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Santiago de los Caballeros

$329+ Cheap flights from Panama City (PTY) to Santiago de los Caballeros (STI)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STI
Feb 3 — Feb 101
Tue 2/3
Tue 2/10
1 adult, Economy
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Cheap flight deals from Panama City to Santiago de los Caballeros

Cheapest flights from Panama City to Santiago de los Caballeros
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 4, 2026.

This Copa Airlines deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/511:26 amPTY - STI
Nonstop2h 30mCopa Airlines
Thu 2/123:51 pmSTI - PTY
Nonstop2h 52mCopa Airlines
Deal found 1/1$329
This FlightHub deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/279:45 amPTY - STI
2 stops47h 52mMultiple Airlines
Tue 2/249:29 amSTI - PTY
2 stops24h 21mMultiple Airlines
Deal found 1/3$793
This Kiwi.com deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1511:33 amPTY - STI
2 stops27h 00mMultiple Airlines
Fri 1/304:40 pmSTI - PTY
1 stop28h 39mMultiple Airlines
Deal found 1/2$851
This Kiwi.com deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/1610:25 amPTY - STI
2 stops28h 08mMultiple Airlines
Fri 1/304:40 pmSTI - PTY
1 stop28h 39mMultiple Airlines
Deal found 1/2$890
This United Airlines deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:45 amPTY - STI
1 stop12h 07mUnited Airlines
Wed 5/62:07 pmSTI - PTY
2 stops25h 07mUnited Airlines
Deal found 1/3$921
This American Airlines deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:49 pmPTY - STI
1 stop21h 34mAmerican Airlines
Mon 4/271:32 pmSTI - PTY
1 stop48h 04mAmerican Airlines
Deal found 1/3$935
This Kiwi.com deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1112:03 pmPTY - STI
1 stop26h 32mMultiple Airlines
Tue 2/174:40 pmSTI - PTY
1 stop28h 39mMultiple Airlines
Deal found 1/2$937
This American Airlines deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/272:27 pmPTY - STI
1 stop24h 05mAmerican Airlines
Tue 2/242:31 pmSTI - PTY
1 stop24h 09mAmerican Airlines
Deal found 1/3$966
This American Airlines deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/112:27 pmPTY - STI
1 stop22h 04mAmerican Airlines
Tue 2/172:31 pmSTI - PTY
1 stop24h 09mAmerican Airlines
Deal found 1/2$1,054

Find flight deals from Panama City to Santiago de los Caballeros

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 4, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$329
(Copa Airlines)

Popular in

April

Cheapest in

February

Average price

$463
Provider with most accurate pricing for Panama City Tocumen Intl-Santiago de los Caballeros flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santiago de los Caballeros flights.
Search Deals
From Panama City Tocumen Intl to Santiago de los Caballeros
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($127 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($35 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 4, 2026.
Use the filters below to find and compare flights from Panama City to Santiago de los Caballeros that are best for you.

Fly from

Panama City

Fly to

Santiago de los Caballeros

Route

Depart

Return

Price

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 2/21

11:26 am-2:56 pm

Nonstop2h 30m

Santiago de los Caballeros

Thu 2/26

3:51 pm-5:43 pm

Nonstop2h 52m

$329

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 2/5

11:26 am-2:56 pm

Nonstop2h 30m

Santiago de los Caballeros

Thu 2/12

3:51 pm-5:43 pm

Nonstop2h 52m

$329

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Mon 6/1

11:26 am-2:59 pm

Nonstop2h 33m

Santiago de los Caballeros

Sat 7/4

4:01 pm-5:43 pm

Nonstop2h 42m

$748

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 1/15

11:33 am-3:33 pm

2 stops27h 00m

Santiago de los Caballeros

Fri 1/30

4:40 pm-8:19 pm

1 stop28h 39m

$851

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 1/16

10:25 am-3:33 pm

2 stops28h 08m

Santiago de los Caballeros

Fri 1/30

4:40 pm-8:19 pm

1 stop28h 39m

$890

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 5/2

9:45 am-10:52 pm

1 stop12h 07m

Santiago de los Caballeros

Wed 5/6

2:07 pm-2:14 pm

2 stops25h 07m

$921

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 4/24

1:49 pm-12:23 pm

1 stop21h 34m

Santiago de los Caballeros

Mon 4/27

1:32 pm-12:36 pm

1 stop48h 04m

$935

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Tue 3/31

3:20 am-1:49 am

2 stops21h 29m

$363

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Mon 3/30

3:25 am-1:49 am

3 stops21h 24m

$420

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sun 3/29

3:20 am-1:49 am

2 stops21h 29m

$434

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/3

Showing 1-10 of 16 results
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Compare providers for flights from Panama City to Santiago de los Caballeros

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santiago de los Caballeros in January.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Santiago de los Caballeros flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Santiago de los Caballeros flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago de los Caballeros

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $235). Flying from Panama City to Santiago de los Caballeros in December is currently the most expensive (average of $363). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Santiago de los Caballeros?

    For as low as $329, Copa Airlines can have you in Santiago de los Caballeros from Panama City in 2h 30m. There are 924 mi between Panama City and Santiago de los Caballeros. Most flights are nonstop.

  • Can I find deals for flights from Panama City to Santiago de los Caballeros that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago de los Caballeros?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago de los Caballeros.

  • Can I find deals for business class flights from Panama City to Santiago de los Caballeros?

    Yes. Cheapflights offers flight deals from Panama City to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $235). Flying from Panama City to Santiago de los Caballeros in December is currently the most expensive (average of $363). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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