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Santiago de los Caballeros

$351+ Cheap flights from Panama City (PTY) to Santiago de los Caballeros (STI)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/29. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STI
Mar 20 — Mar 271
Fri 3/20
Fri 3/27
1 adult, Economy
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Cheap flight deals from Panama City to Santiago de los Caballeros

Cheapest flights from Panama City to Santiago de los Caballeros
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 18, 2026.

This Copa Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2911:26 am
PTY
-
STI
Nonstop2h 33m
Copa Airlines
Mon 9/144:12 pm
STI
-
PTY
Nonstop2h 31m
Copa Airlines
Deal found 2/16$351
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1912:03 pm
PTY
-
STI
1 stop12h 46m
Multiple Airlines
Sun 3/222:46 am
STI
-
PTY
1 stop18h 33m
Multiple Airlines
Deal found 2/16$703
This Copa Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1911:26 am
PTY
-
STI
Nonstop2h 30m
Copa Airlines
Mon 3/233:51 pm
STI
-
PTY
Nonstop2h 52m
Copa Airlines
Deal found 2/16$769
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/101:40 pm
PTY
-
STI
1 stop29h 49m
American Airlines
Thu 3/121:30 pm
STI
-
PTY
1 stop25h 50m
American Airlines
Deal found 2/16$936
This United Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:45 am
PTY
-
STI
1 stop12h 07m
United Airlines
Wed 5/62:07 pm
STI
-
PTY
2 stops25h 07m
United Airlines
Deal found 2/15$1,000

Find flight deals from Panama City to Santiago de los Caballeros

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$351
(Copa Airlines)

Popular in

July

Cheapest in

August

Average price

$448
Provider with most accurate pricing for Panama City Tocumen Intl-Santiago de los Caballeros flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santiago de los Caballeros flights.
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From Panama City Tocumen Intl to Santiago de los Caballeros
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($86 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($52 potential savings vs. average RT price).
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Average for round-trip flights in February 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
Use the filters below to find and compare flights from Panama City to Santiago de los Caballeros that are best for you.

Fly from

Panama City

Fly to

Santiago de los Caballeros

Route

Depart

Return

Price

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 3/19

12:03 pm-1:49 am

1 stop12h 46m

Santiago de los Caballeros

Sun 3/22

2:46 am-8:19 pm

1 stop18h 33m

$703

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 3/19

11:26 am-2:56 pm

Nonstop2h 30m

Santiago de los Caballeros

Mon 3/23

3:51 pm-5:43 pm

Nonstop2h 52m

$769

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 5/2

9:45 am-10:52 pm

1 stop12h 07m

Santiago de los Caballeros

Wed 5/6

2:07 pm-2:14 pm

2 stops25h 07m

$1,000

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 5/2

9:45 am-10:52 pm

1 stop12h 07m

Santiago de los Caballeros

Sat 5/9

4:23 pm-4:04 am

1 stop12h 41m

$1,045

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 5/14

3:30 pm-3:12 pm

2 stops22h 42m

$1,558

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Mon 5/11

3:30 pm-3:12 pm

2 stops22h 42m

$1,558

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Tue 5/12

3:30 pm-3:12 pm

2 stops22h 42m

$1,558

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Wed 5/13

3:30 pm-3:12 pm

2 stops22h 42m

$1,558

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 5/15

3:30 pm-10:52 pm

2 stops30h 22m

$1,604

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/15

  • Most accurate provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago de los Caballeros flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago de los Caballeros

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $193). Flying from Panama City to Santiago de los Caballeros in October is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to STI?

Find hourly flight availability from Panama City to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 18, 2026.

When flying from Panama City to Santiago de los Caballeros, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Santiago de los Caballeros?

    For as low as $351, Copa Airlines can have you in Santiago de los Caballeros from Panama City in 2h 30m. There are 924 mi between Panama City and Santiago de los Caballeros. Most flights are nonstop.

  • Can I find deals for flights from Panama City to Santiago de los Caballeros that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago de los Caballeros?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago de los Caballeros.

  • Can I find deals for business class flights from Panama City to Santiago de los Caballeros?

    Yes. Cheapflights offers flight deals from Panama City to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $193). Flying from Panama City to Santiago de los Caballeros in October is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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