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$308+ Cheap flights from Louisville (SDF) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — SCL
Nov 19 — Nov 261
Wed 11/19
Wed 11/26
1 adult, Economy
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Cheap flight deals from Louisville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$764
(American Airlines)
Provider with most accurate pricing for Louisville Intl-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Louisville Intl-Santiago Arturo Merino Benitez flights.
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From Louisville Intl to Santiago Arturo Merino Benitez
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Find flight deals from Louisville to Santiago

Cheapest flights from Louisville to Santiago
Explore the most affordable flight options available from Louisville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2025.

This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/107:13 amSDF - SCL
1 stop22h 42mAmerican Airlines
Mon 11/1711:15 pmSCL - SDF
1 stop18h 23mAmerican Airlines
Deal found 10/19$764
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/107:10 amSDF - SCL
1 stop23h 40mUnited Airlines
Mon 11/1710:45 pmSCL - SDF
2 stops16h 32mUnited Airlines
Deal found 10/19$769
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:15 amSDF - SCL
1 stop21h 35mUnited Airlines
Mon 11/310:45 pmSCL - SDF
1 stop23h 09mUnited Airlines
Deal found 10/19$804
This Mytrip deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:51 amSDF - SCL
2 stops18h 39mMultiple Airlines
Sun 11/21:35 amSCL - SDF
2 stops18h 41mMultiple Airlines
Deal found 10/19$826
This KAYAK deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/103:09 pmSDF - SCL
2 stops22h 21mLATAM Airlines
Sun 11/164:35 amSCL - SDF
2 stops20h 25mLATAM Airlines
Deal found 10/19$844
This KAYAK deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/203:09 pmSDF - SCL
2 stops20h 56mLATAM Airlines
Sun 11/234:35 amSCL - SDF
2 stops21h 31mLATAM Airlines
Deal found 10/19$1,016
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:00 amSDF - SCL
1 stop25h 00mAmerican Airlines
Mon 11/2411:15 pmSCL - SDF
1 stop20h 24mAmerican Airlines
Deal found 10/19$1,047
This Mytrip deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:48 pmSDF - SCL
2 stops39h 27mMultiple Airlines
Mon 11/249:05 pmSCL - SDF
3 stops22h 48mMultiple Airlines
Deal found 10/19$1,083
This Mytrip deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/109:55 amSDF - SCL
3 stops24h 20mMultiple Airlines
Sun 11/161:35 amSCL - SDF
2 stops19h 21mMultiple Airlines
Deal found 10/19$1,112

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Louisville to Santiago that are best for you.

Fly from

Louisville

Fly to

Santiago

Route

Depart

Return

Price

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Mon 11/10

7:13 am-7:55 am

1 stop22h 42m

Santiago Arturo Merino Benitez

Mon 11/17

11:15 pm-3:38 pm

1 stop18h 23m

$764

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Thu 11/20

11:00 am-8:50 am

2 stops19h 50m

Santiago Arturo Merino Benitez

Mon 11/24

10:45 pm-1:25 pm

1 stop16h 40m

$769

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Mon 11/10

7:10 am-8:50 am

1 stop23h 40m

Santiago Arturo Merino Benitez

Mon 11/17

10:45 pm-1:17 pm

2 stops16h 32m

$769

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Fri 10/31

9:15 am-7:50 am

1 stop21h 35m

Santiago Arturo Merino Benitez

Mon 11/3

10:45 pm-7:54 pm

1 stop23h 09m

$804

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Fri 10/31

9:51 am-5:30 am

2 stops18h 39m

Santiago Arturo Merino Benitez

Sun 11/2

1:35 am-6:16 pm

2 stops18h 41m

$826

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Mon 11/10

3:09 pm-3:30 pm

2 stops22h 21m

Santiago Arturo Merino Benitez

Sun 11/16

4:35 am-11:00 pm

2 stops20h 25m

$844

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Mon 10/27

11:47 am-5:30 am

3 stops40h 43m

$308

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Sun 2/15

9:27 pm-8:44 pm

3 stops45h 17m

$389

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Sat 2/21

10:55 am-7:00 am

3 stops42h 05m

$428

LouisvilleSantiago

SDF - SCL

SDFSCL

Louisville Intl

Wed 2/18

10:55 am-5:14 am

3 stops40h 19m

$447

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/20

Showing 1-10 of 14 results
1
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Compare providers for flights from Louisville to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Santiago in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Louisville-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Louisville-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Santiago

What is the cheapest month to book a flight from Louisville to Santiago?

Currently, November is the cheapest month in which you can book a flight from Louisville to Santiago (average of $549). Flying from Louisville to Santiago in March is currently the most expensive (average of $1,092). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to SCL?

Find hourly flight availability from Louisville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 20, 2025.

It’s typically best to fly out from Louisville to Santiago at noon. Doing so could potentially save you 35% on the flight price compared to flying in the evening, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Santiago?

    A quick flight from Louisville to Santiago can take about 19h 50m. American Airlines provides one of the quickest options available for as low as $769. There are 5034 mi between Louisville and Santiago. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Louisville to Santiago that include hotel bookings?

    Yes. In addition to deals on Louisville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Santiago.

  • Can I find deals for business class flights from Louisville to Santiago?

    Yes. Cheapflights offers flight deals from Louisville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Louisville to Santiago (average of $549). Flying from Louisville to Santiago in March is currently the most expensive (average of $1,092). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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