What are the cheapest airlines flying from Des Moines to Santo Domingo round-trip?

American Airlines, at $594, was found to be the cheapest airline from Des Moines to Santo Domingo. An alternate airline flying to your destination would be United Airlines. American Airlines is priced at 13% lower than the current average price of a flight leaving 3 months from now.

What are the cheapest airlines to fly from Des Moines to Santo Domingo one-way?

$306 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on Copa Airlines and United Airlines, with prices starting from $355 and $362, respectively.

What is the cheapest month to book a flight from Des Moines to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Santo Domingo (average of $362). Flying from Des Moines to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest day to fly from Des Moines to Santo Domingo?

Travelers seeking maximum savings on their Des Moines to Santo Domingo flight should consider departing on Monday mornings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Des Moines to Santo Domingo?

Users have found that leaving on a Monday can be a cost-effective option. It’s possible to save up to 34% on your flight compared to booking on days when demand is much higher.

What is the cheapest month to fly from Des Moines to Santo Domingo?

Flights from Des Moines to Santo Domingo lean towards being more expensive in January. Prices are generally better when you fly from Des Moines to Santo Domingo in October, with the cheapest ticket starting at $514.

Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?

Yes. In addition to deals on Des Moines to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Santo Domingo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santo Domingo.

Can I find deals for business class flights from Des Moines to Santo Domingo?

Yes. Cheapflights offers flight deals from Des Moines to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$306+ Flights from Des Moines to Santo Domingo

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Cheap flight deals from Des Moines to Santo Domingo

Round-trip from	$511 (Mytrip)
One-way from	$306 (Delta)
Popular in	January
Cheapest in	October
Average price	$770

From Des Moines to Santo Domingo Las Americas

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One-way flight from Des Moines to Santo Domingo Las Americas

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Highest demand for flights based on searches. 7% potential increase in price ($57 potential increase over avg. RT price).

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Cheapest flight prices on average. 3% potential price decrease ($21 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from Des Moines to Santo Domingo

Cheapest flights from Des Moines to Santo Domingo
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juin 12, 2025.

ven. 7/256:30 amDSM - SDQ

1 stop26h 20mMultiple Airlines

ven. 8/110:55 amSDQ - DSM

2 stops31h 21mMultiple Airlines

Deal found 6/10

$511

sam. 11/294:26 pmDSM - SDQ

2 stops17h 24mAmerican Airlines

dim. 12/75:50 pmSDQ - DSM

2 stops20h 07mAmerican Airlines

Deal found 6/12

$594

sam. 7/263:34 pmDSM - SDQ

2 stops21h 36mUnited Airlines

sam. 8/23:20 pmSDQ - DSM

2 stops31h 27mUnited Airlines

Deal found 6/11

$877

Best flights from Des Moines to Santo Domingo
Discover carefully curated flight deals from Des Moines to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated juin 12, 2025.

ven. 7/256:30 amDSM - SDQ

1 stop26h 20mMultiple Airlines

ven. 8/110:55 amSDQ - DSM

2 stops31h 21mMultiple Airlines

Deal found 6/10

$511

sam. 11/294:26 pmDSM - SDQ

2 stops17h 24mAmerican Airlines

dim. 12/75:50 pmSDQ - DSM

2 stops20h 07mAmerican Airlines

Deal found 6/12

$594

sam. 7/263:34 pmDSM - SDQ

2 stops21h 36mUnited Airlines

sam. 8/23:20 pmSDQ - DSM

2 stops31h 27mUnited Airlines

Deal found 6/11

$877

Last-minute flights from Des Moines to Santo Domingo
Discover last-minute flight deals from Des Moines to Santo Domingo. Data last updated juin 12, 2025 and is based on user searches.

ven. 7/256:30 amDSM - SDQ

1 stop26h 20mMultiple Airlines

ven. 8/110:55 amSDQ - DSM

2 stops31h 21mMultiple Airlines

Deal found 6/10

$511

sam. 7/265:26 pmDSM - SDQ

2 stops14h 49mAmerican Airlines

sam. 8/27:00 amSDQ - DSM

1 stop16h 33mAmerican Airlines

Deal found 6/11

$654

sam. 7/263:34 pmDSM - SDQ

2 stops21h 36mUnited Airlines

sam. 8/23:20 pmSDQ - DSM

2 stops31h 27mUnited Airlines

Deal found 6/11

$877

One-way flights from Des Moines to Santo Domingo
Search for one-way flight options from Des Moines to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated juin 12, 2025.

dim. 8/2411:23 amDSM - SDQ

2 stops12h 34mDelta

Deal found 6/10

$306

sam. 7/198:00 amDSM - SDQ

2 stops17h 45mCopa Airlines

Deal found 6/9

$355

dim. 8/246:15 pmDSM - SDQ

3 stops18h 55mUnited Airlines

Deal found 6/10

$362

ven. 8/296:12 pmDSM - SDQ

2 stops14h 13mAmerican Airlines

Deal found 6/12

$366

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

ven. 7/25

6:30 am-9:50 am

1 stop26h 20m

Santo Domingo Las Americas

ven. 8/1

10:55 am-5:16 pm

2 stops31h 21m

$511

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

sam. 11/29

4:26 pm-11:50 am

2 stops17h 24m

Santo Domingo Las Americas

dim. 12/7

5:50 pm-11:57 am

2 stops20h 07m

$594

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

sam. 7/26

3:34 pm-2:10 pm

2 stops21h 36m

Santo Domingo Las Americas

sam. 8/2

3:20 pm-9:47 pm

2 stops31h 27m

$877

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

dim. 8/24

11:23 am-12:57 am

2 stops12h 34m

$306

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

sam. 7/19

8:00 am-2:45 am

2 stops17h 45m

$355

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

dim. 8/24

6:15 pm-2:10 pm

3 stops18h 55m

$362

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

ven. 8/29

6:12 pm-9:25 am

2 stops14h 13m

$366

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Des Moines to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santo Domingo

What is the cheapest time of day to fly from DSM to SDQ?

When flying from Des Moines to Santo Domingo, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 3% versus a flight in the morning.

Rainfall in Santo Domingo by month

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

Temperature in Santo Domingo by month

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

Reviews of airlines servicing Santo Domingo

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,950 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Copa Airlines

7.5

Good

1,451 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,790 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Des Moines to Santo Domingo round-trip?
American Airlines, at $594, was found to be the cheapest airline from Des Moines to Santo Domingo. An alternate airline flying to your destination would be United Airlines. American Airlines is priced at 13% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest airlines to fly from Des Moines to Santo Domingo one-way?
$306 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on Copa Airlines and United Airlines, with prices starting from $355 and $362, respectively.
Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?
Yes. In addition to deals on Des Moines to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Santo Domingo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santo Domingo.
Can I find deals for business class flights from Des Moines to Santo Domingo?
Yes. Cheapflights offers flight deals from Des Moines to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Santo Domingo?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Santo Domingo (average of $362). Flying from Des Moines to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Des Moines to Santo Domingo

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$519	Average$725	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$524	Average$879	FlexibilityNo cancel fee	On-timeN/A

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$306+ Cheap flights from Des Moines (DSM) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Santo Domingo with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Santo Domingo

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Santo Domingo

Cheapest flights from Des Moines to Santo DomingoExplore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juin 12, 2025.

Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juin 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Best time to book a flight from Des Moines to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santo Domingo

What is the cheapest time of day to fly from DSM to SDQ?

Find hourly flight availability from Des Moines to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated juin 12, 2025.

Rainfall in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average rainfall totals by month.

Temperature in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average temperature totals by month.

Reviews of airlines servicing Santo Domingo

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Santo Domingo round-trip?

What are the cheapest airlines to fly from Des Moines to Santo Domingo one-way?

Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?

How can I find direct flights from Des Moines to Santo Domingo?

Can I find deals for business class flights from Des Moines to Santo Domingo?

What is the cheapest month to book a flight from Des Moines to Santo Domingo?

Traveling to a place near Des Moines?

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Alternative routes for Des Moines to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Des Moines to Santo Domingo

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Cheapest flights from Des Moines to Santo Domingo
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juin 12, 2025.