$260+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/25. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Jun 23 — Jun 301
Round-trip
1 adult, Economy
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Find cheap flights from Key West to San Francisco with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 24, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 24, 2026.
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:00 pm
EYW
- SFO
1 stop10h 40m
American Airlines
Wed 10/78:24 am
SFO
- EYW
1 stop7h 00m
American Airlines
Deal found 5/22![American Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:57 pm
EYW
- SFO
1 stop8h 42m
Delta
Mon 9/76:00 am
SFO
- EYW
1 stop8h 20m
Delta
Deal found 5/23![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/48:09 pm
EYW
- SFO
1 stop7h 42m
American Airlines
Mon 9/711:30 pm
SFO
- EYW
2 stops10h 35m
American Airlines
Deal found 5/23![American Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/21:01 pm
EYW
- SFO
1 stop10h 05m
American Airlines
Wed 7/87:20 am
SFO
- EYW
1 stop8h 46m
American Airlines
Deal found 5/22![American Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/53:55 pm
EYW
- SFO
1 stop11h 50m
United Airlines
Mon 6/812:50 am
SFO
- EYW
1 stop11h 19m
United Airlines
Deal found 5/21![United Airlines logo]()
$410
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/511:28 am
EYW
- SFO
2 stops10h 42m
American Airlines
Tue 6/95:23 am
SFO
- EYW
1 stop8h 29m
American Airlines
Deal found 5/21![American Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:50 am
EYW
- SFO
1 stop10h 00m
Delta
Wed 6/246:00 am
SFO
- EYW
1 stop8h 27m
Delta
Deal found 5/20![Delta logo]()
$519
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 24, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 24, 2026.
This Delta deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:57 pm
EYW
- SFO
1 stop8h 42m
Delta
Mon 9/76:00 am
SFO
- EYW
1 stop8h 20m
Delta
Deal found 5/23![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/48:09 pm
EYW
- SFO
1 stop7h 42m
American Airlines
Mon 9/711:30 pm
SFO
- EYW
2 stops10h 35m
American Airlines
Deal found 5/23![American Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/511:28 am
EYW
- SFO
2 stops10h 42m
American Airlines
Mon 6/812:26 am
SFO
- EYW
2 stops9h 41m
American Airlines
Deal found 5/21![American Airlines logo]()
$421
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:50 am
EYW
- SFO
1 stop10h 00m
Delta
Wed 6/246:00 am
SFO
- EYW
1 stop8h 27m
Delta
Deal found 5/20![Delta logo]()
$519
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/64:11 pm
EYW
- SFO
1 stop10h 46m
American Airlines
Wed 6/107:46 am
SFO
- EYW
1 stop8h 24m
American Airlines
Deal found 5/22![American Airlines logo]()
$548
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/21:47 pm
EYW
- SFO
2 stops12h 31m
American Airlines
Wed 7/85:29 am
SFO
- EYW
2 stops10h 37m
American Airlines
Deal found 5/22![American Airlines logo]()
$593
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:00 pm
EYW
- SFO
1 stop9h 15m
Delta
Fri 11/69:30 pm
SFO
- EYW
1 stop10h 28m
Delta
Deal found 5/24![Delta logo]()
$747
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:53 pm
EYW
- SFO
1 stop8h 57m
American Airlines
Fri 11/68:00 am
SFO
- EYW
1 stop8h 29m
American Airlines
Deal found 5/23![American Airlines logo]()
$747
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated May 24, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated May 24, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/53:55 pm
EYW
- SFO
1 stop11h 50m
United Airlines
Mon 6/812:50 am
SFO
- EYW
1 stop11h 19m
United Airlines
Deal found 5/21![United Airlines logo]()
$410
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/511:28 am
EYW
- SFO
2 stops10h 42m
American Airlines
Tue 6/95:23 am
SFO
- EYW
1 stop8h 29m
American Airlines
Deal found 5/21![American Airlines logo]()
$415
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/64:11 pm
EYW
- SFO
1 stop10h 46m
American Airlines
Wed 6/107:46 am
SFO
- EYW
1 stop8h 24m
American Airlines
Deal found 5/22![American Airlines logo]()
$548
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1511:54 am
EYW
- SFO
1 stop27h 08m
Multiple Airlines
Wed 6/178:45 pm
SFO
- EYW
2 stops10h 39m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$728
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:24 pm
EYW
- SFO
1 stop9h 21m
Delta
Wed 6/177:50 am
SFO
- EYW
1 stop9h 03m
Delta
Deal found 5/21![Delta logo]()
$963
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/154:44 pm
EYW
- SFO
2 stops11h 04m
American Airlines
Wed 6/175:40 am
SFO
- EYW
2 stops10h 09m
American Airlines
Deal found 5/21![American Airlines logo]()
$1,163
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:50 am
EYW
- SFO
1 stop10h 00m
Delta
Wed 6/246:00 am
SFO
- EYW
1 stop8h 27m
Delta
Deal found 5/20![Delta logo]()
$519
This American Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1811:28 am
EYW
- SFO
2 stops10h 52m
American Airlines
Wed 6/247:46 am
SFO
- EYW
1 stop8h 24m
American Airlines
Deal found 5/20![American Airlines logo]()
$677
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 24, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/252:44 pm
EYW
- SFO
2 stops21h 04m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:11 pm
EYW
- SFO
2 stops33h 23m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:19 pm
EYW
- SFO
1 stop8h 05m
Delta
Deal found 5/20![Delta logo]()
$420
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:39 pm
EYW
- SFO
2 stops12h 10m
American Airlines
Deal found 5/24![American Airlines logo]()
$425
This Delta deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/257:50 am
EYW
- SFO
1 stop10h 08m
Delta
Deal found 5/23![Delta logo]()
$458
This Delta deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2911:48 am
EYW
- SFO
1 stop10h 17m
Delta
Deal found 5/23![Delta logo]()
$509
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 24, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $330 (American Airlines) |
One-way from | $260 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 24, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 9/4
1:57 pm-7:39 pm
1 stop8h 42m
San Francisco
Mon 9/7
6:00 am-5:20 pm
1 stop8h 20m
$369
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 9/4
8:09 pm-12:51 am
1 stop7h 42m
San Francisco
Mon 9/7
11:30 pm-1:05 pm
2 stops10h 35m
$374
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 6/5
11:28 am-7:10 pm
2 stops10h 42m
San Francisco
Mon 6/8
12:26 am-1:07 pm
2 stops9h 41m
$421
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 6/18
7:50 am-2:50 pm
1 stop10h 00m
San Francisco
Wed 6/24
6:00 am-5:27 pm
1 stop8h 27m
$519
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Sat 6/6
4:11 pm-11:57 pm
1 stop10h 46m
San Francisco
Wed 6/10
7:46 am-7:10 pm
1 stop8h 24m
$548
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Thu 7/2
1:47 pm-11:18 pm
2 stops12h 31m
San Francisco
Wed 7/8
5:29 am-7:06 pm
2 stops10h 37m
$593
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 11/2
6:00 pm-12:15 am
1 stop9h 15m
San Francisco
Fri 11/6
9:30 pm-10:58 am
1 stop10h 28m
$747
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 11/2
4:53 pm-10:50 pm
1 stop8h 57m
San Francisco
Fri 11/6
8:00 am-7:29 pm
1 stop8h 29m
$747
Cheapest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 5/29
1:11 pm-7:34 pm
2 stops33h 23m
$274
Quickest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 6/2
1:39 pm-6:41 pm
1 stop8h 02m
$420
Showing 1-10 of 12 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
San Bruno
Watsonville
San Ramon
Vacaville
Roseville
San Carlos
Redwood City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Davis
Emeryville
Manteca
Elk Grove
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