$197+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Feb 13 — Feb 201
1 adult, Economy
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Find cheap flights from Key West to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 14, 2026.
Most accurate provider | Expedia 2 stars |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $264 (American Airlines) |
One-way from | $197 (Kiwi.com) |
Find flight deals from Key West to San Francisco
Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 14, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 14, 2026.
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/201:55 pm
EYW
- SFO
2 stops12h 19m
American Airlines
Mon 2/237:25 am
SFO
- EYW
1 stop8h 50m
American Airlines
Deal found 1/12![American Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:45 pm
EYW
- SFO
1 stop10h 22m
American Airlines
Fri 2/279:14 am
SFO
- EYW
1 stop10h 23m
American Airlines
Deal found 1/12![American Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/241:55 pm
EYW
- SFO
2 stops11h 45m
American Airlines
Fri 2/279:14 am
SFO
- EYW
1 stop10h 23m
American Airlines
Deal found 1/12![American Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/204:55 pm
EYW
- SFO
1 stop10h 04m
United Airlines
Mon 3/239:30 pm
SFO
- EYW
1 stop12h 53m
United Airlines
Deal found 1/13![United Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/284:15 pm
EYW
- SFO
1 stop9h 45m
United Airlines
Sun 2/19:30 pm
SFO
- EYW
1 stop12h 33m
United Airlines
Deal found 1/13![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/281:33 pm
EYW
- SFO
1 stop10h 53m
American Airlines
Sun 2/111:36 pm
SFO
- EYW
2 stops10h 27m
American Airlines
Deal found 1/13![American Airlines logo]()
$400
This United Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:35 pm
EYW
- SFO
1 stop9h 53m
United Airlines
Mon 3/211:55 pm
SFO
- EYW
1 stop10h 20m
United Airlines
Deal found 1/11![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/215:15 pm
EYW
- SFO
1 stop8h 57m
American Airlines
Fri 1/231:15 pm
SFO
- EYW
1 stop7h 41m
American Airlines
Deal found 1/11![American Airlines logo]()
$435
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Key West
Fly to
San Francisco
Route
Depart
Return
Price
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 2/20
1:55 pm-11:14 pm
2 stops12h 19m
San Francisco
Mon 2/23
7:25 am-7:15 pm
1 stop8h 50m
$264
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 2/25
2:45 pm-10:07 pm
1 stop10h 22m
San Francisco
Fri 2/27
9:14 am-10:37 pm
1 stop10h 23m
$337
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 3/20
4:55 pm-11:59 pm
1 stop10h 04m
San Francisco
Mon 3/23
9:30 pm-1:23 pm
1 stop12h 53m
$367
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 1/28
4:15 pm-11:00 pm
1 stop9h 45m
San Francisco
Sun 2/1
9:30 pm-1:03 pm
1 stop12h 33m
$389
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 1/28
1:33 pm-9:26 pm
1 stop10h 53m
San Francisco
Sun 2/1
11:36 pm-1:03 pm
2 stops10h 27m
$400
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 2/26
6:35 pm-1:28 am
1 stop9h 53m
San Francisco
Mon 3/2
11:55 pm-1:15 pm
1 stop10h 20m
$409
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 2/21
11:53 am-9:39 pm
2 stops36h 46m
$197
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 1/22
7:10 am-12:55 pm
1 stop8h 45m
$218
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 1/22
10:06 am-11:56 am
3 stops28h 50m
$229
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 1/22
2:43 pm-10:40 pm
2 stops10h 57m
$233
Showing 1-10 of 15 results
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia 90-95% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated January 14, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.5
Entertainment
6.9
Food
6.4
Comfort
7.2
Crew
8.0
Overall
7.2
Reviews
1 / 20
4.0
OkaySusie,Jan 2026
TPA - CLT
Boarding
7.5
Entertainment
6.9
Food
6.4
Comfort
7.2
Crew
8.0
Overall
7.2
Reviews
1 / 20
4.0
OkaySusie,Jan 2026
TPA - CLT
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsRoseville
South San Francisco
Santa Cruz
Santa Clara
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
San Carlos
San Ramon
Manteca
Vallejo
San Lorenzo
Hollister
Redwood City
Union City
Elk Grove
Foster City
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Alternative routes for Key West to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$313 | Average$453 | FlexibilityNo cancel fee | On-time71% |