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$130+ Cheap flights from Key West to San Francisco (EYW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from Key West to San Francisco

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:40 pm
EYW
-
SFO
1 stop8h 48m
Delta
Mon 4/1311:39 pm
SFO
-
EYW
1 stop8h 11m
Delta
Deal found 2/11$299
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:25 pm
EYW
-
SFO
1 stop9h 10m
Delta
Mon 4/1311:39 pm
SFO
-
EYW
1 stop8h 11m
Delta
Deal found 2/9$359
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:56 pm
EYW
-
SFO
1 stop10h 30m
United Airlines
Sun 3/19:30 pm
SFO
-
EYW
1 stop12h 45m
United Airlines
Deal found 2/10$389
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/251:55 pm
EYW
-
SFO
2 stops11h 45m
American Airlines
Sun 3/17:25 am
SFO
-
EYW
1 stop8h 50m
American Airlines
Deal found 2/10$390
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/73:58 pm
EYW
-
SFO
2 stops10h 11m
American Airlines
Mon 4/136:00 am
SFO
-
EYW
1 stop9h 16m
American Airlines
Deal found 2/11$392
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/192:29 pm
EYW
-
SFO
1 stop8h 02m
American Airlines
Tue 5/2611:49 pm
SFO
-
EYW
1 stop9h 27m
American Airlines
Deal found 2/8$417
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:00 am
EYW
-
SFO
1 stop10h 07m
United Airlines
Mon 3/210:55 pm
SFO
-
EYW
1 stop11h 20m
United Airlines
Deal found 2/8$459
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/63:56 pm
EYW
-
SFO
2 stops11h 52m
American Airlines
Mon 4/136:00 am
SFO
-
EYW
1 stop9h 16m
American Airlines
Deal found 2/9$481

Find flight deals from Key West to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 12, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$299
(Delta)

One-way from

$130
(American Airlines)
Provider with most accurate pricing for Key West-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-San Francisco flights.
Search Deals
From Key West to San Francisco
Search Deals
One-way flight from Key West to San Francisco
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Key West

Fly to

San Francisco

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 4/7

2:40 pm-8:28 pm

1 stop8h 48m

San Francisco

Mon 4/13

11:39 pm-10:50 am

1 stop8h 11m

$299

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 4/6

6:25 pm-12:35 am

1 stop9h 10m

San Francisco

Mon 4/13

11:39 pm-10:50 am

1 stop8h 11m

$359

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 2/25

3:56 pm-11:26 pm

1 stop10h 30m

San Francisco

Sun 3/1

9:30 pm-1:15 pm

1 stop12h 45m

$389

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 2/25

1:55 pm-10:40 pm

2 stops11h 45m

San Francisco

Sun 3/1

7:25 am-7:15 pm

1 stop8h 50m

$390

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 4/7

3:58 pm-11:09 pm

2 stops10h 11m

San Francisco

Mon 4/13

6:00 am-6:16 pm

1 stop9h 16m

$392

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 5/19

2:29 pm-7:31 pm

1 stop8h 02m

San Francisco

Tue 5/26

11:49 pm-12:16 pm

1 stop9h 27m

$417

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 2/26

7:00 am-2:07 pm

1 stop10h 07m

San Francisco

Mon 3/2

10:55 pm-1:15 pm

1 stop11h 20m

$459

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 5/6

2:01 pm-9:28 pm

1 stop10h 27m

$130

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 5/7

2:01 pm-9:28 pm

1 stop10h 27m

$130

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 4/8

11:51 am-9:08 pm

2 stops12h 17m

$163

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Showing 1-10 of 11 results
1
2
  • Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to San Francisco?

    Delta, United Airlines, and American Airlines can get you from Key West to San Francisco in just under 8h 48m. Your travel time can differ by up to 2h 57m. Key West and San Francisco are separated by a distance of 2542 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Key West to San Francisco that include hotel bookings?

    Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.

  • Can I find deals for business class flights from Key West to San Francisco?

    Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
South San Francisco
Santa Clara
Roseville
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Redwood City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City

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