$301+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/6. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Sep 10 — Sep 171
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:19 pm -
1 stop8h 38m
Sat 10/1010:30 pm -
1 stop9h 17m
Deal found 8/9![Delta logo]()
$301
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:28 pm -
1 stop9h 31m
Fri 10/306:47 am -
1 stop7h 07m
Deal found 8/8![American Airlines logo]()
$340
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:00 pm -
1 stop10h 58m
Fri 9/1110:00 pm -
1 stop9h 46m
Deal found 8/7![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:43 pm -
1 stop8h 50m
Sat 10/1010:03 pm -
2 stops12h 00m
Deal found 8/6![American Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:40 pm -
1 stop9h 38m
Sat 8/297:30 am -
1 stop8h 10m
Deal found 8/10![American Airlines logo]()
$401
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:50 pm -
1 stop8h 50m
Tue 9/1511:03 pm -
1 stop11h 08m
Deal found 8/7![American Airlines logo]()
$422
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/237:53 pm -
2 stops26h 10m
Thu 8/2712:47 pm -
1 stop24h 26m
Deal found 8/8![Multiple Airlines logo]()
$481
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:10 pm -
1 stop8h 46m
Sat 10/1010:30 pm -
1 stop9h 17m
Deal found 8/6![Delta logo]()
$301
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:43 pm -
1 stop8h 50m
Sat 10/1010:03 pm -
2 stops12h 00m
Deal found 8/6![American Airlines logo]()
$388
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:19 pm -
1 stop8h 38m
Sat 10/1010:30 pm -
1 stop9h 17m
Deal found 8/9![Delta logo]()
$301
This Priceline deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:14 pm -
1 stop12h 41m
Sat 10/1010:10 pm -
1 stop10h 49m
Deal found 8/11![Multiple Airlines logo]()
$612
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:15 pm -
2 stops25h 57m
Mon 10/510:45 pm -
1 stop11h 44m
Deal found 8/10![United Airlines logo]()
$716
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:00 pm -
1 stop10h 58m
Fri 9/1110:00 pm -
1 stop9h 46m
Deal found 8/7![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:40 pm -
2 stops9h 34m
Sat 8/2911:30 pm -
2 stops10h 35m
Deal found 8/10![American Airlines logo]()
$475
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:28 pm -
2 stops10h 16m
Fri 10/307:11 pm -
2 stops11h 38m
Deal found 8/8![American Airlines logo]()
$609
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:10 pm -
1 stop10h 46m
Fri 11/63:20 pm -
2 stops19h 32m
Deal found 8/10![United Airlines logo]()
$745
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/21:12 pm -
1 stop13h 47m
Fri 11/611:39 pm -
1 stop13h 36m
Deal found 8/6![American Airlines logo]()
$632
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated August 11, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated August 11, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/237:53 pm -
2 stops26h 10m
Thu 8/2712:47 pm -
1 stop24h 26m
Deal found 8/8![Multiple Airlines logo]()
$481
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:40 pm -
1 stop9h 38m
Sat 8/297:30 am -
1 stop8h 10m
Deal found 8/10![American Airlines logo]()
$401
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:50 pm -
1 stop8h 50m
Tue 9/1511:03 pm -
1 stop11h 08m
Deal found 8/7![American Airlines logo]()
$422
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:50 pm -
1 stop8h 50m
Fri 9/48:41 pm -
2 stops13h 24m
Deal found 8/9![American Airlines logo]()
$778
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:00 pm -
1 stop10h 58m
Fri 9/1110:00 pm -
1 stop9h 46m
Deal found 8/7![Delta logo]()
$369
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 11, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $301 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 10/6
6:10 pm-11:56 pm
1 stop8h 46m
San Francisco
Sat 10/10
10:30 pm-10:47 am
1 stop9h 17m
$301
Quickest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sat 10/3
6:19 pm-11:57 pm
1 stop8h 38m
San Francisco
Sat 10/10
10:30 pm-10:47 am
1 stop9h 17m
$301
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sat 9/5
4:00 pm-11:58 pm
1 stop10h 58m
San Francisco
Fri 9/11
10:00 pm-10:46 am
1 stop9h 46m
$369
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 10/6
1:43 pm-7:33 pm
1 stop8h 50m
San Francisco
Sat 10/10
10:03 pm-1:03 pm
2 stops12h 00m
$388
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 8/25
1:40 pm-8:14 pm
2 stops9h 34m
San Francisco
Sat 8/29
11:30 pm-1:05 pm
2 stops10h 35m
$475
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sat 10/24
5:28 pm-12:44 am
2 stops10h 16m
San Francisco
Fri 10/30
7:11 pm-9:49 am
2 stops11h 38m
$609
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sat 10/3
12:14 pm-9:55 pm
1 stop12h 41m
San Francisco
Sat 10/10
10:10 pm-11:59 am
1 stop10h 49m
$612
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 11/2
1:12 pm-11:59 pm
1 stop13h 47m
San Francisco
Fri 11/6
11:39 pm-4:15 pm
1 stop13h 36m
$632
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Fri 10/2
2:15 pm-1:12 pm
2 stops25h 57m
San Francisco
Mon 10/5
10:45 pm-1:29 pm
1 stop11h 44m
$716
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 11/2
4:10 pm-11:56 pm
1 stop10h 46m
San Francisco
Fri 11/6
3:20 pm-1:52 pm
2 stops19h 32m
$745
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated August 11, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Food
6.4
Boarding
7.5
Crew
7.9
Comfort
7.2
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Entertainment
6.8
Food
6.4
Boarding
7.5
Crew
7.9
Comfort
7.2
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
San Bruno
Fairfield
Emeryville
Roseville
Burlingame
Rancho Cordova
Vallejo
Cupertino
Newark
Hayward
San Ramon
Redwood City
San Carlos
Manteca
Turlock
San Lorenzo
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Key West and San Francisco flights
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Other flights from Key West
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Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$419 | FlexibilityNo cancel fee | On-time71% |