How long is the flight from Key West to San Francisco?

American Airlines can get you from Key West to San Francisco in just under 12h 12m. Your travel time can differ by up to . Key West and San Francisco are separated by a distance of 2542 mi.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What is the cheapest time of day to fly from EYW to SFO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Key West to San Francisco as you normally would.

Most accurate provider : When it comes to deals on Key West-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Key West-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Key West to San Francisco that include hotel bookings?

Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Key West to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.

Can I find deals for business class flights from Key West to San Francisco?

Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$130+ Flights from Key West to San Francisco

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Cheap flight deals from Key West to San Francisco

Best flights from Key West to San Francisco
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 27, 2025.

Fri 2/202:02 pmEYW - SFO

1 stop12h 12mAmerican Airlines

Fri 2/278:57 amSFO - EYW

1 stop10h 46mAmerican Airlines

Deal found 12/24

$259

Thu 1/156:05 pmEYW - SFO

1 stop10h 25mUnited Airlines

Sun 1/189:30 pmSFO - EYW

1 stop12h 33mUnited Airlines

Deal found 12/24

$499

Sat 1/107:10 amEYW - SFO

1 stop8h 49mDelta

Wed 1/148:00 amSFO - EYW

1 stop8h 40mDelta

Deal found 12/26

$559

Sat 1/106:06 amEYW - SFO

2 stops11h 59mAmerican Airlines

Wed 1/146:00 amSFO - EYW

2 stops10h 10mAmerican Airlines

Deal found 12/26

$385

Last-minute flights from Key West to San Francisco
Discover last-minute flight deals from Key West to San Francisco. Data last updated December 27, 2025 and is based on user searches.

Thu 1/11:15 pmEYW - SFO

1 stop10h 03mAmerican Airlines

Wed 1/71:15 pmSFO - EYW

1 stop7h 41mAmerican Airlines

Deal found 12/26

$475

Mon 1/51:46 pmEYW - SFO

1 stop10h 53mAmerican Airlines

Wed 2/47:00 amSFO - EYW

1 stop8h 01mAmerican Airlines

Deal found 12/27

$627

Sat 1/106:06 amEYW - SFO

2 stops11h 59mAmerican Airlines

Wed 1/146:00 amSFO - EYW

2 stops10h 10mAmerican Airlines

Deal found 12/26

$385

Sat 1/107:10 amEYW - SFO

1 stop8h 49mDelta

Wed 1/148:00 amSFO - EYW

1 stop8h 40mDelta

Deal found 12/26

$559

Thu 1/156:05 pmEYW - SFO

1 stop10h 25mUnited Airlines

Sun 1/189:30 pmSFO - EYW

1 stop12h 33mUnited Airlines

Deal found 12/24

$499

One-way flights from Key West to San Francisco
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated December 27, 2025.

Wed 2/255:56 pmEYW - SFO

1 stop8h 53mDelta

Deal found 12/27

$130

Mon 2/239:49 amEYW - SFO

2 stops39h 12mMultiple Airlines

Deal found 12/27

$133

Tue 4/74:02 pmEYW - SFO

2 stops10h 37mAmerican Airlines

Deal found 12/25

$135

Tue 2/241:01 pmEYW - SFO

2 stops38h 27mMultiple Airlines

Deal found 12/27

$147

Sun 2/222:25 pmEYW - SFO

3 stops58h 36mMultiple Airlines

Deal found 12/26

$153

Wed 2/2512:55 pmEYW - SFO

1 stop10h 25mAmerican Airlines

Deal found 12/27

$180

Mon 2/24:37 pmEYW - SFO

1 stop9h 59mAmerican Airlines

Deal found 12/25

$188

Mon 3/161:06 pmEYW - SFO

3 stops59h 13mMultiple Airlines

Deal found 12/26

$190

Find flight deals from Key West to San Francisco

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$259 (American Airlines)
One-way from	$130 (Delta)

Provider with most accurate pricing for Key West-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Key West-San Francisco flights.

Search Deals

From Key West to San Francisco

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One-way flight from Key West to San Francisco

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 2/20

2:02 pm-11:14 pm

1 stop12h 12m

San Francisco

Fri 2/27

8:57 am-10:43 pm

1 stop10h 46m

$259

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 1/10

6:06 am-3:05 pm

2 stops11h 59m

San Francisco

Wed 1/14

6:00 am-7:10 pm

2 stops10h 10m

$385

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 1/15

6:05 pm-1:30 am

1 stop10h 25m

San Francisco

Sun 1/18

9:30 pm-1:03 pm

1 stop12h 33m

$499

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 1/10

7:10 am-12:59 pm

1 stop8h 49m

San Francisco

Wed 1/14

8:00 am-7:40 pm

1 stop8h 40m

$559

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 4/7

3:55 pm-11:39 pm

1 stop10h 44m

$130

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 2/25

5:56 pm-11:49 pm

1 stop8h 53m

$130

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 2/23

9:49 am-10:01 pm

2 stops39h 12m

$133

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 2/24

1:01 pm-12:28 am

2 stops38h 27m

$147

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sun 2/22

2:25 pm-10:01 pm

3 stops58h 36m

$153

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 2/25

12:55 pm-8:20 pm

1 stop10h 25m

$180

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/25

Showing 1-10 of 12 results

Compare providers for flights from Key West to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to San Francisco in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing San Francisco

See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,067 reviews

Reviews

1 / 20

2.0

Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

American Airlines

7.2

Good

11,067 reviews

American Airlines

7.2

Good

11,067 reviews

Reviews

1 / 20

2.0

Mediocre

Anonymous,Aug 2025

MIA - DCA

Related info for your journey

How long is the flight from Key West to San Francisco?
American Airlines can get you from Key West to San Francisco in just under 12h 12m. Your travel time can differ by up to . Key West and San Francisco are separated by a distance of 2542 mi.
Can I find deals for flights from Key West to San Francisco that include hotel bookings?
Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Key West to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.
Can I find deals for business class flights from Key West to San Francisco?
Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Foster City

Union City

Davis

Emeryville

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Key West to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$313	Average$453	FlexibilityNo cancel fee	On-time71%

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$130+ Cheap flights from Key West to San Francisco (EYW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Key West to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Key West to San Francisco

Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 27, 2025.

Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 27, 2025.

Find flight deals from Key West to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Compare providers for flights from Key West to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to San Francisco in December.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.

Reviews of airlines servicing San Francisco

See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Key West to San Francisco?

Can I find deals for flights from Key West to San Francisco that include hotel bookings?

How can I find direct flights from Key West to San Francisco?

Can I find deals for business class flights from Key West to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Key West to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Key West to San Francisco

100% Free

Book with Flexibility

Travel Smart

Best flights from Key West to San Francisco
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 27, 2025.