$175+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/2. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Mar 31 — Apr 71
1 adult, Economy
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Find cheap flights from Key West to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Key West to San Francisco
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Best
Last-minute
One-way
Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 1, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 1, 2026.
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:01 pm
EYW
- SFO
1 stop9h 11m
American Airlines
Sat 4/259:08 am
SFO
- EYW
1 stop10h 28m
American Airlines
Deal found 2/28![American Airlines logo]()
$289
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:00 am
EYW
- SFO
1 stop10h 02m
United Airlines
Mon 3/1611:55 pm
SFO
- EYW
1 stop10h 28m
United Airlines
Deal found 2/25![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:26 pm
EYW
- SFO
1 stop9h 32m
American Airlines
Fri 11/69:00 am
SFO
- EYW
1 stop9h 47m
American Airlines
Deal found 2/28![American Airlines logo]()
$489
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/123:56 pm
EYW
- SFO
1 stop11h 03m
American Airlines
Mon 3/1611:35 pm
SFO
- EYW
2 stops12h 05m
American Airlines
Deal found 2/25![American Airlines logo]()
$511
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/52:06 pm
EYW
- SFO
1 stop12h 04m
American Airlines
Sun 3/157:25 am
SFO
- EYW
1 stop8h 47m
American Airlines
Deal found 2/25![American Airlines logo]()
$544
This JetBlue deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2612:48 pm
EYW
- SFO
1 stop14h 43m
JetBlue
Mon 3/28:44 pm
SFO
- EYW
1 stop12h 14m
JetBlue
Deal found 2/25![JetBlue logo]()
$575
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/54:05 pm
EYW
- SFO
1 stop11h 11m
United Airlines
Mon 3/910:55 pm
SFO
- EYW
1 stop11h 28m
United Airlines
Deal found 2/26![United Airlines logo]()
$589
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 1, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 1, 2026.
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:00 am
EYW
- SFO
1 stop10h 02m
United Airlines
Mon 3/1611:55 pm
SFO
- EYW
1 stop10h 28m
United Airlines
Deal found 2/25![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:01 pm
EYW
- SFO
1 stop10h 27m
American Airlines
Sat 4/258:00 am
SFO
- EYW
2 stops11h 58m
American Airlines
Deal found 2/28![American Airlines logo]()
$503
This Delta deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:45 am
EYW
- SFO
2 stops14h 52m
Delta
Sat 4/257:30 pm
SFO
- EYW
2 stops12h 16m
Delta
Deal found 2/28![Delta logo]()
$746
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/123:56 pm
EYW
- SFO
1 stop11h 03m
American Airlines
Mon 3/1611:35 pm
SFO
- EYW
2 stops12h 05m
American Airlines
Deal found 2/25![American Airlines logo]()
$511
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/144:40 pm
EYW
- SFO
1 stop9h 30m
American Airlines
Wed 3/189:14 am
SFO
- EYW
1 stop10h 23m
American Airlines
Deal found 2/27![American Airlines logo]()
$708
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/154:01 pm
EYW
- SFO
1 stop10h 58m
American Airlines
Thu 3/197:25 am
SFO
- EYW
1 stop8h 47m
American Airlines
Deal found 2/28![American Airlines logo]()
$945
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated March 1, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated March 1, 2026 and is based on user searches.
This JetBlue deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2612:48 pm
EYW
- SFO
1 stop14h 43m
JetBlue
Mon 3/28:44 pm
SFO
- EYW
1 stop12h 14m
JetBlue
Deal found 2/25![JetBlue logo]()
$575
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/52:06 pm
EYW
- SFO
1 stop12h 04m
American Airlines
Sun 3/157:25 am
SFO
- EYW
1 stop8h 47m
American Airlines
Deal found 2/25![American Airlines logo]()
$544
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/54:05 pm
EYW
- SFO
1 stop11h 11m
United Airlines
Mon 3/910:55 pm
SFO
- EYW
1 stop11h 28m
United Airlines
Deal found 2/26![United Airlines logo]()
$589
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:00 am
EYW
- SFO
1 stop10h 02m
United Airlines
Mon 3/1611:55 pm
SFO
- EYW
1 stop10h 28m
United Airlines
Deal found 2/25![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/123:56 pm
EYW
- SFO
1 stop11h 03m
American Airlines
Mon 3/1611:35 pm
SFO
- EYW
2 stops12h 05m
American Airlines
Deal found 2/25![American Airlines logo]()
$511
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/144:40 pm
EYW
- SFO
1 stop9h 30m
American Airlines
Wed 3/189:14 am
SFO
- EYW
1 stop10h 23m
American Airlines
Deal found 2/27![American Airlines logo]()
$708
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 1, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 1, 2026.
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/24:16 pm
EYW
- SFO
1 stop10h 31m
American Airlines
Deal found 2/25![American Airlines logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:14 pm
EYW
- SFO
3 stops34h 50m
Multiple Airlines
Deal found 2/28![Multiple Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1212:25 pm
EYW
- SFO
3 stops52h 27m
Multiple Airlines
Deal found 2/27![Multiple Airlines logo]()
$261
This Expedia deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:10 pm
EYW
- SFO
1 stop12h 53m
Alaska Airlines
Deal found 2/28![Alaska Airlines logo]()
$283
This Delta deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:05 pm
EYW
- SFO
1 stop8h 00m
Delta
Deal found 2/28![Delta logo]()
$310
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:30 pm
EYW
- SFO
1 stop16h 46m
American Airlines
Deal found 2/27![American Airlines logo]()
$489
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/103:56 pm
EYW
- SFO
1 stop11h 03m
American Airlines
Deal found 3/1![American Airlines logo]()
$708
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 1, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $289 (American Airlines) |
One-way from | $175 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 1, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 3/12
7:00 am-2:02 pm
1 stop10h 02m
San Francisco
Mon 3/16
11:55 pm-1:23 pm
1 stop10h 28m
$389
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 4/16
2:01 pm-9:28 pm
1 stop10h 27m
San Francisco
Sat 4/25
8:00 am-10:58 pm
2 stops11h 58m
$503
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 3/12
3:56 pm-11:59 pm
1 stop11h 03m
San Francisco
Mon 3/16
11:35 pm-2:40 pm
2 stops12h 05m
$511
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 3/14
4:40 pm-11:10 pm
1 stop9h 30m
San Francisco
Wed 3/18
9:14 am-10:37 pm
1 stop10h 23m
$708
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 4/16
11:45 am-11:37 pm
2 stops14h 52m
San Francisco
Sat 4/25
7:30 pm-10:46 am
2 stops12h 16m
$746
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sun 3/15
4:01 pm-11:59 pm
1 stop10h 58m
San Francisco
Thu 3/19
7:25 am-7:12 pm
1 stop8h 47m
$945
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/2
4:16 pm-11:47 pm
1 stop10h 31m
$175
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/2
1:14 pm-11:04 pm
2 stops36h 50m
$213
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sun 4/12
9:46 am-12:28 am
2 stops41h 42m
$302
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/2
2:05 pm-7:05 pm
1 stop8h 00m
$310
Showing 1-10 of 11 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Watsonville
San Bruno
Daly City
Sunnyvale
Vacaville
Turlock
San Carlos
San Ramon
Redwood City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City
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