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$289+ Cheap flights from Denver (DEN) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/5. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — SCL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Denver Intl to Santiago Arturo Merino Benitez are usually found in October or April, booked 63 days in advance, depart on a Tuesday or Monday and return on a Tuesday

Cheap flight deals from Denver to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$544
(Delta)

One-way from

$289
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$752
From Denver Intl to Santiago Arturo Merino Benitez
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One-way flight from Denver Intl to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 13% potential increase in price ($128 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($40 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Denver to Santiago

Cheapest flights from Denver to Santiago
Explore the most affordable flight options available from Denver to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/32:49 pmDEN - SCL
1 stop13h 06mAmerican Airlines
Tue 2/310:15 pmSCL - DEN
1 stop16h 42mAmerican Airlines
Deal found 9/11$609
This FlightHub deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:25 amDEN - SCL
1 stop19h 35mLATAM Airlines
Wed 12/311:25 pmSCL - DEN
2 stops16h 46mLATAM Airlines
Deal found 9/9$631
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:55 pmDEN - SCL
2 stops24h 20mMultiple Airlines
Thu 10/911:00 amSCL - DEN
1 stop24h 33mMultiple Airlines
Deal found 9/11$639
This FlightHub deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/103:14 pmDEN - SCL
2 stops20h 16mLATAM Airlines
Mon 11/2411:55 pmSCL - DEN
1 stop15h 48mLATAM Airlines
Deal found 9/10$641
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:55 pmDEN - SCL
2 stops40h 50mMultiple Airlines
Wed 10/811:00 amSCL - DEN
1 stop24h 33mMultiple Airlines
Deal found 9/11$645
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:55 pmDEN - SCL
3 stops38h 25mMultiple Airlines
Thu 10/911:00 amSCL - DEN
1 stop24h 33mMultiple Airlines
Deal found 9/11$647
This FlightHub deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/123:14 pmDEN - SCL
2 stops20h 16mLATAM Airlines
Sun 11/2311:55 pmSCL - DEN
1 stop15h 48mLATAM Airlines
Deal found 9/11$650
This FlightHub deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:34 amDEN - SCL
1 stop16h 06mLATAM Airlines
Mon 11/2411:55 pmSCL - DEN
1 stop15h 48mLATAM Airlines
Deal found 9/9$651
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1912:34 amDEN - SCL
2 stops18h 41mMultiple Airlines
Thu 10/3010:50 amSCL - DEN
1 stop24h 43mMultiple Airlines
Deal found 9/9$652

Cheapflights Fare Finder

 
Customize your flight search to find flights from Denver to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Denver to Santiago that are best for you.

Fly from

Denver

Fly to

Santiago

Route

Depart

Return

Price

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 3/8

3:10 pm-3:30 pm

2 stops21h 20m

Santiago Arturo Merino Benitez

Thu 3/19

12:25 am-11:54 pm

2 stops26h 29m

$544

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sat 1/17

6:05 am-5:35 am

2 stops19h 30m

Santiago Arturo Merino Benitez

Sun 2/1

11:15 pm-3:07 pm

1 stop19h 52m

$548

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 3/8

12:00 pm-7:50 am

1 stop16h 50m

Santiago Arturo Merino Benitez

Wed 3/18

9:45 pm-5:54 pm

1 stop23h 09m

$554

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sat 1/17

3:09 pm-8:50 am

1 stop13h 41m

Santiago Arturo Merino Benitez

Wed 2/4

10:45 pm-10:00 am

1 stop15h 15m

$554

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 1/18

7:05 am-6:10 am

1 stop19h 05m

Santiago Arturo Merino Benitez

Mon 2/2

6:30 pm-9:38 am

2 stops19h 08m

$554

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Fri 1/16

7:05 am-7:00 am

1 stop19h 55m

Santiago Arturo Merino Benitez

Mon 2/2

6:30 pm-9:38 am

2 stops19h 08m

$554

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 3/10

3:10 pm-7:00 am

1 stop12h 50m

Santiago Arturo Merino Benitez

Thu 3/19

12:25 am-11:54 pm

2 stops26h 29m

$554

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 3/8

4:40 pm-3:30 pm

2 stops19h 50m

Santiago Arturo Merino Benitez

Mon 3/23

11:15 pm-3:07 pm

1 stop18h 52m

$554

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sat 1/17

7:05 am-5:35 am

2 stops18h 30m

Santiago Arturo Merino Benitez

Thu 2/5

10:35 am-11:54 pm

2 stops17h 19m

$558

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 1/18

7:05 am-5:35 am

2 stops18h 30m

Santiago Arturo Merino Benitez

Thu 2/5

10:35 am-11:54 pm

2 stops17h 19m

$558

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 15 results
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Best time to book a flight from Denver to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Denver with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Denver to Santiago

How far ahead should I book a flight from Denver to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Denver to Santiago. Price data was last updated on August 29, 2025.

The price you pay for your flight from Denver to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Denver to Santiago?

Currently, April is the cheapest month in which you can book a flight from Denver to Santiago (average of $752). Flying from Denver to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DEN to SCL?

Find hourly flight availability from Denver to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Denver to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 17% versus a flight in the morning.

What is the cheapest day to fly from Denver to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Denver to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Denver to Santiago flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown Delta, Copa Airlines, and LATAM Airlines from Denver to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.6
Good
1,531 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,847 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Denver to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Denver to Santiago?

    A quick flight from Denver to Santiago can take about 21h 20m. Delta provides one of the quickest options available for as low as $544. Denver and Santiago are separated by a distance of 5501 mi.

  • What are the cheapest airlines flying from Denver to Santiago round-trip?

    Currently priced at $553, United Airlines will fly you from Denver to Santiago and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and American Airlines - these airlines can fly you to your destination from $573 and $610, respectively. United Airlines is currently priced 34% below the average price you’ll pay for this route.

  • Can I find deals for flights from Denver to Santiago that include hotel bookings?

    Yes. In addition to deals on Denver to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Denver to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Santiago.

  • Can I find deals for business class flights from Denver to Santiago?

    Yes. Cheapflights offers flight deals from Denver to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Denver to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Denver to Santiago (average of $752). Flying from Denver to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Denver to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Denver to Punta Arenas flights
Denver to Easter Island flights
Montrose to Santiago flights
Denver to Temuco flights
Grand Junction to Santiago flights
Denver to La Serena flights

Top 6 airlines flying from Denver to Santiago

Discover the top 6 airlines that operate flights from Denver to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$553Average$845FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$573Average$857FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$610Average$889FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$620Average$704FlexibilityNo cancel feeOn-time70%
DeltaCheapest$653Average$855FlexibilityNo cancel feeOn-timeN/A
AeromexicoCheapest$803Average$1,249FlexibilityNo cancel feeOn-timeN/A

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