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$513+ Cheap flights from Greenville (GSP) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/10. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SCL
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Greenville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Round-trip from

$1,153
(Ovago)

One-way from

$513
(United Airlines)
From Greenville to Santiago Arturo Merino Benitez
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One-way flight from Greenville to Santiago Arturo Merino Benitez
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Find flight deals from Greenville to Santiago

Cheapest flights from Greenville to Santiago
Explore the most affordable flight options available from Greenville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Ovago deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:45 amGSP - SCL
1 stop21h 25mLATAM Airlines
Sat 12/2010:25 pmSCL - GSP
2 stops27h 07mLATAM Airlines
Deal found 10/28$1,153
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1610:08 amGSP - SCL
1 stop18h 02mDelta
Sat 12/209:30 pmSCL - GSP
1 stop13h 49mDelta
Deal found 10/28$1,194

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Greenville to Santiago that are best for you.

Fly from

Greenville

Fly to

Santiago

Route

Depart

Return

Price

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Tue 12/16

6:45 am-6:10 am

1 stop21h 25m

Santiago Arturo Merino Benitez

Sat 12/20

10:25 pm-11:32 pm

2 stops27h 07m

$1,153

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Tue 12/16

10:08 am-6:10 am

1 stop18h 02m

Santiago Arturo Merino Benitez

Sat 12/20

9:30 pm-9:19 am

1 stop13h 49m

$1,194

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 12/10

6:00 am-8:50 am

2 stops24h 50m

$513

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Sat 1/31

10:32 am-9:00 am

2 stops20h 28m

$558

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 12/10

12:00 pm-2:30 pm

3 stops24h 30m

$558

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Sat 1/31

4:01 pm-9:35 pm

3 stops51h 34m

$600

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Best time to book a flight from Greenville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santiago

What is the cheapest month to book a flight from Greenville to Santiago?

Currently, July is the cheapest month in which you can book a flight from Greenville to Santiago (average of $713). Flying from Greenville to Santiago in May is currently the most expensive (average of $1,025). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SCL?

Find hourly flight availability from Greenville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

It’s typically best to fly out from Greenville to Santiago in the morning. Doing so could potentially save you 28% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 30, 2025.
Peruse reviews from past customers who have flown with Delta and LATAM Airlines from Greenville to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Comfort

7.9

Overall

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,993 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Comfort

7.9

Overall

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
LATAM Airlines
7.5
Good
1,872 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Comfort

7.9

Overall

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Santiago?

    Departing from Greenville to Santiago will take you 18h 02m. Greenville and Santiago are separated by a distance of 4773 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Greenville to Santiago round-trip?

    Currently priced at $617, Delta will fly you from Greenville to Santiago and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on LATAM Airlines for as low as $617.

  • Can I find deals for flights from Greenville to Santiago that include hotel bookings?

    Yes. In addition to deals on Greenville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santiago.

  • Can I find deals for business class flights from Greenville to Santiago?

    Yes. Cheapflights offers flight deals from Greenville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Santiago?

    Currently, July is the cheapest month in which you can book a flight from Greenville to Santiago (average of $713). Flying from Greenville to Santiago in May is currently the most expensive (average of $1,025). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Santiago

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Top 2 airlines flying from Greenville to Santiago

Discover the top 2 airlines that operate flights from Greenville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$617Average$894FlexibilityNo cancel feeOn-time81%
DeltaCheapest$617Average$948FlexibilityNo cancel feeOn-timeN/A

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