What is the cheapest airline to fly from Santo Domingo to Santa Cruz de la Sierra round-trip?

Copa Airlines, at $1,228, was found to be the cheapest airline from Santo Domingo to Santa Cruz de la Sierra..

What is the cheapest day to fly from Santo Domingo to Santa Cruz de la Sierra?

Travelers seeking maximum savings on their Santo Domingo to Santa Cruz de la Sierra flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Santo Domingo to Santa Cruz de la Sierra?

Travelers have found that booking a Sunday departure is the best way to save up to 33% on the cost of booking your flights compared to booking on days of the week where this route is of high demand.

What is the cheapest month to fly from Santo Domingo to Santa Cruz de la Sierra?

April can be a great time to fly to Santa Cruz de la Sierra from Santo Domingo with a flight ticket averaging about $669. Cheapflights users have found deals in the month of April for as cheap as $293. The most expensive prices can be found in the month of August.

What is the cheapest time of day to fly from SDQ to VVI?

Unlike in the morning, when flights are generally more expensive, you can save up to 31% on flights from Santo Domingo to Santa Cruz de la Sierra by exploring options for tickets at noon.

How can I find direct flights from Santo Domingo to Santa Cruz de la Sierra?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Santa Cruz de la Sierra.

Can I find deals for business class flights from Santo Domingo to Santa Cruz de la Sierra?

Yes. Cheapflights offers flight deals from Santo Domingo to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$312+ Flights from Santo Domingo to Santa Cruz de la Sierra

Q: How far in advance should I book a flight from Santo Domingo to Santa Cruz de la Sierra?

To save on the cost of your flight from Santo Domingo to Santa Cruz de la Sierra, book at least 29 days before your planned departure. Booking around this time can save you about 108% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $623 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $800.

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Find cheap flights from Santo Domingo to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Santo Domingo Las Americas to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or October, booked 29 days in advance, depart on a Monday or Wednesday and return on a Tuesday

Cheap flight deals from Santo Domingo to Santa Cruz de la Sierra

Round-trip from	$1,228 (Copa Airlines)
One-way from	$312 (FlightHub)
Popular in	August
Cheapest in	April
Average price	$766

From Santo Domingo Las Americas to Santa Cruz de la Sierra Viru Viru Intl

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One-way flight from Santo Domingo Las Americas to Santa Cruz de la Sierra Viru Viru Intl

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Highest demand for flights based on searches. 9% potential increase in price ($73 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($14 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from Santo Domingo to Santa Cruz de la Sierra

Cheapest flights from Santo Domingo to Santa Cruz de la Sierra
Explore the most affordable flight options available from Santo Domingo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 30, 2025.

Tue 7/15:23 amSDQ - VVI

1 stop16h 56mCopa Airlines

Wed 7/3012:15 pmVVI - SDQ

1 stop10h 12mCopa Airlines

Deal found 6/30

$666

Best flights from Santo Domingo to Santa Cruz de la Sierra
Discover carefully curated flight deals from Santo Domingo to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 30, 2025.

Thu 7/178:55 amSDQ - VVI

1 stop13h 24mCopa Airlines

Mon 7/2112:15 pmVVI - SDQ

1 stop14h 30mCopa Airlines

Deal found 6/28

$1,228

Last-minute flights from Santo Domingo to Santa Cruz de la Sierra
Discover last-minute flight deals from Santo Domingo to Santa Cruz de la Sierra. Data last updated June 30, 2025 and is based on user searches.

Tue 7/15:23 amSDQ - VVI

1 stop16h 56mCopa Airlines

Wed 7/3012:15 pmVVI - SDQ

1 stop10h 12mCopa Airlines

Deal found 6/30

$666

One-way flights from Santo Domingo to Santa Cruz de la Sierra
Search for one-way flight options from Santo Domingo to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated June 30, 2025.

Sun 7/136:10 pmSDQ - VVI

1 stop7h 40mAvianca

Deal found 6/27

$312

Tue 7/229:30 pmSDQ - VVI

1 stop31h 05mMultiple Airlines

Deal found 6/30

$385

Fri 7/255:39 pmSDQ - VVI

1 stop28h 40mCopa Airlines

Deal found 6/30

$753

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Thu 7/17

8:55 am-10:19 pm

1 stop13h 24m

Santa Cruz de la Sierra Viru Viru Intl

Mon 7/21

12:15 pm-2:45 am

1 stop14h 30m

$1,228

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Sun 7/13

6:10 pm-1:50 am

1 stop7h 40m

$312

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Tue 7/22

9:30 pm-4:35 am

1 stop31h 05m

$385

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Fri 7/25

5:39 pm-10:19 pm

1 stop28h 40m

$753

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/27

Best time to book a flight from Santo Domingo to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Santo Domingo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Santa Cruz de la Sierra

How far ahead should I book a flight from Santo Domingo to Santa Cruz de la Sierra?

The price you pay for your flight from Santo Domingo to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 28 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santo Domingo to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Santa Cruz de la Sierra (average of $597). Flying from Santo Domingo to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Cruz de la Sierra

See what other customers who have flown with Copa Airlines and Avianca from Santo Domingo to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.5

Good

1,465 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Copa Airlines

7.5

Good

1,465 reviews

Copa Airlines

7.5

Good

1,465 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Avianca

6.7

Okay

2,359 reviews

Copa Airlines

7.5

Good

1,465 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Related info for your journey

What is the cheapest airline to fly from Santo Domingo to Santa Cruz de la Sierra round-trip?
Copa Airlines, at $1,228, was found to be the cheapest airline from Santo Domingo to Santa Cruz de la Sierra..
Can I find deals for flights from Santo Domingo to Santa Cruz de la Sierra that include hotel bookings?
Yes. In addition to deals on Santo Domingo to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santo Domingo to Santa Cruz de la Sierra?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Santa Cruz de la Sierra.
Can I find deals for business class flights from Santo Domingo to Santa Cruz de la Sierra?
Yes. Cheapflights offers flight deals from Santo Domingo to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santo Domingo to Santa Cruz de la Sierra?
Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Santa Cruz de la Sierra (average of $597). Flying from Santo Domingo to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Complete your trip

Santa Cruz de la Sierra car rentals

Santa Cruz de la Sierra Viru Viru Intl Airport car rentals

Cochabamba car rentals

Top 2 airlines flying from Santo Domingo to Santa Cruz de la Sierra

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$505	Average$612	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$810	Average$857	FlexibilityNo cancel fee	On-time70%

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$312+ Cheap flights from Santo Domingo (SDQ) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/13. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santo Domingo to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Santo Domingo Las Americas to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or October, booked 29 days in advance, depart on a Monday or Wednesday and return on a Tuesday

Cheap flight deals from Santo Domingo to Santa Cruz de la Sierra

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Santo Domingo to Santa Cruz de la Sierra

Cheapest flights from Santo Domingo to Santa Cruz de la SierraExplore the most affordable flight options available from Santo Domingo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 30, 2025.

Explore the most affordable flight options available from Santo Domingo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 30, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Santa Cruz de la Sierra that are best for you.

Best time to book a flight from Santo Domingo to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Santo Domingo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Santa Cruz de la Sierra

How far ahead should I book a flight from Santo Domingo to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Santa Cruz de la Sierra. Price data was last updated on June 27, 2025.

What is the cheapest month to book a flight from Santo Domingo to Santa Cruz de la Sierra?

Reviews of airlines servicing Santa Cruz de la Sierra

See what other customers who have flown with Copa Airlines and Avianca from Santo Domingo to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What is the cheapest airline to fly from Santo Domingo to Santa Cruz de la Sierra round-trip?

Can I find deals for flights from Santo Domingo to Santa Cruz de la Sierra that include hotel bookings?

How can I find direct flights from Santo Domingo to Santa Cruz de la Sierra?

Can I find deals for business class flights from Santo Domingo to Santa Cruz de la Sierra?

What is the cheapest month to book a flight from Santo Domingo to Santa Cruz de la Sierra?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.

Top 2 airlines flying from Santo Domingo to Santa Cruz de la Sierra

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Santo Domingo to Santa Cruz de la Sierra
Explore the most affordable flight options available from Santo Domingo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 30, 2025.