew

8.0

Boarding

7.5

Overall

7.2

Entertainment

6.9

Comfort

7.2

Food

6.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
11,048 reviews
American Airlines
7.2
Good
11,048 reviews

Crew

8.0

Boarding

7.5

Overall

7.2

Entertainment

6.9

Comfort

7.2

Food

6.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
Spirit Airlines
6.3
Okay
8,186 reviews
American Airlines
7.2
Good
11,048 reviews

Crew

8.0

Boarding

7.5

Overall

7.2

Entertainment

6.9

Comfort

7.2

Food

6.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
Frontier
5.8
Fair
3,082 reviews
American Airlines
7.2
Good
11,048 reviews

Crew

8.0

Boarding

7.5

Overall

7.2

Entertainment

6.9

Comfort

7.2

Food

6.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Key Largo?

    Santo Domingo Las Americas (SDQ), located 17.5 mi from the city center, is the airport you fly into when you book flights from Key Largo to Santo Domingo. 9 airlines have flights to Las Americas from Key Largo on a regular basis. Booking flights from Key Largo to Santo Domingo Las Americas should not be difficult; the airport handles an average of 6 inbound flights from Key Largo per day.

  • How popular is this Key Largo to Santo Domingo flight route?

    This flight path from Key Largo to Santo Domingo Las Americas was viewed by 66 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Key Largo to Santo Domingo one-way?

    The cheapest airlines for a one-way flight from Key Largo to Santo Domingo are Frontier ($90), Spirit Airlines ($93), and Arajet ($97).

  • What are the most reliable airlines from Key Largo to Santo Domingo?

    The top 3 most reliable airlines when flying from Key Largo to Santo Domingo are British Airways (84%), Arajet (82%) and American Airlines (80%).

  • What are the cheapest flights from Key Largo to Santo Domingo?

    On average you can expect to pay $393 for a flight from Key Largo to Santo Domingo. The cheapest flight overall is $104 while the most popular route, (Miami - Santo Domingo Las Americas) is currently priced at $203.

  • Can I find deals for flights from Key Largo to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Key Largo to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Santo Domingo.

  • Can I find deals for business class flights from Key Largo to Santo Domingo?

    Yes. Cheapflights offers flight deals from Key Largo to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Santo Domingo?

    Currently, April is the cheapest month in which you can book a flight from Key Largo to Santo Domingo (average of $123). Flying from Key Largo to Santo Domingo in December is currently the most expensive (average of $176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top 8 airlines flying from Key Largo to Santo Domingo

Discover the top 8 airlines that operate flights from Key Largo to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$140Average$319FlexibilityNo cancel feeOn-time70%
Spirit AirlinesCheapest$143Average$272FlexibilityNo cancel feeOn-time65%
ArajetCheapest$151Average$281FlexibilityNo cancel feeOn-timeN/A
FrontierCheapest$159Average$313FlexibilityNo cancel feeOn-time62%
Sky HighCheapest$189Average$362FlexibilityNo cancel feeOn-timeN/A
JetBlueCheapest$194Average$348FlexibilityNo cancel feeOn-time62%
Hahn AirCheapest$244Average$381FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$250Average$368FlexibilityNo cancel feeOn-time71%

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