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$246+ Cheap flights from Des Moines to Santa Fe (DSM - SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAF
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Des Moines to Santa Fe

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$246
(American Airlines)

Popular in

July

Cheapest in

October

Average price

$350
From Des Moines to Santa Fe
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Highest demand for flights based on searches. 20% potential increase in price ($118 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Santa Fe

Cheapest flights from Des Moines to Santa Fe
Explore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/253:48 pmDSM - SAF
1 stop6h 13mAmerican Airlines
Sat 11/15:07 pmSAF - DSM
1 stop5h 09mAmerican Airlines
Deal found 9/10$246
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/245:15 pmDSM - SAF
1 stop5h 45mUnited Airlines
Sat 9/275:59 pmSAF - DSM
1 stop4h 57mUnited Airlines
Deal found 9/10$254
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:00 amDSM - SAF
1 stop4h 24mUnited Airlines
Sat 11/13:23 pmSAF - DSM
1 stop4h 22mUnited Airlines
Deal found 9/10$314
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:13 pmDSM - SAF
1 stop5h 50mUnited Airlines
Mon 9/291:23 pmSAF - DSM
1 stop5h 55mUnited Airlines
Deal found 9/10$324
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:00 amDSM - SAF
1 stop4h 24mUnited Airlines
Tue 10/75:59 pmSAF - DSM
1 stop4h 57mUnited Airlines
Deal found 9/11$329
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:30 amDSM - SAF
1 stop5h 09mUnited Airlines
Tue 1/66:05 pmSAF - DSM
1 stop4h 39mUnited Airlines
Deal found 9/11$338
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/194:09 pmDSM - SAF
1 stop6h 47mAmerican Airlines
Wed 9/247:15 amSAF - DSM
1 stop7h 09mAmerican Airlines
Deal found 9/10$345
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/293:48 pmDSM - SAF
1 stop7h 22mAmerican Airlines
Fri 10/314:36 pmSAF - DSM
1 stop20h 59mAmerican Airlines
Deal found 9/10$375

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Fly from

Des Moines

Fly to

Santa Fe

Route

Depart

Return

Price

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 9/24

5:15 pm-10:00 pm

1 stop5h 45m

Santa Fe

Sat 9/27

5:59 pm-11:56 pm

1 stop4h 57m

$254

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Fri 9/26

5:13 pm-10:03 pm

1 stop5h 50m

Santa Fe

Tue 9/30

5:59 pm-11:56 pm

1 stop4h 57m

$254

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 10/25

6:00 am-9:24 am

1 stop4h 24m

Santa Fe

Sat 11/1

3:23 pm-8:45 pm

1 stop4h 22m

$314

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Thu 9/25

5:13 pm-10:03 pm

1 stop5h 50m

Santa Fe

Mon 9/29

1:23 pm-8:18 pm

1 stop5h 55m

$324

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 10/1

6:00 am-9:24 am

1 stop4h 24m

Santa Fe

Tue 10/7

5:59 pm-11:56 pm

1 stop4h 57m

$329

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Tue 12/30

5:30 am-9:39 am

1 stop5h 09m

Santa Fe

Tue 1/6

6:05 pm-11:44 pm

1 stop4h 39m

$338

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 10/25

5:00 am-2:56 pm

2 stops10h 56m

Santa Fe

Sat 11/1

7:15 am-3:03 pm

1 stop6h 48m

$356

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 10/29

3:48 pm-10:10 pm

1 stop7h 22m

Santa Fe

Fri 10/31

4:36 pm-2:35 pm

1 stop20h 59m

$375

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Des Moines to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santa Fe

What is the cheapest month to book a flight from Des Moines to Santa Fe?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Santa Fe (average of $372). Flying from Des Moines to Santa Fe in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated September 11, 2025.
See what other customers who have flown with United Airlines from Des Moines to Santa Fe have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,937 reviews

Entertainment

7.1

Food

6.6

Boarding

7.7

Comfort

7.3

Overall

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,937 reviews
United Airlines
7.4
Good
8,937 reviews

Entertainment

7.1

Food

6.6

Boarding

7.7

Comfort

7.3

Overall

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santa Fe?

    Airlines like United Airlines fly from Des Moines to Santa Fe in about 5h 45m. The time it takes to get you to your destination can typically vary by up to . There are 785 mi between Des Moines and Santa Fe.

  • What is the cheapest airline to fly from Des Moines to Santa Fe round-trip?

    United Airlines, at $289, was found to be the cheapest airline from Des Moines to Santa Fe.. United Airlines is 38% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Fe.

  • Can I find deals for business class flights from Des Moines to Santa Fe?

    Yes. Cheapflights offers flight deals from Des Moines to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Santa Fe?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Santa Fe (average of $372). Flying from Des Moines to Santa Fe in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Top airline flying from Des Moines to Santa Fe

Discover the top airline that operate flights from Des Moines to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$289Average$440FlexibilityNo cancel feeOn-time69%

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