$300+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/1. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Jul 15 — Jul 221
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Key West to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Key West to San Francisco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:39 pm
EYW
- SFO
1 stop9h 38m
American Airlines
Sun 7/511:49 pm
SFO
- EYW
1 stop9h 25m
American Airlines
Deal found 6/13![American Airlines logo]()
$300
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:41 pm
EYW
- SFO
1 stop9h 07m
American Airlines
Wed 7/157:20 am
SFO
- EYW
1 stop8h 46m
American Airlines
Deal found 6/13![American Airlines logo]()
$331
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:15 pm
EYW
- SFO
1 stop8h 43m
Delta
Sun 8/236:00 am
SFO
- EYW
1 stop8h 20m
Delta
Deal found 6/15![Delta logo]()
$394
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:21 pm
EYW
- SFO
1 stop9h 49m
American Airlines
Sat 7/1111:49 pm
SFO
- EYW
1 stop9h 25m
American Airlines
Deal found 6/13![American Airlines logo]()
$409
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:11 pm
EYW
- SFO
2 stops38h 07m
Multiple Airlines
Sun 8/2312:47 pm
SFO
- EYW
1 stop24h 26m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$453
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/144:05 pm
EYW
- SFO
1 stop11h 24m
United Airlines
Tue 11/1710:50 pm
SFO
- EYW
1 stop11h 12m
United Airlines
Deal found 6/10![United Airlines logo]()
$500
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Sun 8/235:30 am
SFO
- EYW
2 stops10h 14m
American Airlines
Deal found 6/13![American Airlines logo]()
$522
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:15 pm
EYW
- SFO
1 stop8h 43m
Delta
Sun 8/236:00 am
SFO
- EYW
1 stop8h 20m
Delta
Deal found 6/15![Delta logo]()
$394
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/144:05 pm
EYW
- SFO
1 stop11h 24m
United Airlines
Tue 11/1710:50 pm
SFO
- EYW
1 stop11h 12m
United Airlines
Deal found 6/10![United Airlines logo]()
$500
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Sun 8/235:30 am
SFO
- EYW
2 stops10h 14m
American Airlines
Deal found 6/15![American Airlines logo]()
$522
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:01 pm
EYW
- SFO
1 stop10h 05m
American Airlines
Wed 7/156:55 pm
SFO
- EYW
2 stops14h 19m
American Airlines
Deal found 6/13![American Airlines logo]()
$592
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:00 pm
EYW
- SFO
1 stop18h 08m
American Airlines
Fri 11/61:07 pm
SFO
- EYW
1 stop19h 01m
American Airlines
Deal found 6/14![American Airlines logo]()
$725
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated June 15, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:39 pm
EYW
- SFO
1 stop9h 38m
American Airlines
Sun 7/511:49 pm
SFO
- EYW
1 stop9h 25m
American Airlines
Deal found 6/13![American Airlines logo]()
$300
This Gotogate deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/111:46 am
EYW
- SFO
2 stops50h 47m
Breeze Airways
Sun 7/512:47 pm
SFO
- EYW
3 stops44h 47m
Breeze Airways
Deal found 6/13![Breeze Airways logo]()
$1,473
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:21 pm
EYW
- SFO
1 stop9h 49m
American Airlines
Sat 7/1111:49 pm
SFO
- EYW
1 stop9h 25m
American Airlines
Deal found 6/13![American Airlines logo]()
$409
This Booking.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/212:05 pm
EYW
- SFO
3 stops50h 32m
Breeze Airways
Sat 7/1112:22 pm
SFO
- EYW
3 stops44h 05m
Breeze Airways
Deal found 6/13![Breeze Airways logo]()
$1,098
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:41 pm
EYW
- SFO
1 stop9h 07m
American Airlines
Wed 7/157:20 am
SFO
- EYW
1 stop8h 46m
American Airlines
Deal found 6/13![American Airlines logo]()
$331
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1111:48 am
EYW
- SFO
1 stop10h 38m
Delta
Deal found 6/15![Delta logo]()
$488
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/112:21 pm
EYW
- SFO
1 stop9h 49m
American Airlines
Deal found 6/11![American Airlines logo]()
$545
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 15, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $300 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 8/14
6:15 pm-11:58 pm
1 stop8h 43m
San Francisco
Sun 8/23
6:00 am-5:20 pm
1 stop8h 20m
$394
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 11/14
4:05 pm-12:29 am
1 stop11h 24m
San Francisco
Tue 11/17
10:50 pm-1:02 pm
1 stop11h 12m
$500
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 8/14
8:09 pm-12:54 am
1 stop7h 45m
San Francisco
Sun 8/23
5:30 am-6:44 pm
2 stops10h 14m
$522
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 7/9
1:01 pm-8:06 pm
1 stop10h 05m
San Francisco
Wed 7/15
6:55 pm-12:14 pm
2 stops14h 19m
$592
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 11/2
8:00 pm-11:08 am
1 stop18h 08m
San Francisco
Fri 11/6
1:07 pm-11:08 am
1 stop19h 01m
$725
Cheapest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 7/11
11:48 am-7:26 pm
1 stop10h 38m
$488
Quickest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 7/11
2:21 pm-9:10 pm
1 stop9h 49m
$545
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated June 15, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Overall
7.1
Entertainment
6.8
Comfort
7.2
Food
6.4
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Crew
7.9
Overall
7.1
Entertainment
6.8
Comfort
7.2
Food
6.4
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
Roseville
Cupertino
Emeryville
Newark
San Bruno
Watsonville
San Ramon
Vacaville
San Carlos
Redwood City
Daly City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Key West
Popular flights
San Francisco flight routes
Alternative routes for Key West to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Key West to San Francisco by cabin class
Find flights from Key West to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Key West and San Francisco flights
Browse other Key West and San Francisco flight options. Last updated on June 15, 2026.
Other flights from Key West
Browse through other flights departing from Key West. Flights are based on user searches made on Cheapflights and were last updated on June 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 15, 2026.
Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$446 | FlexibilityNo cancel fee | On-time71% |