$138+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Nov 6 — Nov 131
Round-trip
1 adult, Economy
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Find cheap flights from Key West to San Francisco with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 7, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 7, 2026.
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:00 pm -
1 stop10h 39m
Fri 11/139:42 pm -
1 stop10h 06m
Deal found 10/5![Delta logo]()
$399
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:34 pm -
1 stop9h 33m
Sat 10/108:33 am -
1 stop8h 00m
Deal found 10/5![American Airlines logo]()
$421
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:11 pm -
1 stop8h 45m
Mon 11/911:59 pm -
1 stop10h 00m
Deal found 10/5![Delta logo]()
$429
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:10 pm -
1 stop8h 46m
Sun 10/258:00 am -
1 stop9h 01m
Deal found 10/6![Delta logo]()
$450
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:36 pm -
2 stops38h 43m
Thu 11/1212:46 pm -
1 stop18h 50m
Deal found 10/5![Multiple Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:24 am -
2 stops11h 39m
Sun 10/256:47 am -
1 stop7h 07m
Deal found 10/6![American Airlines logo]()
$487
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:10 pm -
1 stop10h 16m
Tue 11/1011:59 pm -
1 stop10h 53m
Deal found 10/5![United Airlines logo]()
$490
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:20 pm -
1 stop26h 41m
Mon 11/96:02 am -
2 stops27h 34m
Deal found 10/5![Multiple Airlines logo]()
$499
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:19 pm -
1 stop8h 38m
Wed 10/288:00 am -
1 stop9h 01m
Deal found 10/3![Delta logo]()
$513
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:40 am -
1 stop10h 20m
Mon 10/1910:25 pm -
1 stop9h 22m
Deal found 10/5![Delta logo]()
$529
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 7, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 7, 2026.
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/155:56 pm -
1 stop9h 03m
Thu 1/218:00 am -
1 stop8h 20m
Deal found 10/4![American Airlines logo]()
$399
This KAYAK deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:46 pm -
1 stop14h 39m
Fri 11/1310:10 pm -
1 stop10h 46m
Deal found 10/2![JetBlue logo]()
$399
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:00 pm -
1 stop10h 39m
Fri 11/139:42 pm -
1 stop10h 06m
Deal found 10/2![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:10 pm -
1 stop11h 43m
Mon 11/912:55 am -
1 stop11h 34m
Deal found 10/6![United Airlines logo]()
$490
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:20 pm -
1 stop26h 41m
Mon 11/96:02 am -
2 stops27h 34m
Deal found 10/5![Multiple Airlines logo]()
$499
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:11 pm -
1 stop8h 45m
Mon 11/911:59 pm -
1 stop10h 00m
Deal found 10/5![Delta logo]()
$429
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated October 7, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated October 7, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:34 pm -
1 stop9h 33m
Sat 10/108:33 am -
1 stop8h 00m
Deal found 10/5![American Airlines logo]()
$421
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:40 am -
1 stop10h 20m
Mon 10/1910:25 pm -
1 stop9h 22m
Deal found 10/5![Delta logo]()
$529
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:10 pm -
1 stop8h 46m
Sun 10/258:00 am -
1 stop9h 01m
Deal found 10/6![Delta logo]()
$450
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:24 am -
2 stops11h 39m
Sun 10/256:47 am -
1 stop7h 07m
Deal found 10/6![American Airlines logo]()
$487
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:00 pm -
1 stop10h 39m
Fri 11/139:42 pm -
1 stop10h 06m
Deal found 10/5![Delta logo]()
$399
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:36 pm -
2 stops38h 43m
Thu 11/1212:46 pm -
1 stop18h 50m
Deal found 10/5![Multiple Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:43 pm -
1 stop8h 50m
Fri 11/1311:39 pm -
2 stops10h 33m
Deal found 10/5![American Airlines logo]()
$552
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:11 pm -
1 stop8h 45m
Mon 11/911:59 pm -
1 stop10h 00m
Deal found 10/5![Delta logo]()
$429
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:20 pm -
1 stop26h 41m
Mon 11/96:02 am -
2 stops27h 34m
Deal found 10/5![Multiple Airlines logo]()
$499
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:10 pm -
1 stop10h 16m
Tue 11/1011:59 pm -
1 stop10h 53m
Deal found 10/5![United Airlines logo]()
$490
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 7, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/169:20 am -
3 stops59h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:59 am -
3 stops36h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Multiple Airlines logo]()
$147
This Priceline deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:46 pm -
1 stop14h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![JetBlue logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:01 pm -
2 stops26h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![Breeze Airways logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:04 am -
3 stops42h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:59 am -
3 stops25h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1810:59 am -
2 stops40h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Multiple Airlines logo]()
$277
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 7, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $321 (American Airlines) |
One-way from | $138 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 7, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 11/16
9:20 am-6:19 pm
3 stops59h 59m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$138
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Fri 11/6
10:59 am-8:32 pm
3 stops36h 33m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$147
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Fri 11/6
12:46 pm-12:25 am
1 stop14h 39m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$200
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Thu 12/3
12:01 pm-11:09 am
2 stops26h 08m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$204
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sun 10/18
10:59 am-5:07 pm
3 stops33h 08m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$316
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Mon 11/16
4:44 pm-12:12 am
1 stop10h 28m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$389
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Sat 10/31
4:00 pm-11:56 pm
1 stop10h 56m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$389
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Fri 1/15
5:56 pm-11:59 pm
1 stop9h 03m
San Francisco
Thu 1/21
8:00 am-7:20 pm
1 stop8h 20m
$399
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Thu 10/29
12:46 pm-12:25 am
1 stop14h 39m
San Francisco
Fri 11/13
10:10 pm-11:56 am
1 stop10h 46m
$399
Key WestSan Francisco
EYW Key West - SFO San Francisco
EYWSFO
Key West
Thu 10/29
2:00 pm-9:39 pm
1 stop10h 39m
San Francisco
Fri 11/13
9:42 pm-10:48 am
1 stop10h 06m
$399
Showing 1-10 of 16 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 7, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Comfort
7.2
Boarding
7.4
Overall
7.0
Crew
7.9
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Food
6.4
Comfort
7.2
Boarding
7.4
Overall
7.0
Crew
7.9
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
San Bruno
Emeryville
Hayward
Burlingame
Rancho Cordova
Roseville
Redwood City
Cupertino
Newark
Fairfield
San Ramon
Manteca
Vallejo
San Carlos
Turlock
Davis
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Key West and San Francisco flights
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Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$469 | FlexibilityNo cancel fee | On-time71% |