$145+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Mar 25 — Apr 11
1 adult, Economy
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Find cheap flights from Key West to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Key West to San Francisco
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Best
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/282:29 pm
EYW
- SFO
1 stop10h 35m
American Airlines
Tue 5/59:08 am
SFO
- EYW
1 stop9h 45m
American Airlines
Deal found 2/22![American Airlines logo]()
$289
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:00 am
EYW
- SFO
1 stop10h 02m
United Airlines
Wed 3/115:00 am
SFO
- EYW
1 stop7h 42m
United Airlines
Deal found 2/20![United Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/241:27 pm
EYW
- SFO
1 stop12h 13m
American Airlines
Mon 3/3012:25 am
SFO
- EYW
1 stop11h 15m
American Airlines
Deal found 2/23![American Airlines logo]()
$402
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/243:56 pm
EYW
- SFO
1 stop10h 28m
United Airlines
Mon 3/3012:45 am
SFO
- EYW
1 stop11h 06m
United Airlines
Deal found 2/22![United Airlines logo]()
$417
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/243:56 pm
EYW
- SFO
2 stops10h 29m
American Airlines
Mon 3/3012:30 am
SFO
- EYW
2 stops13h 19m
American Airlines
Deal found 2/19![American Airlines logo]()
$438
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/262:45 pm
EYW
- SFO
1 stop10h 22m
American Airlines
Wed 4/19:14 am
SFO
- EYW
1 stop10h 23m
American Airlines
Deal found 2/23![American Airlines logo]()
$452
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:51 pm
EYW
- SFO
2 stops10h 23m
American Airlines
Mon 3/3012:25 am
SFO
- EYW
1 stop11h 15m
American Airlines
Deal found 2/23![American Airlines logo]()
$461
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:28 pm
EYW
- SFO
1 stop10h 00m
United Airlines
Sat 3/148:30 am
SFO
- EYW
1 stop10h 49m
United Airlines
Deal found 2/23![United Airlines logo]()
$486
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 23, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 23, 2026.
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/282:29 pm
EYW
- SFO
1 stop10h 35m
American Airlines
Tue 5/59:08 am
SFO
- EYW
1 stop9h 45m
American Airlines
Deal found 2/22![American Airlines logo]()
$289
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:00 am
EYW
- SFO
1 stop10h 02m
United Airlines
Wed 3/115:00 am
SFO
- EYW
1 stop7h 42m
United Airlines
Deal found 2/20![United Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:25 pm
EYW
- SFO
1 stop9h 10m
Delta
Fri 3/138:00 am
SFO
- EYW
1 stop8h 41m
Delta
Deal found 2/22![Delta logo]()
$662
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:40 pm
EYW
- SFO
1 stop10h 21m
American Airlines
Tue 3/319:14 am
SFO
- EYW
1 stop10h 04m
American Airlines
Deal found 2/19![American Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:58 pm
EYW
- SFO
1 stop7h 58m
American Airlines
Thu 5/149:08 am
SFO
- EYW
1 stop10h 28m
American Airlines
Deal found 2/23![American Airlines logo]()
$564
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/121:37 pm
EYW
- SFO
1 stop9h 13m
American Airlines
Sat 6/205:14 am
SFO
- EYW
1 stop10h 35m
American Airlines
Deal found 2/20![American Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/103:56 pm
EYW
- SFO
2 stops10h 29m
American Airlines
Sat 3/147:25 am
SFO
- EYW
1 stop8h 47m
American Airlines
Deal found 2/23![American Airlines logo]()
$600
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/132:21 pm
EYW
- SFO
1 stop7h 59m
American Airlines
Sat 6/205:14 am
SFO
- EYW
1 stop10h 35m
American Airlines
Deal found 2/20![American Airlines logo]()
$622
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated February 23, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated February 23, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/241:27 pm
EYW
- SFO
1 stop12h 13m
American Airlines
Mon 3/3012:25 am
SFO
- EYW
1 stop11h 15m
American Airlines
Deal found 2/23![American Airlines logo]()
$402
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/243:56 pm
EYW
- SFO
1 stop10h 28m
United Airlines
Mon 3/3012:45 am
SFO
- EYW
1 stop11h 06m
United Airlines
Deal found 2/22![United Airlines logo]()
$417
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:51 pm
EYW
- SFO
2 stops10h 23m
American Airlines
Mon 3/3012:25 am
SFO
- EYW
1 stop11h 15m
American Airlines
Deal found 2/23![American Airlines logo]()
$461
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/262:45 pm
EYW
- SFO
1 stop10h 22m
American Airlines
Wed 4/19:14 am
SFO
- EYW
1 stop10h 23m
American Airlines
Deal found 2/23![American Airlines logo]()
$452
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:00 am
EYW
- SFO
1 stop10h 02m
United Airlines
Wed 3/115:00 am
SFO
- EYW
1 stop7h 42m
United Airlines
Deal found 2/20![United Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/71:49 pm
EYW
- SFO
2 stops12h 21m
American Airlines
Tue 3/1012:30 am
SFO
- EYW
2 stops12h 27m
American Airlines
Deal found 2/20![American Airlines logo]()
$516
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:28 pm
EYW
- SFO
1 stop10h 00m
United Airlines
Sat 3/148:30 am
SFO
- EYW
1 stop10h 49m
United Airlines
Deal found 2/23![United Airlines logo]()
$486
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/243:56 pm
EYW
- SFO
2 stops10h 29m
American Airlines
Mon 3/3012:30 am
SFO
- EYW
2 stops13h 19m
American Airlines
Deal found 2/19![American Airlines logo]()
$438
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 23, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 23, 2026.
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:20 pm
EYW
- SFO
1 stop9h 55m
American Airlines
Deal found 2/20![American Airlines logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:46 am
EYW
- SFO
3 stops32h 06m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$201
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/412:55 pm
EYW
- SFO
1 stop10h 19m
American Airlines
Deal found 2/19![American Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/412:40 pm
EYW
- SFO
3 stops46h 18m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$292
This Alaska Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:10 pm
EYW
- SFO
1 stop12h 53m
Alaska Airlines
Deal found 2/23![Alaska Airlines logo]()
$318
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:21 pm
EYW
- SFO
1 stop7h 59m
American Airlines
Deal found 2/21![American Airlines logo]()
$323
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:24 am
EYW
- SFO
2 stops10h 56m
American Airlines
Deal found 2/20![American Airlines logo]()
$327
This deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:00 pm
EYW
- SFO
1 stop11h 35m
United Airlines
Deal found 2/20![United Airlines logo]()
$348
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/911:26 am
EYW
- SFO
1 stop10h 34m
American Airlines
Deal found 2/20![American Airlines logo]()
$380
This deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:47 pm
EYW
- SFO
1 stop10h 12m
United Airlines
Deal found 2/20![United Airlines logo]()
$388
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 23, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $289 (American Airlines) |
One-way from | $145 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Key West
Fly to
San Francisco
Route
Depart
Return
Price
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 4/28
2:29 pm-10:04 pm
1 stop10h 35m
San Francisco
Tue 5/5
9:08 am-9:53 pm
1 stop9h 45m
$289
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 3/7
7:00 am-2:02 pm
1 stop10h 02m
San Francisco
Wed 3/11
5:00 am-3:42 pm
1 stop7h 42m
$397
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 3/24
2:40 pm-10:01 pm
1 stop10h 21m
San Francisco
Tue 3/31
9:14 am-10:18 pm
1 stop10h 04m
$397
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 5/5
3:58 pm-8:56 pm
1 stop7h 58m
San Francisco
Thu 5/14
9:08 am-10:36 pm
1 stop10h 28m
$564
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 6/12
1:37 pm-7:50 pm
1 stop9h 13m
San Francisco
Sat 6/20
5:14 am-6:49 pm
1 stop10h 35m
$595
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 3/10
3:56 pm-11:25 pm
2 stops10h 29m
San Francisco
Sat 3/14
7:25 am-7:12 pm
1 stop8h 47m
$600
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 6/13
2:21 pm-7:20 pm
1 stop7h 59m
San Francisco
Sat 6/20
5:14 am-6:49 pm
1 stop10h 35m
$622
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 3/9
6:25 pm-12:35 am
1 stop9h 10m
San Francisco
Fri 3/13
8:00 am-7:41 pm
1 stop8h 41m
$662
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 5/7
2:01 pm-8:12 pm
1 stop9h 11m
$145
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 5/6
4:20 pm-11:15 pm
1 stop9h 55m
$145
Showing 1-10 of 17 results
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Watsonville
San Bruno
Daly City
Sunnyvale
Vacaville
Turlock
San Carlos
San Ramon
Redwood City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City
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