$223+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Find cheap flights from Key West to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:19 pm -
1 stop8h 38m
Sat 10/311:30 pm -
1 stop8h 16m
Deal found 9/14![Delta logo]()
$421
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:47 pm -
1 stop8h 49m
Tue 10/69:46 pm -
1 stop9h 08m
Deal found 9/16![American Airlines logo]()
$450
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:47 pm -
2 stops9h 38m
Sat 10/39:54 pm -
1 stop8h 57m
Deal found 9/14![American Airlines logo]()
$458
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:47 pm -
1 stop8h 49m
Mon 10/59:46 pm -
1 stop9h 08m
Deal found 9/17![American Airlines logo]()
$479
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:26 pm -
1 stop11h 05m
Fri 11/611:39 pm -
1 stop13h 36m
Deal found 9/16![American Airlines logo]()
$762
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/1512:56 pm -
1 stop9h 39m
Thu 1/215:00 am -
1 stop9h 10m
Deal found 9/16![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:19 pm -
1 stop8h 38m
Sat 10/311:30 pm -
1 stop8h 16m
Deal found 9/14![Delta logo]()
$421
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:47 pm -
1 stop8h 49m
Mon 10/59:46 pm -
1 stop9h 08m
Deal found 9/17![American Airlines logo]()
$479
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:15 pm -
1 stop8h 53m
Tue 10/67:57 pm -
2 stops10h 57m
Deal found 9/16![American Airlines logo]()
$487
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/1511:31 am -
1 stop11h 08m
Thu 1/215:30 am -
2 stops10h 33m
Deal found 9/16![American Airlines logo]()
$560
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:26 pm -
1 stop11h 05m
Fri 11/611:39 pm -
1 stop13h 36m
Deal found 9/15![American Airlines logo]()
$762
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated September 18, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/222:00 pm -
1 stop10h 39m
Wed 9/238:00 am -
1 stop9h 00m
Deal found 9/15![Delta logo]()
$869
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/221:47 pm -
2 stops13h 09m
Wed 9/236:12 am -
1 stop8h 43m
Deal found 9/15![American Airlines logo]()
$874
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:19 pm -
1 stop8h 38m
Sat 10/311:30 pm -
1 stop8h 16m
Deal found 9/14![Delta logo]()
$421
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:47 pm -
2 stops9h 38m
Sat 10/39:54 pm -
1 stop8h 57m
Deal found 9/14![American Airlines logo]()
$458
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:47 pm -
1 stop8h 49m
Tue 10/69:46 pm -
1 stop9h 08m
Deal found 9/16![American Airlines logo]()
$450
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:47 pm -
1 stop8h 49m
Mon 10/59:46 pm -
1 stop9h 08m
Deal found 9/17![American Airlines logo]()
$479
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:01 pm -
2 stops32h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2812:59 pm -
2 stops24h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$333
This KAYAK deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/251:12 pm -
1 stop14h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![JetBlue logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2910:59 am -
2 stops35h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$356
This KAYAK deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:29 pm -
1 stop12h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![JetBlue logo]()
$397
This KAYAK deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/291:12 pm -
1 stop14h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![JetBlue logo]()
$400
This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/281:12 pm -
1 stop14h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![JetBlue logo]()
$403
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/285:16 pm -
1 stop9h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$436
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:20 pm -
1 stop8h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Delta logo]()
$440
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/265:52 pm -
1 stop10h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![United Airlines logo]()
$444
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 18, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $399 (United Airlines) |
One-way from | $223 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Thu 10/8
12:01 pm-5:55 pm
2 stops32h 54m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$223
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 12/29
10:59 am-7:50 pm
2 stops35h 51m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$356
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Thu 10/8
12:29 pm-9:44 pm
1 stop12h 15m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$397
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Fri 1/15
12:56 pm-7:35 pm
1 stop9h 39m
San Francisco
Thu 1/21
5:00 am-5:10 pm
1 stop9h 10m
$399
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 12/28
1:12 pm-12:30 am
1 stop14h 18m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$403
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 12/29
1:12 pm-11:24 pm
1 stop13h 12m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$403
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 9/29
6:19 pm-11:57 pm
1 stop8h 38m
San Francisco
Sat 10/3
11:30 pm-10:46 am
1 stop8h 16m
$421
Quickest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Thu 12/31
6:20 pm-11:58 pm
1 stop8h 38m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$440
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sat 12/26
5:52 pm-12:59 am
1 stop10h 07m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$444
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Wed 12/30
1:12 pm-11:24 pm
1 stop13h 12m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$463
Showing 1-10 of 16 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 18, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Overall
7.1
Entertainment
6.8
Comfort
7.2
Crew
7.9
Boarding
7.4
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Food
6.4
Overall
7.1
Entertainment
6.8
Comfort
7.2
Crew
7.9
Boarding
7.4
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
San Bruno
Burlingame
Rancho Cordova
Roseville
Fairfield
Hayward
Cupertino
Newark
San Ramon
Redwood City
Manteca
Vallejo
San Carlos
Turlock
Davis
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Key West and San Francisco flights
Browse other Key West and San Francisco flight options. Last updated on September 18, 2026.
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Browse through other flights departing from Key West. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
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Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$469 | FlexibilityNo cancel fee | On-time71% |