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Santo Domingo

$306+ Cheap flights from Des Moines (DSM) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDQ
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Des Moines to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$488
(Kiwi.com)

One-way from

$306
(Delta)

Popular in

November

Cheapest in

September

Average price

$514
From Des Moines to Santo Domingo Las Americas
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One-way flight from Des Moines to Santo Domingo Las Americas
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Highest demand for flights based on searches. 17% potential increase in price ($137 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Santo Domingo

Cheapest flights from Des Moines to Santo Domingo
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/910:51 amDSM - SDQ
1 stop28h 16mMultiple Airlines
Sun 10/123:54 pmSDQ - DSM
2 stops23h 56mMultiple Airlines
Deal found 9/10$488
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:12 pmDSM - SDQ
2 stops18h 33mAmerican Airlines
Sat 11/17:00 amSDQ - DSM
2 stops15h 56mAmerican Airlines
Deal found 9/10$532
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:05 amDSM - SDQ
2 stops11h 19mDelta
Mon 11/37:05 amSDQ - DSM
2 stops15h 30mDelta
Deal found 9/11$541
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3110:50 amDSM - SDQ
2 stops12h 37mDelta
Mon 11/37:05 amSDQ - DSM
2 stops15h 30mDelta
Deal found 9/10$542
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:48 pmDSM - SDQ
2 stops16h 37mAmerican Airlines
Mon 11/33:05 pmSDQ - DSM
1 stop10h 28mAmerican Airlines
Deal found 9/11$551
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/37:00 amDSM - SDQ
2 stops12h 30mAmerican Airlines
Fri 10/1010:25 amSDQ - DSM
2 stops14h 34mAmerican Airlines
Deal found 9/9$554
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/96:22 pmDSM - SDQ
2 stops18h 13mAmerican Airlines
Sun 10/124:20 pmSDQ - DSM
2 stops17h 02mAmerican Airlines
Deal found 9/10$564
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/298:51 amDSM - SDQ
2 stops12h 54mAmerican Airlines
Sun 12/74:58 pmSDQ - DSM
1 stop8h 31mAmerican Airlines
Deal found 9/9$567
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/142:56 pmDSM - SDQ
1 stop24h 54mMultiple Airlines
Wed 1/710:19 amSDQ - DSM
2 stops50h 00mMultiple Airlines
Deal found 9/11$674
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2512:30 pmDSM - SDQ
2 stops10h 57mDelta
Sat 11/12:56 pmSDQ - DSM
1 stop8h 34mDelta
Deal found 9/10$680

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Des Moines

Fly to

Santo Domingo

Route

Depart

Return

Price

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 10/9

10:51 am-4:07 pm

1 stop28h 16m

Santo Domingo Las Americas

Sun 10/12

3:54 pm-2:50 pm

2 stops23h 56m

$488

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sat 10/25

6:12 pm-1:45 pm

2 stops18h 33m

Santo Domingo Las Americas

Sat 11/1

7:00 am-9:56 pm

2 stops15h 56m

$532

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 10/30

6:05 am-6:24 pm

2 stops11h 19m

Santo Domingo Las Americas

Mon 11/3

7:05 am-8:35 pm

2 stops15h 30m

$541

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 10/31

10:50 am-12:27 am

2 stops12h 37m

Santo Domingo Las Americas

Mon 11/3

7:05 am-8:35 pm

2 stops15h 30m

$542

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 10/31

7:06 am-8:30 pm

2 stops12h 24m

Santo Domingo Las Americas

Mon 11/3

6:00 am-11:33 pm

1 stop19h 33m

$551

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 10/30

3:48 pm-9:25 am

2 stops16h 37m

Santo Domingo Las Americas

Mon 11/3

3:05 pm-11:33 pm

1 stop10h 28m

$551

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 10/3

7:00 am-8:30 pm

2 stops12h 30m

Santo Domingo Las Americas

Fri 10/10

10:25 am-11:59 pm

2 stops14h 34m

$554

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 10/9

6:22 pm-1:35 pm

2 stops18h 13m

Santo Domingo Las Americas

Sun 10/12

4:20 pm-8:22 am

2 stops17h 02m

$564

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sat 11/29

8:51 am-11:45 pm

2 stops12h 54m

Santo Domingo Las Americas

Sun 12/7

4:58 pm-11:29 pm

1 stop8h 31m

$567

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 10/26

5:47 am-1:41 pm

1 stop6h 54m

$306

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 11 results
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Best time to book a flight from Des Moines to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santo Domingo

What is the cheapest time of day to fly from DSM to SDQ?

Find hourly flight availability from Des Moines to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Des Moines to Santo Domingo, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 3% versus a flight in the morning.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santo Domingo?

    American Airlines and Delta can get you from Des Moines to Santo Domingo in just under 11h 19m. Your travel time can differ by up to 7h 14m. The distance between Des Moines and Santo Domingo is about 2131 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Santo Domingo round-trip?

    Delta, at $524, was found to be the cheapest airline from Des Moines to Santo Domingo. An alternate airline flying to your destination would be American Airlines. Delta is priced at 21% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santo Domingo.

  • Can I find deals for business class flights from Des Moines to Santo Domingo?

    Yes. Cheapflights offers flight deals from Des Moines to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Santo Domingo (average of $362). Flying from Des Moines to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top 2 airlines flying from Des Moines to Santo Domingo

Discover the top 2 airlines that operate flights from Des Moines to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$524Average$579FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$529Average$694FlexibilityNo cancel feeOn-time71%

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