What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?

Currently priced at $324, American Airlines will fly you from Panama City, Florida to San Francisco and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and Southwest - these airlines can fly you to your destination from $354 and $504, respectively. American Airlines is priced at 25% lower than the current average price of a flight leaving 3 months from now.

What is the cheapest day to fly from Panama City, Florida to San Francisco?

Travelers seeking maximum savings on their Panama City, Florida to San Francisco flight should consider departing on Saturday at noon when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the most popular airlines that fly from Panama City, Florida to San Francisco?

Consider American Airlines, Delta or Southwest when booking your flight. These represent the most popular airlines when flying from Panama City, Florida to San Francisco.

What is the cheapest day to fly round-trip from Panama City, Florida to San Francisco?

Flights from Panama City, Florida to San Francisco are found to be more expensive on Sunday. This shouldn't discourage you from searching as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to San Francisco.

What is the cheapest month to fly from Panama City, Florida to San Francisco?

April is one of the best times of the year to fly to San Francisco from Panama City, Florida. Prices for April average $434 per person but you can even find prices for as low as $342. The most expensive prices can be found in the month of May. Opting for a April flight can save you 37% on your journey compared to booking in May

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

Can I find deals for business class flights from Panama City to San Francisco?

Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$324+ Flights from Panama City, FL to San Francisco

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Cheap flight deals from Panama City to San Francisco

Round-trip from	$324 (American Airlines)
Popular in	May
Cheapest in	April
Average price	$447

From Panama City NW Florida Beaches to San Francisco

Search Deals

Highest demand for flights based on searches. 1% potential increase in price ($8 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in July 2025

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Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 29, 2025.

sáb. 8/235:45 pmECP - SFO

1 stop7h 07mAmerican Airlines

sáb. 8/307:05 amSFO - ECP

1 stop9h 09mAmerican Airlines

Deal found 7/28

$324

vie. 10/243:33 pmECP - SFO

1 stop22h 58mDelta

mar. 10/289:50 pmSFO - ECP

1 stop8h 54mDelta

Deal found 7/27

$354

jue. 8/216:35 amECP - SFO

2 stops10h 40mSouthwest

jue. 8/284:20 pmSFO - ECP

2 stops15h 35mSouthwest

Deal found 7/27

$504

mar. 8/123:04 pmECP - SFO

1 stop7h 19mUnited Airlines

vie. 8/1512:30 amSFO - ECP

1 stop7h 26mUnited Airlines

Deal found 7/27

$517

Best flights from Panama City to San Francisco
Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 29, 2025.

sáb. 8/235:45 pmECP - SFO

1 stop7h 07mAmerican Airlines

sáb. 8/307:05 amSFO - ECP

1 stop9h 09mAmerican Airlines

Deal found 7/28

$324

vie. 10/243:33 pmECP - SFO

1 stop22h 58mDelta

mar. 10/286:07 amSFO - ECP

1 stop7h 13mDelta

Deal found 7/28

$354

jue. 8/216:35 amECP - SFO

2 stops10h 40mSouthwest

jue. 8/284:20 pmSFO - ECP

2 stops15h 35mSouthwest

Deal found 7/27

$504

mar. 8/128:40 amECP - SFO

1 stop7h 48mUnited Airlines

dom. 8/175:00 amSFO - ECP

1 stop9h 21mUnited Airlines

Deal found 7/29

$517

Last-minute flights from Panama City to San Francisco
Discover last-minute flight deals from Panama City to San Francisco. Data last updated julio 29, 2025 and is based on user searches.

mar. 8/123:04 pmECP - SFO

1 stop7h 19mUnited Airlines

vie. 8/1512:30 amSFO - ECP

1 stop7h 26mUnited Airlines

Deal found 7/27

$517

jue. 8/214:49 pmECP - SFO

1 stop9h 46mDelta

jue. 8/2811:35 amSFO - ECP

1 stop9h 31mDelta

Deal found 7/29

$398

jue. 8/216:35 amECP - SFO

2 stops10h 40mSouthwest

jue. 8/284:20 pmSFO - ECP

2 stops15h 35mSouthwest

Deal found 7/27

$504

sáb. 8/235:45 pmECP - SFO

1 stop7h 07mAmerican Airlines

sáb. 8/307:05 amSFO - ECP

1 stop9h 09mAmerican Airlines

Deal found 7/28

$324

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

sáb. 8/23

5:45 pm-10:52 pm

1 stop7h 07m

San Francisco

sáb. 8/30

7:05 am-6:14 pm

1 stop9h 09m

$324

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

vie. 10/24

3:33 pm-12:31 pm

1 stop22h 58m

San Francisco

mar. 10/28

6:07 am-3:20 pm

1 stop7h 13m

$354

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

jue. 8/21

6:35 am-3:15 pm

2 stops10h 40m

San Francisco

jue. 8/28

4:20 pm-9:55 am

2 stops15h 35m

$504

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

mar. 8/12

8:40 am-2:28 pm

1 stop7h 48m

San Francisco

dom. 8/17

5:00 am-4:21 pm

1 stop9h 21m

$517

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $276). Flying from Panama City, Florida to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SFO?

Unlike at noon, when flights are generally more expensive, you can save up to 23% on flights from Panama City, Florida to San Francisco by exploring options for tickets in the evening.

Reviews of airlines servicing San Francisco

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Panama City to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Southwest

8.0

Very good

4,238 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Delta

8.0

Very good

7,977 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

United Airlines

7.4

Good

8,899 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Related info for your journey

What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?
Currently priced at $324, American Airlines will fly you from Panama City, Florida to San Francisco and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and Southwest - these airlines can fly you to your destination from $354 and $504, respectively. American Airlines is priced at 25% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Panama City to San Francisco that include hotel bookings?
Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.
Can I find deals for business class flights from Panama City to San Francisco?
Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $276). Flying from Panama City, Florida to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Santa Cruz

South San Francisco

Livermore

Turlock

Manteca

Antioch

Hollister

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Sunnyvale

Newark

Milpitas

Campbell

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Santa Clara

San Leandro

Burlingame

Redwood City

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Top 3 airlines flying from Panama City to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Southwest	Cheapest$296	Average$471	FlexibilityNo cancel fee	On-time63%
Delta	Cheapest$296	Average$429	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$360	Average$416	FlexibilityNo cancel fee	On-time71%

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$324+ Cheap flights from Panama City, FL to San Francisco (ECP - SFO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/23. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to San Francisco

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 29, 2025.

Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

What is the cheapest time of day to fly from ECP to SFO?

Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 29, 2025.

Reviews of airlines servicing San Francisco

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Panama City to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

How can I find direct flights from Panama City to San Francisco?

Can I find deals for business class flights from Panama City to San Francisco?

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Panama City to San Francisco

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Travel Smart

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 29, 2025.