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$784+ Cheap flights from Louisville (SDF) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — SCL
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
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Cheap flight deals from Louisville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 20, 2025.

Round-trip from

$784
(LATAM Airlines)
From Louisville Intl to Santiago Arturo Merino Benitez
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Find flight deals from Louisville to Santiago

Cheapest flights from Louisville to Santiago
Explore the most affordable flight options available from Louisville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This LATAM Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/102:59 pmSDF - SCL
1 stop13h 11mLATAM Airlines
Wed 12/1711:15 pmSCL - SDF
1 stop12h 16mLATAM Airlines
Deal found 8/20$784
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/152:24 pmSDF - SCL
2 stops16h 31mAmerican Airlines
Wed 9/249:55 pmSCL - SDF
2 stops22h 37mAmerican Airlines
Deal found 8/17$788
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:36 pmSDF - SCL
1 stop12h 24mDelta
Thu 1/1511:15 pmSCL - SDF
1 stop12h 19mDelta
Deal found 8/20$804
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:00 pmSDF - SCL
2 stops15h 00mDelta
Wed 1/149:30 pmSCL - SDF
1 stop14h 04mDelta
Deal found 8/20$808
This Mytrip deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/110:54 amSDF - SCL
3 stops35h 36mMultiple Airlines
Thu 9/43:35 amSCL - SDF
2 stops18h 29mMultiple Airlines
Deal found 8/19$814
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/157:33 pmSDF - SCL
2 stops16h 47mLATAM Airlines
Tue 9/2312:25 amSCL - SDF
2 stops19h 11mLATAM Airlines
Deal found 8/18$817
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:05 amSDF - SCL
2 stops21h 45mUnited Airlines
Wed 1/1410:45 pmSCL - SDF
2 stops20h 04mUnited Airlines
Deal found 8/20$828
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/109:30 amSDF - SCL
1 stop21h 20mUnited Airlines
Mon 12/2910:45 pmSCL - SDF
1 stop15h 16mUnited Airlines
Deal found 8/20$829
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/147:30 pmSDF - SCL
1 stop33h 30mDelta
Wed 2/1111:15 pmSCL - SDF
1 stop14h 22mDelta
Deal found 8/20$836
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:36 pmSDF - SCL
1 stop12h 24mDelta
Sun 1/1811:15 pmSCL - SDF
1 stop12h 19mDelta
Deal found 8/20$844

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Louisville to Santiago that are best for you.

Fly from

Louisville

Fly to

Santiago

Route

Depart

Return

Price

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Thu 12/11

7:00 am-7:00 am

1 stop22h 00m

Santiago Arturo Merino Benitez

Wed 12/17

11:15 pm-9:31 am

1 stop12h 16m

$784

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Mon 9/15

2:24 pm-7:55 am

2 stops16h 31m

Santiago Arturo Merino Benitez

Wed 9/24

9:55 pm-7:32 pm

2 stops22h 37m

$788

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Mon 9/15

5:53 pm-1:20 pm

2 stops18h 27m

Santiago Arturo Merino Benitez

Wed 9/24

11:30 pm-11:52 pm

2 stops25h 22m

$803

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Thu 1/8

2:59 pm-6:10 am

1 stop13h 11m

Santiago Arturo Merino Benitez

Tue 1/20

8:20 am-11:56 pm

2 stops17h 36m

$804

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Wed 12/31

4:36 pm-7:00 am

1 stop12h 24m

Santiago Arturo Merino Benitez

Mon 1/19

6:30 pm-9:34 am

2 stops17h 04m

$804

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Tue 1/6

2:59 pm-6:10 am

1 stop13h 11m

Santiago Arturo Merino Benitez

Thu 1/29

11:15 pm-9:34 am

1 stop12h 19m

$804

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/20

Best time to book a flight from Louisville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Santiago

What is the cheapest month to book a flight from Louisville to Santiago?

Currently, April is the cheapest month in which you can book a flight from Louisville to Santiago (average of $752). Flying from Louisville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to SCL?

Find hourly flight availability from Louisville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 20, 2025.

It’s typically best to fly out from Louisville to Santiago at noon. Doing so could potentially save you 20% on the flight price compared to flying in the afternoon, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Santiago?

    A quick flight from Louisville to Santiago can take about 16h 31m. LATAM Airlines provides one of the quickest options available for as low as $788. There are 5034 mi between Louisville and Santiago. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Louisville to Santiago that include hotel bookings?

    Yes. In addition to deals on Louisville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Santiago.

  • Can I find deals for business class flights from Louisville to Santiago?

    Yes. Cheapflights offers flight deals from Louisville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Louisville to Santiago (average of $752). Flying from Louisville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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