What are the cheapest airlines flying from Denver to Santiago round-trip?

Currently priced at $609, American Airlines will fly you from Denver to Santiago and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and Copa Airlines - these airlines can fly you to your destination from $654 and $752, respectively. American Airlines is currently priced 27% below the average price you’ll pay for this route.

What are the cheapest airlines to fly from Denver to Santiago one-way?

To fly one-way, consider booking your trip with LATAM Airlines, which is currently one of the cheapest options available, starting at $397. Delta flights start at $434 while deals on Copa Airlines start at $1,298 one-way.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

What are the most popular airlines that fly from Denver to Santiago?

Consider American Airlines, Aeromexico or Copa Airlines when booking your flight. These represent the most popular airlines when flying from Denver to Santiago.

What is the cheapest day to fly round-trip from Denver to Santiago?

Monday is generally a great day to depart. Flying on this day could help you save up to 29%.

How far in advance should I book a flight from Denver to Santiago?

Users have found that booking a flight from Denver to Santiago at least 60 days early can save you up to 37% on average compared to booking a flight this week. If booking 60 days before your flight isn’t an option for you, users have found flights from Denver to Santiago for as little as $842 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $857 for flights departing within the next 3 days.

What is the cheapest month to fly from Denver to Santiago?

April is one of the best times of the year to fly to Santiago from Denver. Prices for April average $843 per person but you can even find prices for as low as $622. The most expensive prices can be found in the month of December. Opting for a April flight can save you 47% on your journey compared to booking in December

Can I find deals for flights from Denver to Santiago that include hotel bookings?

Yes. In addition to deals on Denver to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Denver to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Santiago.

Can I find deals for business class flights from Denver to Santiago?

Yes. Cheapflights offers flight deals from Denver to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$339+ Flights from Denver to Santiago

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Cheapflights Tip: The best prices from Denver Intl to Santiago Arturo Merino Benitez are usually found in April or September, booked 63 days in advance, depart on a Tuesday or Monday and return on a Tuesday

Cheap flight deals from Denver to Santiago

Round-trip from	$609 (American Airlines)
One-way from	$339 (Kiwi.com)
Popular in	December
Cheapest in	April
Average price	$941

From Denver Intl to Santiago Arturo Merino Benitez

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One-way flight from Denver Intl to Santiago Arturo Merino Benitez

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Highest demand for flights based on searches. 12% potential increase in price ($117 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($37 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Denver to Santiago

Cheapest flights from Denver to Santiago
Explore the most affordable flight options available from Denver to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Thu 12/47:05 amDEN - SCL

2 stops18h 30mLATAM Airlines

Sun 12/1410:35 amSCL - DEN

2 stops17h 12mLATAM Airlines

Deal found 7/27

$548

Thu 12/42:51 pmDEN - SCL

1 stop12h 59mAmerican Airlines

Sun 12/1411:15 pmSCL - DEN

1 stop14h 09mAmerican Airlines

Deal found 7/28

$554

Sun 11/29:36 pmDEN - SCL

1 stop22h 05mCopa Airlines

Fri 11/71:29 amSCL - DEN

1 stop19h 48mCopa Airlines

Deal found 7/29

$572

Sat 9/66:55 pmDEN - SCL

2 stops31h 20mMultiple Airlines

Fri 9/197:10 amSCL - DEN

2 stops29h 05mMultiple Airlines

Deal found 7/29

$610

Best flights from Denver to Santiago
Discover carefully curated flight deals from Denver to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2025.

Tue 10/142:36 pmDEN - SCL

1 stop14h 24mAmerican Airlines

Tue 10/2810:15 pmSCL - DEN

1 stop16h 31mAmerican Airlines

Deal found 7/27

$609

Sat 9/66:55 pmDEN - SCL

2 stops31h 20mMultiple Airlines

Fri 9/197:10 amSCL - DEN

2 stops29h 05mMultiple Airlines

Deal found 7/29

$610

Mon 10/1312:50 amDEN - SCL

2 stops34h 40mLATAM Airlines

Tue 10/2811:15 pmSCL - DEN

1 stop21h 33mLATAM Airlines

Deal found 7/27

$654

Mon 9/810:47 pmDEN - SCL

1 stop21h 53mCopa Airlines

Sun 9/213:26 amSCL - DEN

1 stop17h 41mCopa Airlines

Deal found 7/29

$752

Last-minute flights from Denver to Santiago
Discover last-minute flight deals from Denver to Santiago. Data last updated July 29, 2025 and is based on user searches.

Wed 8/612:34 amDEN - SCL

2 stops19h 56mMultiple Airlines

Thu 8/2111:00 amSCL - DEN

1 stop23h 21mMultiple Airlines

Deal found 7/27

$744

Wed 8/612:15 pmDEN - SCL

2 stops16h 35mLATAM Airlines

Sun 8/2411:05 pmSCL - DEN

2 stops23h 11mLATAM Airlines

Deal found 7/27

$838

Thu 8/72:09 pmDEN - SCL

1 stop14h 46mAmerican Airlines

Thu 8/219:55 pmSCL - DEN

1 stop16h 13mAmerican Airlines

Deal found 7/27

$844

Thu 8/71:41 pmDEN - SCL

2 stops15h 04mDelta

Sat 8/2310:55 pmSCL - DEN

2 stops20h 25mDelta

Deal found 7/27

$903

Thu 8/710:47 pmDEN - SCL

1 stop18h 37mCopa Airlines

Sun 8/172:26 amSCL - DEN

1 stop17h 37mCopa Airlines

Deal found 7/28

$972

Mon 8/1112:34 amDEN - SCL

2 stops34h 51mMultiple Airlines

Wed 8/2011:00 amSCL - DEN

1 stop23h 21mMultiple Airlines

Deal found 7/28

$628

Thu 8/142:09 pmDEN - SCL

1 stop14h 46mAmerican Airlines

Thu 8/289:55 pmSCL - DEN

1 stop16h 13mAmerican Airlines

Deal found 7/28

$814

Thu 8/2110:47 pmDEN - SCL

1 stop18h 37mCopa Airlines

Thu 8/282:26 amSCL - DEN

1 stop17h 37mCopa Airlines

Deal found 7/28

$792

Thu 8/2812:32 pmDEN - SCL

1 stop15h 28mLATAM Airlines

Thu 9/410:45 pmSCL - DEN

1 stop21h 36mLATAM Airlines

Deal found 7/26

$725

Fri 8/299:36 amDEN - SCL

2 stops19h 14mDelta

Sat 9/610:55 pmSCL - DEN

2 stops20h 16mDelta

Deal found 7/28

$828

One-way flights from Denver to Santiago
Search for one-way flight options from Denver to Santiago. Find affordable one-way fares based on user searches. Data last updated July 29, 2025.

Sun 9/1412:04 amDEN - SCL

2 stops26h 11mMultiple Airlines

Deal found 7/28

$339

Tue 10/76:15 amDEN - SCL

1 stop20h 45mLATAM Airlines

Deal found 7/29

$397

Mon 10/612:50 amDEN - SCL

1 stop27h 10mDelta

Deal found 7/29

$434

Mon 8/1110:47 pmDEN - SCL

1 stop21h 57mCopa Airlines

Deal found 7/27

$1,298

Fly from

Fly to

Route

Depart

Return

Price

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 10/14

2:36 pm-8:00 am

1 stop14h 24m

Santiago Arturo Merino Benitez

Tue 10/28

10:15 pm-11:46 am

1 stop16h 31m

$609

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sat 9/6

6:55 pm-4:15 am

2 stops31h 20m

Santiago Arturo Merino Benitez

Fri 9/19

7:10 am-9:15 am

2 stops29h 05m

$610

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 10/13

12:50 am-2:30 pm

2 stops34h 40m

Santiago Arturo Merino Benitez

Tue 10/28

11:15 pm-5:48 pm

1 stop21h 33m

$654

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 9/8

10:47 pm-11:40 pm

1 stop21h 53m

Santiago Arturo Merino Benitez

Sun 9/21

3:26 am-6:07 pm

1 stop17h 41m

$752

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 9/14

12:04 am-5:15 am

2 stops26h 11m

$339

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 10/7

6:15 am-6:00 am

1 stop20h 45m

$397

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 10/6

12:50 am-7:00 am

1 stop27h 10m

$434

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 8/11

10:47 pm-10:44 pm

1 stop21h 57m

$1,298

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Denver to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Denver with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Denver to Santiago

How far ahead should I book a flight from Denver to Santiago?

The price you pay for your flight from Denver to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Denver to Santiago?

Currently, April is the cheapest month in which you can book a flight from Denver to Santiago (average of $752). Flying from Denver to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DEN to SCL?

When flying from Denver to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 17% versus a flight in the morning.

What is the cheapest day to fly from Denver to Santiago?

Travelers seeking maximum savings on their Denver to Santiago flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santiago

Read reviews from past customers who have flown Delta, LATAM Airlines, and Copa Airlines from Denver to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,977 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

LATAM Airlines

7.5

Good

1,821 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Copa Airlines

7.5

Good

1,493 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Denver to Santiago round-trip?
Currently priced at $609, American Airlines will fly you from Denver to Santiago and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and Copa Airlines - these airlines can fly you to your destination from $654 and $752, respectively. American Airlines is currently priced 27% below the average price you’ll pay for this route.
What are the cheapest airlines to fly from Denver to Santiago one-way?
To fly one-way, consider booking your trip with LATAM Airlines, which is currently one of the cheapest options available, starting at $397. Delta flights start at $434 while deals on Copa Airlines start at $1,298 one-way.
Can I find deals for flights from Denver to Santiago that include hotel bookings?
Yes. In addition to deals on Denver to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Denver to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Santiago.
Can I find deals for business class flights from Denver to Santiago?
Yes. Cheapflights offers flight deals from Denver to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Denver to Santiago?
Currently, April is the cheapest month in which you can book a flight from Denver to Santiago (average of $752). Flying from Denver to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Denver to Santiago

Denver to Punta Arenas flights

Denver to Easter Island flights

Montrose to Santiago flights

Denver to Temuco flights

Grand Junction to Santiago flights

Denver to La Serena flights

Other flights to Santiago

Top 6 airlines flying from Denver to Santiago

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$592	Average$817	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$602	Average$888	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$620	Average$713	FlexibilityNo cancel fee	On-time70%
LATAM Airlines	Cheapest$635	Average$860	FlexibilityNo cancel fee	On-time81%
Delta	Cheapest$752	Average$856	FlexibilityNo cancel fee	On-timeN/A
Aeromexico	Cheapest$803	Average$1,241	FlexibilityNo cancel fee	On-timeN/A

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$339+ Cheap flights from Denver (DEN) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/14. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Denver to Santiago with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Denver Intl to Santiago Arturo Merino Benitez are usually found in April or September, booked 63 days in advance, depart on a Tuesday or Monday and return on a Tuesday

Cheap flight deals from Denver to Santiago

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Denver to Santiago

Cheapest flights from Denver to SantiagoExplore the most affordable flight options available from Denver to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Explore the most affordable flight options available from Denver to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Denver to Santiago that are best for you.

Best time to book a flight from Denver to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Denver with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Denver to Santiago

How far ahead should I book a flight from Denver to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Denver to Santiago. Price data was last updated on July 25, 2025.

What is the cheapest month to book a flight from Denver to Santiago?

What is the cheapest time of day to fly from DEN to SCL?

Find hourly flight availability from Denver to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

What is the cheapest day to fly from Denver to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Denver to Santiago. Price data was last updated on December 16, 2024.

Reviews of airlines servicing Santiago

Read reviews from past customers who have flown Delta, LATAM Airlines, and Copa Airlines from Denver to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Denver to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Denver to Santiago round-trip?

What are the cheapest airlines to fly from Denver to Santiago one-way?

Can I find deals for flights from Denver to Santiago that include hotel bookings?

How can I find direct flights from Denver to Santiago?

Can I find deals for business class flights from Denver to Santiago?

What is the cheapest month to book a flight from Denver to Santiago?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Denver to Santiago

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from Denver to Santiago

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Cheapest flights from Denver to Santiago
Explore the most affordable flight options available from Denver to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.