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$162+ Cheap flights from Key West to San Francisco (EYW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Key West to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$309
(Delta)

One-way from

$162
(Delta)
From Key West to San Francisco
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One-way flight from Key West to San Francisco
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Find flight deals from Key West to San Francisco

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/241:57 pmEYW - SFO
1 stop7h 59mDelta
Sat 11/17:15 amSFO - EYW
1 stop9h 51mDelta
Deal found 9/14$309
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/242:14 pmEYW - SFO
1 stop9h 27mAmerican Airlines
Sat 11/17:00 amSFO - EYW
2 stops11h 56mAmerican Airlines
Deal found 9/15$314
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/65:47 pmEYW - SFO
2 stops9h 30mAmerican Airlines
Tue 10/148:00 amSFO - EYW
1 stop8h 22mAmerican Airlines
Deal found 9/16$345
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1711:50 amEYW - SFO
1 stop9h 58mDelta
Wed 9/246:15 amSFO - EYW
1 stop8h 00mDelta
Deal found 9/15$462
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1712:00 pmEYW - SFO
1 stop10h 58mAmerican Airlines
Wed 9/245:45 amSFO - EYW
2 stops10h 14mAmerican Airlines
Deal found 9/14$529
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/243:50 pmEYW - SFO
2 stops24h 20mUnited Airlines
Sat 9/2711:25 pmSFO - EYW
1 stop12h 04mUnited Airlines
Deal found 9/15$783

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Key West

Fly to

San Francisco

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 10/24

1:57 pm-6:56 pm

1 stop7h 59m

San Francisco

Sat 11/1

7:15 am-8:06 pm

1 stop9h 51m

$309

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 10/24

2:32 pm-8:42 pm

1 stop9h 10m

San Francisco

Sat 11/1

11:59 pm-11:14 am

1 stop9h 15m

$309

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 10/6

6:17 pm-12:05 am

1 stop8h 48m

San Francisco

Tue 10/14

7:15 am-8:06 pm

1 stop9h 51m

$309

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 10/6

5:47 pm-12:17 am

2 stops9h 30m

San Francisco

Tue 10/14

8:00 am-7:22 pm

1 stop8h 22m

$345

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 3/6

4:53 pm-12:25 am

1 stop10h 32m

San Francisco

Tue 3/10

10:45 pm-12:46 pm

1 stop11h 01m

$409

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 10/24

6:17 pm-12:05 am

1 stop8h 48m

$162

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 10/24

8:55 am-9:29 am

2 stops27h 34m

$163

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sun 11/16

2:25 pm-2:40 pm

3 stops27h 15m

$213

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 10/11

10:47 am-12:09 am

3 stops40h 22m

$247

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 10/24

1:04 pm-9:53 pm

1 stop11h 49m

$265

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 12 results
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Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to San Francisco?

    Delta and American Airlines can get you from Key West to San Francisco in just under 7h 59m. Your travel time can differ by up to 1h 11m. Key West and San Francisco are separated by a distance of 2542 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Key West to San Francisco that include hotel bookings?

    Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.

  • Can I find deals for business class flights from Key West to San Francisco?

    Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Key West to San Francisco (average of $276). Flying from Key West to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Santa Clara
Manteca
Sunnyvale
Hollister
Vacaville
Foster City
Union City
Vallejo
Burlingame
Redwood City
San Mateo
San Leandro
Lathrop

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