$178+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/10. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Nov 19 — Nov 261
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/102:36 pm -
1 stop9h 30m
Tue 12/155:00 am -
1 stop9h 44m
Deal found 10/18![American Airlines logo]()
$370
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1712:22 pm -
1 stop11h 57m
Tue 12/2211:30 pm -
1 stop9h 11m
Deal found 10/18![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/254:43 pm -
1 stop9h 10m
Wed 12/26:38 am -
1 stop7h 14m
Deal found 10/20![American Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:59 am -
2 stops33h 36m
Sun 12/612:46 pm -
1 stop19h 27m
Deal found 10/16![Multiple Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:06 pm -
1 stop8h 49m
Mon 12/149:59 pm -
1 stop9h 49m
Deal found 10/20![Delta logo]()
$399
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:45 pm -
1 stop9h 14m
Wed 11/185:00 am -
1 stop10h 01m
Deal found 10/19![American Airlines logo]()
$422
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:05 pm -
1 stop10h 20m
Tue 12/2211:30 pm -
1 stop9h 11m
Deal found 10/18![United Airlines logo]()
$429
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:05 pm -
1 stop10h 20m
Mon 12/2111:30 pm -
1 stop9h 11m
Deal found 10/18![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:43 pm -
1 stop8h 50m
Tue 11/36:38 am -
1 stop7h 17m
Deal found 10/15![American Airlines logo]()
$460
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:59 am -
2 stops33h 36m
Sun 12/612:46 pm -
1 stop19h 27m
Deal found 10/16![Multiple Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:05 pm -
1 stop10h 20m
Tue 12/2211:30 pm -
1 stop9h 11m
Deal found 10/18![United Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:43 pm -
1 stop8h 50m
Tue 11/36:10 pm -
2 stops12h 38m
Deal found 10/15![American Airlines logo]()
$497
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:05 pm -
1 stop10h 20m
Mon 12/2111:30 pm -
1 stop9h 11m
Deal found 10/18![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1512:05 pm -
1 stop12h 22m
Mon 12/2111:30 pm -
1 stop9h 11m
Deal found 10/20![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1012:05 pm -
1 stop10h 20m
Mon 12/2111:30 pm -
1 stop9h 11m
Deal found 10/18![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:10 pm -
1 stop11h 43m
Mon 11/912:55 am -
1 stop11h 34m
Deal found 10/16![United Airlines logo]()
$529
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated October 20, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated October 20, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:43 pm -
1 stop8h 50m
Tue 11/36:38 am -
1 stop7h 17m
Deal found 10/15![American Airlines logo]()
$460
This KAYAK deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:46 pm -
1 stop14h 39m
Fri 11/610:10 pm -
1 stop10h 46m
Deal found 10/20![JetBlue logo]()
$660
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:10 pm -
1 stop11h 43m
Mon 11/912:55 am -
1 stop11h 34m
Deal found 10/15![United Airlines logo]()
$529
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:45 pm -
1 stop9h 14m
Wed 11/185:00 am -
1 stop10h 01m
Deal found 10/19![American Airlines logo]()
$422
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/254:43 pm -
1 stop9h 10m
Wed 12/26:38 am -
1 stop7h 14m
Deal found 10/20![American Airlines logo]()
$391
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/103:21 pm -
2 stops27h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/113:58 pm -
3 stops31h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:26 pm -
2 stops24h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$190
This Priceline deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/31:14 pm -
1 stop12h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![JetBlue logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:01 pm -
2 stops26h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Breeze Airways logo]()
$204
This Trip.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1710:59 am -
2 stops15h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/412:59 pm -
3 stops55h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/3112:01 pm -
2 stops38h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2912:01 pm -
2 stops14h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/289:11 pm -
2 stops29h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$240
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 20, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $370 (American Airlines) |
One-way from | $200 (Priceline) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 1/4
10:59 am-9:00 am
2 stops25h 01m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$260
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Fri 12/25
12:59 pm-11:15 pm
2 stops13h 16m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$290
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Wed 12/30
5:35 pm-8:28 pm
2 stops29h 53m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$311
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Thu 12/31
12:01 pm-12:35 am
3 stops39h 34m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$318
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 12/28
12:59 pm-7:04 am
3 stops45h 05m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$322
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 1/18
12:59 pm-12:49 pm
3 stops50h 50m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$379
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 12/1
10:59 am-5:35 pm
2 stops33h 36m
San Francisco
Sun 12/6
12:46 pm-11:13 am
1 stop19h 27m
$394
Quickest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Fri 12/25
2:50 pm-8:10 pm
1 stop8h 20m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$399
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 12/28
1:13 pm-12:37 am
1 stop14h 24m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$408
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 12/29
1:13 pm-12:37 am
1 stop14h 24m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$408
Showing 1-10 of 16 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 20, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Food
6.4
Comfort
7.1
Overall
7.0
Crew
7.9
Boarding
7.4
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Entertainment
6.8
Food
6.4
Comfort
7.1
Overall
7.0
Crew
7.9
Boarding
7.4
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Hayward
San Bruno
Emeryville
Burlingame
Roseville
Redwood City
Rancho Cordova
Cupertino
Newark
Fairfield
San Ramon
Manteca
San Carlos
Vallejo
Turlock
Davis
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Key West and San Francisco flights
Browse other Key West and San Francisco flight options. Last updated on October 20, 2026.
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Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$469 | FlexibilityNo cancel fee | On-time71% |