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Santo Domingo

$440+ Cheap flights from Des Moines (DSM) to Santo Domingo (SDQ)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDQ
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Des Moines to Santo Domingo

Cheapest flights from Des Moines to Santo Domingo
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/241:23 pm
DSM
-
SDQ
1 stop23h 02m
Multiple Airlines
Tue 3/313:35 pm
SDQ
-
DSM
2 stops47h 11m
Multiple Airlines
Deal found 1/27$440
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2710:26 am
DSM
-
SDQ
2 stops14h 24m
Multiple Airlines
Sat 4/43:55 am
SDQ
-
DSM
1 stop10h 51m
Multiple Airlines
Deal found 1/27$457
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:27 pm
DSM
-
SDQ
2 stops39h 43m
Multiple Airlines
Thu 3/53:32 pm
SDQ
-
DSM
1 stop9h 19m
Multiple Airlines
Deal found 1/27$489
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:00 am
DSM
-
SDQ
1 stop7h 03m
American Airlines
Tue 3/312:15 pm
SDQ
-
DSM
1 stop10h 41m
American Airlines
Deal found 1/27$539
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:45 am
DSM
-
SDQ
1 stop6h 36m
Delta
Tue 5/127:00 am
SDQ
-
DSM
2 stops14h 45m
Delta
Deal found 1/25$553
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2610:40 am
DSM
-
SDQ
2 stops11h 52m
Delta
Thu 3/57:30 am
SDQ
-
DSM
2 stops15h 19m
Delta
Deal found 1/27$613
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/304:25 pm
DSM
-
SDQ
2 stops17h 56m
American Airlines
Sun 2/86:29 pm
SDQ
-
DSM
2 stops18h 21m
American Airlines
Deal found 1/27$618
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:59 pm
DSM
-
SDQ
2 stops15h 33m
Multiple Airlines
Mon 6/13:37 pm
SDQ
-
DSM
1 stop8h 47m
Multiple Airlines
Deal found 1/28$622

Find flight deals from Des Moines to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$440
(Kiwi.com)

Popular in

November

Cheapest in

January

Average price

$544
Provider with most accurate pricing for Des Moines-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santo Domingo Las Americas flights.
Search Deals
From Des Moines to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($168 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Des Moines

Fly to

Santo Domingo

Route

Depart

Return

Price

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Tue 3/24

1:23 pm-1:25 pm

1 stop23h 02m

Santo Domingo Las Americas

Tue 3/31

3:35 pm-1:46 pm

2 stops47h 11m

$440

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 3/27

10:26 am-1:50 am

2 stops14h 24m

Santo Domingo Las Americas

Sat 4/4

3:55 am-1:46 pm

1 stop10h 51m

$457

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 2/26

7:27 pm-1:10 pm

2 stops39h 43m

Santo Domingo Las Americas

Thu 3/5

3:32 pm-10:51 pm

1 stop9h 19m

$489

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Tue 3/24

7:00 am-3:03 pm

1 stop7h 03m

Santo Domingo Las Americas

Tue 3/31

2:15 pm-11:56 pm

1 stop10h 41m

$539

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Tue 5/26

7:00 am-10:59 pm

2 stops14h 59m

Santo Domingo Las Americas

Tue 6/2

7:38 pm-12:56 pm

2 stops18h 18m

$543

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 5/8

5:45 am-1:21 pm

1 stop6h 36m

Santo Domingo Las Americas

Tue 5/12

7:00 am-8:45 pm

2 stops14h 45m

$553

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 5/8

8:01 pm-1:18 pm

2 stops16h 17m

Santo Domingo Las Americas

Tue 5/12

10:20 am-11:29 pm

2 stops14h 09m

$553

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 2/26

10:40 am-12:32 am

2 stops11h 52m

Santo Domingo Las Americas

Thu 3/5

7:30 am-8:49 pm

2 stops15h 19m

$613

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 5/25

9:59 pm-2:32 pm

2 stops15h 33m

Santo Domingo Las Americas

Mon 6/1

3:37 pm-11:24 pm

1 stop8h 47m

$622

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Compare providers for flights from Des Moines to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santo Domingo in January.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated January 28, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,123 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,123 reviews
Delta
7.9
Good
8,123 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,201 reviews
Delta
7.9
Good
8,123 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santo Domingo?

    American Airlines can get you from Des Moines to Santo Domingo in just under 7h 03m. Your travel time can differ by up to . The distance between Des Moines and Santo Domingo is about 2131 mi.

  • What are the cheapest airlines flying from Des Moines to Santo Domingo round-trip?

    Delta, at $524, was found to be the cheapest airline from Des Moines to Santo Domingo. An alternate airline flying to your destination would be American Airlines. Delta is priced at 21% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santo Domingo.

  • Can I find deals for business class flights from Des Moines to Santo Domingo?

    Yes. Cheapflights offers flight deals from Des Moines to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top 2 airlines flying from Des Moines to Santo Domingo

Discover the top 2 airlines that operate flights from Des Moines to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$524Average$574FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$542Average$664FlexibilityNo cancel feeOn-time71%

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