What are the cheapest airlines flying from Greenville to Santo Domingo round-trip?

Our cheapest airline available from Greenville to Santo Domingo is American Airlines. Our recent data shows that you can find tickets from as low as $465 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $475 and $900 round-trip. American Airlines is priced at 25% lower than the current average price of a flight leaving 3 months from now.

What are the cheapest airlines to fly from Greenville to Santo Domingo one-way?

The cheapest airlines for a one-way flight from Greenville to Santo Domingo are Delta ($281), American Airlines ($286), and Aeromexico ($1,026).

What is the cheapest day to fly from Greenville to Santo Domingo?

Travelers seeking maximum savings on their Greenville to Santo Domingo flight should consider departing on Tuesday mornings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

What is the cheapest day to fly round-trip from Greenville to Santo Domingo?

Wednesday is generally a great day to depart. Flying on this day could help you save up to 28%.

What is the cheapest month to fly from Greenville to Santo Domingo?

Due to multiple factors, expect to potentially pay more when booking in December. For low rates, May can be a great choice for travel to Santo Domingo. Flights to Santo Domingo from Greenville in May are about $620 on average during May, but can be found for as low as $484.

What is the cheapest time of day to fly from GSP to SDQ?

Unlike in the morning, when flights are generally more expensive, you can save up to 5% on flights from Greenville to Santo Domingo by exploring options for tickets at noon.

Can I find deals for flights from Greenville to Santo Domingo that include hotel bookings?

Yes. In addition to deals on Greenville to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Greenville to Santo Domingo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santo Domingo.

Can I find deals for business class flights from Greenville to Santo Domingo?

Yes. Cheapflights offers flight deals from Greenville to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$173+ Flights from Greenville to Santo Domingo

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Cheap flight deals from Greenville to Santo Domingo

Round-trip from	$465 (American Airlines)
One-way from	$173 (Kiwi.com)
Popular in	December
Cheapest in	May
Average price	$785

From Greenville to Santo Domingo Las Americas

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One-way flight from Greenville to Santo Domingo Las Americas

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Highest demand for flights based on searches. 9% potential increase in price ($62 potential increase over avg. RT price).

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Cheapest flight prices on average. 5% potential price decrease ($32 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Greenville to Santo Domingo

Cheapest flights from Greenville to Santo Domingo
Explore the most affordable flight options available from Greenville to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Sat 8/166:05 pmGSP - SDQ

1 stop15h 20mAmerican Airlines

Wed 8/2010:25 amSDQ - GSP

1 stop13h 10mAmerican Airlines

Deal found 7/1

$465

Sun 8/310:06 pmGSP - SDQ

1 stop13h 45mMultiple Airlines

Sun 8/104:52 pmSDQ - GSP

1 stop22h 23mMultiple Airlines

Deal found 6/30

$468

Sun 9/145:30 amGSP - SDQ

1 stop7h 54mDelta

Sun 9/212:50 pmSDQ - GSP

1 stop7h 23mDelta

Deal found 7/1

$475

Tue 11/116:00 amGSP - SDQ

1 stop8h 06mUnited Airlines

Mon 11/172:53 pmSDQ - GSP

1 stop10h 06mUnited Airlines

Deal found 6/30

$900

Best flights from Greenville to Santo Domingo
Discover carefully curated flight deals from Greenville to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 1, 2025.

Sat 8/166:05 pmGSP - SDQ

1 stop15h 20mAmerican Airlines

Wed 8/2010:25 amSDQ - GSP

1 stop13h 10mAmerican Airlines

Deal found 7/1

$465

Sun 8/310:06 pmGSP - SDQ

1 stop13h 45mMultiple Airlines

Sun 8/104:52 pmSDQ - GSP

1 stop22h 23mMultiple Airlines

Deal found 6/30

$468

Sun 9/145:30 amGSP - SDQ

1 stop7h 54mDelta

Sun 9/212:50 pmSDQ - GSP

1 stop7h 23mDelta

Deal found 7/1

$475

Tue 11/116:00 amGSP - SDQ

1 stop8h 06mUnited Airlines

Mon 11/172:53 pmSDQ - GSP

1 stop10h 06mUnited Airlines

Deal found 6/30

$900

Last-minute flights from Greenville to Santo Domingo
Discover last-minute flight deals from Greenville to Santo Domingo. Data last updated July 1, 2025 and is based on user searches.

Thu 7/107:16 pmGSP - SDQ

2 stops13h 59mAmerican Airlines

Sat 8/167:20 pmSDQ - GSP

2 stops15h 17mAmerican Airlines

Deal found 6/30

$514

Thu 7/1010:06 pmGSP - SDQ

3 stops35h 44mMultiple Airlines

Sat 8/165:05 pmSDQ - GSP

2 stops21h 30mMultiple Airlines

Deal found 6/30

$575

Sun 8/310:06 pmGSP - SDQ

1 stop13h 45mMultiple Airlines

Sun 8/104:52 pmSDQ - GSP

1 stop22h 23mMultiple Airlines

Deal found 6/30

$468

Sat 8/166:05 pmGSP - SDQ

1 stop15h 20mAmerican Airlines

Wed 8/2010:25 amSDQ - GSP

1 stop13h 10mAmerican Airlines

Deal found 7/1

$465

One-way flights from Greenville to Santo Domingo
Search for one-way flight options from Greenville to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated July 1, 2025.

Wed 8/69:41 pmGSP - SDQ

1 stop18h 06mMultiple Airlines

Deal found 6/30

$173

Sun 8/106:30 amGSP - SDQ

1 stop6h 42mDelta

Deal found 6/30

$281

Wed 7/3010:41 amGSP - SDQ

2 stops10h 14mAmerican Airlines

Deal found 6/30

$286

Sat 8/911:44 amGSP - SDQ

3 stops43h 02mAeromexico

Deal found 7/1

$1,026

Cheapflights Fare Finder

Use the filters below to find and compare flights from Greenville to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sat 8/16

6:05 pm-9:25 am

1 stop15h 20m

Santo Domingo Las Americas

Wed 8/20

10:25 am-11:35 pm

1 stop13h 10m

$465

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 8/3

10:06 pm-11:51 am

1 stop13h 45m

Santo Domingo Las Americas

Sun 8/10

4:52 pm-3:15 pm

1 stop22h 23m

$468

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 9/14

5:30 am-1:24 pm

1 stop7h 54m

Santo Domingo Las Americas

Sun 9/21

2:50 pm-10:13 pm

1 stop7h 23m

$475

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 11/11

6:00 am-3:06 pm

1 stop8h 06m

Santo Domingo Las Americas

Mon 11/17

2:53 pm-11:59 pm

1 stop10h 06m

$900

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 8/6

9:41 pm-3:47 pm

1 stop18h 06m

$173

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 8/10

6:30 am-1:12 pm

1 stop6h 42m

$281

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 7/30

10:41 am-8:55 pm

2 stops10h 14m

$286

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sat 8/9

11:44 am-6:46 am

3 stops43h 02m

$1,026

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Greenville to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Greenville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santo Domingo

What is the cheapest month to book a flight from Greenville to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Greenville to Santo Domingo (average of $362). Flying from Greenville to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santo Domingo

Read through reviews of airlines operating flights from Greenville to Santo Domingo, such as Delta, Aeromexico, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,974 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,974 reviews

Delta

8.0

Very good

7,974 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Aeromexico

7.5

Good

1,718 reviews

Delta

8.0

Very good

7,974 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,858 reviews

Delta

8.0

Very good

7,974 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,974 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Greenville to Santo Domingo round-trip?
Our cheapest airline available from Greenville to Santo Domingo is American Airlines. Our recent data shows that you can find tickets from as low as $465 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $475 and $900 round-trip. American Airlines is priced at 25% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest airlines to fly from Greenville to Santo Domingo one-way?
The cheapest airlines for a one-way flight from Greenville to Santo Domingo are Delta ($281), American Airlines ($286), and Aeromexico ($1,026).
Can I find deals for flights from Greenville to Santo Domingo that include hotel bookings?
Yes. In addition to deals on Greenville to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Greenville to Santo Domingo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santo Domingo.
Can I find deals for business class flights from Greenville to Santo Domingo?
Yes. Cheapflights offers flight deals from Greenville to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Greenville to Santo Domingo?
Currently, January is the cheapest month in which you can book a flight from Greenville to Santo Domingo (average of $362). Flying from Greenville to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Greenville to Santo Domingo

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$434	Average$484	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$483	Average$691	FlexibilityNo cancel fee	On-time71%

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$173+ Cheap flights from Greenville (GSP) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/6. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Greenville to Santo Domingo with Cheapflights

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2. Select your favorite providers

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Cheap flight deals from Greenville to Santo Domingo

Round-trip from

One-way from

Popular in

Cheapest in

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Find flight deals from Greenville to Santo Domingo

Cheapest flights from Greenville to Santo DomingoExplore the most affordable flight options available from Greenville to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Explore the most affordable flight options available from Greenville to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Greenville to Santo Domingo that are best for you.

Best time to book a flight from Greenville to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Greenville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santo Domingo

What is the cheapest month to book a flight from Greenville to Santo Domingo?

Reviews of airlines servicing Santo Domingo

Read through reviews of airlines operating flights from Greenville to Santo Domingo, such as Delta, Aeromexico, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Greenville to Santo Domingo round-trip?

What are the cheapest airlines to fly from Greenville to Santo Domingo one-way?

Can I find deals for flights from Greenville to Santo Domingo that include hotel bookings?

How can I find direct flights from Greenville to Santo Domingo?

Can I find deals for business class flights from Greenville to Santo Domingo?

What is the cheapest month to book a flight from Greenville to Santo Domingo?

Traveling to a place near Greenville?

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Alternative routes for Greenville to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Greenville to Santo Domingo

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Book with Flexibility

Travel Smart

Cheapest flights from Greenville to Santo Domingo
Explore the most affordable flight options available from Greenville to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.