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$417+ Cheap flights from Louisville (SDF) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — SCL
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Louisville to Santiago

Cheapest flights from Louisville to Santiago
Explore the most affordable flight options available from Louisville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:01 pm
SDF
-
SCL
1 stop16h 04m
American Airlines
Mon 3/169:20 pm
SCL
-
SDF
2 stops18h 43m
American Airlines
Deal found 1/27$853
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/179:15 am
SDF
-
SCL
1 stop21h 35m
United Airlines
Wed 2/2510:45 pm
SCL
-
SDF
1 stop23h 06m
United Airlines
Deal found 1/27$933
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:54 pm
SDF
-
SCL
2 stops60h 56m
United Airlines
Mon 2/2310:45 pm
SCL
-
SDF
2 stops25h 28m
United Airlines
Deal found 1/26$955
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:19 pm
SDF
-
SCL
3 stops23h 21m
Multiple Airlines
Mon 3/163:42 pm
SCL
-
SDF
3 stops21h 37m
Multiple Airlines
Deal found 1/27$970
This Mytrip deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1412:00 pm
SDF
-
SCL
2 stops16h 40m
Multiple Airlines
Mon 2/238:25 am
SCL
-
SDF
3 stops32h 13m
Multiple Airlines
Deal found 1/26$975
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:03 pm
SDF
-
SCL
1 stop11h 37m
Delta
Mon 2/2311:10 pm
SCL
-
SDF
1 stop19h 51m
Delta
Deal found 1/26$980
This LATAM Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/297:00 am
SDF
-
SCL
2 stops23h 00m
LATAM Airlines
Mon 7/68:40 pm
SCL
-
SDF
1 stop13h 13m
LATAM Airlines
Deal found 1/26$985
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/173:33 pm
SDF
-
SCL
3 stops38h 14m
Multiple Airlines
Wed 2/2511:24 am
SCL
-
SDF
2 stops29h 14m
Multiple Airlines
Deal found 1/27$1,092
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/293:50 pm
SDF
-
SCL
1 stop15h 00m
United Airlines
Mon 11/210:45 pm
SCL
-
SDF
1 stop22h 50m
United Airlines
Deal found 1/25$1,145

Find flight deals from Louisville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$853
(American Airlines)

One-way from

$417
(KAYAK)
Provider with most accurate pricing for Louisville Intl-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Louisville Intl-Santiago Arturo Merino Benitez flights.
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From Louisville Intl to Santiago Arturo Merino Benitez
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One-way flight from Louisville Intl to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Louisville to Santiago that are best for you.

Fly from

Louisville

Fly to

Santiago

Route

Depart

Return

Price

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Mon 3/2

2:01 pm-8:05 am

1 stop16h 04m

Santiago Arturo Merino Benitez

Mon 3/16

9:20 pm-3:03 pm

2 stops18h 43m

$853

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Tue 2/17

9:15 am-8:50 am

1 stop21h 35m

Santiago Arturo Merino Benitez

Wed 2/25

10:45 pm-7:51 pm

1 stop23h 06m

$933

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Sat 2/14

5:54 pm-8:50 am

2 stops60h 56m

Santiago Arturo Merino Benitez

Mon 2/23

10:45 pm-1:31 pm

1 stop16h 46m

$955

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Mon 3/2

1:19 pm-2:40 pm

3 stops23h 21m

Santiago Arturo Merino Benitez

Mon 3/16

3:42 pm-12:19 pm

3 stops21h 37m

$970

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Sat 2/14

12:00 pm-6:40 am

2 stops16h 40m

Santiago Arturo Merino Benitez

Mon 2/23

8:25 am-2:38 pm

3 stops32h 13m

$975

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Sat 2/14

6:03 pm-7:40 am

1 stop11h 37m

Santiago Arturo Merino Benitez

Mon 2/23

11:10 pm-5:01 pm

1 stop19h 51m

$980

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Mon 6/29

7:00 am-6:00 am

2 stops23h 00m

Santiago Arturo Merino Benitez

Mon 7/6

8:40 pm-9:53 am

1 stop13h 13m

$985

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Wed 2/25

5:49 pm-5:30 pm

2 stops21h 41m

$417

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Wed 2/25

10:49 am-8:05 am

1 stop19h 16m

$417

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Wed 2/25

1:19 pm-5:30 pm

3 stops26h 11m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

  • Most accurate provider: When it comes to deals on Louisville-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Louisville-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Santiago

What is the cheapest month to book a flight from Louisville to Santiago?

Currently, November is the cheapest month in which you can book a flight from Louisville to Santiago (average of $549). Flying from Louisville to Santiago in May is currently the most expensive (average of $1,017). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Santiago?

    A quick flight from Louisville to Santiago can take about 16h 04m. American Airlines provides one of the quickest options available for as low as $853. There are 5034 mi between Louisville and Santiago. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Louisville to Santiago that include hotel bookings?

    Yes. In addition to deals on Louisville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Santiago.

  • Can I find deals for business class flights from Louisville to Santiago?

    Yes. Cheapflights offers flight deals from Louisville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Louisville to Santiago (average of $549). Flying from Louisville to Santiago in May is currently the most expensive (average of $1,017). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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