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$324+ Cheap flights from Greenville (GSP) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SCL
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Greenville to Santiago

Best flights from Greenville to Santiago
Discover carefully curated flight deals from Greenville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:12 pmGSP - SCL
1 stop11h 53mAmerican Airlines
Wed 4/158:50 pmSCL - GSP
1 stop21h 21mAmerican Airlines
Deal found 12/10$804
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:52 amGSP - SCL
1 stop23h 58mUnited Airlines
Wed 3/259:45 pmSCL - GSP
1 stop19h 00mUnited Airlines
Deal found 12/9$1,074

Find flight deals from Greenville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Ovago
2 stars

Round-trip from

$804
(American Airlines)

One-way from

$324
(Kiwi.com)
Provider with most accurate pricing for Greenville-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Santiago Arturo Merino Benitez flights.
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From Greenville to Santiago Arturo Merino Benitez
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One-way flight from Greenville to Santiago Arturo Merino Benitez
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Greenville to Santiago that are best for you.

Fly from

Greenville

Fly to

Santiago

Route

Depart

Return

Price

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 4/1

7:12 pm-8:05 am

1 stop11h 53m

Santiago Arturo Merino Benitez

Wed 4/15

8:50 pm-6:11 pm

1 stop21h 21m

$804

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 3/23

6:52 am-7:50 am

1 stop23h 58m

Santiago Arturo Merino Benitez

Wed 3/25

9:45 pm-3:45 pm

1 stop19h 00m

$1,074

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 1/12

9:48 am-5:14 am

2 stops17h 26m

$324

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 2/16

4:07 pm-3:20 pm

2 stops45h 13m

$387

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 1/12

6:49 am-8:50 am

1 stop24h 01m

$518

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 1/12

6:56 pm-9:00 am

1 stop12h 04m

$518

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Compare providers for flights from Greenville to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Santiago in December.
ProviderPrice AccuracyTrust Score*
OvagoPrice Accuracy2 starsTrust Score*2 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santiago

What is the cheapest month to book a flight from Greenville to Santiago?

Currently, March is the cheapest month in which you can book a flight from Greenville to Santiago (average of $673). Flying from Greenville to Santiago in May is currently the most expensive (average of $1,025). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SCL?

Find hourly flight availability from Greenville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s typically best to fly out from Greenville to Santiago in the morning. Doing so could potentially save you 28% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with Delta and LATAM Airlines from Greenville to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,889 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Santiago?

    Departing from Greenville to Santiago will take you 11h 53m. Greenville and Santiago are separated by a distance of 4773 mi.

  • What are the cheapest airlines flying from Greenville to Santiago round-trip?

    Currently priced at $758, LATAM Airlines will fly you from Greenville to Santiago and back. In addition to LATAM Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $793.

  • Can I find deals for flights from Greenville to Santiago that include hotel bookings?

    Yes. In addition to deals on Greenville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santiago.

  • Can I find deals for business class flights from Greenville to Santiago?

    Yes. Cheapflights offers flight deals from Greenville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Santiago?

    Currently, March is the cheapest month in which you can book a flight from Greenville to Santiago (average of $673). Flying from Greenville to Santiago in May is currently the most expensive (average of $1,025). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Greenville to Santiago

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Top 2 airlines flying from Greenville to Santiago

Discover the top 2 airlines that operate flights from Greenville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$793Average$944FlexibilityNo cancel feeOn-time81%
DeltaCheapest$793Average$948FlexibilityNo cancel feeOn-timeN/A

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