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$425+ Cheap flights from Greenville (GSP) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/29. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SCL
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheap flight deals from Greenville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated junio 12, 2025.

Round-trip from

$754
(American Airlines)

One-way from

$425
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$1,288
From Greenville to Santiago Arturo Merino Benitez
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One-way flight from Greenville to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 20% potential increase in price ($255 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($34 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Greenville to Santiago

Cheapest flights from Greenville to Santiago
Explore the most affordable flight options available from Greenville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/157:46 pmGSP - SCL
1 stop11h 19mAmerican Airlines
lun. 10/2710:15 pmSCL - GSP
1 stop20h 26mAmerican Airlines
Deal found 6/12$754
This Justfly.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/155:05 pmGSP - SCL
1 stop12h 55mLATAM Airlines
dom. 10/2612:25 amSCL - GSP
2 stops19h 24mLATAM Airlines
Deal found 6/12$789
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/1512:00 pmGSP - SCL
2 stops17h 40mDelta
dom. 10/2612:25 amSCL - GSP
2 stops19h 24mDelta
Deal found 6/10$794
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/2211:03 amGSP - SCL
3 stops41h 14mMultiple Airlines
sáb. 10/183:30 pmSCL - GSP
3 stops30h 33mMultiple Airlines
Deal found 6/11$1,059
This Copa Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/267:45 pmGSP - SCL
2 stops23h 39mCopa Airlines
vie. 8/2212:12 amSCL - GSP
2 stops18h 40mCopa Airlines
Deal found 6/12$1,472

Cheapflights Fare Finder

Customize your flight search to find flights from Greenville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Greenville to Santiago that are best for you.

Fly from

Greenville

Fly to

Santiago

Route

Depart

Return

Price

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

mié. 10/15

7:46 pm-8:05 am

1 stop11h 19m

Santiago Arturo Merino Benitez

lun. 10/27

10:15 pm-5:41 pm

1 stop20h 26m

$754

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

mié. 10/15

5:05 pm-7:00 am

1 stop12h 55m

Santiago Arturo Merino Benitez

dom. 10/26

12:25 am-6:49 pm

2 stops19h 24m

$789

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

mié. 10/15

12:00 pm-6:40 am

2 stops17h 40m

Santiago Arturo Merino Benitez

dom. 10/26

12:25 am-6:49 pm

2 stops19h 24m

$794

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

mar. 7/22

11:03 am-4:17 am

3 stops41h 14m

Santiago Arturo Merino Benitez

sáb. 10/18

3:30 pm-9:03 pm

3 stops30h 33m

$1,059

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

jue. 6/26

7:45 pm-7:24 pm

2 stops23h 39m

Santiago Arturo Merino Benitez

vie. 8/22

12:12 am-6:52 pm

2 stops18h 40m

$1,472

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

sáb. 11/29

3:18 pm-4:55 am

2 stops35h 37m

$425

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

mié. 10/29

7:46 pm-9:05 am

1 stop12h 19m

$518

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

mié. 10/29

5:05 pm-9:35 pm

3 stops27h 30m

$562

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

sáb. 11/29

4:56 pm-8:50 am

1 stop13h 54m

$568

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Greenville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santiago

What is the cheapest month to book a flight from Greenville to Santiago?

Currently, April is the cheapest month in which you can book a flight from Greenville to Santiago (average of $752). Flying from Greenville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SCL?

Find hourly flight availability from Greenville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

It’s typically best to fly out from Greenville to Santiago in the morning. Doing so could potentially save you 13% on the flight price compared to flying at noon, which is usually more expensive.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated junio 12, 2025.
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,785 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,451 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Greenville to Santiago round-trip?

    Currently priced at $754, American Airlines will fly you from Greenville to Santiago and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and Delta - these airlines can fly you to your destination from $789 and $794, respectively. Users have found that American Airlines is 23% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Greenville to Santiago one-way?

    The cheapest airlines for a one-way flight from Greenville to Santiago are American Airlines ($518), LATAM Airlines ($562), and United Airlines ($568).

  • Can I find deals for flights from Greenville to Santiago that include hotel bookings?

    Yes. In addition to deals on Greenville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santiago.

  • Can I find deals for business class flights from Greenville to Santiago?

    Yes. Cheapflights offers flight deals from Greenville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Greenville to Santiago (average of $752). Flying from Greenville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Greenville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Greenville to Santiago

Discover the top 2 airlines that operate flights from Greenville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$617Average$902FlexibilityNo cancel feeOn-time81%
DeltaCheapest$617Average$988FlexibilityNo cancel feeOn-timeN/A

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