How long is the flight from Key West to San Francisco?

Delta can get you from Key West to San Francisco in just under 17h 45m. Your travel time can differ by up to . Key West and San Francisco are separated by a distance of 2542 mi.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What is the cheapest time of day to fly from EYW to SFO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Key West to San Francisco as you normally would.

Most accurate provider : When it comes to deals on Key West-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Key West-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Key West to San Francisco that include hotel bookings?

Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Key West to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.

Can I find deals for business class flights from Key West to San Francisco?

Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$130+ Flights from Key West to San Francisco

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheap flight deals from Key West to San Francisco

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$306 (Delta)
One-way from	$130 (American Airlines)

Provider with most accurate pricing for Key West-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Key West-San Francisco flights.

Search Deals

From Key West to San Francisco

Search Deals

One-way flight from Key West to San Francisco

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Find flight deals from Key West to San Francisco

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Fri 12/123:02 pmEYW - SFO

1 stop11h 18mDelta

Sun 12/147:15 amSFO - EYW

1 stop9h 51mDelta

Deal found 11/23

$317

Thu 12/112:50 pmEYW - SFO

1 stop10h 59mAmerican Airlines

Mon 12/159:15 amSFO - EYW

2 stops10h 52mAmerican Airlines

Deal found 11/26

$380

Fri 12/121:45 pmEYW - SFO

1 stop9h 42mAmerican Airlines

Sat 12/1312:25 amSFO - EYW

1 stop10h 50mAmerican Airlines

Deal found 11/23

$417

Thu 11/277:40 amEYW - SFO

1 stop10h 03mDelta

Mon 12/16:00 amSFO - EYW

1 stop8h 23mDelta

Deal found 11/23

$487

Best flights from Key West to San Francisco
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 26, 2025.

Wed 1/77:10 amEYW - SFO

2 stops17h 45mDelta

Tue 2/36:00 amSFO - EYW

1 stop8h 11mDelta

Deal found 11/25

$306

Thu 12/112:50 pmEYW - SFO

1 stop10h 59mAmerican Airlines

Mon 12/159:15 amSFO - EYW

2 stops10h 52mAmerican Airlines

Deal found 11/26

$380

Thu 1/87:10 amEYW - SFO

1 stop8h 45mDelta

Tue 2/36:00 amSFO - EYW

1 stop8h 11mDelta

Deal found 11/25

$309

Fri 12/123:02 pmEYW - SFO

1 stop11h 18mDelta

Sun 12/147:15 amSFO - EYW

1 stop9h 51mDelta

Deal found 11/23

$317

Fri 12/121:45 pmEYW - SFO

1 stop9h 42mAmerican Airlines

Sat 12/1312:25 amSFO - EYW

1 stop10h 50mAmerican Airlines

Deal found 11/23

$417

Thu 1/87:10 amEYW - SFO

1 stop8h 45mDelta

Sat 2/75:55 amSFO - EYW

2 stops26h 30mDelta

Deal found 11/25

$356

Wed 1/77:10 amEYW - SFO

2 stops17h 45mDelta

Wed 2/48:00 amSFO - EYW

1 stop8h 40mDelta

Deal found 11/25

$371

Thu 1/87:10 amEYW - SFO

1 stop8h 45mDelta

Wed 2/48:00 amSFO - EYW

1 stop8h 40mDelta

Deal found 11/25

$374

Thu 1/87:10 amEYW - SFO

1 stop8h 45mDelta

Sun 2/111:05 pmSFO - EYW

1 stop9h 20mDelta

Deal found 11/25

$374

Thu 12/117:40 amEYW - SFO

1 stop10h 07mDelta

Mon 12/157:15 amSFO - EYW

1 stop9h 51mDelta

Deal found 11/26

$375

Wed 1/77:10 amEYW - SFO

2 stops17h 45mDelta

Mon 2/24:40 pmSFO - EYW

2 stops15h 45mDelta

Deal found 11/25

$380

Last-minute flights from Key West to San Francisco
Discover last-minute flight deals from Key West to San Francisco. Data last updated November 26, 2025 and is based on user searches.

Thu 11/277:40 amEYW - SFO

1 stop10h 03mDelta

Mon 12/16:00 amSFO - EYW

1 stop8h 23mDelta

Deal found 11/23

$487

Thu 12/112:50 pmEYW - SFO

1 stop10h 59mAmerican Airlines

Mon 12/159:15 amSFO - EYW

2 stops10h 52mAmerican Airlines

Deal found 11/26

$380

Fri 12/123:02 pmEYW - SFO

1 stop11h 18mDelta

Sun 12/147:15 amSFO - EYW

1 stop9h 51mDelta

Deal found 11/23

$317

Fri 12/121:45 pmEYW - SFO

1 stop9h 42mAmerican Airlines

Sat 12/1312:25 amSFO - EYW

1 stop10h 50mAmerican Airlines

Deal found 11/23

$417

One-way flights from Key West to San Francisco
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 26, 2025.

Tue 12/161:33 pmEYW - SFO

1 stop10h 29mAmerican Airlines

Deal found 11/24

$130

Wed 1/72:30 pmEYW - SFO

3 stops44h 33mMultiple Airlines

Deal found 11/24

$160

Tue 1/612:20 pmEYW - SFO

3 stops46h 33mMultiple Airlines

Deal found 11/24

$166

Mon 1/510:01 pmEYW - SFO

3 stops44h 05mMultiple Airlines

Deal found 11/24

$169

Tue 12/166:10 pmEYW - SFO

1 stop9h 10mDelta

Deal found 11/24

$180

Wed 1/75:15 pmEYW - SFO

1 stop8h 57mAmerican Airlines

Deal found 11/24

$230

Sun 1/410:37 pmEYW - SFO

3 stops40h 17mMultiple Airlines

Deal found 11/24

$233

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 1/7

7:10 am-9:55 pm

2 stops17h 45m

San Francisco

Tue 2/3

6:00 am-5:11 pm

1 stop8h 11m

$306

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 1/8

7:10 am-12:55 pm

1 stop8h 45m

San Francisco

Tue 2/3

6:00 am-5:11 pm

1 stop8h 11m

$309

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 12/12

3:02 pm-11:20 pm

1 stop11h 18m

San Francisco

Sun 12/14

7:15 am-8:06 pm

1 stop9h 51m

$317

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 1/8

7:10 am-12:55 pm

1 stop8h 45m

San Francisco

Sat 2/7

5:55 am-11:25 am

2 stops26h 30m

$356

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 1/7

7:10 am-9:55 pm

2 stops17h 45m

San Francisco

Wed 2/4

8:00 am-7:40 pm

1 stop8h 40m

$371

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 1/8

7:10 am-12:55 pm

1 stop8h 45m

San Francisco

Wed 2/4

8:00 am-7:40 pm

1 stop8h 40m

$374

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 1/8

7:10 am-12:55 pm

1 stop8h 45m

San Francisco

Sun 2/1

11:05 pm-11:25 am

1 stop9h 20m

$374

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 12/11

7:40 am-2:47 pm

1 stop10h 07m

San Francisco

Mon 12/15

7:15 am-8:06 pm

1 stop9h 51m

$375

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 12/11

2:50 pm-10:49 pm

1 stop10h 59m

San Francisco

Mon 12/15

9:15 am-11:07 pm

2 stops10h 52m

$380

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 1/7

7:10 am-9:55 pm

2 stops17h 45m

San Francisco

Mon 2/2

4:40 pm-11:25 am

2 stops15h 45m

$380

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Showing 1-10 of 18 results

Compare providers for flights from Key West to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to San Francisco in November.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing San Francisco

See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,038 reviews

Reviews

1 / 20

2.0

Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

American Airlines

7.2

Good

11,038 reviews

American Airlines

7.2

Good

11,038 reviews

Reviews

1 / 20

2.0

Mediocre

Anonymous,Aug 2025

MIA - DCA

Related info for your journey

How long is the flight from Key West to San Francisco?
Delta can get you from Key West to San Francisco in just under 17h 45m. Your travel time can differ by up to . Key West and San Francisco are separated by a distance of 2542 mi.
Can I find deals for flights from Key West to San Francisco that include hotel bookings?
Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Key West to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.
Can I find deals for business class flights from Key West to San Francisco?
Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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South San Francisco

Santa Cruz

Livermore

Turlock

Manteca

Watsonville

Sunnyvale

Santa Clara

San Bruno

Daly City

Redwood City

Vallejo

Hollister

Foster City

Milpitas

Union City

Davis

Hayward

Burlingame

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Key West to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$313	Average$453	FlexibilityNo cancel fee	On-time71%

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$130+ Cheap flights from Key West to San Francisco (EYW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Key West to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Key West to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Find flight deals from Key West to San Francisco

Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Compare providers for flights from Key West to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to San Francisco in November.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.

Reviews of airlines servicing San Francisco

See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Key West to San Francisco?

Can I find deals for flights from Key West to San Francisco that include hotel bookings?

How can I find direct flights from Key West to San Francisco?

Can I find deals for business class flights from Key West to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key West to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Key West to San Francisco

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.