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$244+ Cheap flights from Des Moines to Santa Fe (DSM - SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAF
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Des Moines to Santa Fe

Cheapest flights from Des Moines to Santa Fe
Explore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:30 amDSM - SAF
1 stop5h 09mUnited Airlines
Fri 12/266:02 pmSAF - DSM
1 stop4h 56mUnited Airlines
Deal found 12/10$304
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/275:30 amDSM - SAF
1 stop5h 09mUnited Airlines
Wed 12/316:02 pmSAF - DSM
1 stop4h 56mUnited Airlines
Deal found 12/11$780
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/275:07 amDSM - SAF
1 stop5h 28mAmerican Airlines
Wed 12/316:15 amSAF - DSM
1 stop5h 09mAmerican Airlines
Deal found 12/11$931
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:45 amDSM - SAF
2 stops10h 12mAmerican Airlines
Fri 12/263:27 pmSAF - DSM
2 stops7h 08mAmerican Airlines
Deal found 12/10$962

Find flight deals from Des Moines to Santa Fe

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$244
(American Airlines)

One-way from

$244
(American Airlines)

Popular in

July

Cheapest in

October

Average price

$528
Provider with most accurate pricing for Des Moines-Santa Fe flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santa Fe flights.
Search Deals
From Des Moines to Santa Fe
Search Deals
One-way flight from Des Moines to Santa Fe
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($125 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Fly from

Des Moines

Fly to

Santa Fe

Route

Depart

Return

Price

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Fri 1/9

4:00 pm-9:09 pm

1 stop6h 09m

Santa Fe

Wed 1/14

6:25 am-3:15 pm

1 stop7h 50m

$244

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sun 1/25

4:00 pm-9:09 pm

1 stop6h 09m

Santa Fe

Sun 2/1

3:23 pm-11:58 pm

1 stop7h 35m

$285

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Fri 1/9

4:00 pm-9:09 pm

1 stop6h 09m

Santa Fe

Sat 1/17

5:18 pm-11:23 pm

1 stop5h 05m

$289

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 1/24

4:00 pm-9:09 pm

1 stop6h 09m

Santa Fe

Sat 1/31

6:25 am-3:15 pm

1 stop7h 50m

$290

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 1/24

5:09 pm-8:47 pm

1 stop4h 38m

Santa Fe

Sat 1/31

6:05 pm-11:44 pm

1 stop4h 39m

$314

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 1/24

1:35 pm-4:56 pm

1 stop4h 21m

Santa Fe

Wed 1/28

1:16 pm-8:34 pm

1 stop6h 18m

$314

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 2/4

4:00 pm-9:09 pm

1 stop6h 09m

Santa Fe

Sun 2/8

3:23 pm-11:58 pm

1 stop7h 35m

$329

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sun 1/25

4:00 pm-9:09 pm

1 stop6h 09m

$244

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Fri 1/16

4:00 pm-9:09 pm

1 stop6h 09m

$300

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Fri 1/16

8:00 am-4:56 pm

2 stops9h 56m

$432

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 11 results
1
2

Compare providers for flights from Des Moines to Santa Fe

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Fe in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santa Fe flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Santa Fe flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Fe flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santa Fe flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santa Fe

What is the cheapest month to book a flight from Des Moines to Santa Fe?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Santa Fe (average of $220). Flying from Des Moines to Santa Fe in July is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated December 12, 2025.
See what other customers who have flown with United Airlines from Des Moines to Santa Fe have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,095 reviews

Food

6.6

Boarding

7.7

Entertainment

7.1

Overall

7.4

Comfort

7.3

Crew

8.1

Reviews

1 / 20
10.0
Excellent

Sunderesh,Dec 2025

AUS - EWR

Smooth flight from Austin to Newark. The crew was friendly.
United Airlines
7.4
Good
9,095 reviews
United Airlines
7.4
Good
9,095 reviews

Food

6.6

Boarding

7.7

Entertainment

7.1

Overall

7.4

Comfort

7.3

Crew

8.1

Reviews

1 / 20
10.0
Excellent

Sunderesh,Dec 2025

AUS - EWR

Smooth flight from Austin to Newark. The crew was friendly.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santa Fe?

    Airlines like American Airlines fly from Des Moines to Santa Fe in about 6h 09m. The time it takes to get you to your destination can typically vary by up to . There are 785 mi between Des Moines and Santa Fe.

  • What is the cheapest airline to fly from Des Moines to Santa Fe round-trip?

    United Airlines, at $249, was found to be the cheapest airline from Des Moines to Santa Fe.. United Airlines is 46% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Fe.

  • Can I find deals for business class flights from Des Moines to Santa Fe?

    Yes. Cheapflights offers flight deals from Des Moines to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Santa Fe?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Santa Fe (average of $220). Flying from Des Moines to Santa Fe in July is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Top airline flying from Des Moines to Santa Fe

Discover the top airline that operate flights from Des Moines to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$249Average$439FlexibilityNo cancel feeOn-time69%

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