$135+ Cheap flights from Panama City, FL to San Francisco (ECP - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/27. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SFO
ago. 12 — ago. 191
1 adult, Economy
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 7, 2025.
Round-trip from | $269 (Delta) |
|---|---|
One-way from | $259 (American Airlines) |
Popular in | May |
Cheapest in | April |
Average price | $498 |
Find flight deals from Panama City to San Francisco
Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 7, 2025.
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 7, 2025.
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/96:17 pmECP - SFO
1 stop7h 39mDelta
mar. 1/208:00 amSFO - ECP
1 stop7h 52mDelta
Deal found 8/7![Delta logo]()
$269
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/811:28 amECP - SFO
2 stops12h 15mAmerican Airlines
mar. 1/206:10 amSFO - ECP
1 stop6h 09mAmerican Airlines
Deal found 8/6![American Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/412:00 pmECP - SFO
2 stops10h 28mAmerican Airlines
sáb. 11/88:20 amSFO - ECP
2 stops9h 20mAmerican Airlines
Deal found 8/6![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/177:00 amECP - SFO
2 stops10h 55mSouthwest
lun. 9/227:45 pmSFO - ECP
2 stops14h 45mSouthwest
Deal found 8/6![Southwest logo]()
$286
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/64:25 pmECP - SFO
1 stop8h 06mDelta
sáb. 1/179:30 pmSFO - ECP
1 stop8h 50mDelta
Deal found 8/7![Delta logo]()
$287
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/94:25 pmECP - SFO
1 stop9h 31mDelta
mié. 1/214:15 pmSFO - ECP
2 stops14h 05mDelta
Deal found 8/7![Delta logo]()
$299
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/64:25 pmECP - SFO
1 stop9h 31mDelta
jue. 1/222:00 pmSFO - ECP
1 stop6h 42mDelta
Deal found 8/6![Delta logo]()
$305
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/196:54 pmECP - SFO
1 stop7h 03mDelta
jue. 9/257:25 amSFO - ECP
1 stop8h 31mDelta
Deal found 8/6![Delta logo]()
$306
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/76:00 amECP - SFO
2 stops12h 02mDelta
lun. 1/196:00 amSFO - ECP
1 stop7h 17mDelta
Deal found 8/6![Delta logo]()
$307
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/205:02 pmECP - SFO
2 stops16h 48mDelta
lun. 9/2210:50 pmSFO - ECP
1 stop9h 05mDelta
Deal found 8/6![Delta logo]()
$308
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/177:16 pmECP - SFO
1 stop7h 01mAmerican Airlines
mar. 10/218:30 amSFO - ECP
2 stops9h 02mAmerican Airlines
Deal found 8/5![American Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/94:25 pmECP - SFO
1 stop9h 31mDelta
lun. 1/196:05 amSFO - ECP
2 stops14h 37mDelta
Deal found 8/7![Delta logo]()
$312
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 7, 2025.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.
Fly from
Panama City
Fly to
San Francisco
Route
Depart
Return
Price
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
jue. 10/9
6:17 pm-11:56 pm
1 stop7h 39m
San Francisco
mar. 1/20
8:00 am-5:52 pm
1 stop7h 52m
$269
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
mié. 10/8
11:28 am-9:43 pm
2 stops12h 15m
San Francisco
mar. 1/20
6:10 am-2:19 pm
1 stop6h 09m
$274
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
mar. 11/4
12:00 pm-8:28 pm
2 stops10h 28m
San Francisco
sáb. 11/8
8:20 am-7:40 pm
2 stops9h 20m
$279
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
mié. 9/17
7:00 am-3:55 pm
2 stops10h 55m
San Francisco
lun. 9/22
7:45 pm-12:30 pm
2 stops14h 45m
$286
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
lun. 10/6
4:25 pm-10:31 pm
1 stop8h 06m
San Francisco
sáb. 1/17
9:30 pm-8:20 am
1 stop8h 50m
$287
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
jue. 10/9
4:25 pm-11:56 pm
1 stop9h 31m
San Francisco
jue. 1/22
6:00 am-10:42 pm
2 stops14h 42m
$299
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
lun. 10/6
4:25 pm-11:56 pm
1 stop9h 31m
San Francisco
jue. 1/22
2:00 pm-10:42 pm
1 stop6h 42m
$305
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
vie. 9/19
6:54 pm-11:57 pm
1 stop7h 03m
San Francisco
sáb. 9/20
1:44 pm-11:03 pm
1 stop7h 19m
$306
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
mar. 10/7
6:00 am-4:02 pm
2 stops12h 02m
San Francisco
lun. 1/19
6:00 am-3:17 pm
1 stop7h 17m
$307
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
sáb. 9/20
5:02 pm-7:50 am
2 stops16h 48m
San Francisco
mar. 9/23
9:38 pm-8:08 am
1 stop8h 30m
$308
Showing 1-10 of 21 results
Best time to book a flight from Panama City to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to San Francisco
What is the cheapest month to book a flight from Panama City, Florida to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $276). Flying from Panama City, Florida to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ECP to SFO?
Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 7, 2025.
Unlike at noon, when flights are generally more expensive, you can save up to 23% on flights from Panama City, Florida to San Francisco by exploring options for tickets in the evening.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated agosto 7, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Panama City to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentMerlyn,Feb 2025
LAX - SMF
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentMerlyn,Feb 2025
LAX - SMF
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentMerlyn,Feb 2025
LAX - SMF
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentMerlyn,Feb 2025
LAX - SMF
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentMerlyn,Feb 2025
LAX - SMF
Related info for your journey
Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsRoseville
Mountain View
Santa Cruz
Livermore
South San Francisco
Turlock
Hollister
Antioch
Watsonville
Manteca
Sunnyvale
Newark
Milpitas
Santa Clara
Campbell
Foster City
San Leandro
Burlingame
Redwood City
Vallejo
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Panama City to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from Panama City to San Francisco
Discover the top 3 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 7, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$296 | Average$471 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$296 | Average$427 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$360 | Average$441 | FlexibilityNo cancel fee | On-time71% |