Santo Domingo

$176+ Cheap flights from Des Moines (DSM) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDQ
Apr 13 — Apr 201
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Cheap flight deals from Des Moines to Santo Domingo

Cheapest flights from Des Moines to Santo Domingo
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:00 am
DSM
-
SDQ
2 stops32h 29m
Multiple Airlines
Thu 4/302:35 pm
SDQ
-
DSM
1 stop8h 31m
Multiple Airlines
Deal found 3/9$515
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/268:30 am
DSM
-
SDQ
1 stop27h 59m
Multiple Airlines
Sun 5/32:35 pm
SDQ
-
DSM
1 stop8h 31m
Multiple Airlines
Deal found 3/12$518
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
-
SDQ
2 stops18h 20m
Multiple Airlines
Thu 6/186:59 am
SDQ
-
DSM
1 stop31h 51m
Multiple Airlines
Deal found 3/11$533
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:00 am
DSM
-
SDQ
1 stop18h 35m
Multiple Airlines
Sat 4/183:55 am
SDQ
-
DSM
1 stop10h 51m
Multiple Airlines
Deal found 3/13$537
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:50 am
DSM
-
SDQ
1 stop8h 28m
American Airlines
Wed 6/171:45 pm
SDQ
-
DSM
1 stop9h 13m
American Airlines
Deal found 3/9$589
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/37:40 pm
DSM
-
SDQ
2 stops28h 58m
Multiple Airlines
Sat 4/113:55 am
SDQ
-
DSM
1 stop10h 51m
Multiple Airlines
Deal found 3/9$603

Find flight deals from Des Moines to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$492
(Kiwi.com)

One-way from

$176
(Kiwi.com)

Popular in

November

Cheapest in

January

Average price

$769
Provider with most accurate pricing for Des Moines-Santo Domingo Las Americas flight deals.
Provider most trusted by Cheapflights users for Des Moines-Santo Domingo Las Americas flights.
From Des Moines to Santo Domingo Las Americas
One-way flight from Des Moines to Santo Domingo Las Americas
Highest demand for flights based on searches. 14% potential increase in price ($117 potential increase over avg. RT price).
Cheapest flight prices on average. 4% potential price decrease ($29 potential savings vs. average RT price).
Average for round-trip flights in March 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Wed 6/3

5:50 am-10:55 pm

1 stop16h 05m

Santo Domingo Las Americas

Wed 6/17

7:00 am-6:36 pm

2 stops12h 36m

$593

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 6/1

6:02 am-10:55 pm

2 stops15h 53m

Santo Domingo Las Americas

Tue 6/16

7:40 pm-12:52 pm

2 stops18h 12m

$613

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 4/27

6:00 am-10:52 pm

2 stops15h 52m

Santo Domingo Las Americas

Mon 5/4

6:00 am-10:18 pm

2 stops17h 18m

$633

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 4/23

5:00 am-10:52 pm

2 stops16h 52m

Santo Domingo Las Americas

Thu 4/30

4:00 pm-8:26 am

2 stops17h 26m

$638

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sat 4/25

6:19 am-6:34 pm

2 stops11h 15m

Santo Domingo Las Americas

Sat 5/2

6:05 am-5:45 pm

2 stops12h 40m

$653
Quickest round-trip

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Tue 4/28

5:45 am-1:12 pm

1 stop6h 27m

Santo Domingo Las Americas

Tue 5/5

6:05 am-8:39 pm

2 stops15h 34m

$663

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 6/8

1:33 pm-12:45 pm

1 stop22h 12m

Santo Domingo Las Americas

Mon 6/22

7:40 pm-12:52 pm

2 stops18h 12m

$675

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 3/26

6:00 am-1:38 am

1 stop18h 38m

Santo Domingo Las Americas

Sat 3/28

2:52 am-1:59 pm

1 stop12h 07m

$705
Cheapest one-way

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 4/19

7:00 am-2:35 am

1 stop18h 35m

$205
Quickest one-way

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 4/2

3:21 pm-1:38 am

1 stop9h 17m

$255

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/10

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santo Domingo in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated March 14, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Des Moines to Santo Domingo?

    American Airlines can get you from Des Moines to Santo Domingo in just under 16h 05m. Your travel time can differ by up to . The distance between Des Moines and Santo Domingo is about 2131 mi.

  • What are the cheapest airlines flying from Des Moines to Santo Domingo round-trip?

    Delta, at $524, was found to be the cheapest airline from Des Moines to Santo Domingo. An alternate airline flying to your destination would be American Airlines. Delta is priced at 26% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santo Domingo.

  • Can I find deals for business class flights from Des Moines to Santo Domingo?

    Yes. Cheapflights offers flight deals from Des Moines to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Des Moines to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Des Moines to Santo Domingo

Discover the top 2 airlines that operate flights from Des Moines to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$524Average$663FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$542Average$684FlexibilityNo cancel feeOn-time71%

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