$157+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/10. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Dec 3 — Dec 101
Round-trip
1 adult, Economy
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2026.
This KAYAK deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:46 pm -
1 stop14h 39m
Fri 11/610:10 pm -
1 stop10h 46m
Deal found 10/30![JetBlue logo]()
$755
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:41 am -
1 stop28h 20m
Sat 11/1410:20 pm -
2 stops34h 59m
Deal found 11/2![Multiple Airlines logo]()
$885
This FlightHub deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:46 pm -
1 stop14h 39m
Fri 11/611:54 am -
3 stops18h 30m
Deal found 10/30![Multiple Airlines logo]()
$927
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:26 pm -
1 stop7h 57m
Fri 11/139:35 pm -
1 stop9h 13m
Deal found 10/29![American Airlines logo]()
$951
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:37 pm -
1 stop8h 21m
Wed 12/29:35 pm -
1 stop9h 09m
Deal found 10/30![American Airlines logo]()
$974
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2711:25 am -
1 stop10h 58m
Wed 12/25:35 am -
1 stop8h 17m
Deal found 10/29![American Airlines logo]()
$979
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:08 pm -
1 stop8h 50m
Sat 11/1411:59 pm -
1 stop7h 49m
Deal found 11/2![Delta logo]()
$983
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2026.
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/304:09 pm -
1 stop10h 14m
Wed 2/311:30 pm -
1 stop9h 46m
Deal found 11/2![United Airlines logo]()
$807
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:26 pm -
1 stop7h 57m
Fri 11/139:35 pm -
1 stop9h 13m
Deal found 10/29![American Airlines logo]()
$951
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2711:25 am -
2 stops11h 05m
Wed 12/26:10 pm -
2 stops12h 34m
Deal found 10/30![American Airlines logo]()
$1,019
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated November 3, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated November 3, 2026 and is based on user searches.
This KAYAK deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:46 pm -
1 stop14h 39m
Fri 11/610:10 pm -
1 stop10h 46m
Deal found 10/30![JetBlue logo]()
$755
This FlightHub deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:46 pm -
1 stop14h 39m
Fri 11/611:54 am -
3 stops18h 30m
Deal found 10/30![Multiple Airlines logo]()
$927
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:41 am -
1 stop28h 20m
Sat 11/1410:20 pm -
2 stops34h 59m
Deal found 11/2![Multiple Airlines logo]()
$885
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:08 pm -
1 stop8h 50m
Sat 11/1411:59 pm -
1 stop7h 49m
Deal found 11/2![Delta logo]()
$983
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:26 pm -
1 stop7h 57m
Fri 11/139:35 pm -
1 stop9h 13m
Deal found 10/29![American Airlines logo]()
$951
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2711:25 am -
1 stop10h 58m
Wed 12/25:35 am -
1 stop8h 17m
Deal found 10/29![American Airlines logo]()
$979
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:37 pm -
1 stop8h 21m
Wed 12/29:35 pm -
1 stop9h 09m
Deal found 10/30![American Airlines logo]()
$974
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 3, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1012:19 pm -
3 stops23h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/412:59 pm -
3 stops47h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$179
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/222:45 pm -
1 stop10h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2212:01 pm -
2 stops39h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2211:35 am -
2 stops12h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/88:54 pm -
3 stops38h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$295
This Priceline deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1012:54 pm -
1 stop12h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![JetBlue logo]()
$308
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/224:43 pm -
1 stop11h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$324
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 3, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $807 (United Airlines) |
One-way from | $157 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 3, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Wed 2/10
12:19 pm-8:49 am
3 stops23h 30m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$157
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 12/22
2:45 pm-10:17 pm
1 stop10h 32m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$200
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sun 11/22
12:01 pm-12:43 am
2 stops39h 42m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$201
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 12/22
11:35 am-8:38 pm
2 stops12h 03m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$217
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 1/4
12:59 pm-8:15 pm
2 stops34h 16m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$263
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sun 11/8
8:54 pm-8:19 am
3 stops38h 25m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$295
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sun 11/22
4:43 pm-12:58 am
1 stop11h 15m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$324
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sun 11/29
3:33 pm-5:35 pm
3 stops53h 02m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$368
Quickest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Tue 12/22
12:22 pm-7:36 pm
1 stop10h 14m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$454
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sat 1/30
4:09 pm-11:23 pm
1 stop10h 14m
San Francisco
Wed 2/3
11:30 pm-12:16 pm
1 stop9h 46m
$807
Showing 1-10 of 12 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated November 3, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Boarding
7.4
Food
6.4
Overall
7.0
Comfort
7.2
Crew
7.9
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Entertainment
6.8
Boarding
7.4
Food
6.4
Overall
7.0
Comfort
7.2
Crew
7.9
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Hayward
Emeryville
Newark
Burlingame
San Bruno
Rancho Cordova
Vallejo
Cupertino
Fairfield
Redwood City
San Carlos
Sunnyvale
Turlock
Davis
Morgan Hill
Roseville
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Key West and San Francisco flights
Browse other Key West and San Francisco flight options. Last updated on November 3, 2026.
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Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$469 | FlexibilityNo cancel fee | On-time71% |