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$244+ Cheap flights from Des Moines to Santa Fe (DSM - SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAF
ago. 3 — ago. 101
dom. 8/3
dom. 8/10
1 adult, Economy
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Cheap flight deals from Des Moines to Santa Fe

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated julio 29, 2025.

Round-trip from

$244
(American Airlines)

Popular in

July

Cheapest in

October

Average price

$644
From Des Moines to Santa Fe
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Highest demand for flights based on searches. 18% potential increase in price ($99 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Santa Fe

Cheapest flights from Des Moines to Santa Fe
Explore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 29, 2025.

This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/255:00 amDSM - SAF
1 stop5h 50mAmerican Airlines
sáb. 11/15:07 pmSAF - DSM
1 stop5h 09mAmerican Airlines
Deal found 7/28$244
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/136:00 amDSM - SAF
1 stop4h 24mUnited Airlines
mié. 10/151:23 pmSAF - DSM
1 stop5h 55mUnited Airlines
Deal found 7/28$472

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 29, 2025.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Fly from

Des Moines

Fly to

Santa Fe

Route

Depart

Return

Price

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

sáb. 10/25

5:00 am-9:50 am

1 stop5h 50m

Santa Fe

sáb. 11/1

5:07 pm-11:16 pm

1 stop5h 09m

$244

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

lun. 10/13

6:00 am-9:24 am

1 stop4h 24m

Santa Fe

mié. 10/15

1:23 pm-8:18 pm

1 stop5h 55m

$472

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

dom. 10/26

5:45 am-9:25 am

1 stop4h 40m

$256

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Des Moines to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santa Fe

What is the cheapest month to book a flight from Des Moines to Santa Fe?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Santa Fe (average of $372). Flying from Des Moines to Santa Fe in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated julio 29, 2025.
See what other customers who have flown with United Airlines and American Airlines from Des Moines to Santa Fe have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,899 reviews

Crew

8.1

Boarding

7.7

Entertainment

7.1

Comfort

7.3

Food

6.6

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,899 reviews
United Airlines
7.4
Good
8,899 reviews

Crew

8.1

Boarding

7.7

Entertainment

7.1

Comfort

7.3

Food

6.6

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,899 reviews

Crew

8.1

Boarding

7.7

Entertainment

7.1

Comfort

7.3

Food

6.6

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Santa Fe round-trip?

    American Airlines, at $244, was found to be the cheapest airline from Des Moines to Santa Fe. An alternate airline flying to your destination would be United Airlines. American Airlines is 45% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Fe.

  • Can I find deals for business class flights from Des Moines to Santa Fe?

    Yes. Cheapflights offers flight deals from Des Moines to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Santa Fe?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Santa Fe (average of $372). Flying from Des Moines to Santa Fe in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Top airline flying from Des Moines to Santa Fe

Discover the top airline that operate flights from Des Moines to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$270Average$451FlexibilityNo cancel feeOn-time69%

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