$220+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Jun 18 — Jun 251
Round-trip
1 adult, Economy
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Find cheap flights from Key West to San Francisco with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 19, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 19, 2026.
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/194:47 pm
EYW
- SFO
1 stop9h 05m
United Airlines
Mon 5/2512:50 am
SFO
- EYW
1 stop11h 17m
United Airlines
Deal found 5/18![United Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:24 am
EYW
- SFO
2 stops10h 56m
American Airlines
Tue 5/2611:58 pm
SFO
- EYW
1 stop7h 58m
American Airlines
Deal found 5/18![American Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/152:26 pm
EYW
- SFO
1 stop11h 33m
United Airlines
Mon 6/2211:59 pm
SFO
- EYW
1 stop10h 31m
United Airlines
Deal found 5/16![United Airlines logo]()
$484
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1511:54 am
EYW
- SFO
1 stop27h 08m
Multiple Airlines
Mon 6/2210:10 pm
SFO
- EYW
2 stops33h 56m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$699
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3112:00 pm
EYW
- SFO
2 stops34h 57m
Multiple Airlines
Thu 6/412:47 pm
SFO
- EYW
1 stop17h 27m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$755
This American Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/171:47 pm
EYW
- SFO
1 stop9h 33m
American Airlines
Fri 7/1711:49 pm
SFO
- EYW
1 stop9h 25m
American Airlines
Deal found 5/16![American Airlines logo]()
$833
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:20 pm
EYW
- SFO
1 stop22h 58m
United Airlines
Mon 8/3111:59 pm
SFO
- EYW
1 stop10h 30m
United Airlines
Deal found 5/16![United Airlines logo]()
$995
This American Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1511:28 am
EYW
- SFO
2 stops10h 52m
American Airlines
Mon 6/229:52 pm
SFO
- EYW
2 stops12h 15m
American Airlines
Deal found 5/16![American Airlines logo]()
$1,002
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 19, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 19, 2026.
This American Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/171:47 pm
EYW
- SFO
1 stop9h 33m
American Airlines
Fri 7/1711:49 pm
SFO
- EYW
1 stop9h 25m
American Airlines
Deal found 5/16![American Airlines logo]()
$833
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:20 pm
EYW
- SFO
1 stop22h 58m
United Airlines
Mon 8/3111:59 pm
SFO
- EYW
1 stop10h 30m
United Airlines
Deal found 5/16![United Airlines logo]()
$995
This American Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1511:28 am
EYW
- SFO
2 stops10h 52m
American Airlines
Mon 6/229:52 pm
SFO
- EYW
2 stops12h 15m
American Airlines
Deal found 5/16![American Airlines logo]()
$1,002
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated May 19, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated May 19, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/194:47 pm
EYW
- SFO
1 stop9h 05m
United Airlines
Mon 5/2512:50 am
SFO
- EYW
1 stop11h 17m
United Airlines
Deal found 5/18![United Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:24 am
EYW
- SFO
2 stops10h 56m
American Airlines
Tue 5/2611:58 pm
SFO
- EYW
1 stop7h 58m
American Airlines
Deal found 5/18![American Airlines logo]()
$428
This Gotogate deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/191:14 pm
EYW
- SFO
3 stops49h 48m
Breeze Airways
Tue 5/2612:47 pm
SFO
- EYW
3 stops43h 38m
Breeze Airways
Deal found 5/18![Breeze Airways logo]()
$1,503
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3112:00 pm
EYW
- SFO
2 stops34h 57m
Multiple Airlines
Thu 6/412:47 pm
SFO
- EYW
1 stop17h 27m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$755
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:40 pm
EYW
- SFO
1 stop18h 14m
American Airlines
Thu 6/45:00 am
SFO
- EYW
1 stop10h 49m
American Airlines
Deal found 5/15![American Airlines logo]()
$1,426
This Delta deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/312:00 pm
EYW
- SFO
2 stops13h 12m
Delta
Thu 6/45:40 am
SFO
- EYW
2 stops11h 09m
Delta
Deal found 5/15![Delta logo]()
$2,230
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/152:26 pm
EYW
- SFO
1 stop11h 33m
United Airlines
Mon 6/2211:59 pm
SFO
- EYW
1 stop10h 31m
United Airlines
Deal found 5/16![United Airlines logo]()
$484
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1511:54 am
EYW
- SFO
1 stop27h 08m
Multiple Airlines
Mon 6/2210:10 pm
SFO
- EYW
2 stops33h 56m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$699
This American Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1511:28 am
EYW
- SFO
2 stops10h 52m
American Airlines
Mon 6/229:52 pm
SFO
- EYW
2 stops12h 15m
American Airlines
Deal found 5/16![American Airlines logo]()
$1,002
This Gotogate deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1512:07 pm
EYW
- SFO
3 stops50h 30m
Breeze Airways
Mon 6/2212:18 pm
SFO
- EYW
3 stops43h 48m
Breeze Airways
Deal found 5/16![Breeze Airways logo]()
$1,963
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 19, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:14 pm
EYW
- SFO
2 stops28h 02m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$220
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1711:46 am
EYW
- SFO
2 stops35h 09m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/512:05 pm
EYW
- SFO
2 stops31h 01m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$301
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1611:28 am
EYW
- SFO
1 stop10h 12m
American Airlines
Deal found 5/17![American Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:14 pm
EYW
- SFO
3 stops54h 16m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:19 pm
EYW
- SFO
1 stop8h 05m
Delta
Deal found 5/18![Delta logo]()
$420
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:39 pm
EYW
- SFO
2 stops12h 10m
American Airlines
Deal found 5/19![American Airlines logo]()
$425
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:48 am
EYW
- SFO
1 stop10h 17m
Delta
Deal found 5/18![Delta logo]()
$500
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 19, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $484 (United Airlines) |
One-way from | $220 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 19, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 7/17
1:47 pm-8:20 pm
1 stop9h 33m
San Francisco
Fri 7/17
11:49 pm-12:14 pm
1 stop9h 25m
$833
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 8/27
2:20 pm-10:18 am
1 stop22h 58m
San Francisco
Mon 8/31
11:59 pm-1:29 pm
1 stop10h 30m
$995
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 6/15
11:28 am-7:20 pm
2 stops10h 52m
San Francisco
Mon 6/22
9:52 pm-1:07 pm
2 stops12h 15m
$1,002
Cheapest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/16
1:14 pm-2:16 pm
2 stops28h 02m
$220
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 6/17
11:46 am-7:55 pm
2 stops35h 09m
$246
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/16
11:28 am-6:40 pm
1 stop10h 12m
$303
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 6/17
1:39 pm-8:17 pm
1 stop9h 38m
$303
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sun 7/5
8:48 pm-10:09 pm
3 stops28h 21m
$357
Quickest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/2
6:19 pm-11:24 pm
1 stop8h 05m
$420
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/2
4:44 pm-10:49 pm
1 stop9h 05m
$420
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 19, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.9
Food
6.4
Comfort
7.2
Overall
7.1
Crew
7.9
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Entertainment
6.9
Food
6.4
Comfort
7.2
Overall
7.1
Crew
7.9
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
San Bruno
Watsonville
San Ramon
Vacaville
Roseville
San Carlos
Redwood City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Davis
Emeryville
Manteca
Elk Grove
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Key West and San Francisco flights
Browse other Key West and San Francisco flight options. Last updated on May 19, 2026.
Other flights from Key West
Browse through other flights departing from Key West. Flights are based on user searches made on Cheapflights and were last updated on May 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 19, 2026.
Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$348 | FlexibilityNo cancel fee | On-time71% |