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$351+ Cheap flights from San Diego (SAN) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/8. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — SCL
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheapflights Tip: The best prices from San Diego to Santiago Arturo Merino Benitez are usually found in November or September, booked 79 days in advance, depart on a Sunday or Saturday and return on a Friday

Cheap flight deals from San Diego to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$503
(Copa Airlines)

One-way from

$351
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$1,069
From San Diego to Santiago Arturo Merino Benitez
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One-way flight from San Diego to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 7% potential increase in price ($78 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from San Diego to Santiago

Cheapest flights from San Diego to Santiago
Explore the most affordable flight options available from San Diego to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Copa Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/249:03 pmSAN - SCL
1 stop22h 41mCopa Airlines
Sat 8/302:26 amSCL - SAN
1 stop18h 18mCopa Airlines
Deal found 7/27$503
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2812:30 pmSAN - SCL
1 stop16h 25mAmerican Airlines
Sun 11/211:15 pmSCL - SAN
1 stop28h 05mAmerican Airlines
Deal found 7/29$516
This LATAM Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/169:59 amSAN - SCL
1 stop16h 01mLATAM Airlines
Mon 9/2911:05 pmSCL - SAN
1 stop14h 14mLATAM Airlines
Deal found 7/29$675
This LATAM Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/168:37 pmSAN - SCL
1 stop29h 23mMultiple Airlines
Sun 9/2812:25 amSCL - SAN
2 stops26h 59mMultiple Airlines
Deal found 7/29$710
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/710:10 pmSAN - SCL
1 stop27h 45mDelta
Thu 1/159:30 pmSCL - SAN
1 stop30h 41mDelta
Deal found 7/29$715
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2612:07 pmSAN - SCL
1 stop15h 43mUnited Airlines
Tue 12/910:45 pmSCL - SAN
1 stop17h 16mUnited Airlines
Deal found 7/27$804

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from San Diego to Santiago that are best for you.

Fly from

San Diego

Fly to

Santiago

Route

Depart

Return

Price

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Sun 8/24

9:03 pm-10:44 pm

1 stop22h 41m

Santiago Arturo Merino Benitez

Sat 8/30

2:26 am-5:44 pm

1 stop18h 18m

$503

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Tue 10/28

12:30 pm-8:55 am

1 stop16h 25m

Santiago Arturo Merino Benitez

Sun 11/2

11:15 pm-10:20 pm

1 stop28h 05m

$516

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Tue 9/16

9:59 am-6:00 am

1 stop16h 01m

Santiago Arturo Merino Benitez

Mon 9/29

11:05 pm-9:19 am

1 stop14h 14m

$675

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Tue 9/16

8:37 pm-6:00 am

1 stop29h 23m

Santiago Arturo Merino Benitez

Sun 9/28

12:25 am-11:24 pm

2 stops26h 59m

$710

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Sun 12/7

10:10 pm-6:55 am

1 stop27h 45m

Santiago Arturo Merino Benitez

Thu 1/15

9:30 pm-11:11 pm

1 stop30h 41m

$715

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Wed 11/26

8:00 am-8:50 am

1 stop19h 50m

Santiago Arturo Merino Benitez

Wed 12/10

10:45 pm-6:21 pm

1 stop24h 36m

$804

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Fri 8/8

7:05 pm-10:30 pm

3 stops24h 25m

$351

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 9/15

9:59 am-6:00 am

1 stop16h 01m

$518

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Fri 8/8

9:03 pm-7:24 pm

1 stop19h 21m

$531

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Best time to book a flight from San Diego to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Santiago

How far ahead should I book a flight from San Diego to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from San Diego to Santiago. Price data was last updated on July 25, 2025.

Booking 77 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Diego to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Diego to Santiago?

Currently, April is the cheapest month in which you can book a flight from San Diego to Santiago (average of $752). Flying from San Diego to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to SCL?

Find hourly flight availability from San Diego to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

When flying from San Diego to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 18% versus a flight in the afternoon.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 29, 2025.
See what other customers who have flown with Delta, LATAM Airlines, and Copa Airlines from San Diego to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,979 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,822 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,493 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from San Diego to Santiago round-trip?

    Our cheapest airline available from San Diego to Santiago is Copa Airlines. Our recent data shows that you can find tickets from as low as $503 on this airline. Additional options worth looking into are American Airlines and LATAM Airlines, starting at $516 and $675 round-trip. You may be able to fly from San Diego to Santiago for 50% less than the average price by searching for these airlines.

  • Can I find deals for flights from San Diego to Santiago that include hotel bookings?

    Yes. In addition to deals on San Diego to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Santiago.

  • Can I find deals for business class flights from San Diego to Santiago?

    Yes. Cheapflights offers flight deals from San Diego to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Santiago?

    Currently, April is the cheapest month in which you can book a flight from San Diego to Santiago (average of $752). Flying from San Diego to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Diego to Santiago

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Top 5 airlines flying from San Diego to Santiago

Discover the top 5 airlines that operate flights from San Diego to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$453Average$820FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$542Average$938FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$792Average$1,009FlexibilityNo cancel feeOn-time81%
DeltaCheapest$792Average$983FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$802Average$1,056FlexibilityNo cancel feeOn-time71%

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