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$254+ Cheap flights from Denver (DEN) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — SCL
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Find cheap flights from Denver to Santiago with Cheapflights

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Cheapflights Tip: The best prices from Denver Intl to Santiago Arturo Merino Benitez are usually found in September or April, booked 63 days in advance, depart on a Tuesday or Monday and return on a Tuesday

Cheap flight deals from Denver to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$538
(FlightHub)

One-way from

$254
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$753
Provider with most accurate pricing for Denver Intl-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Denver Intl-Santiago Arturo Merino Benitez flights.
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From Denver Intl to Santiago Arturo Merino Benitez
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One-way flight from Denver Intl to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 17% potential increase in price ($175 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($46 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Denver to Santiago

Cheapest flights from Denver to Santiago
Explore the most affordable flight options available from Denver to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This KAYAK deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:54 amDEN - SCL
1 stop15h 16mLATAM Airlines
Wed 1/288:15 amSCL - DEN
2 stops18h 37mLATAM Airlines
Deal found 10/26$654
This KAYAK deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:05 amDEN - SCL
3 stops26h 25mLATAM Airlines
Thu 1/2912:20 amSCL - DEN
2 stops26h 32mLATAM Airlines
Deal found 10/26$659
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/291:25 pmDEN - SCL
1 stop15h 25mUnited Airlines
Tue 2/310:45 pmSCL - DEN
1 stop28h 56mUnited Airlines
Deal found 10/26$663
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/259:38 pmDEN - SCL
2 stops27h 36mMultiple Airlines
Wed 12/310:35 amSCL - DEN
1 stop26h 33mMultiple Airlines
Deal found 10/28$664
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:20 amDEN - SCL
2 stops21h 20mMultiple Airlines
Mon 12/810:35 amSCL - DEN
1 stop26h 08mMultiple Airlines
Deal found 10/28$666
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:20 amDEN - SCL
2 stops21h 20mMultiple Airlines
Thu 12/44:20 amSCL - DEN
2 stops32h 23mMultiple Airlines
Deal found 10/28$682
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:20 amDEN - SCL
2 stops21h 20mMultiple Airlines
Wed 12/310:35 amSCL - DEN
1 stop26h 33mMultiple Airlines
Deal found 10/28$692
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:42 pmDEN - SCL
1 stop13h 08mUnited Airlines
Sat 12/2710:45 pmSCL - DEN
1 stop13h 33mUnited Airlines
Deal found 10/26$709
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/98:10 amDEN - SCL
1 stop19h 35mAmerican Airlines
Sat 12/2011:15 pmSCL - DEN
1 stop28h 41mAmerican Airlines
Deal found 10/27$717
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1212:34 amDEN - SCL
2 stops17h 41mMultiple Airlines
Sat 11/228:30 amSCL - DEN
2 stops28h 33mMultiple Airlines
Deal found 10/28$724

Cheapflights Fare Finder

 
Customize your flight search to find flights from Denver to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Denver to Santiago that are best for you.

Fly from

Denver

Fly to

Santiago

Route

Depart

Return

Price

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 2/9

4:30 pm-8:50 am

1 stop12h 20m

Santiago Arturo Merino Benitez

Wed 2/25

10:45 pm-8:10 am

1 stop13h 25m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 2/1

12:00 pm-3:30 pm

2 stops23h 30m

Santiago Arturo Merino Benitez

Tue 2/17

8:15 am-12:24 am

2 stops20h 09m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 2/2

1:16 pm-7:40 am

1 stop14h 24m

Santiago Arturo Merino Benitez

Tue 2/17

8:15 am-12:24 am

2 stops20h 09m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 2/10

4:30 pm-8:50 am

1 stop12h 20m

Santiago Arturo Merino Benitez

Tue 2/24

10:45 pm-11:35 pm

1 stop28h 50m

$552

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 3/1

7:45 am-8:50 am

1 stop21h 05m

Santiago Arturo Merino Benitez

Sun 3/8

9:45 pm-6:40 am

1 stop35h 55m

$552

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 1/26

4:30 pm-8:50 am

1 stop12h 20m

Santiago Arturo Merino Benitez

Tue 2/3

10:45 pm-11:41 pm

1 stop28h 56m

$603

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sat 2/21

8:33 pm-8:50 am

1 stop32h 17m

Santiago Arturo Merino Benitez

Fri 3/6

10:45 pm-11:40 pm

1 stop28h 55m

$610

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 1/12

2:42 pm-7:40 am

1 stop12h 58m

Santiago Arturo Merino Benitez

Thu 2/19

8:50 am-12:24 am

2 stops19h 34m

$654

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Thu 1/15

1:15 pm-7:40 am

1 stop14h 25m

Santiago Arturo Merino Benitez

Tue 2/17

11:15 pm-2:14 pm

1 stop18h 59m

$654

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 1/11

6:23 pm-5:25 pm

2 stops19h 02m

Santiago Arturo Merino Benitez

Sat 2/14

8:15 am-11:54 pm

2 stops19h 39m

$654

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 21 results
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Compare providers for flights from Denver to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Denver to Santiago in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Denver-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Denver-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Denver-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Denver-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Denver-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Denver to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Denver with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Denver to Santiago

How far ahead should I book a flight from Denver to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Denver to Santiago. Price data was last updated on October 24, 2025.

The price you pay for your flight from Denver to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Denver to Santiago?

Currently, July is the cheapest month in which you can book a flight from Denver to Santiago (average of $384). Flying from Denver to Santiago in June is currently the most expensive (average of $698). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DEN to SCL?

Find hourly flight availability from Denver to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

When flying from Denver to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 16% versus a flight in the morning.

What is the cheapest day to fly from Denver to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Denver to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Denver to Santiago flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 28, 2025.
Read reviews from past customers who have flown Delta, Copa Airlines, and LATAM Airlines from Denver to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Copa Airlines
7.6
Good
1,562 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
LATAM Airlines
7.5
Good
1,871 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Denver to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Denver to Santiago?

    A quick flight from Denver to Santiago can take about 12h 20m. United Airlines provides one of the quickest options available for as low as $544. Denver and Santiago are separated by a distance of 5501 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Denver to Santiago round-trip?

    Currently priced at $551, United Airlines will fly you from Denver to Santiago and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and Copa Airlines - these airlines can fly you to your destination from $563 and $575, respectively. United Airlines is currently priced 34% below the average price you’ll pay for this route.

  • Can I find deals for flights from Denver to Santiago that include hotel bookings?

    Yes. In addition to deals on Denver to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Denver to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Santiago.

  • Can I find deals for business class flights from Denver to Santiago?

    Yes. Cheapflights offers flight deals from Denver to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Denver to Santiago?

    Currently, July is the cheapest month in which you can book a flight from Denver to Santiago (average of $384). Flying from Denver to Santiago in June is currently the most expensive (average of $698). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Denver to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Denver to Santiago

Discover the top 6 airlines that operate flights from Denver to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$551Average$767FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$563Average$833FlexibilityNo cancel feeOn-time81%
Copa AirlinesCheapest$575Average$641FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$632Average$879FlexibilityNo cancel feeOn-time71%
DeltaCheapest$653Average$855FlexibilityNo cancel feeOn-timeN/A
AeromexicoCheapest$803Average$1,249FlexibilityNo cancel feeOn-timeN/A

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