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$334+ Cheap flights from Denver (DEN) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/2. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — SCL
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Denver to Santiago

Cheapest flights from Denver to Santiago
Explore the most affordable flight options available from Denver to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This LATAM Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:25 pm
DEN
-
SCL
2 stops15h 30m
LATAM Airlines
Mon 5/411:00 pm
SCL
-
DEN
2 stops23h 19m
LATAM Airlines
Deal found 1/25$548
This Copa Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/910:43 pm
DEN
-
SCL
1 stop22h 43m
Copa Airlines
Thu 8/204:46 am
SCL
-
DEN
1 stop15h 34m
Copa Airlines
Deal found 1/27$553
This LATAM Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:30 am
DEN
-
SCL
1 stop21h 05m
LATAM Airlines
Fri 9/115:40 am
SCL
-
DEN
2 stops21h 05m
LATAM Airlines
Deal found 1/27$558
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:05 am
DEN
-
SCL
1 stop23h 10m
Delta
Thu 7/211:05 pm
SCL
-
DEN
2 stops26h 40m
Delta
Deal found 1/25$565
This Delta deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:43 am
DEN
-
SCL
2 stops17h 12m
Delta
Sat 5/210:55 pm
SCL
-
DEN
1 stop22h 47m
Delta
Deal found 1/24$570
This Copa Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2110:43 pm
DEN
-
SCL
1 stop22h 43m
Copa Airlines
Thu 9/101:06 am
SCL
-
DEN
1 stop20h 05m
Copa Airlines
Deal found 1/24$573
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2712:59 am
DEN
-
SCL
2 stops27h 01m
Delta
Sun 8/238:40 pm
SCL
-
DEN
1 stop25h 39m
Delta
Deal found 1/25$574
This KAYAK deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1012:20 pm
DEN
-
SCL
1 stop16h 30m
LATAM Airlines
Sat 8/2210:55 pm
SCL
-
DEN
1 stop21h 39m
LATAM Airlines
Deal found 1/25$588
This KAYAK deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:30 am
DEN
-
SCL
2 stops21h 05m
LATAM Airlines
Tue 7/77:45 pm
SCL
-
DEN
2 stops24h 49m
LATAM Airlines
Deal found 1/25$593
This BusinessClass deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3010:51 pm
DEN
-
SCL
1 stop22h 35m
Copa Airlines
Fri 6/1212:01 am
SCL
-
DEN
1 stop20h 24m
Copa Airlines
Deal found 1/25$603

Find flight deals from Denver to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$548
(LATAM Airlines)

One-way from

$334
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$843
Provider with most accurate pricing for Denver Intl-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Denver Intl-Santiago Arturo Merino Benitez flights.
Search Deals
From Denver Intl to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Denver Intl to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($109 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Denver to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Denver to Santiago that are best for you.

Fly from

Denver

Fly to

Santiago

Route

Depart

Return

Price

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Fri 4/24

6:00 am-7:15 am

1 stop23h 15m

Santiago Arturo Merino Benitez

Mon 5/4

10:55 pm-10:49 pm

1 stop25h 54m

$565

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Fri 4/24

11:43 am-6:55 am

2 stops17h 12m

Santiago Arturo Merino Benitez

Sat 5/2

10:55 pm-7:42 pm

1 stop22h 47m

$570

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 4/21

4:25 pm-2:05 pm

2 stops19h 40m

Santiago Arturo Merino Benitez

Wed 5/6

11:05 pm-6:03 pm

2 stops20h 58m

$675

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sat 4/11

6:30 am-5:35 am

1 stop21h 05m

Santiago Arturo Merino Benitez

Mon 4/13

11:05 pm-8:19 pm

2 stops23h 14m

$675

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Thu 3/19

7:05 am-7:40 am

1 stop21h 35m

Santiago Arturo Merino Benitez

Wed 4/1

11:55 pm-7:36 pm

1 stop22h 41m

$675

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 4/19

11:43 am-7:15 am

1 stop17h 32m

Santiago Arturo Merino Benitez

Mon 5/4

10:55 pm-7:42 pm

1 stop22h 47m

$675

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Wed 4/22

4:30 pm-2:05 pm

2 stops19h 35m

Santiago Arturo Merino Benitez

Wed 5/6

10:55 pm-10:49 pm

1 stop25h 54m

$675

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 4/20

1:25 pm-7:15 am

1 stop15h 50m

Santiago Arturo Merino Benitez

Mon 5/4

10:55 pm-7:42 pm

1 stop22h 47m

$675

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 4/21

10:30 am-7:15 am

1 stop18h 45m

Santiago Arturo Merino Benitez

Mon 5/4

10:55 pm-7:42 pm

1 stop22h 47m

$675

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Thu 4/2

9:00 pm-6:40 am

3 stops30h 40m

$334

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 19 results
1
2

Compare providers for flights from Denver to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Denver to Santiago in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Denver-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Denver-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Denver-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Denver-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Denver-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Denver to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Denver with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Denver to Santiago

How far ahead should I book a flight from Denver to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Denver to Santiago. Price data was last updated on January 23, 2026.

The price you pay for your flight from Denver to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Denver to Santiago?

Currently, July is the cheapest month in which you can book a flight from Denver to Santiago (average of $384). Flying from Denver to Santiago in December is currently the most expensive (average of $662). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated January 27, 2026.
Read reviews from past customers who have flown Delta, LATAM Airlines, and Copa Airlines from Denver to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,119 reviews

Comfort

7.9

Boarding

8.1

Food

7.2

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,119 reviews
Delta
7.9
Good
8,119 reviews

Comfort

7.9

Boarding

8.1

Food

7.2

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,912 reviews
Delta
7.9
Good
8,119 reviews

Comfort

7.9

Boarding

8.1

Food

7.2

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Copa Airlines
7.5
Good
1,560 reviews
Delta
7.9
Good
8,119 reviews

Comfort

7.9

Boarding

8.1

Food

7.2

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,206 reviews
Delta
7.9
Good
8,119 reviews

Comfort

7.9

Boarding

8.1

Food

7.2

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,198 reviews
Delta
7.9
Good
8,119 reviews

Comfort

7.9

Boarding

8.1

Food

7.2

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Denver to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Denver to Santiago?

    A quick flight from Denver to Santiago can take about 23h 15m. Delta provides one of the quickest options available for as low as $565. Denver and Santiago are separated by a distance of 5501 mi.

  • What are the cheapest airlines flying from Denver to Santiago round-trip?

    Currently priced at $369, Copa Airlines will fly you from Denver to Santiago and back. In addition to Copa Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and Delta - these airlines can fly you to your destination from $537 and $544, respectively. Copa Airlines is currently priced 54% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Denver to Santiago one-way?

    To fly one-way, consider booking your trip with LATAM Airlines, which is currently one of the cheapest options available, starting at $404. American Airlines flights start at $422 while deals on Delta start at $422 one-way.

  • Can I find deals for flights from Denver to Santiago that include hotel bookings?

    Yes. In addition to deals on Denver to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Denver to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Santiago.

  • Can I find deals for business class flights from Denver to Santiago?

    Yes. Cheapflights offers flight deals from Denver to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Denver to Santiago?

    Currently, July is the cheapest month in which you can book a flight from Denver to Santiago (average of $384). Flying from Denver to Santiago in December is currently the most expensive (average of $662). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Denver to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Grand Junction to Santiago flights
Montrose to Santiago flights

Top 6 airlines flying from Denver to Santiago

Discover the top 6 airlines that operate flights from Denver to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$369Average$638FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$537Average$753FlexibilityNo cancel feeOn-time81%
DeltaCheapest$544Average$823FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$551Average$798FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$613Average$854FlexibilityNo cancel feeOn-time71%
AeromexicoCheapest$823Average$1,249FlexibilityNo cancel feeOn-timeN/A

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