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$318+ Cheap flights from Greenville (GSP) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SCL
Oct 14 — Oct 211
Tue 10/14
Tue 10/21
1 adult, Economy
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Cheap flight deals from Greenville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 14, 2025.

Round-trip from

$703
(FlightHub)

One-way from

$318
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$863
From Greenville to Santiago Arturo Merino Benitez
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One-way flight from Greenville to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 22% potential increase in price ($280 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($38 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Greenville to Santiago

Cheapest flights from Greenville to Santiago
Explore the most affordable flight options available from Greenville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2025.

This FlightHub deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:13 pmGSP - SCL
2 stops19h 12mLATAM Airlines
Tue 10/1410:55 pmSCL - GSP
2 stops21h 01mLATAM Airlines
Deal found 9/14$703
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/159:54 amGSP - SCL
2 stops19h 51mDelta
Sun 10/2612:20 amSCL - GSP
2 stops22h 58mDelta
Deal found 9/13$714
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:00 amGSP - SCL
1 stop24h 55mAmerican Airlines
Tue 10/149:55 pmSCL - GSP
1 stop19h 03mAmerican Airlines
Deal found 9/13$944
This Expedia deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/165:19 pmGSP - SCL
2 stops18h 46mLATAM Airlines
Tue 1/610:15 pmSCL - GSP
2 stops27h 21mLATAM Airlines
Deal found 9/13$1,274
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:45 amGSP - SCL
1 stop22h 55mDelta
Tue 1/69:30 pmSCL - GSP
1 stop18h 24mDelta
Deal found 9/13$1,477

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
Use the filters below to find and compare flights from Greenville to Santiago that are best for you.

Fly from

Greenville

Fly to

Santiago

Route

Depart

Return

Price

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/15

1:45 pm-5:45 am

2 stops15h 00m

Santiago Arturo Merino Benitez

Mon 10/27

11:25 pm-6:56 pm

2 stops20h 31m

$703

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/1

6:13 pm-2:25 pm

2 stops19h 12m

Santiago Arturo Merino Benitez

Tue 10/14

10:55 pm-6:56 pm

2 stops21h 01m

$703

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/15

4:46 pm-8:00 am

1 stop14h 14m

Santiago Arturo Merino Benitez

Mon 10/27

10:15 pm-11:43 am

1 stop14h 28m

$714

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/15

9:54 am-6:45 am

2 stops19h 51m

Santiago Arturo Merino Benitez

Sun 10/26

12:20 am-10:18 pm

2 stops22h 58m

$714

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/1

6:13 pm-1:55 pm

2 stops18h 42m

Santiago Arturo Merino Benitez

Tue 10/14

9:40 pm-10:09 am

1 stop13h 29m

$714

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 12/8

3:00 pm-3:20 pm

3 stops22h 20m

$345

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Sun 12/7

9:33 am-3:20 pm

3 stops51h 47m

$384

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 12/10

9:19 am-8:50 am

2 stops21h 31m

$513

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 12/10

12:01 pm-7:40 am

1 stop17h 39m

$518

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Tue 12/2

7:45 am-2:30 pm

3 stops28h 45m

$518

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 12 results
1
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Best time to book a flight from Greenville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santiago

What is the cheapest month to book a flight from Greenville to Santiago?

Currently, April is the cheapest month in which you can book a flight from Greenville to Santiago (average of $752). Flying from Greenville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SCL?

Find hourly flight availability from Greenville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 14, 2025.

It’s typically best to fly out from Greenville to Santiago in the morning. Doing so could potentially save you 13% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 14, 2025.
Peruse reviews from past customers who have flown with Delta and LATAM Airlines from Greenville to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,956 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,956 reviews
Delta
8.0
Very good
7,956 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,847 reviews
Delta
8.0
Very good
7,956 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Santiago?

    Departing from Greenville to Santiago will take you 14h 14m. Greenville and Santiago are separated by a distance of 4773 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Greenville to Santiago round-trip?

    Currently priced at $617, Delta will fly you from Greenville to Santiago and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on LATAM Airlines for as low as $617. Users have found that Delta is 35% cheaper than the other options available to this destination.

  • Can I find deals for flights from Greenville to Santiago that include hotel bookings?

    Yes. In addition to deals on Greenville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santiago.

  • Can I find deals for business class flights from Greenville to Santiago?

    Yes. Cheapflights offers flight deals from Greenville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Greenville to Santiago (average of $752). Flying from Greenville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Greenville to Santiago

Discover the top 2 airlines that operate flights from Greenville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$617Average$894FlexibilityNo cancel feeOn-time81%
DeltaCheapest$617Average$988FlexibilityNo cancel feeOn-timeN/A

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