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$309+ Cheap flights from Knoxville to Santa Fe (TYS - SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAF
Mar 10 — Mar 171
Tue 3/10
Tue 3/17
1 adult, Economy
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Cheap flight deals from Knoxville to Santa Fe

Cheapest flights from Knoxville to Santa Fe
Explore the most affordable flight options available from Knoxville to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 8, 2026.

This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:40 am
TYS
-
SAF
1 stop5h 59m
American Airlines
Mon 3/24:15 pm
SAF
-
TYS
1 stop6h 13m
American Airlines
Deal found 2/7$309
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/204:29 pm
TYS
-
SAF
1 stop6h 40m
American Airlines
Tue 2/244:15 pm
SAF
-
TYS
1 stop5h 05m
American Airlines
Deal found 2/5$334
This American Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/215:40 am
TYS
-
SAF
1 stop5h 59m
American Airlines
Wed 2/256:42 pm
SAF
-
TYS
2 stops12h 00m
American Airlines
Deal found 2/6$344
This deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:40 am
TYS
-
SAF
1 stop5h 59m
American Airlines
Tue 4/74:09 pm
SAF
-
TYS
1 stop5h 47m
American Airlines
Deal found 2/7$350
This deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/35:40 am
TYS
-
SAF
1 stop5h 59m
American Airlines
Tue 4/74:09 pm
SAF
-
TYS
1 stop5h 47m
American Airlines
Deal found 2/7$382
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:30 pm
TYS
-
SAF
1 stop6h 43m
United Airlines
Sun 4/197:00 am
SAF
-
TYS
1 stop6h 06m
United Airlines
Deal found 2/5$465
This deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:40 am
TYS
-
SAF
1 stop5h 59m
American Airlines
Sun 4/54:15 pm
SAF
-
TYS
1 stop5h 36m
American Airlines
Deal found 2/7$488

Find flight deals from Knoxville to Santa Fe

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 8, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$309
(American Airlines)

Popular in

March

Cheapest in

May

Average price

$511
Provider with most accurate pricing for Knoxville McGhee Tyson-Santa Fe flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santa Fe flights.
Search Deals
From Knoxville McGhee Tyson to Santa Fe
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($72 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($46 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Fe that are best for you.

Fly from

Knoxville

Fly to

Santa Fe

Route

Depart

Return

Price

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Thu 2/26

5:40 am-9:39 am

1 stop5h 59m

Santa Fe

Mon 3/2

4:15 pm-12:28 am

1 stop6h 13m

$309

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Fri 2/20

4:29 pm-9:09 pm

1 stop6h 40m

Santa Fe

Tue 2/24

4:15 pm-11:20 pm

1 stop5h 05m

$334

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sat 2/21

5:40 am-9:39 am

1 stop5h 59m

Santa Fe

Wed 2/25

4:15 pm-12:28 am

1 stop6h 13m

$334

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Fri 4/3

5:40 am-9:39 am

1 stop5h 59m

Santa Fe

Tue 4/7

4:09 pm-11:56 pm

1 stop5h 47m

$382

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sat 4/4

5:40 am-9:39 am

1 stop5h 59m

Santa Fe

Mon 4/6

4:15 pm-11:51 pm

1 stop5h 36m

$382

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/6

Compare providers for flights from Knoxville to Santa Fe

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Fe in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santa Fe flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Fe flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Fe flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santa Fe flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Fe

What is the cheapest month to book a flight from Knoxville to Santa Fe?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Santa Fe (average of $138). Flying from Knoxville to Santa Fe in November is currently the most expensive (average of $282). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated February 8, 2026.
Read through reviews of airlines operating flights from Knoxville to Santa Fe, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,254 reviews

Food

6.4

Comfort

7.2

Entertainment

6.9

Boarding

7.5

Overall

7.2

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,254 reviews
American Airlines
7.2
Good
11,254 reviews

Food

6.4

Comfort

7.2

Entertainment

6.9

Boarding

7.5

Overall

7.2

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santa Fe?

    Airlines like American Airlines fly from Knoxville to Santa Fe in about 5h 59m. The time it takes to get you to your destination can typically vary by up to . The distance from Knoxville to Santa Fe is about 1236 mi.

  • What is the cheapest airline to fly from Knoxville to Santa Fe round-trip?

    Our cheapest airline available from Knoxville to Santa Fe is American Airlines. Our recent data shows that you can find tickets from as low as $264 on this airline. You may be able to fly from Knoxville to Santa Fe for 52% less than the average price by searching for this airline.

  • Can I find deals for flights from Knoxville to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Fe.

  • Can I find deals for business class flights from Knoxville to Santa Fe?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Fe?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Santa Fe (average of $138). Flying from Knoxville to Santa Fe in November is currently the most expensive (average of $282). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Knoxville to Santa Fe

Discover the top airline that operate flights from Knoxville to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$494FlexibilityNo cancel feeOn-time71%

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