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$834+ Cheap flights from Greenville (GSP) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/18. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SCL
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
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Cheap flight deals from Greenville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 30, 2025.

Round-trip from

$834
(LATAM Airlines)

Popular in

June

Cheapest in

November

Average price

$1,185
From Greenville to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($273 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($37 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Greenville to Santiago

Cheapest flights from Greenville to Santiago
Explore the most affordable flight options available from Greenville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This LATAM Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/187:50 pmGSP - SCL
2 stops20h 35mLATAM Airlines
Fri 8/2212:40 pmSCL - GSP
2 stops22h 49mLATAM Airlines
Deal found 7/28$834
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/154:46 pmGSP - SCL
1 stop14h 14mAmerican Airlines
Mon 10/2710:15 pmSCL - GSP
1 stop14h 28mAmerican Airlines
Deal found 7/29$904
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/185:59 pmGSP - SCL
2 stops20h 01mDelta
Fri 8/227:50 amSCL - GSP
2 stops16h 09mDelta
Deal found 7/29$934
This Copa Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1810:27 amGSP - SCL
2 stops18h 35mCopa Airlines
Thu 8/2112:24 amSCL - GSP
2 stops18h 28mCopa Airlines
Deal found 7/29$1,791

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Greenville to Santiago that are best for you.

Fly from

Greenville

Fly to

Santiago

Route

Depart

Return

Price

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 8/18

7:50 pm-4:25 pm

2 stops20h 35m

Santiago Arturo Merino Benitez

Fri 8/22

12:40 pm-11:29 am

2 stops22h 49m

$834

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/15

4:46 pm-8:00 am

1 stop14h 14m

Santiago Arturo Merino Benitez

Mon 10/27

10:15 pm-11:43 am

1 stop14h 28m

$904

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 8/18

5:59 pm-2:00 pm

2 stops20h 01m

Santiago Arturo Merino Benitez

Fri 8/22

7:50 am-11:59 pm

2 stops16h 09m

$934

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 8/18

10:27 am-5:02 am

2 stops18h 35m

Santiago Arturo Merino Benitez

Thu 8/21

12:24 am-6:52 pm

2 stops18h 28m

$1,791

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Greenville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santiago

What is the cheapest month to book a flight from Greenville to Santiago?

Currently, April is the cheapest month in which you can book a flight from Greenville to Santiago (average of $752). Flying from Greenville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SCL?

Find hourly flight availability from Greenville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

It’s typically best to fly out from Greenville to Santiago in the morning. Doing so could potentially save you 13% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 30, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and Copa Airlines from Greenville to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,822 reviews
Delta
8.0
Very good
7,980 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,493 reviews
Delta
8.0
Very good
7,980 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Greenville to Santiago round-trip?

    Currently priced at $834, LATAM Airlines will fly you from Greenville to Santiago and back. In addition to LATAM Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Delta - these airlines can fly you to your destination from $904 and $934, respectively. Users have found that LATAM Airlines is 13% cheaper than the other options available to this destination.

  • Can I find deals for flights from Greenville to Santiago that include hotel bookings?

    Yes. In addition to deals on Greenville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santiago.

  • Can I find deals for business class flights from Greenville to Santiago?

    Yes. Cheapflights offers flight deals from Greenville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Greenville to Santiago (average of $752). Flying from Greenville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Greenville to Santiago

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Top 2 airlines flying from Greenville to Santiago

Discover the top 2 airlines that operate flights from Greenville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$617Average$894FlexibilityNo cancel feeOn-time81%
DeltaCheapest$721Average$988FlexibilityNo cancel feeOn-timeN/A

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