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$397+ Cheap flights from Greenville (GSP) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SCL
Apr 17 — Apr 241
Fri 4/17
Fri 4/24
1 adult, Economy
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Cheap flight deals from Greenville to Santiago

Cheapest flights from Greenville to Santiago
Explore the most affordable flight options available from Greenville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 18, 2026.

This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:56 pm
GSP
-
SCL
1 stop13h 54m
American Airlines
Mon 10/199:30 pm
SCL
-
GSP
1 stop18h 56m
American Airlines
Deal found 3/16$875
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/712:02 pm
GSP
-
SCL
1 stop17h 43m
American Airlines
Mon 1/1110:15 pm
SCL
-
GSP
2 stops15h 09m
American Airlines
Deal found 3/17$880
This FlightHub deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:45 am
GSP
-
SCL
2 stops20h 50m
LATAM Airlines
Mon 10/1911:00 pm
SCL
-
GSP
2 stops20h 49m
LATAM Airlines
Deal found 3/16$894
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2810:00 am
GSP
-
SCL
1 stop21h 15m
Delta
Tue 5/58:40 pm
SCL
-
GSP
1 stop13h 40m
Delta
Deal found 3/13$920
This LATAM Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2811:06 am
GSP
-
SCL
3 stops26h 19m
LATAM Airlines
Tue 5/54:10 am
SCL
-
GSP
2 stops19h 46m
LATAM Airlines
Deal found 3/13$925
This Expedia deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/75:05 pm
GSP
-
SCL
1 stop12h 35m
LATAM Airlines
Mon 1/1112:05 am
SCL
-
GSP
2 stops20h 44m
LATAM Airlines
Deal found 3/17$956
This Expedia deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:45 am
GSP
-
SCL
2 stops20h 50m
LATAM Airlines
Mon 10/1912:00 am
SCL
-
GSP
2 stops24h 37m
LATAM Airlines
Deal found 3/16$960
This KAYAK deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:42 pm
GSP
-
SCL
1 stop15h 33m
LATAM Airlines
Sun 11/111:25 pm
SCL
-
GSP
2 stops23h 56m
LATAM Airlines
Deal found 3/14$975
This FlightHub deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:45 am
GSP
-
SCL
2 stops22h 50m
LATAM Airlines
Wed 4/1511:00 pm
SCL
-
GSP
2 stops19h 55m
LATAM Airlines
Deal found 3/16$990

Find flight deals from Greenville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$920
(Delta)

One-way from

$397
(Kiwi.com)
Provider with most accurate pricing for Greenville-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Santiago Arturo Merino Benitez flights.
Search Deals
From Greenville to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Greenville to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
Use the filters below to find and compare flights from Greenville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Tue 4/28

10:00 am-7:15 am

1 stop21h 15m

Santiago Arturo Merino Benitez

Tue 5/5

8:40 pm-10:20 am

1 stop13h 40m

$920

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 4/1

7:26 pm-7:50 am

1 stop11h 24m

Santiago Arturo Merino Benitez

Wed 4/15

8:35 pm-6:15 pm

1 stop21h 40m

$996
Quickest round-trip

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Fri 5/1

7:59 pm-2:05 pm

2 stops18h 06m

Santiago Arturo Merino Benitez

Fri 5/8

8:40 pm-10:50 am

1 stop14h 10m

$1,020

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Fri 5/1

12:07 pm-5:10 am

2 stops17h 03m

Santiago Arturo Merino Benitez

Thu 5/7

2:22 am-10:14 pm

2 stops19h 52m

$1,241

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Sat 8/15

10:14 am-4:50 am

2 stops18h 36m

Santiago Arturo Merino Benitez

Wed 8/19

7:50 am-11:38 pm

2 stops15h 48m

$1,245
Cheapest one-way

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Thu 4/16

2:12 pm-4:45 am

2 stops38h 33m

$397

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 4/15

3:03 pm-1:25 pm

3 stops22h 22m

$448

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 4/15

6:45 pm-7:05 am

1 stop12h 20m

$448
Quickest one-way

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Thu 4/16

7:59 pm-7:15 am

1 stop11h 16m

$467

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 3/25

4:30 pm-7:00 am

1 stop13h 30m

$668

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/13

Sorted by cheapest first

Compare providers for flights from Greenville to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Santiago in March.
ProviderPrice AccuracyTrust Score*
OvagoPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santiago

What is the cheapest month to book a flight from Greenville to Santiago?

Currently, December is the cheapest month in which you can book a flight from Greenville to Santiago (average of $686). Flying from Greenville to Santiago in May is currently the most expensive (average of $1,025). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated March 18, 2026.
Peruse reviews from past customers who have flown with Delta and LATAM Airlines from Greenville to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,288 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Crew

8.5

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,288 reviews
Delta
7.9
Good
8,288 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Crew

8.5

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.4
Good
1,914 reviews
Delta
7.9
Good
8,288 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Crew

8.5

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Santiago?

    Departing from Greenville to Santiago will take you 11h 24m. Greenville and Santiago are separated by a distance of 4773 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Greenville to Santiago round-trip?

    Currently priced at $753, Delta will fly you from Greenville to Santiago and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on LATAM Airlines for as low as $758.

  • Can I find deals for flights from Greenville to Santiago that include hotel bookings?

    Yes. In addition to deals on Greenville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santiago.

  • Can I find deals for business class flights from Greenville to Santiago?

    Yes. Cheapflights offers flight deals from Greenville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Santiago?

    Currently, December is the cheapest month in which you can book a flight from Greenville to Santiago (average of $686). Flying from Greenville to Santiago in May is currently the most expensive (average of $1,025). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Santiago flights
Savannah to Santiago flights

Top 2 airlines flying from Greenville to Santiago

Discover the top 2 airlines that operate flights from Greenville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$753Average$943FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$758Average$944FlexibilityNo cancel feeOn-time81%

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