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$844+ Cheap flights from Louisville (SDF) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — SCL
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
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Cheap flight deals from Louisville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 15, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$863
(American Airlines)
Provider with most accurate pricing for Louisville Intl-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Louisville Intl-Santiago Arturo Merino Benitez flights.
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From Louisville Intl to Santiago Arturo Merino Benitez
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Find flight deals from Louisville to Santiago

Cheapest flights from Louisville to Santiago
Explore the most affordable flight options available from Louisville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This KAYAK deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/179:15 am
SDF
-
SCL
1 stop21h 35m
Multiple Airlines
Thu 2/1910:45 pm
SCL
-
SDF
1 stop23h 06m
Multiple Airlines
Deal found 1/15$844
This KAYAK deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/179:15 am
SDF
-
SCL
1 stop21h 35m
Avianca
Thu 2/1910:45 pm
SCL
-
SDF
2 stops16h 38m
Avianca
Deal found 1/15$848
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/63:33 pm
SDF
-
SCL
2 stops16h 17m
American Airlines
Thu 4/168:30 pm
SCL
-
SDF
2 stops22h 32m
American Airlines
Deal found 1/14$863
This KAYAK deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/173:30 pm
SDF
-
SCL
1 stop15h 20m
Multiple Airlines
Fri 2/2010:45 pm
SCL
-
SDF
1 stop18h 26m
Multiple Airlines
Deal found 1/15$882
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/189:00 am
SDF
-
SCL
2 stops21h 50m
United Airlines
Fri 2/2010:45 pm
SCL
-
SDF
2 stops23h 24m
United Airlines
Deal found 1/15$918
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/155:54 pm
SDF
-
SCL
2 stops36h 56m
United Airlines
Sun 2/2210:45 pm
SCL
-
SDF
2 stops49h 28m
United Airlines
Deal found 1/14$920
This LATAM Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1812:12 pm
SDF
-
SCL
1 stop17h 28m
LATAM Airlines
Thu 2/1910:35 am
SCL
-
SDF
2 stops15h 23m
LATAM Airlines
Deal found 1/15$927
This KAYAK deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/612:48 pm
SDF
-
SCL
3 stops21h 16m
LATAM Airlines
Thu 4/165:40 am
SCL
-
SDF
2 stops18h 19m
LATAM Airlines
Deal found 1/14$928

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Louisville to Santiago that are best for you.

Fly from

Louisville

Fly to

Santiago

Route

Depart

Return

Price

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Tue 2/17

9:15 am-8:50 am

1 stop21h 35m

Santiago Arturo Merino Benitez

Thu 2/19

10:45 pm-7:51 pm

1 stop23h 06m

$844

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Tue 2/17

9:15 am-8:50 am

1 stop21h 35m

Santiago Arturo Merino Benitez

Thu 2/19

10:45 pm-1:23 pm

2 stops16h 38m

$848

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Mon 4/6

3:33 pm-7:50 am

2 stops16h 17m

Santiago Arturo Merino Benitez

Thu 4/16

8:30 pm-7:02 pm

2 stops22h 32m

$863

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Wed 2/18

3:30 pm-8:50 am

1 stop15h 20m

Santiago Arturo Merino Benitez

Fri 2/20

10:45 pm-3:11 pm

1 stop18h 26m

$882

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Tue 2/17

2:05 pm-8:50 am

2 stops16h 45m

Santiago Arturo Merino Benitez

Fri 2/20

10:45 pm-1:23 pm

2 stops16h 38m

$887

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Wed 2/18

3:33 pm-7:40 am

1 stop14h 07m

Santiago Arturo Merino Benitez

Thu 2/19

11:10 pm-11:27 am

1 stop14h 17m

$918

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Wed 2/18

9:00 am-8:50 am

2 stops21h 50m

Santiago Arturo Merino Benitez

Fri 2/20

10:45 pm-8:09 pm

2 stops23h 24m

$918

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Sun 2/15

5:54 pm-8:50 am

2 stops36h 56m

Santiago Arturo Merino Benitez

Sun 2/22

10:45 pm-10:13 pm

2 stops49h 28m

$920

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/15

Compare providers for flights from Louisville to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Santiago in January.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Louisville-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Louisville-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Louisville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Louisville-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Santiago

What is the cheapest month to book a flight from Louisville to Santiago?

Currently, November is the cheapest month in which you can book a flight from Louisville to Santiago (average of $549). Flying from Louisville to Santiago in May is currently the most expensive (average of $1,053). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Santiago?

    A quick flight from Louisville to Santiago can take about 16h 17m. Avianca provides one of the quickest options available for as low as $863. There are 5034 mi between Louisville and Santiago. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Louisville to Santiago that include hotel bookings?

    Yes. In addition to deals on Louisville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Santiago.

  • Can I find deals for business class flights from Louisville to Santiago?

    Yes. Cheapflights offers flight deals from Louisville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Louisville to Santiago (average of $549). Flying from Louisville to Santiago in May is currently the most expensive (average of $1,053). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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