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Santo Domingo

$103+ Cheap flights from Key Largo, FL to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SDQ
oct. 15 — oct. 221
mié. 10/15
mié. 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Santo Domingo Las Americas are usually found in August or July, booked 80 days in advance, depart on a Tuesday or Wednesday and return on a Friday

Cheap flight deals from Key Largo to Santo Domingo

Keep the following information in mind while searching for Key Largo to Santo Domingo flight deals. Data was last updated septiembre 15, 2025.

Round-trip from

$220
(Expedia)

One-way from

$103
(eDestinos)

Popular in

December

Cheapest in

August

Average price

$330
From Key Largo to Santo Domingo Las Americas
Search Deals
One-way flight from Key Largo to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($53 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Key Largo to Santo Domingo

Cheapest flights from Key Largo to Santo Domingo
Explore the most affordable flight options available from Key Largo to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 15, 2025.

This Expedia deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/217:25 pmMIA - SDQ
Nonstop2h 20mArajet
dom. 10/193:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/14$220
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/147:25 pmMIA - SDQ
Nonstop2h 20mArajet
mié. 10/2910:19 amSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/14$221
This eDestinos deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/222:09 pmMIA - SDQ
Nonstop2h 20mArajet
jue. 9/253:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/13$222
This eDestinos deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/121:09 pmMIA - SDQ
Nonstop2h 20mArajet
dom. 12/213:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/13$223
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/307:25 pmMIA - SDQ
Nonstop2h 20mArajet
jue. 11/133:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/14$224
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/262:09 pmMIA - SDQ
Nonstop2h 20mArajet
lun. 9/2910:19 amSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/13$225
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/197:25 pmMIA - SDQ
Nonstop2h 20mArajet
lun. 10/2710:19 amSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/14$226
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/202:09 pmMIA - SDQ
Nonstop2h 20mArajet
sáb. 11/13:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/13$227
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/307:25 pmMIA - SDQ
Nonstop2h 20mArajet
mié. 11/510:19 amSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/14$228
This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/156:25 pmMIA - SDQ
Nonstop2h 20mArajet
mar. 11/183:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/14$229
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/62:09 pmMIA - SDQ
Nonstop2h 20mArajet
sáb. 10/113:35 pmSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/15$230
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/121:09 pmMIA - SDQ
Nonstop2h 20mArajet
lun. 11/1710:19 amSDQ - MIA
Nonstop2h 20mArajet
Deal found 9/13$231

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from Key Largo to Santo Domingo that are best for you.

Fly from

Key Largo

Fly to

Santo Domingo

Route

Depart

Return

Price

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

vie. 10/10

6:09 am-4:15 pm

1 stop10h 06m

Santo Domingo Las Americas

lun. 10/13

11:57 am-1:42 am

1 stop13h 45m

$299

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

vie. 9/26

6:27 am-4:17 pm

1 stop9h 50m

Santo Domingo Las Americas

jue. 10/9

8:58 am-1:42 am

1 stop16h 44m

$299

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

sáb. 10/11

5:21 pm-2:43 am

1 stop9h 22m

Santo Domingo Las Americas

sáb. 10/18

8:58 am-10:42 pm

1 stop13h 44m

$299

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

sáb. 10/11

5:21 pm-2:43 am

1 stop9h 22m

Santo Domingo Las Americas

mar. 10/14

2:10 pm-10:42 pm

1 stop8h 32m

$299

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

jue. 10/2

6:27 am-4:15 pm

1 stop9h 48m

Santo Domingo Las Americas

sáb. 10/4

11:57 am-1:42 am

1 stop13h 45m

$299

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

jue. 10/16

6:27 am-10:25 pm

1 stop15h 58m

Santo Domingo Las Americas

sáb. 10/18

11:57 am-10:42 pm

1 stop10h 45m

$299

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

mar. 10/7

6:09 am-4:15 pm

1 stop10h 06m

Santo Domingo Las Americas

mié. 10/8

2:10 pm-10:26 pm

1 stop8h 16m

$299

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

jue. 9/25

5:21 pm-10:58 am

1 stop17h 37m

Santo Domingo Las Americas

lun. 9/29

8:59 am-10:42 pm

1 stop13h 43m

$299

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

vie. 9/26

6:09 am-4:17 pm

1 stop10h 08m

Santo Domingo Las Americas

dom. 9/28

11:56 am-10:26 pm

1 stop10h 30m

$299

MiamiSanto Domingo

MIA - SDQ

MIASDQ

Miami

jue. 10/2

6:27 am-4:15 pm

1 stop9h 48m

Santo Domingo Las Americas

lun. 10/6

2:10 pm-10:42 pm

1 stop8h 32m

$299

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 24 results
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Best time to book a flight from Key Largo to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Santo Domingo

How far ahead should I book a flight from Key Largo to Santo Domingo?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Santo Domingo. Price data was last updated on September 12, 2025.

The best time to book flights from Key Largo to Santo Domingo is 80 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Key Largo to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Key Largo to Santo Domingo (average of $362). Flying from Key Largo to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SDQ?

Find hourly flight availability from Key Largo to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 15, 2025.

When flying from Key Largo to Santo Domingo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to Santo Domingo?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Santo Domingo. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Santo Domingo flight should consider departing on Wednesday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Santo Domingo

Explore weekly flight availability from Key Largo to Santo Domingo. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated septiembre 15, 2025.

The most flights from KE9 to SDQ are scheduled on a Tuesday (8 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (7 on average).

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated septiembre 15, 2025.
Read reviews from past customers who have flown American Airlines, Spirit Airlines, and Frontier from Key Largo to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Overall

7.2

Boarding

7.5

Comfort

7.2

Crew

8.0

Entertainment

6.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Overall

7.2

Boarding

7.5

Comfort

7.2

Crew

8.0

Entertainment

6.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
Spirit Airlines
6.3
Okay
8,015 reviews
American Airlines
7.2
Good
10,000 reviews

Overall

7.2

Boarding

7.5

Comfort

7.2

Crew

8.0

Entertainment

6.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
Frontier
5.8
Fair
3,172 reviews
American Airlines
7.2
Good
10,000 reviews

Overall

7.2

Boarding

7.5

Comfort

7.2

Crew

8.0

Entertainment

6.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Key Largo?

    Santo Domingo Las Americas (SDQ), located 17.5 mi from the city center, is the airport you fly into when you book flights from Key Largo to Santo Domingo. 9 airlines have flights to Las Americas from Key Largo on a regular basis. Booking flights from Key Largo to Santo Domingo Las Americas should not be difficult; the airport handles an average of 7 inbound flights from Key Largo per day.

  • How popular is this Key Largo to Santo Domingo flight route?

    This flight path from Key Largo to Santo Domingo Las Americas was viewed by 60 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Key Largo to Santo Domingo?

    Copa Airlines can get you from Key Largo to Santo Domingo in just under 10h 06m. Your travel time can differ by up to . Airlines will cover a distance of 848 mi.

  • What are the most reliable airlines from Key Largo to Santo Domingo?

    The top 3 most reliable airlines when flying from Key Largo to Santo Domingo are Frontier (100%), American Airlines (74%) and Arajet (72%).

  • What are the cheapest flights from Key Largo to Santo Domingo?

    On average you can expect to pay $243 for a flight from Key Largo to Santo Domingo. The cheapest flight overall is $103 while the most popular route, (Miami - Santo Domingo Las Americas) is currently priced at $175.

  • Can I find deals for flights from Key Largo to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Key Largo to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Santo Domingo.

  • Can I find deals for business class flights from Key Largo to Santo Domingo?

    Yes. Cheapflights offers flight deals from Key Largo to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Key Largo to Santo Domingo (average of $362). Flying from Key Largo to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Key Largo to Santo Domingo

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Top 8 airlines flying from Key Largo to Santo Domingo

Discover the top 8 airlines that operate flights from Key Largo to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$121Average$276FlexibilityNo cancel feeOn-time65%
ArajetCheapest$136Average$275FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$152Average$329FlexibilityNo cancel feeOn-time70%
FrontierCheapest$154Average$316FlexibilityNo cancel feeOn-time62%
JetBlueCheapest$191Average$384FlexibilityNo cancel feeOn-time62%
Sky HighCheapest$213Average$405FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$279Average$381FlexibilityNo cancel feeOn-time71%
Hahn AirCheapest$334Average$569FlexibilityNo cancel feeOn-timeN/A

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