HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago de los Caballeros

$427+ Cheap flights from Panama City (PTY) to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STI
Nov 2 — Nov 91
Sun 11/2
Sun 11/9
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Santiago de los Caballeros

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 3, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$594
(Kiwi.com)

One-way from

$427
(Kiwi.com)

Popular in

April

Cheapest in

November

Average price

$388

Good one-way deal

$464 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Santiago de los Caballeros flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santiago de los Caballeros flights.
Search Deals
From Panama City Tocumen Intl to Santiago de los Caballeros
Search Deals
One-way flight from Panama City Tocumen Intl to Santiago de los Caballeros
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($235 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($45 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Santiago de los Caballeros.
Search Deals

Find flight deals from Panama City to Santiago de los Caballeros

Cheapest flights from Panama City to Santiago de los Caballeros
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 3, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/712:03 pmPTY - STI
1 stop23h 19mMultiple Airlines
Tue 11/111:17 pmSTI - PTY
1 stop8h 02mMultiple Airlines
Deal found 10/1$594
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1510:00 amPTY - STI
1 stop12h 51mUnited Airlines
Mon 12/154:00 pmSTI - PTY
2 stops23h 45mUnited Airlines
Deal found 10/2$927
This Mytrip deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:55 amPTY - STI
3 stops30h 43mMultiple Airlines
Sun 11/91:17 pmSTI - PTY
3 stops20h 33mMultiple Airlines
Deal found 10/1$1,004
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:00 amPTY - STI
1 stop12h 51mUnited Airlines
Tue 11/114:00 pmSTI - PTY
2 stops23h 45mUnited Airlines
Deal found 10/2$1,120
This United Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:00 amPTY - STI
1 stop12h 51mUnited Airlines
Thu 12/114:00 pmSTI - PTY
2 stops26h 07mUnited Airlines
Deal found 10/3$1,132
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/152:49 pmPTY - STI
1 stop23h 44mAmerican Airlines
Mon 12/156:00 amSTI - PTY
1 stop8h 47mAmerican Airlines
Deal found 10/1$1,139

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 3, 2025.
Use the filters below to find and compare flights from Panama City to Santiago de los Caballeros that are best for you.

Fly from

Panama City

Fly to

Santiago de los Caballeros

Route

Depart

Return

Price

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 11/7

12:03 pm-12:22 pm

1 stop23h 19m

Santiago de los Caballeros

Tue 11/11

1:17 pm-8:19 pm

1 stop8h 02m

$594

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 11/15

10:00 am-11:51 pm

1 stop12h 51m

Santiago de los Caballeros

Mon 12/15

12:52 pm-2:45 pm

2 stops26h 53m

$927

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 10/30

2:55 am-10:38 am

3 stops30h 43m

Santiago de los Caballeros

Sun 11/9

1:17 pm-8:50 am

3 stops20h 33m

$1,004

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 11/7

10:00 am-11:51 pm

1 stop12h 51m

Santiago de los Caballeros

Tue 11/11

4:00 pm-2:45 pm

2 stops23h 45m

$1,120

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Wed 1/21

9:34 am-5:06 pm

2 stops30h 32m

$427

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 10/31

2:21 pm-7:06 pm

2 stops27h 45m

$492

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Wed 12/31

7:50 pm-5:06 pm

3 stops20h 16m

$508

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Wed 12/31

2:53 pm-5:27 pm

1 stop25h 34m

$538

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Tue 12/30

2:53 pm-2:24 pm

1 stop22h 31m

$560

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Tue 12/30

9:25 am-5:06 pm

2 stops30h 41m

$600

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/2

Compare providers for flights from Panama City to Santiago de los Caballeros

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santiago de los Caballeros in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago de los Caballeros flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago de los Caballeros

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $347). Flying from Panama City to Santiago de los Caballeros in July is currently the most expensive (average of $600). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City to Santiago de los Caballeros?

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Santiago de los Caballeros?

    For as low as $927, United Airlines can have you in Santiago de los Caballeros from Panama City in 12h 51m. There are 924 mi between Panama City and Santiago de los Caballeros.

  • What are the cheapest flights from Panama City to Santiago de los Caballeros?

    While on average a flight from Panama City to Santiago de los Caballeros is generally $464, our data shows the cheapest flight currently is $464. When looking at the most popular route, (Panama City Tocumen Intl - Santiago de los Caballeros), you can expect to pay $927 for that flight.

  • Can I find deals for flights from Panama City to Santiago de los Caballeros that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago de los Caballeros?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago de los Caballeros.

  • Can I find deals for business class flights from Panama City to Santiago de los Caballeros?

    Yes. Cheapflights offers flight deals from Panama City to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

    Currently, May is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $347). Flying from Panama City to Santiago de los Caballeros in July is currently the most expensive (average of $600). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Punta Cana flights
Panama City to Santo Domingo flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.