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$310+ Cheap flights from Denver (DEN) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — SCL
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Find cheap flights from Denver to Santiago with Cheapflights

1. Tell us where you want to go

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Cheapflights Tip: The best prices from Denver Intl to Santiago Arturo Merino Benitez are usually found in September or October, booked 63 days in advance, depart on a Tuesday or Monday and return on a Tuesday

Cheap flight deals from Denver to Santiago

Cheapest flights from Denver to Santiago
Explore the most affordable flight options available from Denver to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:06 pmDEN - SCL
1 stop26h 29mMultiple Airlines
Mon 1/195:20 amSCL - DEN
2 stops42h 56mMultiple Airlines
Deal found 12/11$771
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:06 pmDEN - SCL
1 stop26h 29mMultiple Airlines
Sun 1/184:25 pmSCL - DEN
2 stops44h 24mMultiple Airlines
Deal found 12/11$794
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:06 pmDEN - SCL
1 stop26h 29mMultiple Airlines
Wed 1/219:05 pmSCL - DEN
2 stops27h 33mMultiple Airlines
Deal found 12/11$808
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/293:41 pmDEN - SCL
1 stop13h 09mUnited Airlines
Wed 1/2110:45 pmSCL - DEN
1 stop27h 21mUnited Airlines
Deal found 12/11$823
This Copa Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:36 pmDEN - SCL
1 stop22h 48mCopa Airlines
Tue 12/303:23 amSCL - DEN
1 stop17h 54mCopa Airlines
Deal found 12/10$852
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/293:41 pmDEN - SCL
1 stop13h 09mUnited Airlines
Sun 1/1810:45 pmSCL - DEN
1 stop28h 56mUnited Airlines
Deal found 12/11$854
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2910:54 amDEN - SCL
1 stop15h 16mDelta
Wed 1/218:50 pmSCL - DEN
2 stops25h 20mDelta
Deal found 12/11$864
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:06 pmDEN - SCL
1 stop26h 29mMultiple Airlines
Tue 1/2012:28 pmSCL - DEN
2 stops26h 53mMultiple Airlines
Deal found 12/11$866
This KAYAK deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:05 amDEN - SCL
3 stops26h 25mLATAM Airlines
Mon 1/199:30 pmSCL - DEN
1 stop16h 10mLATAM Airlines
Deal found 12/11$869
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2912:29 pmDEN - SCL
1 stop15h 01mMultiple Airlines
Sun 1/184:25 pmSCL - DEN
2 stops26h 56mMultiple Airlines
Deal found 12/11$908
This KAYAK deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:27 pmDEN - SCL
2 stops31h 08mLATAM Airlines
Mon 1/199:30 pmSCL - DEN
1 stop18h 40mLATAM Airlines
Deal found 12/11$910
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:06 pmDEN - SCL
1 stop26h 29mMultiple Airlines
Fri 1/169:05 pmSCL - DEN
2 stops19h 09mMultiple Airlines
Deal found 12/11$912

Find flight deals from Denver to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$532
(Copa Airlines)

One-way from

$310
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$1,152
Provider with most accurate pricing for Denver Intl-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Denver Intl-Santiago Arturo Merino Benitez flights.
Search Deals
From Denver Intl to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Denver Intl to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($108 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Denver to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Denver to Santiago that are best for you.

Fly from

Denver

Fly to

Santiago

Route

Depart

Return

Price

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 3/24

11:43 am-7:40 am

1 stop16h 57m

Santiago Arturo Merino Benitez

Wed 4/8

10:55 pm-7:36 pm

1 stop22h 41m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 3/23

6:00 am-7:40 am

1 stop22h 40m

Santiago Arturo Merino Benitez

Wed 4/8

7:45 pm-6:00 pm

2 stops24h 15m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 3/23

12:55 am-4:30 am

2 stops24h 35m

Santiago Arturo Merino Benitez

Thu 4/9

7:15 am-12:09 am

2 stops18h 54m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 3/24

6:00 am-4:30 am

2 stops19h 30m

Santiago Arturo Merino Benitez

Fri 4/3

7:45 pm-5:52 pm

2 stops25h 07m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Wed 3/25

3:05 pm-3:05 pm

2 stops21h 00m

Santiago Arturo Merino Benitez

Wed 4/8

10:55 pm-10:39 pm

1 stop25h 44m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 3/23

3:05 pm-7:40 am

1 stop13h 35m

Santiago Arturo Merino Benitez

Thu 4/9

7:45 am-12:09 am

2 stops18h 24m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Wed 3/25

3:05 pm-7:40 am

1 stop13h 35m

Santiago Arturo Merino Benitez

Fri 4/3

7:45 pm-5:52 pm

2 stops25h 07m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 3/22

1:15 pm-7:40 am

1 stop15h 25m

Santiago Arturo Merino Benitez

Wed 4/8

7:45 pm-7:36 pm

2 stops25h 51m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Thu 3/26

1:15 pm-7:40 am

1 stop15h 25m

Santiago Arturo Merino Benitez

Wed 4/8

10:55 pm-10:39 pm

1 stop25h 44m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Thu 3/26

7:05 am-7:00 am

2 stops20h 55m

Santiago Arturo Merino Benitez

Fri 4/3

7:45 pm-5:52 pm

2 stops25h 07m

$549

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 20 results
1
2

Compare providers for flights from Denver to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Denver to Santiago in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Denver-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Denver-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Denver-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Denver-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Denver-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Denver to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Denver with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Denver to Santiago

How far ahead should I book a flight from Denver to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Denver to Santiago. Price data was last updated on December 5, 2025.

The price you pay for your flight from Denver to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Denver to Santiago?

Currently, July is the cheapest month in which you can book a flight from Denver to Santiago (average of $384). Flying from Denver to Santiago in June is currently the most expensive (average of $698). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DEN to SCL?

Find hourly flight availability from Denver to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

When flying from Denver to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 16% versus a flight in the morning.

What is the cheapest day to fly from Denver to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Denver to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Denver to Santiago flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated December 12, 2025.
Read reviews from past customers who have flown Delta, Copa Airlines, and LATAM Airlines from Denver to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Copa Airlines
7.6
Good
1,558 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,887 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Denver to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Denver to Santiago?

    A quick flight from Denver to Santiago can take about 16h 57m. Delta provides one of the quickest options available for as low as $544. Denver and Santiago are separated by a distance of 5501 mi.

  • What are the cheapest airlines flying from Denver to Santiago round-trip?

    Currently priced at $369, Copa Airlines will fly you from Denver to Santiago and back. In addition to Copa Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and United Airlines - these airlines can fly you to your destination from $537 and $551, respectively. Copa Airlines is currently priced 54% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Denver to Santiago one-way?

    To fly one-way, consider booking your trip with LATAM Airlines, which is currently one of the cheapest options available, starting at $404. American Airlines flights start at $422 while deals on Delta start at $422 one-way.

  • Can I find deals for flights from Denver to Santiago that include hotel bookings?

    Yes. In addition to deals on Denver to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Denver to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Santiago.

  • Can I find deals for business class flights from Denver to Santiago?

    Yes. Cheapflights offers flight deals from Denver to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Denver to Santiago?

    Currently, July is the cheapest month in which you can book a flight from Denver to Santiago (average of $384). Flying from Denver to Santiago in June is currently the most expensive (average of $698). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Denver to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Denver to Punta Arenas flights
Montrose to Santiago flights
Grand Junction to Santiago flights
Denver to Easter Island flights
Denver to La Serena flights
Denver to Temuco flights

Top 6 airlines flying from Denver to Santiago

Discover the top 6 airlines that operate flights from Denver to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$551Average$748FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$562Average$778FlexibilityNo cancel feeOn-time81%
Copa AirlinesCheapest$575Average$638FlexibilityNo cancel feeOn-time70%
DeltaCheapest$623Average$844FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$626Average$838FlexibilityNo cancel feeOn-time71%
AeromexicoCheapest$823Average$1,249FlexibilityNo cancel feeOn-timeN/A

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