HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Fe

$244+ Cheap flights from Des Moines to Santa Fe (DSM - SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAF
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Santa Fe with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Des Moines to Santa Fe

Cheapest flights from Des Moines to Santa Fe
Explore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/143:39 pmDSM - SAF
1 stop5h 42mAmerican Airlines
Mon 11/175:16 pmSAF - DSM
1 stop4h 43mAmerican Airlines
Deal found 10/28$274
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/295:14 pmDSM - SAF
1 stop5h 45mUnited Airlines
Sat 11/13:23 pmSAF - DSM
1 stop4h 22mUnited Airlines
Deal found 10/25$329
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/295:00 amDSM - SAF
2 stops10h 56mAmerican Airlines
Sat 11/17:15 amSAF - DSM
1 stop6h 48mAmerican Airlines
Deal found 10/25$339
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:00 amDSM - SAF
1 stop5h 28mAmerican Airlines
Thu 12/186:15 amSAF - DSM
1 stop7h 53mAmerican Airlines
Deal found 10/27$344
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:00 amDSM - SAF
1 stop5h 28mAmerican Airlines
Fri 12/193:27 pmSAF - DSM
1 stop8h 02mAmerican Airlines
Deal found 10/28$347
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/109:00 amDSM - SAF
1 stop6h 39mUnited Airlines
Wed 12/171:20 pmSAF - DSM
1 stop6h 28mUnited Airlines
Deal found 10/26$349
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/15:00 amDSM - SAF
2 stops10h 56mAmerican Airlines
Tue 11/45:16 pmSAF - DSM
1 stop4h 43mAmerican Airlines
Deal found 10/26$390
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:45 amDSM - SAF
1 stop17h 14mUnited Airlines
Thu 12/184:40 pmSAF - DSM
1 stop6h 18mUnited Airlines
Deal found 10/27$428
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/125:14 pmDSM - SAF
1 stop5h 45mUnited Airlines
Sun 11/166:00 pmSAF - DSM
1 stop4h 44mUnited Airlines
Deal found 10/28$435

Cheap flight deals from Des Moines to Santa Fe

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$244
(American Airlines)

Popular in

July

Cheapest in

November

Average price

$359
Provider with most accurate pricing for Des Moines-Santa Fe flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santa Fe flights.
Search Deals
From Des Moines to Santa Fe
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($118 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Fly from

Des Moines

Fly to

Santa Fe

Route

Depart

Return

Price

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 2/4

11:35 am-4:35 pm

1 stop6h 00m

Santa Fe

Sun 2/8

3:23 pm-11:58 pm

1 stop7h 35m

$244

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Fri 11/14

3:39 pm-8:21 pm

1 stop5h 42m

Santa Fe

Mon 11/17

5:16 pm-10:59 pm

1 stop4h 43m

$274

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 12/10

9:00 am-2:39 pm

1 stop6h 39m

Santa Fe

Wed 12/17

1:20 pm-8:48 pm

1 stop6h 28m

$349

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 4/4

5:21 am-9:26 am

1 stop5h 05m

Santa Fe

Wed 4/8

6:21 am-11:57 am

1 stop4h 36m

$349

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Thu 12/11

5:45 am-9:59 pm

1 stop17h 14m

Santa Fe

Thu 12/18

4:40 pm-11:58 pm

1 stop6h 18m

$428

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 11/12

5:14 pm-9:59 pm

1 stop5h 45m

Santa Fe

Sun 11/16

6:00 pm-11:44 pm

1 stop4h 44m

$435

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Tue 11/11

5:14 pm-4:57 pm

1 stop24h 43m

$377

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Compare providers for flights from Des Moines to Santa Fe

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Fe in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santa Fe flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Fe flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Fe flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santa Fe flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santa Fe

What is the cheapest month to book a flight from Des Moines to Santa Fe?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Santa Fe (average of $220). Flying from Des Moines to Santa Fe in July is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Santa Fe?

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated October 28, 2025.
See what other customers who have flown with United Airlines from Des Moines to Santa Fe have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,001 reviews

Boarding

7.7

Overall

7.4

Comfort

7.3

Food

6.6

Entertainment

7.1

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
9,001 reviews
United Airlines
7.4
Good
9,001 reviews

Boarding

7.7

Overall

7.4

Comfort

7.3

Food

6.6

Entertainment

7.1

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santa Fe?

    Airlines like American Airlines and United Airlines fly from Des Moines to Santa Fe in about 6h. The time it takes to get you to your destination can typically vary by up to 39m. There are 785 mi between Des Moines and Santa Fe. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Des Moines to Santa Fe round-trip?

    United Airlines, at $265, was found to be the cheapest airline from Des Moines to Santa Fe.. United Airlines is 43% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Fe.

  • Can I find deals for business class flights from Des Moines to Santa Fe?

    Yes. Cheapflights offers flight deals from Des Moines to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Santa Fe?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Santa Fe (average of $220). Flying from Des Moines to Santa Fe in July is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Des Moines to Santa Fe

Discover the top airline that operate flights from Des Moines to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$265Average$443FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.