$253+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Jun 28 — Jul 51
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 29, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 29, 2026.
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:55 pm
EYW
- SFO
1 stop11h 50m
United Airlines
Sun 6/1411:59 pm
SFO
- EYW
1 stop10h 31m
United Airlines
Deal found 5/26![United Airlines logo]()
$420
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:40 am
EYW
- SFO
1 stop10h 06m
Delta
Sat 10/1010:30 pm
SFO
- EYW
1 stop9h 28m
Delta
Deal found 5/26![Delta logo]()
$444
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:01 pm
EYW
- SFO
1 stop9h 59m
American Airlines
Tue 6/165:23 am
SFO
- EYW
1 stop8h 29m
American Airlines
Deal found 5/26![American Airlines logo]()
$452
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:05 pm
EYW
- SFO
1 stop10h 43m
Delta
Tue 6/97:50 am
SFO
- EYW
1 stop9h 03m
Delta
Deal found 5/26![Delta logo]()
$455
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:12 pm
EYW
- SFO
1 stop8h 36m
American Airlines
Sat 10/1011:36 pm
SFO
- EYW
2 stops10h 16m
American Airlines
Deal found 5/26![American Airlines logo]()
$462
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:05 pm
EYW
- SFO
1 stop10h 43m
Delta
Sun 6/710:59 pm
SFO
- EYW
1 stop9h 03m
Delta
Deal found 5/26![Delta logo]()
$470
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:26 pm
EYW
- SFO
1 stop11h 33m
United Airlines
Mon 6/812:50 am
SFO
- EYW
1 stop11h 19m
United Airlines
Deal found 5/26![United Airlines logo]()
$501
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:24 pm
EYW
- SFO
1 stop9h 21m
Delta
Mon 6/159:56 pm
SFO
- EYW
1 stop10h 06m
Delta
Deal found 5/26![Delta logo]()
$513
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:55 pm
EYW
- SFO
1 stop11h 50m
United Airlines
Mon 6/1511:59 pm
SFO
- EYW
1 stop10h 31m
United Airlines
Deal found 5/26![United Airlines logo]()
$520
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/171:39 pm
EYW
- SFO
1 stop9h 38m
American Airlines
Wed 6/247:46 am
SFO
- EYW
1 stop8h 24m
American Airlines
Deal found 5/26![American Airlines logo]()
$524
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 29, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 29, 2026.
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:55 pm
EYW
- SFO
1 stop11h 50m
United Airlines
Sun 6/1411:59 pm
SFO
- EYW
1 stop10h 31m
United Airlines
Deal found 5/26![United Airlines logo]()
$420
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:40 am
EYW
- SFO
1 stop10h 06m
Delta
Sat 10/1010:30 pm
SFO
- EYW
1 stop9h 28m
Delta
Deal found 5/26![Delta logo]()
$444
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:12 pm
EYW
- SFO
1 stop8h 36m
American Airlines
Sat 10/1011:36 pm
SFO
- EYW
2 stops10h 16m
American Airlines
Deal found 5/26![American Airlines logo]()
$462
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/127:53 pm
EYW
- SFO
2 stops26h 25m
Multiple Airlines
Sun 7/1912:47 pm
SFO
- EYW
1 stop19h 20m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$685
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:21 pm
EYW
- SFO
2 stops10h 45m
American Airlines
Sun 6/147:46 am
SFO
- EYW
1 stop8h 24m
American Airlines
Deal found 5/26![American Airlines logo]()
$533
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:24 pm
EYW
- SFO
1 stop9h 21m
Delta
Tue 6/167:50 am
SFO
- EYW
1 stop9h 03m
Delta
Deal found 5/26![Delta logo]()
$564
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/124:41 pm
EYW
- SFO
1 stop9h 07m
American Airlines
Sun 7/195:00 am
SFO
- EYW
1 stop10h 48m
American Airlines
Deal found 5/27![American Airlines logo]()
$692
This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:35 pm
EYW
- SFO
1 stop11h 16m
Delta
Fri 11/66:00 am
SFO
- EYW
1 stop8h 11m
Delta
Deal found 5/29![Delta logo]()
$747
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated May 29, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated May 29, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:26 pm
EYW
- SFO
1 stop11h 33m
United Airlines
Mon 6/812:50 am
SFO
- EYW
1 stop11h 19m
United Airlines
Deal found 5/26![United Airlines logo]()
$501
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:05 pm
EYW
- SFO
1 stop10h 43m
Delta
Tue 6/97:50 am
SFO
- EYW
1 stop9h 03m
Delta
Deal found 5/26![Delta logo]()
$455
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:05 pm
EYW
- SFO
1 stop10h 43m
Delta
Sun 6/710:59 pm
SFO
- EYW
1 stop9h 03m
Delta
Deal found 5/26![Delta logo]()
$470
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:55 pm
EYW
- SFO
1 stop11h 50m
United Airlines
Sun 6/1411:59 pm
SFO
- EYW
1 stop10h 31m
United Airlines
Deal found 5/26![United Airlines logo]()
$420
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:01 pm
EYW
- SFO
1 stop9h 59m
American Airlines
Tue 6/165:23 am
SFO
- EYW
1 stop8h 29m
American Airlines
Deal found 5/26![American Airlines logo]()
$452
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:55 pm
EYW
- SFO
1 stop11h 50m
United Airlines
Mon 6/1511:59 pm
SFO
- EYW
1 stop10h 31m
United Airlines
Deal found 5/26![United Airlines logo]()
$520
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:21 pm
EYW
- SFO
2 stops10h 45m
American Airlines
Sun 6/147:46 am
SFO
- EYW
1 stop8h 24m
American Airlines
Deal found 5/26![American Airlines logo]()
$533
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:24 pm
EYW
- SFO
1 stop9h 21m
Delta
Mon 6/159:56 pm
SFO
- EYW
1 stop10h 06m
Delta
Deal found 5/26![Delta logo]()
$513
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/171:39 pm
EYW
- SFO
1 stop9h 38m
American Airlines
Wed 6/247:46 am
SFO
- EYW
1 stop8h 24m
American Airlines
Deal found 5/26![American Airlines logo]()
$524
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 29, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/151:11 pm
EYW
- SFO
2 stops25h 32m
Multiple Airlines
Deal found 5/25![Multiple Airlines logo]()
$253
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/154:41 pm
EYW
- SFO
1 stop9h 07m
American Airlines
Deal found 5/25![American Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/412:05 pm
EYW
- SFO
2 stops29h 21m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$329
This Alaska Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1111:59 am
EYW
- SFO
1 stop12h 57m
Alaska Airlines
Deal found 5/28![Alaska Airlines logo]()
$440
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/41:01 pm
EYW
- SFO
1 stop11h 18m
American Airlines
Deal found 5/29![American Airlines logo]()
$509
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/112:21 pm
EYW
- SFO
2 stops11h 02m
American Airlines
Deal found 5/28![American Airlines logo]()
$550
This KAYAK deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1511:46 am
EYW
- SFO
3 stops27h 16m
Breeze Airways
Deal found 5/25![Breeze Airways logo]()
$730
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 29, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $420 (United Airlines) |
One-way from | $253 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 6/10
3:55 pm-12:45 am
1 stop11h 50m
San Francisco
Sun 6/14
11:59 pm-1:30 pm
1 stop10h 31m
$420
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 10/5
7:40 am-2:46 pm
1 stop10h 06m
San Francisco
Sat 10/10
10:30 pm-10:58 am
1 stop9h 28m
$444
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 10/5
5:12 pm-10:48 pm
1 stop8h 36m
San Francisco
Sat 10/10
11:36 pm-12:52 pm
2 stops10h 16m
$462
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 6/10
2:21 pm-10:06 pm
2 stops10h 45m
San Francisco
Sun 6/14
7:46 am-7:10 pm
1 stop8h 24m
$533
Quickest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 6/11
6:24 pm-12:45 am
1 stop9h 21m
San Francisco
Tue 6/16
7:50 am-7:53 pm
1 stop9h 03m
$564
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sun 7/12
7:53 pm-7:18 pm
2 stops26h 25m
San Francisco
Sun 7/19
12:47 pm-11:07 am
1 stop19h 20m
$685
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sun 7/12
4:41 pm-10:48 pm
1 stop9h 07m
San Francisco
Sun 7/19
5:00 am-6:48 pm
1 stop10h 48m
$692
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 11/2
2:35 pm-10:51 pm
1 stop11h 16m
San Francisco
Fri 11/6
6:00 am-5:11 pm
1 stop8h 11m
$747
Cheapest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 6/15
1:11 pm-11:43 am
2 stops25h 32m
$253
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 6/4
12:05 pm-2:26 pm
2 stops29h 21m
$329
Showing 1-10 of 14 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 29, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Comfort
7.2
Overall
7.1
Entertainment
6.9
Food
6.4
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Crew
7.9
Comfort
7.2
Overall
7.1
Entertainment
6.9
Food
6.4
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
Cupertino
San Bruno
Watsonville
San Ramon
Vacaville
Roseville
San Carlos
Redwood City
Daly City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Davis
Emeryville
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Key West and San Francisco flights
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Browse through other flights departing from Key West. Flights are based on user searches made on Cheapflights and were last updated on May 29, 2026.
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Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$348 | FlexibilityNo cancel fee | On-time71% |