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$264+ Cheap flights from Knoxville to Santa Fe (TYS - SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/18. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAF
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Knoxville to Santa Fe

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$264
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$605
From Knoxville McGhee Tyson to Santa Fe
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Highest demand for flights based on searches. 17% potential increase in price ($107 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($48 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Knoxville to Santa Fe

Cheapest flights from Knoxville to Santa Fe
Explore the most affordable flight options available from Knoxville to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/186:39 pmTYS - SAF
1 stop5h 20mAmerican Airlines
Sat 8/236:15 amSAF - TYS
1 stop5h 23mAmerican Airlines
Deal found 7/27$264
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/232:30 pmTYS - SAF
2 stops9h 30mUnited Airlines
Sat 8/3010:45 amSAF - TYS
2 stops9h 52mUnited Airlines
Deal found 7/29$329

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Knoxville to Santa Fe that are best for you.

Fly from

Knoxville

Fly to

Santa Fe

Route

Depart

Return

Price

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Mon 8/18

6:39 pm-9:59 pm

1 stop5h 20m

Santa Fe

Sat 8/23

6:15 am-1:38 pm

1 stop5h 23m

$264

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sat 8/23

2:30 pm-10:00 pm

2 stops9h 30m

Santa Fe

Sat 8/30

10:45 am-10:37 pm

2 stops9h 52m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Best time to book a flight from Knoxville to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Fe

What is the cheapest month to book a flight from Knoxville to Santa Fe?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Fe (average of $372). Flying from Knoxville to Santa Fe in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated July 29, 2025.
Read through reviews of airlines operating flights from Knoxville to Santa Fe, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,893 reviews

Comfort

7.3

Boarding

7.7

Crew

8.1

Entertainment

7.1

Food

6.6

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,893 reviews
United Airlines
7.4
Good
8,893 reviews

Comfort

7.3

Boarding

7.7

Crew

8.1

Entertainment

7.1

Food

6.6

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,893 reviews

Comfort

7.3

Boarding

7.7

Crew

8.1

Entertainment

7.1

Food

6.6

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Santa Fe round-trip?

    Our cheapest airline available from Knoxville to Santa Fe is American Airlines. Our recent data shows that you can find tickets from as low as $264 on this airline. An additional option worth looking into is United Airlines, starting at $329. You may be able to fly from Knoxville to Santa Fe for 46% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Fe.

  • Can I find deals for business class flights from Knoxville to Santa Fe?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Fe?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Fe (average of $372). Flying from Knoxville to Santa Fe in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Top airline flying from Knoxville to Santa Fe

Discover the top airline that operate flights from Knoxville to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$444FlexibilityNo cancel feeOn-time71%

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