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$394+ Cheap flights from Knoxville to Santa Fe (TYS - SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAF
Ağu 16 — Ağu 231
Cmt 8/16
Cmt 8/23
1 adult, Economy
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Cheap flight deals from Knoxville to Santa Fe

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated Ağustos 11, 2025.

Round-trip from

$394
(American Airlines)

Popular in

March

Cheapest in

May

Average price

$369
From Knoxville McGhee Tyson to Santa Fe
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Highest demand for flights based on searches. 17% potential increase in price ($102 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($48 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Knoxville to Santa Fe

Cheapest flights from Knoxville to Santa Fe
Explore the most affordable flight options available from Knoxville to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Ağustos 11, 2025.

This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cmt 8/236:39 pmTYS - SAF
1 stop5h 20mAmerican Airlines
Sal 8/2611:42 amSAF - TYS
1 stop8h 03mAmerican Airlines
Deal found 8/9$394
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cum 11/144:27 pmTYS - SAF
1 stop7h 23mAmerican Airlines
Per 11/209:58 amSAF - TYS
1 stop5h 30mAmerican Airlines
Deal found 8/10$401
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cmt 8/237:20 amTYS - SAF
2 stops11h 49mUnited Airlines
Sal 8/2610:45 amSAF - TYS
2 stops9h 52mUnited Airlines
Deal found 8/9$465
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cum 11/144:55 pmTYS - SAF
1 stop23h 47mUnited Airlines
Per 11/207:00 amSAF - TYS
1 stop13h 19mUnited Airlines
Deal found 8/9$608
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cmt 10/46:24 pmTYS - SAF
1 stop5h 32mAmerican Airlines
Cmt 10/115:07 pmSAF - TYS
1 stop5h 16mAmerican Airlines
Deal found 8/10$682
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Per 11/275:40 amTYS - SAF
1 stop7h 31mAmerican Airlines
Paz 11/304:56 pmSAF - TYS
1 stop4h 56mAmerican Airlines
Deal found 8/10$727
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Paz 8/246:39 pmTYS - SAF
1 stop5h 14mAmerican Airlines
Per 8/286:15 amSAF - TYS
1 stop5h 21mAmerican Airlines
Deal found 8/9$764

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Ağustos 11, 2025.
Use the filters below to find and compare flights from Knoxville to Santa Fe that are best for you.

Fly from

Knoxville

Fly to

Santa Fe

Route

Depart

Return

Price

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Cmt 8/23

6:39 pm-9:59 pm

1 stop5h 20m

Santa Fe

Sal 8/26

11:42 am-9:45 pm

1 stop8h 03m

$394

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Cum 11/14

4:27 pm-9:50 pm

1 stop7h 23m

Santa Fe

Per 11/20

9:58 am-5:28 pm

1 stop5h 30m

$401

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Cmt 8/23

7:20 am-5:09 pm

2 stops11h 49m

Santa Fe

Sal 8/26

10:45 am-10:37 pm

2 stops9h 52m

$465

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Pzt 2/2

4:27 pm-7:55 pm

1 stop5h 28m

Santa Fe

Per 2/26

7:22 pm-8:27 am

2 stops11h 05m

$529

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Pzt 2/2

2:00 pm-9:54 pm

2 stops9h 54m

Santa Fe

Per 2/26

6:01 pm-1:18 pm

2 stops17h 17m

$563

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Cum 11/14

4:55 pm-2:42 pm

1 stop23h 47m

Santa Fe

Per 11/20

7:00 am-10:19 pm

1 stop13h 19m

$608

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Cmt 10/4

6:24 pm-9:56 pm

1 stop5h 32m

Santa Fe

Cmt 10/11

5:07 pm-12:23 am

1 stop5h 16m

$682

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Per 11/27

5:40 am-11:11 am

1 stop7h 31m

Santa Fe

Paz 11/30

4:56 pm-11:52 pm

1 stop4h 56m

$727

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/9

Best time to book a flight from Knoxville to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Fe

What is the cheapest month to book a flight from Knoxville to Santa Fe?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Fe (average of $372). Flying from Knoxville to Santa Fe in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Santa Fe?

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated Ağustos 11, 2025.
Read through reviews of airlines operating flights from Knoxville to Santa Fe, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,920 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Crew

8.1

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,920 reviews
United Airlines
7.4
Good
8,920 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Crew

8.1

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,920 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Crew

8.1

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What is the cheapest airline to fly from Knoxville to Santa Fe round-trip?

    Our cheapest airline available from Knoxville to Santa Fe is American Airlines. Our recent data shows that you can find tickets from as low as $394 on this airline. You may be able to fly from Knoxville to Santa Fe for 21% less than the average price by searching for this airline.

  • Can I find deals for flights from Knoxville to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Fe.

  • Can I find deals for business class flights from Knoxville to Santa Fe?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Fe?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Fe (average of $372). Flying from Knoxville to Santa Fe in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Knoxville to Santa Fe

Discover the top airline that operate flights from Knoxville to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Ağustos 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$444FlexibilityNo cancel feeOn-time71%

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