HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$200+ Cheap flights from Panama City, FL to San Francisco (ECP - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SFO
Apr 23 — Apr 301
Thu 4/23
Thu 4/30
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.

This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:29 am
ECP
-
SFO
1 stop10h 09m
United Airlines
Sat 4/1812:35 pm
SFO
-
ECP
1 stop7h 24m
United Airlines
Deal found 3/24$324
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:57 pm
ECP
-
SFO
1 stop7h 33m
United Airlines
Tue 4/2112:45 am
SFO
-
ECP
1 stop6h 50m
United Airlines
Deal found 3/24$345
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:43 am
ECP
-
SFO
1 stop9h 24m
American Airlines
Wed 5/2710:07 am
SFO
-
ECP
2 stops10h 29m
American Airlines
Deal found 3/20$380
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:43 am
ECP
-
SFO
1 stop11h 21m
American Airlines
Fri 5/296:45 am
SFO
-
ECP
1 stop9h 30m
American Airlines
Deal found 3/24$400
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1510:48 am
ECP
-
SFO
2 stops10h 32m
American Airlines
Wed 4/221:16 pm
SFO
-
ECP
1 stop8h 30m
American Airlines
Deal found 3/24$408
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:43 am
ECP
-
SFO
1 stop11h 21m
American Airlines
Sat 4/189:00 am
SFO
-
ECP
2 stops10h 58m
American Airlines
Deal found 3/24$410
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:55 pm
ECP
-
SFO
2 stops8h 35m
Southwest
Mon 6/1510:50 pm
SFO
-
ECP
1 stop8h 40m
Southwest
Deal found 3/23$411

Find flight deals from Panama City to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$380
(American Airlines)

One-way from

$200
(Delta)

Popular in

May

Cheapest in

June

Average price

$478
Provider with most accurate pricing for Panama City NW Florida Beaches-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-San Francisco flights.
Search Deals
From Panama City NW Florida Beaches to San Francisco
Search Deals
One-way flight from Panama City NW Florida Beaches to San Francisco
Search Deals
Highest demand for flights based on searches. 0% potential increase in price ($0 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 4/22

6:30 am-12:18 pm

1 stop7h 48m

San Francisco

Sat 4/25

7:00 am-4:12 pm

1 stop7h 12m

$434

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 4/15

4:57 pm-10:30 pm

1 stop7h 33m

San Francisco

Tue 4/21

12:45 am-1:23 pm

1 stop10h 38m

$435

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Mon 4/20

6:40 am-1:45 pm

2 stops9h 05m

San Francisco

Mon 4/27

10:55 pm-9:30 am

1 stop8h 35m

$441

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 7/15

6:00 am-11:35 am

1 stop7h 35m

San Francisco

Fri 7/24

9:56 pm-8:20 am

1 stop8h 24m

$457

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 7/22

3:17 pm-10:28 pm

1 stop9h 11m

San Francisco

Sat 8/29

12:22 pm-9:44 pm

1 stop7h 22m

$457

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Thu 6/11

2:55 pm-8:20 pm

1 stop7h 25m

San Francisco

Fri 6/12

5:00 am-5:15 pm

2 stops10h 15m

$462

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 5/27

3:00 pm-10:10 pm

1 stop9h 10m

San Francisco

Sun 5/31

11:25 pm-11:35 am

1 stop10h 10m

$467

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 6/24

3:55 pm-11:15 pm

2 stops9h 20m

San Francisco

Mon 6/29

5:10 am-5:15 pm

2 stops10h 05m

$467

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sun 8/23

5:50 am-2:10 pm

1 stop10h 20m

San Francisco

Fri 8/28

11:40 pm-9:55 am

1 stop8h 15m

$472

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Mon 4/20

5:27 pm-9:00 am

1 stop17h 33m

San Francisco

Fri 4/24

5:46 pm-4:47 pm

1 stop21h 01m

$491

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/20

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Panama City to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

Currently, December is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $101). Flying from Panama City, Florida to San Francisco in July is currently the most expensive (average of $354). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated March 24, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Panama City to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,329 reviews

Entertainment

7.5

Crew

8.6

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,329 reviews
Southwest
8.0
Very good
4,329 reviews

Entertainment

7.5

Crew

8.6

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,320 reviews
Southwest
8.0
Very good
4,329 reviews

Entertainment

7.5

Crew

8.6

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
United Airlines
7.4
Good
9,469 reviews
Southwest
8.0
Very good
4,329 reviews

Entertainment

7.5

Crew

8.6

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,492 reviews
Southwest
8.0
Very good
4,329 reviews

Entertainment

7.5

Crew

8.6

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to San Francisco?

    United Airlines, Southwest, and Delta can get you from Panama City, Florida to San Francisco in just under 7h 35m. Your travel time can differ by up to 1h 30m. Panama City, Florida and San Francisco are separated by a distance of 2139 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?

    Currently priced at $297, Delta will fly you from Panama City, Florida to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from United Airlines and American Airlines - these airlines can fly you to your destination from $306 and $358, respectively. Delta is priced at 36% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Panama City, Florida to San Francisco one-way?

    $134 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $153 and $168, respectively.

  • Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

  • Can I find deals for business class flights from Panama City to San Francisco?

    Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

    Currently, December is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $101). Flying from Panama City, Florida to San Francisco in July is currently the most expensive (average of $354). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Rancho Cordova
San Bruno
Watsonville
San Ramon
Sunnyvale
Vacaville
San Carlos
Turlock
Redwood City
San Lorenzo
Davis
Manteca
Union City
Elk Grove
Rohnert Park

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Las Vegas flights
Orlando to Los Angeles flights
Fort Lauderdale to Las Vegas flights
Miami to Los Angeles flights
Miami to Las Vegas flights
Tampa to Las Vegas flights
Fort Lauderdale to Los Angeles flights
Tampa to Los Angeles flights
Orlando to San Francisco flights
Miami to San Francisco flights
Fort Lauderdale to San Francisco flights
Tampa to San Francisco flights
West Palm Beach to Las Vegas flights
Orlando to San Diego flights
Miami to Ontario flights
Orlando to Ontario flights
Pensacola to Las Vegas flights
Jacksonville to Las Vegas flights
Fort Lauderdale to Burbank flights
Miami to San Diego flights
Fort Myers to Las Vegas flights
West Palm Beach to Los Angeles flights
Tampa to San Diego flights
Fort Lauderdale to Santa Ana flights
Fort Lauderdale to Ontario flights
Orlando to Santa Ana flights
Orlando to Burbank flights
Tampa to Ontario flights
Fort Lauderdale to San Diego flights
Orlando to Sacramento flights
Jacksonville to San Francisco flights
Miami to Burbank flights
Jacksonville to Los Angeles flights
Fort Myers to Los Angeles flights
West Palm Beach to San Francisco flights
Orlando to Reno flights
Pensacola to Los Angeles flights
Tampa to Santa Ana flights
Panama City to Las Vegas flights
Orlando to San Jose flights
Jacksonville to San Diego flights
Orlando to Palm Springs flights
Tampa to San Jose flights
Tampa to Reno flights
Jacksonville to Ontario flights
Tampa to Fresno flights
Tampa to Sacramento flights
Fort Lauderdale to San Jose flights
Fort Myers to San Francisco flights
Miami to Santa Ana flights

Top 4 airlines flying from Panama City to San Francisco

Discover the top 4 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$297Average$425FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$306Average$471FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$358Average$469FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$389Average$493FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.