How long is the flight from Key West to San Francisco?

American Airlines, Delta, and United Airlines can get you from Key West to San Francisco in just under 8h 55m. Your travel time can differ by up to 17h 35m. Key West and San Francisco are separated by a distance of 2542 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What is the cheapest time of day to fly from EYW to SFO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Key West to San Francisco as you normally would.

Most accurate provider : When it comes to deals on Key West-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Key West-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Key West to San Francisco that include hotel bookings?

Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Key West to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.

Can I find deals for business class flights from Key West to San Francisco?

Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$162+ Flights from Key West to San Francisco

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Key West to San Francisco

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$344 (Delta)
One-way from	$162 (Delta)

Provider with most accurate pricing for Key West-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Key West-San Francisco flights.

Search Deals

From Key West to San Francisco

Search Deals

One-way flight from Key West to San Francisco

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Find flight deals from Key West to San Francisco

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

Fri 11/212:39 pmEYW - SFO

1 stop11h 16mAmerican Airlines

Tue 11/2511:15 amSFO - EYW

2 stops9h 35mAmerican Airlines

Deal found 11/6

$394

Fri 11/216:18 pmEYW - SFO

1 stop8h 55mDelta

Tue 11/256:00 amSFO - EYW

1 stop8h 23mDelta

Deal found 11/6

$424

Fri 11/712:22 pmEYW - SFO

1 stop9h 34mDelta

Fri 11/146:00 amSFO - EYW

1 stop8h 23mDelta

Deal found 11/6

$529

Fri 11/71:23 pmEYW - SFO

1 stop10h 07mAmerican Airlines

Fri 11/147:10 amSFO - EYW

2 stops12h 17mAmerican Airlines

Deal found 11/6

$534

Thu 11/204:00 pmEYW - SFO

2 stops26h 30mUnited Airlines

Mon 11/2411:45 pmSFO - EYW

1 stop11h 04mUnited Airlines

Deal found 11/4

$613

Fri 11/74:00 pmEYW - SFO

1 stop9h 37mUnited Airlines

Fri 11/144:15 pmSFO - EYW

2 stops18h 49mUnited Airlines

Deal found 11/6

$794

Fri 11/712:45 pmEYW - SFO

1 stop14h 14mJetBlue

Fri 11/149:10 pmSFO - EYW

1 stop11h 43mJetBlue

Deal found 11/6

$830

Best flights from Key West to San Francisco
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 6, 2025.

Fri 11/212:39 pmEYW - SFO

1 stop11h 16mAmerican Airlines

Tue 11/2511:15 amSFO - EYW

2 stops9h 35mAmerican Airlines

Deal found 11/6

$394

Fri 11/216:18 pmEYW - SFO

1 stop8h 55mDelta

Tue 11/256:00 amSFO - EYW

1 stop8h 23mDelta

Deal found 11/6

$424

Thu 11/204:00 pmEYW - SFO

2 stops26h 30mUnited Airlines

Mon 11/2411:45 pmSFO - EYW

1 stop11h 04mUnited Airlines

Deal found 11/4

$613

Last-minute flights from Key West to San Francisco
Discover last-minute flight deals from Key West to San Francisco. Data last updated November 6, 2025 and is based on user searches.

Fri 11/712:22 pmEYW - SFO

1 stop9h 34mDelta

Fri 11/146:00 amSFO - EYW

1 stop8h 23mDelta

Deal found 11/6

$529

Fri 11/71:23 pmEYW - SFO

1 stop10h 07mAmerican Airlines

Fri 11/147:10 amSFO - EYW

2 stops12h 17mAmerican Airlines

Deal found 11/6

$534

Fri 11/74:00 pmEYW - SFO

1 stop9h 37mUnited Airlines

Fri 11/144:15 pmSFO - EYW

2 stops18h 49mUnited Airlines

Deal found 11/6

$794

Fri 11/712:45 pmEYW - SFO

1 stop14h 14mJetBlue

Fri 11/149:10 pmSFO - EYW

1 stop11h 43mJetBlue

Deal found 11/6

$830

Thu 11/204:00 pmEYW - SFO

2 stops26h 30mUnited Airlines

Mon 11/2411:45 pmSFO - EYW

1 stop11h 04mUnited Airlines

Deal found 11/4

$613

Fri 11/212:39 pmEYW - SFO

1 stop11h 16mAmerican Airlines

Tue 11/2511:15 amSFO - EYW

2 stops9h 35mAmerican Airlines

Deal found 11/6

$394

Fri 11/216:18 pmEYW - SFO

1 stop8h 55mDelta

Tue 11/256:00 amSFO - EYW

1 stop8h 23mDelta

Deal found 11/6

$424

One-way flights from Key West to San Francisco
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 6, 2025.

Tue 12/166:10 pmEYW - SFO

1 stop9h 10mDelta

Deal found 11/6

$162

Tue 12/161:33 pmEYW - SFO

2 stops12h 52mAmerican Airlines

Deal found 11/6

$167

Sat 1/37:47 amEYW - SFO

3 stops51h 01mMultiple Airlines

Deal found 11/4

$293

Fri 11/2812:49 pmEYW - SFO

1 stop14h 08mJetBlue

Deal found 11/5

$694

Fri 11/284:00 pmEYW - SFO

2 stops18h 44mUnited Airlines

Deal found 11/5

$697

Sat 1/38:09 pmEYW - SFO

1 stop18h 00mAmerican Airlines

Deal found 11/4

$838

Sat 11/293:00 pmEYW - SFO

2 stops21h 04mUnited Airlines

Deal found 11/6

$1,445

Sat 11/2912:49 pmEYW - SFO

1 stop14h 33mJetBlue

Deal found 11/6

$1,656

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 11/21

2:39 pm-10:55 pm

1 stop11h 16m

San Francisco

Tue 11/25

11:15 am-11:50 pm

2 stops9h 35m

$394

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 11/21

6:18 pm-12:13 am

1 stop8h 55m

San Francisco

Tue 11/25

6:00 am-5:23 pm

1 stop8h 23m

$424

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 11/20

4:00 pm-3:30 pm

2 stops26h 30m

San Francisco

Mon 11/24

11:45 pm-1:49 pm

1 stop11h 04m

$613

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 12/16

6:10 pm-12:20 am

1 stop9h 10m

$162

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 12/16

7:00 am-3:05 pm

2 stops11h 05m

$167

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 1/3

2:30 pm-7:48 am

2 stops20h 18m

$439

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 11/28

12:49 pm-11:57 pm

1 stop14h 08m

$694

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 11/28

4:00 pm-7:44 am

2 stops18h 44m

$697

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 1/3

8:09 pm-11:09 am

1 stop18h 00m

$838

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 11/29

3:00 pm-9:04 am

2 stops21h 04m

$1,445

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 11 results

Compare providers for flights from Key West to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to San Francisco in November.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing San Francisco

See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,040 reviews

Reviews

1 / 20

2.0

Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

American Airlines

7.2

Good

11,040 reviews

American Airlines

7.2

Good

11,040 reviews

Reviews

1 / 20

2.0

Mediocre

Anonymous,Aug 2025

MIA - DCA

Related info for your journey

How long is the flight from Key West to San Francisco?
American Airlines, Delta, and United Airlines can get you from Key West to San Francisco in just under 8h 55m. Your travel time can differ by up to 17h 35m. Key West and San Francisco are separated by a distance of 2542 mi. This flight may include one or multiple stops.
Can I find deals for flights from Key West to San Francisco that include hotel bookings?
Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Key West to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.
Can I find deals for business class flights from Key West to San Francisco?
Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Santa Clara

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Hollister

San Bruno

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Lodi

San Mateo

Vacaville

Lathrop

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Key West to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$313	Average$453	FlexibilityNo cancel fee	On-time71%

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$162+ Cheap flights from Key West to San Francisco (EYW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Key West to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Key West to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Find flight deals from Key West to San Francisco

Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Compare providers for flights from Key West to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to San Francisco in November.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.

Reviews of airlines servicing San Francisco

See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Key West to San Francisco?

Can I find deals for flights from Key West to San Francisco that include hotel bookings?

How can I find direct flights from Key West to San Francisco?

Can I find deals for business class flights from Key West to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key West to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Key West to San Francisco

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.