$188+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Aug 13 — Aug 201
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 14, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 14, 2026.
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:40 am
EYW
- SFO
1 stop9h 02m
Delta
Sat 11/77:30 am
SFO
- EYW
1 stop9h 21m
Delta
Deal found 7/10![Delta logo]()
$291
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Thu 8/279:35 pm
SFO
- EYW
1 stop9h 09m
American Airlines
Deal found 7/11![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:11 pm
EYW
- SFO
1 stop9h 04m
Delta
Sat 10/1011:45 pm
SFO
- EYW
1 stop8h 03m
Delta
Deal found 7/10![Delta logo]()
$385
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1712:07 pm
EYW
- SFO
2 stops34h 49m
Multiple Airlines
Thu 8/2712:47 pm
SFO
- EYW
1 stop24h 26m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$438
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:28 pm
EYW
- SFO
1 stop9h 31m
American Airlines
Sat 10/1011:27 pm
SFO
- EYW
2 stops10h 36m
American Airlines
Deal found 7/10![American Airlines logo]()
$442
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:59 am
EYW
- SFO
2 stops30h 51m
Multiple Airlines
Thu 11/512:46 pm
SFO
- EYW
1 stop18h 50m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$451
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:59 am
EYW
- SFO
2 stops30h 51m
Multiple Airlines
Sun 11/812:46 pm
SFO
- EYW
1 stop18h 05m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$466
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/211:09 am
EYW
- SFO
2 stops26h 20m
Multiple Airlines
Thu 11/512:46 pm
SFO
- EYW
1 stop18h 50m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$483
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/211:09 am
EYW
- SFO
2 stops26h 20m
Multiple Airlines
Sun 11/812:46 pm
SFO
- EYW
1 stop18h 05m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$499
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:33 pm
EYW
- SFO
1 stop22h 28m
Multiple Airlines
Fri 10/99:00 pm
SFO
- EYW
2 stops34h 19m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$517
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 14, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 14, 2026.
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:40 am
EYW
- SFO
1 stop9h 02m
Delta
Sat 11/75:45 pm
SFO
- EYW
2 stops14h 03m
Delta
Deal found 7/10![Delta logo]()
$434
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/21:23 pm
EYW
- SFO
1 stop13h 36m
American Airlines
Fri 11/611:59 pm
SFO
- EYW
1 stop8h 09m
American Airlines
Deal found 7/14![American Airlines logo]()
$675
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:15 am
EYW
- SFO
2 stops12h 12m
American Airlines
Thu 8/278:41 pm
SFO
- EYW
2 stops10h 03m
American Airlines
Deal found 7/12![American Airlines logo]()
$703
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:00 pm
EYW
- SFO
1 stop8h 37m
Delta
Fri 11/611:45 pm
SFO
- EYW
1 stop8h 03m
Delta
Deal found 7/10![Delta logo]()
$747
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated July 14, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated July 14, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1311:57 am
EYW
- SFO
1 stop27h 05m
Multiple Airlines
Wed 7/157:08 pm
SFO
- EYW
2 stops13h 17m
Multiple Airlines
Deal found 7/9![Multiple Airlines logo]()
$848
This Delta deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:18 pm
EYW
- SFO
1 stop9h 18m
Delta
Wed 7/156:00 am
SFO
- EYW
1 stop8h 23m
Delta
Deal found 7/9![Delta logo]()
$928
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/132:21 pm
EYW
- SFO
2 stops11h 02m
American Airlines
Wed 7/155:50 am
SFO
- EYW
2 stops10h 16m
American Airlines
Deal found 7/9![American Airlines logo]()
$1,089
This United Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/244:00 pm
EYW
- SFO
1 stop11h 32m
United Airlines
Mon 7/2712:50 am
SFO
- EYW
1 stop11h 29m
United Airlines
Deal found 7/9![United Airlines logo]()
$584
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/168:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Wed 8/267:30 am
SFO
- EYW
1 stop9h 09m
American Airlines
Deal found 7/10![American Airlines logo]()
$655
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Thu 8/279:35 pm
SFO
- EYW
1 stop9h 09m
American Airlines
Deal found 7/11![American Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1712:07 pm
EYW
- SFO
2 stops34h 49m
Multiple Airlines
Thu 8/2712:47 pm
SFO
- EYW
1 stop24h 26m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$438
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 14, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1010:04 am
EYW
- SFO
2 stops11h 16m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/307:53 pm
EYW
- SFO
2 stops15h 55m
Multiple Airlines
Deal found 7/9![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:48 pm
EYW
- SFO
2 stops30h 15m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:16 pm
EYW
- SFO
2 stops30h 41m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$233
This Priceline deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:50 pm
EYW
- SFO
1 stop15h 08m
JetBlue
Deal found 7/10![JetBlue logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/198:48 pm
EYW
- SFO
2 stops40h 42m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/138:03 pm
EYW
- SFO
1 stop17h 26m
American Airlines
Deal found 7/10![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/301:47 pm
EYW
- SFO
1 stop9h 33m
American Airlines
Deal found 7/9![American Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:45 am
EYW
- SFO
2 stops14h 56m
Delta
Deal found 7/14![Delta logo]()
$376
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 14, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $291 (Delta) |
One-way from | $188 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 14, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 11/3
7:40 am-1:42 pm
1 stop9h 02m
San Francisco
Sat 11/7
5:45 pm-10:48 am
2 stops14h 03m
$434
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 11/2
1:23 pm-11:59 pm
1 stop13h 36m
San Francisco
Fri 11/6
11:59 pm-11:08 am
1 stop8h 09m
$675
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 8/17
10:15 am-7:27 pm
2 stops12h 12m
San Francisco
Thu 8/27
8:41 pm-9:44 am
2 stops10h 03m
$703
Quickest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 11/2
2:00 pm-7:37 pm
1 stop8h 37m
San Francisco
Fri 11/6
11:45 pm-10:48 am
1 stop8h 03m
$747
Cheapest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 9/5
3:48 pm-8:40 pm
3 stops31h 52m
$240
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 10/10
10:04 am-9:18 pm
3 stops14h 14m
$240
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 7/30
10:55 am-10:30 am
3 stops26h 35m
$254
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 10/10
12:50 pm-12:58 am
1 stop15h 08m
$318
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sun 7/19
8:48 pm-10:30 am
2 stops40h 42m
$319
Quickest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 9/5
1:31 pm-7:39 pm
1 stop9h 08m
$374
Showing 1-10 of 14 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated July 14, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Overall
7.1
Comfort
7.2
Crew
7.9
Entertainment
6.8
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Food
6.4
Overall
7.1
Comfort
7.2
Crew
7.9
Entertainment
6.8
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Fairfield
Burlingame
Rancho Cordova
Roseville
Cupertino
Emeryville
Newark
Watsonville
San Bruno
Hayward
San Ramon
Redwood City
San Carlos
Turlock
Vallejo
San Lorenzo
Davis
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Key West and San Francisco flights
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Other flights from Key West
Browse through other flights departing from Key West. Flights are based on user searches made on Cheapflights and were last updated on July 14, 2026.
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Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$348 | FlexibilityNo cancel fee | On-time71% |