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$193+ Cheap flights from Panama City, FL to San Francisco (ECP - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SFO
Mar 12 — Mar 191
Thu 3/12
Thu 3/19
1 adult, Economy
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Cheap flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 10, 2026.

This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/249:25 am
ECP
-
SFO
1 stop10h 11m
Delta
Tue 3/312:20 pm
SFO
-
ECP
1 stop6h 44m
Delta
Deal found 2/9$359
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:23 pm
ECP
-
SFO
1 stop10h 12m
Delta
Tue 3/312:20 pm
SFO
-
ECP
1 stop6h 44m
Delta
Deal found 2/9$372
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/91:06 pm
ECP
-
SFO
1 stop10h 54m
American Airlines
Wed 5/1310:13 am
SFO
-
ECP
2 stops9h 45m
American Airlines
Deal found 2/9$377
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:43 pm
ECP
-
SFO
1 stop7h 52m
Delta
Mon 3/302:20 pm
SFO
-
ECP
1 stop6h 44m
Delta
Deal found 2/9$385
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/243:05 pm
ECP
-
SFO
1 stop10h 40m
Southwest
Thu 4/25:30 am
SFO
-
ECP
1 stop8h 20m
Southwest
Deal found 2/9$398

Find flight deals from Panama City to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$359
(Delta)

One-way from

$193
(Southwest)

Popular in

September

Cheapest in

April

Average price

$428
Provider with most accurate pricing for Panama City NW Florida Beaches-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-San Francisco flights.
Search Deals
From Panama City NW Florida Beaches to San Francisco
Search Deals
One-way flight from Panama City NW Florida Beaches to San Francisco
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 10, 2026.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Panama City

Fly to

San Francisco

Route

Depart

Return

Price

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Thu 3/26

6:43 pm-12:35 am

1 stop7h 52m

San Francisco

Tue 3/31

2:20 pm-11:04 pm

1 stop6h 44m

$372

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Mon 3/23

6:43 pm-12:35 am

1 stop7h 52m

San Francisco

Tue 3/31

2:20 pm-11:04 pm

1 stop6h 44m

$382

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Tue 3/24

1:30 pm-8:33 pm

1 stop9h 03m

San Francisco

Mon 3/30

11:35 pm-8:40 am

1 stop7h 05m

$382

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Tue 3/24

5:30 pm-11:19 pm

1 stop7h 49m

San Francisco

Tue 3/31

2:20 pm-11:04 pm

1 stop6h 44m

$385

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Mon 3/23

4:23 pm-12:35 am

1 stop10h 12m

San Francisco

Mon 3/30

2:20 pm-11:04 pm

1 stop6h 44m

$385

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Thu 3/26

6:43 pm-12:35 am

1 stop7h 52m

San Francisco

Mon 3/30

9:35 pm-8:40 am

1 stop9h 05m

$385

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 3/25

1:30 pm-8:33 pm

1 stop9h 03m

San Francisco

Sun 4/5

11:25 pm-8:40 am

1 stop7h 15m

$398

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Mon 3/30

4:30 pm-11:20 pm

1 stop8h 50m

$193

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Mon 4/20

6:30 am-12:18 pm

1 stop7h 48m

$193

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Mon 4/20

6:40 am-3:25 pm

2 stops10h 45m

$198

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Showing 1-10 of 17 results
1
2

Compare providers for flights from Panama City to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

Currently, December is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $101). Flying from Panama City, Florida to San Francisco in July is currently the most expensive (average of $354). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated February 10, 2026.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Panama City to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,279 reviews

Overall

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,279 reviews
Southwest
8.0
Very good
4,279 reviews

Overall

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
8,178 reviews
Southwest
8.0
Very good
4,279 reviews

Overall

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
9,269 reviews
Southwest
8.0
Very good
4,279 reviews

Overall

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,262 reviews
Southwest
8.0
Very good
4,279 reviews

Overall

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to San Francisco?

    Delta can get you from Panama City, Florida to San Francisco in just under 7h 52m. Your travel time can differ by up to . Panama City, Florida and San Francisco are separated by a distance of 2139 mi.

  • What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?

    Currently priced at $297, Delta will fly you from Panama City, Florida to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from United Airlines and American Airlines - these airlines can fly you to your destination from $306 and $360, respectively. Delta is priced at 33% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Panama City, Florida to San Francisco one-way?

    $153 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $168 and $199, respectively.

  • Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

  • Can I find deals for business class flights from Panama City to San Francisco?

    Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

    Currently, December is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $101). Flying from Panama City, Florida to San Francisco in July is currently the most expensive (average of $354). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
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Santa Clara
Roseville
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Redwood City
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Davis
Hollister
Manteca
Union City

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Top 4 airlines flying from Panama City to San Francisco

Discover the top 4 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$297Average$402FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$306Average$471FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$360Average$469FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$389Average$457FlexibilityNo cancel feeOn-time63%

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