$505+ Cheap flights from Santa Cruz de la Sierra (VVI) to Santo Domingo (SDQ)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
VVI — SDQ
Sep 19 — Sep 261
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Santa Cruz de la Sierra to Santo Domingo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Cruz de la Sierra to Santo Domingo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Santa Cruz de la Sierra to Santo DomingoExplore the most affordable flight options available from Santa Cruz de la Sierra to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2026.
Explore the most affordable flight options available from Santa Cruz de la Sierra to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:12 am -
1 stop21h 44m
Mon 9/2812:42 pm -
1 stop14h 56m
Deal found 8/19![Copa Airlines logo]()
$918
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:47 am -
1 stop11h 09m
Mon 9/1412:41 pm -
2 stops37h 49m
Deal found 8/18![Multiple Airlines logo]()
$934
This Copa Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/271:08 am -
1 stop15h 04m
Sat 12/1212:43 pm -
1 stop10h 05m
Deal found 8/17![Copa Airlines logo]()
$935
This Copa Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/191:10 am -
1 stop12h 04m
Sat 1/27:05 pm -
1 stop27h 41m
Deal found 8/17![Copa Airlines logo]()
$1,034
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/201:12 am -
2 stops22h 45m
Sun 8/236:42 pm -
1 stop8h 53m
Deal found 8/17![Multiple Airlines logo]()
$1,043
This FlightHub deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/53:35 am -
1 stop14h 20m
Wed 10/1412:45 pm -
2 stops15h 45m
Deal found 8/17![Multiple Airlines logo]()
$1,113
This FlightHub deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/163:35 am -
1 stop14h 20m
Wed 10/1412:45 pm -
2 stops15h 45m
Deal found 8/16![Multiple Airlines logo]()
$1,144
Best flights from Santa Cruz de la Sierra to Santo DomingoDiscover carefully curated flight deals from Santa Cruz de la Sierra to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2026.
Discover carefully curated flight deals from Santa Cruz de la Sierra to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:47 am -
1 stop23h 55m
Thu 11/512:45 pm -
1 stop9h 53m
Deal found 8/19![Copa Airlines logo]()
$918
This Mytrip deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/89:05 pm -
3 stops27h 40m
Mon 9/146:50 pm -
1 stop7h 40m
Deal found 8/18![Multiple Airlines logo]()
$1,066
This Copa Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:12 am -
1 stop10h 30m
Tue 9/156:06 am -
1 stop16h 38m
Deal found 8/19![Copa Airlines logo]()
$918
This Copa Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:12 am -
1 stop21h 44m
Mon 9/2812:42 pm -
1 stop14h 56m
Deal found 8/19![Copa Airlines logo]()
$918
This Copa Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:47 am -
1 stop11h 09m
Mon 9/1412:12 pm -
1 stop15h 26m
Deal found 8/18![Copa Airlines logo]()
$918
This Copa Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/611:47 am -
1 stop23h 07m
Wed 10/1412:12 pm -
1 stop10h 32m
Deal found 8/17![Copa Airlines logo]()
$918
This Copa Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2811:49 am -
1 stop11h 09m
Sat 12/128:55 am -
1 stop13h 53m
Deal found 8/19![Copa Airlines logo]()
$935
This Copa Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/191:10 am -
1 stop12h 04m
Sat 1/27:05 pm -
1 stop27h 41m
Deal found 8/17![Copa Airlines logo]()
$1,034
Last-minute flights from Santa Cruz de la Sierra to Santo DomingoDiscover last-minute flight deals from Santa Cruz de la Sierra to Santo Domingo. Data last updated August 20, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Cruz de la Sierra to Santo Domingo. Data last updated August 20, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/201:12 am -
2 stops22h 45m
Sun 8/236:42 pm -
1 stop8h 53m
Deal found 8/17![Multiple Airlines logo]()
$1,043
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/711:47 am -
2 stops48h 08m
Fri 9/186:00 am -
2 stops40h 44m
Deal found 8/19![United Airlines logo]()
$6,805
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/711:47 am -
2 stops50h 23m
Sun 9/136:00 am -
2 stops40h 44m
Deal found 8/19![United Airlines logo]()
$6,871
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:47 am -
1 stop11h 09m
Mon 9/1412:41 pm -
2 stops37h 49m
Deal found 8/18![Multiple Airlines logo]()
$934
This Copa Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:12 am -
1 stop21h 44m
Mon 9/2812:42 pm -
1 stop14h 56m
Deal found 8/19![Copa Airlines logo]()
$918
One-way flights from Santa Cruz de la Sierra to Santo DomingoSearch for one-way flight options from Santa Cruz de la Sierra to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated August 20, 2026.
Search for one-way flight options from Santa Cruz de la Sierra to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated August 20, 2026.
This Avianca deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:35 am -
1 stop8h 15m
Deal found 8/15![Avianca logo]()
$505
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:35 am -
3 stops31h 20m
Deal found 8/15![Multiple Airlines logo]()
$539
Find flight deals from Santa Cruz de la Sierra to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from Santa Cruz de la Sierra (VVI) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $918 (Copa Airlines) |
One-way from | $505 (Avianca) |
Popular in | November |
Cheapest in | May |
Average price | $879 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Cruz de la Sierra to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 20, 2026.
Use the filters below to find and compare flights from Santa Cruz de la Sierra to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santa Cruz de la SierraSanto Domingo
VVI Santa Cruz de la Sierra Viru Viru Intl - SDQ Santo Domingo Las Americas
VVISDQ
Santa Cruz de la Sierra Viru Viru Intl
Thu 9/10
11:47 am-11:42 am
1 stop23h 55m
Santo Domingo Las Americas
Thu 11/5
12:45 pm-10:38 pm
1 stop9h 53m
$918
Santa Cruz de la SierraSanto Domingo
VVI Santa Cruz de la Sierra Viru Viru Intl - SDQ Santo Domingo Las Americas
VVISDQ
Santa Cruz de la Sierra Viru Viru Intl
Wed 9/2
1:12 am-11:42 am
1 stop10h 30m
Santo Domingo Las Americas
Tue 9/15
6:06 am-10:44 pm
1 stop16h 38m
$918
Santa Cruz de la SierraSanto Domingo
VVI Santa Cruz de la Sierra Viru Viru Intl - SDQ Santo Domingo Las Americas
VVISDQ
Santa Cruz de la Sierra Viru Viru Intl
Sun 9/20
1:12 am-10:56 pm
1 stop21h 44m
Santo Domingo Las Americas
Mon 9/28
12:42 pm-3:38 am
1 stop14h 56m
$918
Santa Cruz de la SierraSanto Domingo
VVI Santa Cruz de la Sierra Viru Viru Intl - SDQ Santo Domingo Las Americas
VVISDQ
Santa Cruz de la Sierra Viru Viru Intl
Tue 9/8
11:47 am-10:56 pm
1 stop11h 09m
Santo Domingo Las Americas
Mon 9/14
12:12 pm-3:38 am
1 stop15h 26m
$918
Santa Cruz de la SierraSanto Domingo
VVI Santa Cruz de la Sierra Viru Viru Intl - SDQ Santo Domingo Las Americas
VVISDQ
Santa Cruz de la Sierra Viru Viru Intl
Tue 10/6
11:47 am-10:54 am
1 stop23h 07m
Santo Domingo Las Americas
Wed 10/14
12:12 pm-10:44 pm
1 stop10h 32m
$918
Quickest round-trip
Santa Cruz de la SierraSanto Domingo
VVI Santa Cruz de la Sierra Viru Viru Intl - SDQ Santo Domingo Las Americas
VVISDQ
Santa Cruz de la Sierra Viru Viru Intl
Sat 11/28
11:49 am-10:58 pm
1 stop11h 09m
Santo Domingo Las Americas
Sat 12/12
8:55 am-10:48 pm
1 stop13h 53m
$935
Santa Cruz de la SierraSanto Domingo
VVI Santa Cruz de la Sierra Viru Viru Intl - SDQ Santo Domingo Las Americas
VVISDQ
Santa Cruz de la Sierra Viru Viru Intl
Sat 12/19
1:10 am-1:14 pm
1 stop12h 04m
Santo Domingo Las Americas
Sat 1/2
7:05 pm-10:46 pm
1 stop27h 41m
$1,034
Santa Cruz de la SierraSanto Domingo
VVI Santa Cruz de la Sierra Viru Viru Intl - SDQ Santo Domingo Las Americas
VVISDQ
Santa Cruz de la Sierra Viru Viru Intl
Tue 9/8
9:05 pm-12:45 am
3 stops27h 40m
Santo Domingo Las Americas
Mon 9/14
6:50 pm-2:30 am
1 stop7h 40m
$1,066
Cheapest one-way
Quickest one-way
Santa Cruz de la SierraSanto Domingo
VVI Santa Cruz de la Sierra Viru Viru Intl - SDQ Santo Domingo Las Americas
VVISDQ
Santa Cruz de la Sierra Viru Viru Intl
Thu 9/10
3:35 am-11:50 am
1 stop8h 15m
$505
Santa Cruz de la SierraSanto Domingo
VVI Santa Cruz de la Sierra Viru Viru Intl - SDQ Santo Domingo Las Americas
VVISDQ
Santa Cruz de la Sierra Viru Viru Intl
Thu 9/10
3:35 am-10:55 am
3 stops31h 20m
$539
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Santa Cruz de la Sierra-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Cruz de la Sierra-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Cruz de la Sierra-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Cruz de la Sierra-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Cruz de la Sierra-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Cruz de la Sierra to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Santa Cruz de la Sierra with our price prediction graph.
VVI-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santa Cruz de la Sierra to Santo Domingo
What is the cheapest month to book a flight from Santa Cruz de la Sierra to Santo Domingo?
Currently, May is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to Santo Domingo (average of $706). Flying from Santa Cruz de la Sierra to Santo Domingo in November is currently the most expensive (average of $1,034). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santa Cruz de la Sierra to Santo Domingo?
Airfare is above average for this route at the moment.
Santa Cruz de la Sierra to Santo Domingo flights typically cost between $722 and $881 in September.The cheapest round-trip price found within the last 5 days was $918 on Copa Airlines (Sep 20-Sep 28).
Reviews of airlines servicing Santo Domingo
Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated August 20, 2026.
Read reviews from past customers who have flown Copa Airlines and Avianca from Santa Cruz de la Sierra to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Comfort
7.4
Entertainment
6.8
Overall
7.6
Food
6.9
Crew
8.1
Reviews
1 / 20
4.0
OkayAnonymous,Jan 2025
PTY - ORD
Boarding
7.8
Comfort
7.4
Entertainment
6.8
Overall
7.6
Food
6.9
Crew
8.1
Reviews
1 / 20
4.0
OkayAnonymous,Jan 2025
PTY - ORD
Boarding
7.8
Comfort
7.4
Entertainment
6.8
Overall
7.6
Food
6.9
Crew
8.1
Reviews
1 / 20
4.0
OkayAnonymous,Jan 2025
PTY - ORD
Related info for your journey
Find useful and relevant information for your journey from Santa Cruz de la Sierra to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Santo Domingo flight routes
Complete your trip
Complete your trip to Santo Domingo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Santa Cruz de la Sierra to Santo Domingo by cabin class
Find flights from Santa Cruz de la Sierra to Santo Domingo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Santa Cruz de la Sierra and Santo Domingo flights
Browse other Santa Cruz de la Sierra and Santo Domingo flight options. Last updated on August 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santo Domingo
Explore flights to Santo Domingo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 20, 2026.
Top 2 airlines flying from Santa Cruz de la Sierra to Santo Domingo
Discover the top 2 airlines that operate flights from Santa Cruz de la Sierra to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$463 | Average$807 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$729 | Average$751 | FlexibilityNo cancel fee | On-time71% |