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$164+ Cheap flights from Key West to San Francisco (EYW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/24. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Apr 19 — Apr 261
Sun 4/19
Sun 4/26
1 adult, Economy
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Cheap flight deals from Key West to San Francisco

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 20, 2026.

This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:56 am
EYW
-
SFO
1 stop11h 16m
American Airlines
Wed 4/229:08 am
SFO
-
EYW
1 stop10h 28m
American Airlines
Deal found 3/20$349
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/133:58 pm
EYW
-
SFO
2 stops10h 53m
American Airlines
Sun 5/175:14 am
SFO
-
EYW
1 stop8h 48m
American Airlines
Deal found 3/20$354
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:38 pm
EYW
-
SFO
1 stop10h 21m
United Airlines
Tue 4/75:00 am
SFO
-
EYW
1 stop7h 57m
United Airlines
Deal found 3/19$447
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/14:38 pm
EYW
-
SFO
1 stop8h 52m
United Airlines
Sun 4/55:00 am
SFO
-
EYW
1 stop7h 57m
United Airlines
Deal found 3/17$451
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:47 pm
EYW
-
SFO
1 stop10h 12m
United Airlines
Mon 5/1111:05 pm
SFO
-
EYW
1 stop11h 40m
United Airlines
Deal found 3/19$479
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:46 am
EYW
-
SFO
2 stops35h 03m
Multiple Airlines
Sun 5/318:44 pm
SFO
-
EYW
1 stop11h 43m
Multiple Airlines
Deal found 3/17$490
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:01 pm
EYW
-
SFO
1 stop9h 11m
American Airlines
Thu 4/239:08 am
SFO
-
EYW
1 stop10h 28m
American Airlines
Deal found 3/17$492
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:58 pm
EYW
-
SFO
1 stop10h 03m
American Airlines
Wed 5/139:08 am
SFO
-
EYW
1 stop10h 28m
American Airlines
Deal found 3/16$529

Find flight deals from Key West to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 20, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$447
(United Airlines)

One-way from

$164
(American Airlines)
Provider with most accurate pricing for Key West-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-San Francisco flights.
Search Deals
From Key West to San Francisco
Search Deals
One-way flight from Key West to San Francisco
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 20, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 5/13

2:29 pm-7:31 pm

1 stop8h 02m

San Francisco

Sun 5/17

10:28 pm-11:16 am

1 stop9h 48m

$349

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 4/3

4:38 pm-11:59 pm

1 stop10h 21m

San Francisco

Tue 4/7

5:00 am-3:57 pm

1 stop7h 57m

$447
Quickest round-trip

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 4/1

4:38 pm-10:30 pm

1 stop8h 52m

San Francisco

Sun 4/5

5:00 am-3:57 pm

1 stop7h 57m

$451

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 5/7

4:47 pm-11:59 pm

1 stop10h 12m

San Francisco

Mon 5/11

11:55 pm-1:45 pm

1 stop10h 50m

$479

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 5/12

3:58 pm-11:01 pm

1 stop10h 03m

San Francisco

Wed 5/13

9:08 am-10:36 pm

1 stop10h 28m

$529

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 5/27

11:28 am-7:10 pm

2 stops10h 42m

San Francisco

Sun 5/31

8:13 pm-10:56 am

2 stops11h 43m

$577

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 5/12

11:24 am-9:04 pm

2 stops12h 40m

San Francisco

Thu 5/14

9:08 am-10:36 pm

1 stop10h 28m

$684
Cheapest one-way

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 4/24

3:58 pm-10:59 pm

2 stops10h 01m

$169

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 6/2

1:14 pm-10:41 am

3 stops24h 27m

$196

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 4/24

2:30 pm-11:25 pm

3 stops35h 55m

$205

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/15

Showing 1-10 of 17 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to San Francisco?

    United Airlines and American Airlines can get you from Key West to San Francisco in just under 10h 03m. Your travel time can differ by up to 18m. Key West and San Francisco are separated by a distance of 2542 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Key West to San Francisco that include hotel bookings?

    Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.

  • Can I find deals for business class flights from Key West to San Francisco?

    Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Clara
Santa Cruz
Livermore
Roseville
Watsonville
Rancho Cordova
San Bruno
San Ramon
Sunnyvale
Vacaville
San Carlos
Redwood City
Turlock
San Lorenzo
Davis
Manteca
Union City
Elk Grove
Rohnert Park

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