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Santiago de los Caballeros

$375+ Cheap flights from Panama City (PTY) to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STI
May 3 — May 101
Sun 5/3
Sun 5/10
1 adult, Economy
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Cheap flight deals from Panama City to Santiago de los Caballeros

Cheapest flights from Panama City to Santiago de los Caballeros
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.

This Copa Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:26 am
PTY
-
STI
Nonstop2h 24m
Copa Airlines
Sat 4/253:59 pm
STI
-
PTY
Nonstop2h 44m
Copa Airlines
Deal found 3/29$527
This Copa Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:26 am
PTY
-
STI
Nonstop2h 24m
Copa Airlines
Mon 6/154:01 pm
STI
-
PTY
Nonstop2h 42m
Copa Airlines
Deal found 3/31$529
This Mytrip deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/74:25 am
PTY
-
STI
2 stops20h 24m
Multiple Airlines
Wed 4/82:46 am
STI
-
PTY
2 stops31h 29m
Multiple Airlines
Deal found 3/30$768
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:25 am
PTY
-
STI
2 stops20h 24m
Multiple Airlines
Tue 4/143:28 pm
STI
-
PTY
3 stops26h 32m
Multiple Airlines
Deal found 3/31$788
This Mytrip deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/83:10 pm
PTY
-
STI
2 stops33h 39m
Multiple Airlines
Sat 4/112:46 am
STI
-
PTY
3 stops31h 29m
Multiple Airlines
Deal found 4/1$815
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:03 pm
PTY
-
STI
1 stop24h 59m
Multiple Airlines
Thu 4/303:07 pm
STI
-
PTY
2 stops30h 13m
Multiple Airlines
Deal found 3/31$881

Find flight deals from Panama City to Santiago de los Caballeros

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$527
(Copa Airlines)

One-way from

$375
(Mytrip)

Popular in

July

Cheapest in

February

Average price

$527
Provider with most accurate pricing for Panama City Tocumen Intl-Santiago de los Caballeros flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santiago de los Caballeros flights.
Search Deals
From Panama City Tocumen Intl to Santiago de los Caballeros
Search Deals
One-way flight from Panama City Tocumen Intl to Santiago de los Caballeros
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($222 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($61 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Panama City to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Mon 4/20

11:26 am-2:50 pm

Nonstop2h 24m

Santiago de los Caballeros

Sat 4/25

3:59 pm-5:43 pm

Nonstop2h 44m

$527

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 5/14

11:26 am-2:50 pm

Nonstop2h 24m

Santiago de los Caballeros

Mon 6/15

4:01 pm-5:43 pm

Nonstop2h 42m

$529
Quickest round-trip

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 8/29

11:26 am-2:59 pm

Nonstop2h 33m

Santiago de los Caballeros

Mon 9/14

4:12 pm-5:43 pm

Nonstop2h 31m

$529

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 4/17

5:55 pm-7:20 am

2 stops36h 25m

Santiago de los Caballeros

Mon 4/20

8:01 am-5:00 pm

2 stops33h 59m

$1,072

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Mon 4/20

9:45 am-10:52 pm

1 stop12h 07m

Santiago de los Caballeros

Sat 4/25

4:23 pm-4:04 am

1 stop12h 41m

$1,082

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Tue 4/21

9:45 am-10:52 pm

1 stop12h 07m

Santiago de los Caballeros

Fri 4/24

4:23 pm-4:04 am

1 stop12h 41m

$1,125

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Wed 5/27

9:45 am-10:52 pm

1 stop12h 07m

Santiago de los Caballeros

Sun 5/31

4:23 pm-4:04 am

1 stop12h 41m

$1,201

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 8/29

10:55 pm-12:57 pm

1 stop13h 02m

Santiago de los Caballeros

Mon 9/14

2:07 pm-2:14 pm

2 stops25h 07m

$1,227

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Mon 6/1

11:26 am-2:59 pm

Nonstop2h 33m

Santiago de los Caballeros

Sat 6/27

4:01 pm-5:43 pm

Nonstop2h 42m

$1,342
Cheapest one-way

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Mon 4/13

4:25 am-1:49 am

2 stops20h 24m

$375

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 17 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago de los Caballeros flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago de los Caballeros

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $193). Flying from Panama City to Santiago de los Caballeros in December is currently the most expensive (average of $322). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to STI?

Find hourly flight availability from Panama City to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 3, 2026.

When flying from Panama City to Santiago de los Caballeros, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Panama City to Santiago de los Caballeros?

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Santiago de los Caballeros?

    For as low as $527, Copa Airlines can have you in Santiago de los Caballeros from Panama City in 2h 24m. There are 924 mi between Panama City and Santiago de los Caballeros. Most flights are nonstop.

  • Can I find deals for flights from Panama City to Santiago de los Caballeros that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago de los Caballeros?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago de los Caballeros.

  • Can I find deals for business class flights from Panama City to Santiago de los Caballeros?

    Yes. Cheapflights offers flight deals from Panama City to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $193). Flying from Panama City to Santiago de los Caballeros in December is currently the most expensive (average of $322). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.
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