HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$180+ Cheap flights from Panama City, FL to San Francisco (ECP - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SFO
Dec 11 — Dec 181
Thu 12/11
Thu 12/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 11, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$372
(United Airlines)

One-way from

$180
(American Airlines)

Popular in

May

Cheapest in

April

Average price

$478
Provider with most accurate pricing for Panama City NW Florida Beaches-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-San Francisco flights.
Search Deals
From Panama City NW Florida Beaches to San Francisco
Search Deals
One-way flight from Panama City NW Florida Beaches to San Francisco
Search Deals
High demand for flights, 4% potential price rise
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 11, 2025.

This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:00 pmECP - SFO
1 stop7h 59mUnited Airlines
Fri 11/285:15 amSFO - ECP
1 stop6h 42mUnited Airlines
Deal found 11/9$454
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:23 amECP - SFO
1 stop9h 20mDelta
Sun 11/309:30 pmSFO - ECP
1 stop9h 05mDelta
Deal found 11/9$459
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:23 amECP - SFO
1 stop9h 20mDelta
Sat 11/296:00 amSFO - ECP
1 stop8h 01mDelta
Deal found 11/9$495
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:47 amECP - SFO
1 stop8h 29mAmerican Airlines
Fri 11/287:12 amSFO - ECP
2 stops12h 03mAmerican Airlines
Deal found 11/9$513
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/262:37 pmECP - SFO
1 stop8h 48mAmerican Airlines
Mon 12/111:59 pmSFO - ECP
2 stops9h 30mAmerican Airlines
Deal found 11/9$532
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:00 amECP - SFO
1 stop8h 30mDelta
Mon 12/16:00 amSFO - ECP
1 stop7h 26mDelta
Deal found 11/9$538
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2511:11 amECP - SFO
1 stop9h 03mDelta
Sat 11/296:00 amSFO - ECP
1 stop8h 01mDelta
Deal found 11/10$557
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:00 pmECP - SFO
1 stop9h 19mDelta
Sat 12/2011:45 pmSFO - ECP
1 stop6h 52mDelta
Deal found 11/10$559
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/237:30 amECP - SFO
1 stop9h 35mSouthwest
Wed 11/265:15 amSFO - ECP
2 stops10h 40mSouthwest
Deal found 11/9$562
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/297:30 amECP - SFO
1 stop9h 15mSouthwest
Wed 12/315:50 amSFO - ECP
2 stops11h 15mSouthwest
Deal found 11/9$582

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 11, 2025.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Panama City

Fly to

San Francisco

Route

Depart

Return

Price

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Thu 2/26

5:00 pm-11:59 pm

1 stop8h 59m

San Francisco

Mon 3/2

12:43 am-12:04 pm

1 stop9h 21m

$372

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Thu 2/26

1:06 pm-10:25 pm

1 stop11h 19m

San Francisco

Tue 3/3

11:05 am-9:54 pm

2 stops8h 49m

$377

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Thu 2/26

12:35 pm-5:55 pm

1 stop7h 20m

San Francisco

Tue 3/3

5:05 am-6:10 pm

2 stops11h 05m

$377

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Fri 1/9

4:54 pm-11:59 pm

1 stop9h 05m

San Francisco

Sun 1/11

12:43 am-12:02 pm

1 stop9h 19m

$411

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Fri 1/9

12:03 pm-10:41 pm

2 stops12h 38m

San Francisco

Mon 1/12

7:00 am-5:33 pm

1 stop8h 33m

$416

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Thu 11/27

7:23 am-2:43 pm

1 stop9h 20m

San Francisco

Sun 11/30

9:30 pm-8:35 am

1 stop9h 05m

$459

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Thu 11/27

7:23 am-2:43 pm

1 stop9h 20m

San Francisco

Sat 11/29

6:00 am-4:01 pm

1 stop8h 01m

$495

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 4/1

2:58 pm-10:33 pm

2 stops9h 35m

$185

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sat 4/11

11:05 am-4:15 pm

1 stop7h 10m

$219

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sun 4/12

5:35 am-12:05 pm

1 stop8h 30m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/10

Showing 1-10 of 11 results
1
2

Compare providers for flights from Panama City to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

Currently, February is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $180). Flying from Panama City, Florida to San Francisco in July is currently the most expensive (average of $342). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SFO?

Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 11, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 22% on flights from Panama City, Florida to San Francisco by exploring options for tickets in the evening.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated November 11, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Panama City to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,235 reviews

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,235 reviews
Southwest
8.0
Very good
4,235 reviews

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
8,007 reviews
Southwest
8.0
Very good
4,235 reviews

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
9,012 reviews
Southwest
8.0
Very good
4,235 reviews

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,045 reviews
Southwest
8.0
Very good
4,235 reviews

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to San Francisco?

    United Airlines, Southwest, and American Airlines can get you from Panama City, Florida to San Francisco in just under 7h 20m. Your travel time can differ by up to 2h 18m. Panama City, Florida and San Francisco are separated by a distance of 2139 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?

    Currently priced at $268, United Airlines will fly you from Panama City, Florida to San Francisco and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and American Airlines - these airlines can fly you to your destination from $297 and $360, respectively. United Airlines is priced at 42% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

  • Can I find deals for business class flights from Panama City to San Francisco?

    Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

    Currently, February is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $180). Flying from Panama City, Florida to San Francisco in July is currently the most expensive (average of $342). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Sunnyvale
Santa Clara
Vallejo
Hollister
San Bruno
Foster City
Redwood City
Union City
Burlingame
Lodi
San Mateo
Vacaville
Lathrop

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Las Vegas flights
Orlando to Los Angeles flights
Tampa to Las Vegas flights
Fort Lauderdale to Las Vegas flights
Miami to Las Vegas flights
Miami to Los Angeles flights
Fort Lauderdale to Los Angeles flights
Orlando to San Francisco flights
Miami to San Francisco flights
Tampa to Los Angeles flights
Fort Lauderdale to San Francisco flights
Tampa to San Francisco flights
Orlando to Ontario flights
Fort Myers to Las Vegas flights
Jacksonville to Las Vegas flights
Fort Lauderdale to Burbank flights
Orlando to Santa Ana flights
Miami to Ontario flights
West Palm Beach to Los Angeles flights
West Palm Beach to Las Vegas flights
Orlando to San Diego flights
Miami to San Diego flights
Tampa to San Diego flights
Fort Lauderdale to Santa Ana flights
Jacksonville to Los Angeles flights
Pensacola to Las Vegas flights
Fort Lauderdale to Ontario flights
Fort Myers to Los Angeles flights
Sarasota to Las Vegas flights
Jacksonville to San Francisco flights
Orlando to Burbank flights
Jacksonville to San Diego flights
Tampa to Santa Ana flights
Miami to Santa Ana flights
Fort Lauderdale to San Diego flights
Pensacola to Los Angeles flights
Fort Myers to San Francisco flights
Orlando Sanford Intl to Las Vegas flights
Tampa to Ontario flights
Sarasota to Los Angeles flights
Tampa to Reno flights
Orlando to San Jose flights
Jacksonville to San Jose flights
Panama City to Las Vegas flights
Tampa to San Jose flights
Orlando to Palm Springs flights
Miami to San Jose flights
Fort Lauderdale to San Jose flights
Orlando to Sacramento flights
Tampa to Sacramento flights

Top 4 airlines flying from Panama City to San Francisco

Discover the top 4 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$268Average$511FlexibilityNo cancel feeOn-time69%
DeltaCheapest$297Average$396FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$360Average$469FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$389Average$498FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.