What is the cheapest airline to fly from Key West to San Francisco round-trip?

American Airlines, at $313, was found to be the cheapest airline from Key West to San Francisco..

What is the cheapest month to book a flight from Key West to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Key West to San Francisco (average of $276). Flying from Key West to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest day to fly from Key West to San Francisco?

Travelers seeking maximum savings on their Key West to San Francisco flight should consider departing on Saturday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What is the cheapest day to fly round-trip from Key West to San Francisco?

Friday is generally a great day to depart. Flying on this day could help you save up to 56%.

What is the cheapest time of day to fly from EYW to SFO?

When flying from Key West to San Francisco, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 10% versus a flight at noon.

Can I find deals for flights from Key West to San Francisco that include hotel bookings?

Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Key West to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.

Can I find deals for business class flights from Key West to San Francisco?

Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$145+ Flights from Key West to San Francisco

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Cheap flight deals from Key West to San Francisco

Round-trip from	$289 (Delta)
One-way from	$145 (American Airlines)

From Key West to San Francisco

Search Deals

One-way flight from Key West to San Francisco

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Find flight deals from Key West to San Francisco

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2025.

Wed 9/172:00 pmEYW - SFO

1 stop7h 48mDelta

Wed 9/247:25 amSFO - EYW

1 stop9h 42mDelta

Deal found 8/15

$289

Thu 9/412:09 pmEYW - SFO

1 stop10h 53mAmerican Airlines

Sat 9/611:52 pmSFO - EYW

1 stop9h 13mAmerican Airlines

Deal found 8/15

$319

Wed 9/173:45 pmEYW - SFO

1 stop9h 07mAmerican Airlines

Wed 9/245:45 amSFO - EYW

2 stops10h 14mAmerican Airlines

Deal found 8/15

$334

Sat 8/303:15 pmEYW - SFO

1 stop11h 16mUnited Airlines

Wed 9/310:45 pmSFO - EYW

1 stop12h 16mUnited Airlines

Deal found 8/14

$369

Sat 8/301:41 pmEYW - SFO

1 stop8h 19mAmerican Airlines

Wed 9/35:45 amSFO - EYW

2 stops10h 14mAmerican Airlines

Deal found 8/14

$394

Best flights from Key West to San Francisco
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 16, 2025.

Wed 9/1711:50 amEYW - SFO

1 stop9h 58mDelta

Wed 9/247:25 amSFO - EYW

1 stop9h 42mDelta

Deal found 8/14

$289

Thu 9/412:09 pmEYW - SFO

1 stop10h 53mAmerican Airlines

Sat 9/611:52 pmSFO - EYW

1 stop9h 13mAmerican Airlines

Deal found 8/15

$319

Sat 8/303:15 pmEYW - SFO

1 stop11h 16mUnited Airlines

Wed 9/310:45 pmSFO - EYW

1 stop12h 16mUnited Airlines

Deal found 8/14

$369

Wed 9/173:45 pmEYW - SFO

1 stop9h 07mAmerican Airlines

Wed 9/245:45 amSFO - EYW

2 stops10h 14mAmerican Airlines

Deal found 8/14

$334

Last-minute flights from Key West to San Francisco
Discover last-minute flight deals from Key West to San Francisco. Data last updated August 16, 2025 and is based on user searches.

Sat 8/303:15 pmEYW - SFO

1 stop11h 16mUnited Airlines

Wed 9/310:45 pmSFO - EYW

1 stop12h 16mUnited Airlines

Deal found 8/14

$369

Sat 8/301:41 pmEYW - SFO

1 stop8h 19mAmerican Airlines

Wed 9/35:45 amSFO - EYW

2 stops10h 14mAmerican Airlines

Deal found 8/14

$394

Thu 9/412:09 pmEYW - SFO

1 stop10h 53mAmerican Airlines

Sat 9/611:52 pmSFO - EYW

1 stop9h 13mAmerican Airlines

Deal found 8/15

$319

Wed 9/172:00 pmEYW - SFO

1 stop7h 48mDelta

Wed 9/247:25 amSFO - EYW

1 stop9h 42mDelta

Deal found 8/15

$289

Wed 9/173:45 pmEYW - SFO

1 stop9h 07mAmerican Airlines

Wed 9/245:45 amSFO - EYW

2 stops10h 14mAmerican Airlines

Deal found 8/15

$334

One-way flights from Key West to San Francisco
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated August 16, 2025.

Wed 9/2412:00 pmEYW - SFO

1 stop10h 58mAmerican Airlines

Deal found 8/15

$145

Tue 9/2311:25 amEYW - SFO

2 stops13h 27mAmerican Airlines

Deal found 8/15

$150

Tue 9/232:00 pmEYW - SFO

1 stop9h 28mDelta

Deal found 8/15

$180

Sun 9/712:29 pmEYW - SFO

3 stops35h 52mMultiple Airlines

Deal found 8/14

$182

Wed 9/2410:02 amEYW - SFO

3 stops41h 14mMultiple Airlines

Deal found 8/15

$247

Sun 9/711:52 amEYW - SFO

1 stop8h 40mDelta

Deal found 8/14

$460

Tue 9/2312:24 pmEYW - SFO

3 stops48h 06mMultiple Airlines

Deal found 8/15

$616

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 9/17

11:50 am-6:48 pm

1 stop9h 58m

San Francisco

Wed 9/24

7:25 am-8:07 pm

1 stop9h 42m

$289

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 9/4

12:09 pm-8:02 pm

1 stop10h 53m

San Francisco

Sat 9/6

11:52 pm-12:05 pm

1 stop9h 13m

$319

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 9/17

3:45 pm-9:52 pm

1 stop9h 07m

San Francisco

Wed 9/24

5:45 am-6:59 pm

2 stops10h 14m

$334

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 8/30

3:15 pm-11:31 pm

1 stop11h 16m

San Francisco

Wed 9/3

10:45 pm-2:01 pm

1 stop12h 16m

$369

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 9/24

12:00 pm-7:58 pm

1 stop10h 58m

$145

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 9/23

11:25 am-9:52 pm

2 stops13h 27m

$150

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 9/23

2:00 pm-8:28 pm

1 stop9h 28m

$180

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sun 9/7

12:29 pm-9:21 pm

3 stops35h 52m

$182

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 9/24

10:02 am-12:16 am

3 stops41h 14m

$247

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sun 9/7

11:52 am-5:32 pm

1 stop8h 40m

$460

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/15

Showing 1-10 of 11 results

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing San Francisco

See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

2.0

Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

American Airlines

7.2

Good

10,000 reviews

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

2.0

Mediocre

Anonymous,Aug 2025

MIA - DCA

Related info for your journey

What is the cheapest airline to fly from Key West to San Francisco round-trip?
American Airlines, at $313, was found to be the cheapest airline from Key West to San Francisco..
Can I find deals for flights from Key West to San Francisco that include hotel bookings?
Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Key West to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.
Can I find deals for business class flights from Key West to San Francisco?
Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Key West to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Key West to San Francisco (average of $276). Flying from Key West to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Santa Cruz

Livermore

South San Francisco

Mountain View

Turlock

Santa Clara

Hollister

Antioch

Watsonville

Manteca

Sunnyvale

Newark

Milpitas

Campbell

Foster City

San Leandro

Burlingame

Redwood City

Vallejo

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Key West to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$313	Average$508	FlexibilityNo cancel fee	On-time71%

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$145+ Cheap flights from Key West to San Francisco (EYW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/24. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Key West to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Key West to San Francisco

Round-trip from

One-way from

Find flight deals from Key West to San Francisco

Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2025.

Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.

Reviews of airlines servicing San Francisco

See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What is the cheapest airline to fly from Key West to San Francisco round-trip?

Can I find deals for flights from Key West to San Francisco that include hotel bookings?

How can I find direct flights from Key West to San Francisco?

Can I find deals for business class flights from Key West to San Francisco?

What is the cheapest month to book a flight from Key West to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key West to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Key West to San Francisco

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2025.