$181+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/26. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Aug 27 — Sep 31
Round-trip
1 adult, Economy
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Find cheap flights from Key West to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:43 pm
EYW
- SFO
1 stop8h 50m
American Airlines
Sat 10/109:46 pm
SFO
- EYW
1 stop9h 03m
American Airlines
Deal found 7/23![American Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/114:56 pm
EYW
- SFO
1 stop9h 49m
American Airlines
Tue 8/257:30 am
SFO
- EYW
1 stop8h 01m
American Airlines
Deal found 7/25![American Airlines logo]()
$447
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/114:56 pm
EYW
- SFO
1 stop9h 49m
American Airlines
Sat 8/159:35 pm
SFO
- EYW
1 stop10h 21m
American Airlines
Deal found 7/27![American Airlines logo]()
$491
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/141:26 pm
EYW
- SFO
1 stop25h 35m
Multiple Airlines
Fri 9/186:04 am
SFO
- EYW
2 stops24h 20m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$516
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:21 am
EYW
- SFO
2 stops10h 30m
American Airlines
Fri 9/119:54 pm
SFO
- EYW
1 stop8h 57m
American Airlines
Deal found 7/26![American Airlines logo]()
$539
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1011:57 am
EYW
- SFO
1 stop27h 05m
Multiple Airlines
Fri 8/1411:05 pm
SFO
- EYW
2 stops32h 19m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$590
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 28, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 28, 2026.
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:28 pm
EYW
- SFO
1 stop9h 31m
American Airlines
Sat 10/1011:27 pm
SFO
- EYW
2 stops10h 36m
American Airlines
Deal found 7/23![American Airlines logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/141:26 pm
EYW
- SFO
1 stop25h 35m
Multiple Airlines
Fri 9/186:04 am
SFO
- EYW
2 stops24h 20m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$516
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/114:56 pm
EYW
- SFO
1 stop9h 49m
American Airlines
Sat 8/159:35 pm
SFO
- EYW
1 stop10h 21m
American Airlines
Deal found 7/27![American Airlines logo]()
$491
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:21 am
EYW
- SFO
2 stops10h 30m
American Airlines
Fri 9/119:54 pm
SFO
- EYW
1 stop8h 57m
American Airlines
Deal found 7/26![American Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Fri 9/45:05 am
SFO
- EYW
1 stop8h 13m
American Airlines
Deal found 7/27![American Airlines logo]()
$767
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:26 pm
EYW
- SFO
2 stops12h 14m
American Airlines
Fri 11/65:30 am
SFO
- EYW
1 stop8h 25m
American Airlines
Deal found 7/23![American Airlines logo]()
$772
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated July 28, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated July 28, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/912:05 pm
EYW
- SFO
2 stops31h 01m
Multiple Airlines
Thu 8/1312:47 pm
SFO
- EYW
1 stop19h 20m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$770
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1011:57 am
EYW
- SFO
1 stop27h 05m
Multiple Airlines
Fri 8/1411:05 pm
SFO
- EYW
2 stops32h 19m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$590
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/114:56 pm
EYW
- SFO
1 stop9h 49m
American Airlines
Tue 8/257:30 am
SFO
- EYW
1 stop8h 01m
American Airlines
Deal found 7/25![American Airlines logo]()
$447
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/114:56 pm
EYW
- SFO
1 stop9h 49m
American Airlines
Sat 8/159:35 pm
SFO
- EYW
1 stop10h 21m
American Airlines
Deal found 7/27![American Airlines logo]()
$491
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Fri 9/45:05 am
SFO
- EYW
1 stop8h 13m
American Airlines
Deal found 7/27![American Airlines logo]()
$767
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 28, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2611:46 am
EYW
- SFO
2 stops34h 17m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:46 am
EYW
- SFO
2 stops15h 32m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:04 am
EYW
- SFO
2 stops11h 16m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:31 pm
EYW
- SFO
2 stops21h 35m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$318
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/261:59 pm
EYW
- SFO
1 stop11h 01m
Delta
Deal found 7/27![Delta logo]()
$384
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/121:49 pm
EYW
- SFO
1 stop9h 29m
American Airlines
Deal found 7/23![American Airlines logo]()
$425
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/97:14 pm
EYW
- SFO
1 stop22h 23m
American Airlines
Deal found 7/27![American Airlines logo]()
$1,040
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 28, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $335 (American Airlines) |
One-way from | $181 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 10/6
5:28 pm-11:59 pm
1 stop9h 31m
San Francisco
Sat 10/10
11:27 pm-1:03 pm
2 stops10h 36m
$378
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 8/11
4:56 pm-11:45 pm
1 stop9h 49m
San Francisco
Sat 8/15
9:35 pm-10:56 am
1 stop10h 21m
$491
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 9/14
1:26 pm-12:01 pm
1 stop25h 35m
San Francisco
Fri 9/18
6:04 am-9:24 am
2 stops24h 20m
$516
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 9/11
10:21 am-5:51 pm
2 stops10h 30m
San Francisco
Fri 9/11
9:54 pm-9:51 am
1 stop8h 57m
$539
Quickest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 8/31
8:09 pm-12:54 am
1 stop7h 45m
San Francisco
Fri 9/4
5:05 am-4:18 pm
1 stop8h 13m
$767
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 11/2
2:26 pm-11:40 pm
2 stops12h 14m
San Francisco
Fri 11/6
5:30 am-4:55 pm
1 stop8h 25m
$772
Cheapest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 8/12
11:46 am-12:18 am
2 stops15h 32m
$209
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 10/17
10:04 am-9:18 pm
3 stops14h 14m
$268
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sun 8/9
9:31 pm-4:06 pm
2 stops21h 35m
$318
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 8/26
1:59 pm-10:00 pm
1 stop11h 01m
$384
Showing 1-10 of 12 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated July 28, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.1
Entertainment
6.8
Boarding
7.5
Crew
7.9
Food
6.4
Comfort
7.2
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Overall
7.1
Entertainment
6.8
Boarding
7.5
Crew
7.9
Food
6.4
Comfort
7.2
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Fairfield
Roseville
Burlingame
Rancho Cordova
San Bruno
Cupertino
Emeryville
Newark
Watsonville
Hayward
Redwood City
San Carlos
San Ramon
Turlock
Vallejo
San Lorenzo
Davis
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Key West and San Francisco flights
Browse other Key West and San Francisco flight options. Last updated on July 28, 2026.
Other flights from Key West
Browse through other flights departing from Key West. Flights are based on user searches made on Cheapflights and were last updated on July 28, 2026.
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Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 28, 2026.
Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$419 | FlexibilityNo cancel fee | On-time71% |