$134+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
May 19 — May 261
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
Last-minute
One-way
Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 19, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 19, 2026.
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:19 pm
EYW
- SFO
1 stop9h 27m
Delta
Sat 5/2311:59 pm
SFO
- EYW
1 stop7h 54m
Delta
Deal found 4/14![Delta logo]()
$340
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:22 pm
EYW
- SFO
1 stop9h 55m
United Airlines
Tue 4/2812:45 am
SFO
- EYW
1 stop11h 06m
United Airlines
Deal found 4/16![United Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:20 am
EYW
- SFO
2 stops12h 19m
American Airlines
Wed 4/299:08 am
SFO
- EYW
1 stop10h 28m
American Airlines
Deal found 4/16![American Airlines logo]()
$396
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:40 pm
EYW
- SFO
1 stop8h 44m
Delta
Tue 5/58:00 am
SFO
- EYW
1 stop8h 40m
Delta
Deal found 4/16![Delta logo]()
$410
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:20 pm
EYW
- SFO
1 stop9h 55m
American Airlines
Tue 5/58:00 am
SFO
- EYW
2 stops11h 58m
American Airlines
Deal found 4/16![American Airlines logo]()
$415
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/51:11 pm
EYW
- SFO
2 stops22h 38m
Multiple Airlines
Wed 6/108:51 pm
SFO
- EYW
1 stop11h 34m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$454
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:19 pm
EYW
- SFO
1 stop9h 27m
Delta
Wed 6/107:50 am
SFO
- EYW
1 stop9h 03m
Delta
Deal found 4/16![Delta logo]()
$497
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:05 pm
EYW
- SFO
1 stop12h 45m
United Airlines
Tue 5/511:05 pm
SFO
- EYW
1 stop11h 40m
United Airlines
Deal found 4/14![United Airlines logo]()
$519
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 19, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 19, 2026.
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:19 pm
EYW
- SFO
1 stop9h 27m
Delta
Sat 5/2311:59 pm
SFO
- EYW
1 stop7h 54m
Delta
Deal found 4/14![Delta logo]()
$340
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:05 pm
EYW
- SFO
1 stop12h 45m
United Airlines
Tue 5/511:05 pm
SFO
- EYW
1 stop11h 40m
United Airlines
Deal found 4/14![United Airlines logo]()
$519
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:58 pm
EYW
- SFO
2 stops10h 56m
American Airlines
Sat 5/239:50 pm
SFO
- EYW
1 stop10h 06m
American Airlines
Deal found 4/14![American Airlines logo]()
$557
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/312:34 pm
EYW
- SFO
2 stops23h 39m
Multiple Airlines
Thu 5/712:47 pm
SFO
- EYW
1 stop19h 24m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$702
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated April 19, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated April 19, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:22 pm
EYW
- SFO
1 stop9h 55m
United Airlines
Tue 4/2812:45 am
SFO
- EYW
1 stop11h 06m
United Airlines
Deal found 4/16![United Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:20 am
EYW
- SFO
2 stops12h 19m
American Airlines
Wed 4/299:08 am
SFO
- EYW
1 stop10h 28m
American Airlines
Deal found 4/16![American Airlines logo]()
$396
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:40 pm
EYW
- SFO
1 stop8h 44m
Delta
Tue 5/58:00 am
SFO
- EYW
1 stop8h 40m
Delta
Deal found 4/16![Delta logo]()
$410
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:20 pm
EYW
- SFO
1 stop9h 55m
American Airlines
Tue 5/58:00 am
SFO
- EYW
2 stops11h 58m
American Airlines
Deal found 4/16![American Airlines logo]()
$415
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:05 pm
EYW
- SFO
1 stop12h 45m
United Airlines
Tue 5/511:05 pm
SFO
- EYW
1 stop11h 40m
United Airlines
Deal found 4/14![United Airlines logo]()
$519
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:19 pm
EYW
- SFO
1 stop9h 27m
Delta
Sat 5/2311:59 pm
SFO
- EYW
1 stop7h 54m
Delta
Deal found 4/14![Delta logo]()
$340
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated April 19, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated April 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:46 am
EYW
- SFO
2 stops23h 44m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:14 pm
EYW
- SFO
2 stops21h 47m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$161
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:40 pm
EYW
- SFO
1 stop8h 44m
Delta
Deal found 4/15![Delta logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2212:07 pm
EYW
- SFO
2 stops11h 23m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$231
This Alaska Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:18 pm
EYW
- SFO
1 stop12h 45m
Alaska Airlines
Deal found 4/15![Alaska Airlines logo]()
$245
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:30 am
EYW
- SFO
1 stop10h 26m
Delta
Deal found 4/18![Delta logo]()
$370
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/24:44 pm
EYW
- SFO
2 stops11h 04m
American Airlines
Deal found 4/14![American Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:30 pm
EYW
- SFO
2 stops10h 48m
American Airlines
Deal found 4/19![American Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:26 pm
EYW
- SFO
2 stops25h 04m
United Airlines
Deal found 4/15![United Airlines logo]()
$422
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 19, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $340 (Delta) |
One-way from | $134 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 19, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 5/14
6:19 pm-12:46 am
1 stop9h 27m
San Francisco
Sat 5/23
11:59 pm-10:53 am
1 stop7h 54m
$340
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 5/1
4:05 pm-1:50 am
1 stop12h 45m
San Francisco
Tue 5/5
11:05 pm-1:45 pm
1 stop11h 40m
$519
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 5/14
3:58 pm-11:54 pm
2 stops10h 56m
San Francisco
Sat 5/23
9:50 pm-10:56 am
1 stop10h 06m
$557
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sun 5/3
12:34 pm-9:13 am
2 stops23h 39m
San Francisco
Thu 5/7
12:47 pm-11:11 am
1 stop19h 24m
$702
Cheapest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 5/6
11:46 am-8:30 am
2 stops23h 44m
$134
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/2
1:14 pm-8:01 am
2 stops21h 47m
$161
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 5/6
2:40 pm-8:24 pm
1 stop8h 44m
$185
Quickest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sun 9/6
8:09 pm-12:51 am
1 stop7h 42m
$185
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/2
7:30 am-2:56 pm
1 stop10h 26m
$370
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/2
2:21 pm-9:01 pm
1 stop9h 40m
$370
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated April 19, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Overall
7.1
Entertainment
6.9
Comfort
7.2
Boarding
7.5
Crew
7.9
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Food
6.4
Overall
7.1
Entertainment
6.9
Comfort
7.2
Boarding
7.5
Crew
7.9
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Livermore
Rancho Cordova
San Bruno
Watsonville
San Ramon
Union City
Emeryville
Newark
Vacaville
Roseville
San Carlos
Redwood City
Sunnyvale
Turlock
San Lorenzo
Davis
Manteca
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Key West and San Francisco flights
Browse other Key West and San Francisco flight options. Last updated on April 19, 2026.
Other flights from Key West
Browse through other flights departing from Key West. Flights are based on user searches made on Cheapflights and were last updated on April 19, 2026.
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Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$348 | FlexibilityNo cancel fee | On-time71% |