What are the cheapest airlines flying from Des Moines to Santo Domingo round-trip?

Delta, at $524, was found to be the cheapest airline from Des Moines to Santo Domingo. An alternate airline flying to your destination would be American Airlines. Delta is priced at 19% lower than the current average price of a flight leaving 3 months from now.

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

Most accurate provider : When it comes to deals on Des Moines-Santo Domingo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Santo Domingo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Santo Domingo flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Santo Domingo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?

Yes. In addition to deals on Des Moines to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Santo Domingo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santo Domingo.

Can I find deals for business class flights from Des Moines to Santo Domingo?

Yes. Cheapflights offers flight deals from Des Moines to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$203+ Flights from Des Moines to Santo Domingo

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Cheap flight deals from Des Moines to Santo Domingo

Cheapest flights from Des Moines to Santo Domingo
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Tue 12/2311:14 amDSM - SDQ

2 stops50h 10mFrontier

Mon 12/2912:35 pmSDQ - DSM

1 stop23h 44mFrontier

Deal found 12/10

$534

Sat 12/203:47 pmDSM - SDQ

2 stops33h 45mMultiple Airlines

Thu 12/253:59 amSDQ - DSM

1 stop16h 27mMultiple Airlines

Deal found 12/11

$660

Thu 12/183:44 pmDSM - SDQ

1 stop17h 36mMultiple Airlines

Sun 12/2112:35 pmSDQ - DSM

1 stop11h 51mMultiple Airlines

Deal found 12/10

$665

Tue 12/233:45 pmDSM - SDQ

1 stop9h 09mMultiple Airlines

Mon 12/296:10 amSDQ - DSM

1 stop8h 45mMultiple Airlines

Deal found 12/10

$761

Wed 12/106:50 pmDSM - SDQ

2 stops26h 56mUnited Airlines

Thu 1/86:00 amSDQ - DSM

2 stops30h 55mUnited Airlines

Deal found 12/10

$982

Best flights from Des Moines to Santo Domingo
Discover carefully curated flight deals from Des Moines to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

Fri 1/2311:09 amDSM - SDQ

2 stops50h 26mMultiple Airlines

Thu 1/294:40 pmSDQ - DSM

1 stop8h 06mMultiple Airlines

Deal found 12/9

$432

Fri 1/235:35 amDSM - SDQ

1 stop6h 46mDelta

Wed 1/287:30 amSDQ - DSM

2 stops15h 24mDelta

Deal found 12/9

$532

Fri 1/238:00 amDSM - SDQ

2 stops13h 46mUnited Airlines

Wed 1/286:00 amSDQ - DSM

2 stops17h 50mUnited Airlines

Deal found 12/9

$532

Mon 1/264:25 pmDSM - SDQ

2 stops19h 35mAmerican Airlines

Mon 2/23:00 pmSDQ - DSM

1 stop10h 29mAmerican Airlines

Deal found 12/11

$532

Sun 1/252:58 pmDSM - SDQ

1 stop21h 29mMultiple Airlines

Sun 2/13:32 pmSDQ - DSM

2 stops20h 47mMultiple Airlines

Deal found 12/11

$442

Mon 1/268:00 amDSM - SDQ

2 stops13h 46mUnited Airlines

Mon 2/24:18 pmSDQ - DSM

2 stops20h 37mUnited Airlines

Deal found 12/11

$532

Last-minute flights from Des Moines to Santo Domingo
Discover last-minute flight deals from Des Moines to Santo Domingo. Data last updated December 12, 2025 and is based on user searches.

Fri 1/2311:09 amDSM - SDQ

2 stops50h 26mMultiple Airlines

Thu 1/294:40 pmSDQ - DSM

1 stop8h 06mMultiple Airlines

Deal found 12/9

$432

Fri 1/235:35 amDSM - SDQ

1 stop6h 46mDelta

Wed 1/287:30 amSDQ - DSM

2 stops15h 24mDelta

Deal found 12/9

$532

Sat 1/245:00 pmDSM - SDQ

2 stops19h 00mAmerican Airlines

Sat 1/316:00 amSDQ - DSM

2 stops12h 24mAmerican Airlines

Deal found 12/10

$533

Sun 1/252:58 pmDSM - SDQ

1 stop21h 29mMultiple Airlines

Sun 2/13:32 pmSDQ - DSM

2 stops20h 47mMultiple Airlines

Deal found 12/11

$442

One-way flights from Des Moines to Santo Domingo
Search for one-way flight options from Des Moines to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated December 12, 2025.

Sun 1/254:30 pmDSM - SDQ

2 stops43h 57mMultiple Airlines

Deal found 12/10

$203

Sun 1/254:21 pmDSM - SDQ

2 stops18h 49mDelta

Deal found 12/10

$307

Sun 1/258:00 amDSM - SDQ

2 stops13h 46mUnited Airlines

Deal found 12/11

$362

Find flight deals from Des Moines to Santo Domingo

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$432 (Kiwi.com)
One-way from	$203 (Kiwi.com)
Popular in	November
Cheapest in	August
Average price	$694

Provider with most accurate pricing for Des Moines-Santo Domingo Las Americas flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Santo Domingo Las Americas flights.

Search Deals

From Des Moines to Santo Domingo Las Americas

Search Deals

One-way flight from Des Moines to Santo Domingo Las Americas

Search Deals

Highest demand for flights based on searches. 22% potential increase in price ($184 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($37 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 1/23

11:09 am-3:35 pm

2 stops50h 26m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$432

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 1/25

2:58 pm-2:27 pm

1 stop21h 29m

Santo Domingo Las Americas

Sun 2/1

3:32 pm-10:19 am

2 stops20h 47m

$442

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 1/23

5:35 am-2:21 pm

1 stop6h 46m

Santo Domingo Las Americas

Wed 1/28

7:30 am-8:54 pm

2 stops15h 24m

$532

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 1/23

8:00 am-11:46 pm

2 stops13h 46m

Santo Domingo Las Americas

Wed 1/28

6:00 am-9:50 pm

2 stops17h 50m

$532

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 1/26

4:25 pm-2:00 pm

2 stops19h 35m

Santo Domingo Las Americas

Mon 2/2

3:00 pm-11:29 pm

1 stop10h 29m

$532

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 1/26

8:00 am-11:46 pm

2 stops13h 46m

Santo Domingo Las Americas

Mon 2/2

4:18 pm-10:55 am

2 stops20h 37m

$532

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 1/25

2:58 pm-2:27 pm

1 stop21h 29m

$211

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 1/25

6:24 am-7:14 pm

2 stops10h 50m

$307

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 1/25

8:00 am-11:46 pm

2 stops13h 46m

$362

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Compare providers for flights from Des Moines to Santo Domingo

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santo Domingo in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Santo Domingo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Santo Domingo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Santo Domingo flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Santo Domingo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santo Domingo

What is the cheapest time of day to fly from DSM to SDQ?

When flying from Des Moines to Santo Domingo, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 51% versus a flight at noon.

Reviews of airlines servicing Santo Domingo

Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

8,008 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

American Airlines

7.2

Good

11,050 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

What are the cheapest airlines flying from Des Moines to Santo Domingo round-trip?
Delta, at $524, was found to be the cheapest airline from Des Moines to Santo Domingo. An alternate airline flying to your destination would be American Airlines. Delta is priced at 19% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?
Yes. In addition to deals on Des Moines to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Santo Domingo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santo Domingo.
Can I find deals for business class flights from Des Moines to Santo Domingo?
Yes. Cheapflights offers flight deals from Des Moines to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Des Moines to Santo Domingo

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$524	Average$574	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$529	Average$649	FlexibilityNo cancel fee	On-time71%

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$203+ Cheap flights from Des Moines (DSM) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Santo Domingo with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Santo Domingo

Cheapest flights from Des Moines to Santo DomingoExplore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Find flight deals from Des Moines to Santo Domingo

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Compare providers for flights from Des Moines to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santo Domingo in December.

Best time to book a flight from Des Moines to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santo Domingo

What is the cheapest time of day to fly from DSM to SDQ?

Reviews of airlines servicing Santo Domingo

Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Santo Domingo round-trip?

Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?

How can I find direct flights from Des Moines to Santo Domingo?

Can I find deals for business class flights from Des Moines to Santo Domingo?

Traveling to a place near Santo Domingo?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Des Moines to Santo Domingo

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Cheapest flights from Des Moines to Santo Domingo
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.