HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago de los Caballeros

$134+ Cheap flights from Irvine, CA to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — STI
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Irvine to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Irvine to Santiago de los Caballeros

Cheapest flights from Irvine to Santiago de los Caballeros
Explore the most affordable flight options available from Irvine to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:43 pmLAX - STI
1 stop22h 59mSpirit Airlines
Mon 1/53:43 amSTI - LAX
2 stops22h 55mSpirit Airlines
Deal found 12/16$599
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:43 pmLAX - STI
1 stop22h 59mSpirit Airlines
Tue 1/63:43 amSTI - LAX
2 stops31h 32mSpirit Airlines
Deal found 12/16$651
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:43 pmLAX - STI
1 stop22h 59mSpirit Airlines
Thu 1/84:40 pmSTI - LAX
2 stops18h 35mSpirit Airlines
Deal found 12/16$654
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:00 amLAX - STI
1 stop10h 04mAmerican Airlines
Mon 12/226:17 pmSTI - LAX
1 stop10h 37mAmerican Airlines
Deal found 12/15$702
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/261:32 pmLAX - STI
1 stop20h 52mAmerican Airlines
Thu 1/16:00 amSTI - LAX
2 stops13h 17mAmerican Airlines
Deal found 12/16$703
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2710:59 pmLAX - STI
1 stop18h 05mAmerican Airlines
Wed 1/74:33 pmSTI - LAX
1 stop20h 32mAmerican Airlines
Deal found 12/16$728
This KAYAK deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:00 amLAX - STI
2 stops16h 42mSpirit Airlines
Tue 1/63:43 amSTI - LAX
2 stops22h 55mSpirit Airlines
Deal found 12/16$766

Find flight deals from Irvine to Santiago de los Caballeros

Keep the following information in mind while searching for Irvine to Santiago de los Caballeros flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$335
(Priceline)

One-way from

$134
(Priceline)

Popular in

December

Cheapest in

May

Average price

$809
Provider with most accurate pricing for Los Angeles-Santiago de los Caballeros flight deals.
Search Deals
Provider most trusted by Cheapflights users for Los Angeles-Santiago de los Caballeros flights.
Search Deals
From Irvine to Santiago de los Caballeros
Search Deals
One-way flight from Irvine to Santiago de los Caballeros
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($104 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Irvine to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Irvine to Santiago de los Caballeros that are best for you.

Fly from

Irvine

Fly to

Santiago de los Caballeros

Route

Depart

Return

Price

Los AngelesSantiago de los Caballeros

LAX - STI

LAXSTI

Los Angeles

Sun 1/18

7:07 pm-3:33 pm

2 stops16h 26m

Santiago de los Caballeros

Mon 1/26

4:40 pm-10:56 pm

1 stop10h 16m

$341

Los AngelesSantiago de los Caballeros

LAX - STI

LAXSTI

Los Angeles

Sat 1/31

6:44 pm-3:33 pm

2 stops16h 49m

Santiago de los Caballeros

Sat 2/7

4:40 pm-10:56 pm

1 stop10h 16m

$354

Los AngelesSantiago de los Caballeros

LAX - STI

LAXSTI

Los Angeles

Wed 2/18

4:07 pm-3:35 pm

2 stops19h 28m

Santiago de los Caballeros

Sun 3/1

4:40 pm-11:50 pm

1 stop11h 10m

$359

Los AngelesSantiago de los Caballeros

LAX - STI

LAXSTI

Los Angeles

Sat 1/10

6:44 pm-3:33 pm

2 stops16h 49m

Santiago de los Caballeros

Fri 1/23

4:40 pm-10:56 pm

1 stop10h 16m

$374

Los AngelesSantiago de los Caballeros

LAX - STI

LAXSTI

Los Angeles

Wed 2/18

6:00 am-2:44 am

1 stop16h 44m

Santiago de los Caballeros

Sun 3/1

4:40 pm-11:50 pm

1 stop11h 10m

$388

Los AngelesSantiago de los Caballeros

LAX - STI

LAXSTI

Los Angeles

Wed 2/18

6:00 am-1:45 am

1 stop15h 45m

Santiago de los Caballeros

Mon 3/2

4:40 pm-11:50 pm

1 stop11h 10m

$388

Los AngelesSantiago de los Caballeros

LAX - STI

LAXSTI

Los Angeles

Tue 2/24

7:45 pm-3:35 pm

2 stops15h 50m

$134

Los AngelesSantiago de los Caballeros

LAX - STI

LAXSTI

Los Angeles

Fri 1/30

7:07 pm-3:33 pm

2 stops16h 26m

$175

Los AngelesSantiago de los Caballeros

LAX - STI

LAXSTI

Los Angeles

Wed 1/28

7:07 pm-3:33 pm

2 stops16h 26m

$180

Los AngelesSantiago de los Caballeros

LAX - STI

LAXSTI

Los Angeles

Fri 1/30

12:33 am-3:33 pm

2 stops35h 00m

$191

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 16 results
1
2

Best time to book a flight from Irvine to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Irvine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Irvine to Santiago de los Caballeros

What is the cheapest month to book a flight from Irvine to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Irvine to Santiago de los Caballeros (average of $270). Flying from Irvine to Santiago de los Caballeros in July is currently the most expensive (average of $490). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IR9 to STI?

Find hourly flight availability from Irvine to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s typically best to fly out from Irvine to Santiago de los Caballeros at noon. Doing so could potentially save you 42% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Santiago de los Caballeros

Get insights into the airlines that provide service to Santiago de los Caballeros. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago de los Caballeros. Reviews last updated December 18, 2025.
Read through reviews of airlines operating flights from Irvine to Santiago de los Caballeros, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
9,092 reviews
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
11,055 reviews
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
JetBlue
7.2
Good
2,897 reviews
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Irvine to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago de los Caballeros from Irvine?

    Most people fly into Santiago de los Caballeros (STI) if they book a flight to Santiago de los Caballeros from Irvine. On average, Santiago has 0 inbound flights from Irvine per day from 4 airlines. Santiago de los Caballeros is conveniently located just 6.8 mi from Santiago de los Caballeros’s city center.

  • How long is the flight from Irvine to Santiago de los Caballeros?

    Departing from Irvine to Santiago de los Caballeros will take you 16h 26m. Airlines will cover a distance of 3085 mi.

  • What are the cheapest airlines to fly from Irvine to Santiago de los Caballeros one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $214. JetBlue flights start at $229 while deals on Delta start at $260 one-way.

  • Can I find deals for flights from Irvine to Santiago de los Caballeros that include hotel bookings?

    Yes. In addition to deals on Irvine to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Irvine to Santiago de los Caballeros?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Irvine to Santiago de los Caballeros.

  • Can I find deals for business class flights from Irvine to Santiago de los Caballeros?

    Yes. Cheapflights offers flight deals from Irvine to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Irvine to Santiago de los Caballeros?

    Currently, May is the cheapest month in which you can book a flight from Irvine to Santiago de los Caballeros (average of $270). Flying from Irvine to Santiago de los Caballeros in July is currently the most expensive (average of $490). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Irvine to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to Punta Cana flights
San Francisco to Punta Cana flights
Ontario to Punta Cana flights
Los Angeles to Santo Domingo flights
Los Angeles to Puerto Plata flights
San Diego to Punta Cana flights
Las Vegas to Punta Cana flights
Burbank to Punta Cana flights
Sacramento to Punta Cana flights
San Diego to Santo Domingo flights
San Francisco to Santo Domingo flights
San Francisco to Santiago de los Caballeros flights
San Francisco to Puerto Plata flights
Los Angeles to Santiago de los Caballeros flights
Ontario to Santo Domingo flights
Fresno to Punta Cana flights
Las Vegas to Santo Domingo flights
San Diego to Puerto Plata flights
San Jose to Punta Cana flights
Burbank to Santo Domingo flights
Santa Ana to Santo Domingo flights
Reno to Punta Cana flights
Sacramento to Santo Domingo flights
Ontario to Santiago de los Caballeros flights
San Jose to Santo Domingo flights
Oakland to Punta Cana flights
Ontario to Puerto Plata flights
Sacramento to Santiago de los Caballeros flights
San Diego to Santiago de los Caballeros flights
Sacramento to Puerto Plata flights
Santa Ana to Punta Cana flights
Las Vegas to Puerto Plata flights
Oakland to Santo Domingo flights
Santa Ana to Santiago de los Caballeros flights
San Francisco to La Romana flights
San Jose to Puerto Plata flights
Santa Ana to Puerto Plata flights
Fresno to Santo Domingo flights
Las Vegas to Santiago de los Caballeros flights
Fresno to Santiago de los Caballeros flights
San Jose to Santiago de los Caballeros flights
Reno to Puerto Plata flights
Palm Springs to Punta Cana flights
Oakland to Santiago de los Caballeros flights
Reno to Santiago de los Caballeros flights
Reno to Santo Domingo flights
Los Angeles to Nagua flights
Fresno to Puerto Plata flights
San Jose to Nagua flights
San Francisco to Nagua flights

Top 4 airlines flying from Irvine to Santiago de los Caballeros

Discover the top 4 airlines that operate flights from Irvine to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$417Average$594FlexibilityNo cancel feeOn-timeN/A
JetBlueCheapest$451Average$682FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$451Average$674FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$492Average$644FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.