$180+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Sep 20 — Sep 271
Round-trip
1 adult, Economy
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Find cheap flights from Key West to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:15 pm -
1 stop8h 43m
Sat 9/1911:30 pm -
1 stop8h 16m
Deal found 8/17![Delta logo]()
$351
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/181:40 pm -
2 stops9h 34m
Sat 9/199:54 pm -
1 stop8h 57m
Deal found 8/16![American Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:03 pm -
1 stop7h 50m
Sun 9/208:35 am -
1 stop7h 42m
Deal found 8/16![American Airlines logo]()
$390
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/191:59 pm -
1 stop11h 01m
Tue 8/258:00 am -
1 stop8h 57m
Deal found 8/17![Delta logo]()
$401
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:59 pm -
1 stop8h 40m
Sat 9/510:00 pm -
1 stop9h 50m
Deal found 8/18![Delta logo]()
$430
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/191:49 pm -
2 stops11h 51m
Tue 8/259:35 pm -
1 stop9h 09m
Deal found 8/17![American Airlines logo]()
$438
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:59 pm -
1 stop11h 01m
Thu 9/249:55 pm -
1 stop9h 51m
Deal found 8/18![Delta logo]()
$449
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:09 pm -
1 stop7h 45m
Sat 9/199:54 pm -
1 stop8h 57m
Deal found 8/16![American Airlines logo]()
$454
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:50 pm -
1 stop8h 28m
Sat 9/54:31 pm -
2 stops14h 13m
Deal found 8/18![American Airlines logo]()
$467
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:59 pm -
1 stop8h 40m
Sat 9/510:00 pm -
1 stop9h 50m
Deal found 8/17![Delta logo]()
$401
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:09 pm -
1 stop7h 45m
Mon 9/75:05 am -
1 stop8h 13m
Deal found 8/19![American Airlines logo]()
$559
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:10 pm -
1 stop10h 46m
Fri 11/63:20 pm -
2 stops19h 32m
Deal found 8/19![United Airlines logo]()
$793
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:59 pm -
1 stop11h 01m
Thu 9/249:55 pm -
1 stop9h 51m
Deal found 8/18![Delta logo]()
$449
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/411:30 am -
2 stops10h 35m
Sat 9/510:53 pm -
2 stops11h 12m
Deal found 8/18![American Airlines logo]()
$581
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/21:12 pm -
1 stop13h 47m
Fri 11/611:39 pm -
1 stop13h 36m
Deal found 8/20![American Airlines logo]()
$695
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:50 pm -
2 stops21h 29m
Mon 11/94:25 pm -
2 stops18h 27m
Deal found 8/19![United Airlines logo]()
$805
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated August 21, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated August 21, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:59 pm -
1 stop8h 40m
Sat 9/510:00 pm -
1 stop9h 50m
Deal found 8/17![Delta logo]()
$401
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:50 pm -
2 stops11h 28m
Sat 9/511:29 pm -
1 stop9h 58m
Deal found 8/17![American Airlines logo]()
$438
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:09 pm -
1 stop7h 45m
Mon 9/75:05 am -
1 stop8h 13m
Deal found 8/19![American Airlines logo]()
$559
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:59 pm -
1 stop8h 40m
Sat 9/510:00 pm -
1 stop9h 50m
Deal found 8/18![Delta logo]()
$430
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:59 pm -
1 stop11h 01m
Thu 9/249:55 pm -
1 stop9h 51m
Deal found 8/18![Delta logo]()
$449
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:50 pm -
1 stop8h 28m
Sat 9/54:31 pm -
2 stops14h 13m
Deal found 8/18![American Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/411:30 am -
2 stops10h 57m
Tue 9/87:30 am -
1 stop8h 01m
Deal found 8/20![American Airlines logo]()
$543
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/44:50 pm -
1 stop8h 50m
Thu 9/247:04 pm -
2 stops11h 54m
Deal found 8/18![American Airlines logo]()
$572
This Trip.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/412:07 pm -
2 stops39h 11m
Thu 9/2411:42 am -
2 stops19h 37m
Deal found 8/18![Multiple Airlines logo]()
$574
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.
This JetBlue deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:50 pm -
1 stop12h 10m
Deal found 8/19![JetBlue logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:59 pm -
2 stops32h 11m
Deal found 8/19![Multiple Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/410:59 am -
2 stops26h 48m
Deal found 8/20![Multiple Airlines logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:11 pm -
2 stops32h 34m
Deal found 8/18![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1412:59 pm -
3 stops38h 15m
Deal found 8/21![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:01 pm -
2 stops32h 54m
Deal found 8/19![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:59 am -
3 stops27h 18m
Deal found 8/19![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:59 am -
2 stops27h 18m
Deal found 8/19![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:04 am -
3 stops17h 16m
Deal found 8/19![Multiple Airlines logo]()
$218
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 21, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $401 (Delta) |
One-way from | $180 (JetBlue) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 9/1
1:59 pm-7:39 pm
1 stop8h 40m
San Francisco
Sat 9/5
10:00 pm-10:50 am
1 stop9h 50m
$401
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Fri 9/4
1:59 pm-10:00 pm
1 stop11h 01m
San Francisco
Thu 9/24
9:55 pm-10:46 am
1 stop9h 51m
$449
Quickest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Thu 9/3
8:09 pm-12:54 am
1 stop7h 45m
San Francisco
Mon 9/7
5:05 am-4:18 pm
1 stop8h 13m
$559
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Fri 9/4
11:30 am-7:05 pm
2 stops10h 35m
San Francisco
Sat 9/5
10:53 pm-1:05 pm
2 stops11h 12m
$581
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 11/2
1:12 pm-11:59 pm
1 stop13h 47m
San Francisco
Fri 11/6
11:39 pm-4:15 pm
1 stop13h 36m
$695
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 11/2
4:10 pm-11:56 pm
1 stop10h 46m
San Francisco
Fri 11/6
3:20 pm-1:52 pm
2 stops19h 32m
$793
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Thu 11/5
2:50 pm-9:19 am
2 stops21h 29m
San Francisco
Mon 11/9
4:25 pm-1:52 pm
2 stops18h 27m
$805
Cheapest one-way
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Fri 10/23
12:50 pm-10:00 pm
1 stop12h 10m
$180
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sat 11/14
10:04 am-12:15 am
2 stops41h 11m
$206
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 9/14
10:59 am-10:47 am
3 stops26h 48m
$219
Showing 1-10 of 16 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated August 21, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Food
6.4
Boarding
7.5
Crew
7.9
Comfort
7.2
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Entertainment
6.8
Food
6.4
Boarding
7.5
Crew
7.9
Comfort
7.2
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
San Bruno
Emeryville
Roseville
Burlingame
Rancho Cordova
Fairfield
Vallejo
Cupertino
Newark
Hayward
San Ramon
Redwood City
Manteca
San Carlos
Turlock
San Lorenzo
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Key West and San Francisco flights
Browse other Key West and San Francisco flight options. Last updated on August 21, 2026.
Other flights from Key West
Browse through other flights departing from Key West. Flights are based on user searches made on Cheapflights and were last updated on August 21, 2026.
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Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$419 | FlexibilityNo cancel fee | On-time71% |