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$323+ Cheap flights from Santiago (SCL) to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/22. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SAN
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to San Diego are usually found in August or October, booked 37 days in advance, depart on a Friday or Tuesday and return on a Sunday

Cheap flight deals from Santiago to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$487
(United Airlines)

One-way from

$323
(LATAM Airlines)

Popular in

April

Cheapest in

August

Average price

$804
From Santiago Arturo Merino Benitez to San Diego
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One-way flight from Santiago Arturo Merino Benitez to San Diego
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Highest demand for flights based on searches. 13% potential increase in price ($133 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santiago to San Diego

Cheapest flights from Santiago to San Diego
Explore the most affordable flight options available from Santiago to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1010:45 pmSCL - SAN
2 stops21h 15mUnited Airlines
Fri 11/1411:02 amSAN - SCL
2 stops16h 48mUnited Airlines
Deal found 9/15$487
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:45 pmSCL - SAN
2 stops23h 43mUnited Airlines
Thu 11/1311:02 amSAN - SCL
2 stops16h 48mUnited Airlines
Deal found 9/16$497
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/912:55 amSCL - SAN
2 stops22h 16mDelta
Fri 11/1410:00 amSAN - SCL
1 stop15h 00mDelta
Deal found 9/15$505
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/299:45 pmSCL - SAN
1 stop22h 40mUnited Airlines
Sun 11/28:00 amSAN - SCL
1 stop19h 50mUnited Airlines
Deal found 9/16$514
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/199:55 pmSCL - SAN
1 stop17h 35mAmerican Airlines
Thu 10/307:15 amSAN - SCL
1 stop20h 15mAmerican Airlines
Deal found 9/16$516
This LATAM Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3011:25 pmSCL - SAN
2 stops23h 07mLATAM Airlines
Thu 11/612:00 pmSAN - SCL
2 stops22h 30mLATAM Airlines
Deal found 9/15$518
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/309:15 pmSCL - SAN
2 stops18h 34mAmerican Airlines
Thu 11/610:09 amSAN - SCL
2 stops16h 46mAmerican Airlines
Deal found 9/15$521
This LATAM Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1910:55 pmSCL - SAN
2 stops28h 19mLATAM Airlines
Thu 10/306:15 amSAN - SCL
2 stops19h 45mLATAM Airlines
Deal found 9/16$522
This LATAM Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2111:55 pmSCL - SAN
1 stop24h 24mLATAM Airlines
Wed 12/36:15 amSAN - SCL
1 stop18h 20mLATAM Airlines
Deal found 9/16$534
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2110:45 pmSCL - SAN
2 stops29h 59mUnited Airlines
Wed 12/31:53 pmSAN - SCL
1 stop13h 57mUnited Airlines
Deal found 9/16$537

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Santiago to San Diego that are best for you.

Fly from

Santiago

Fly to

San Diego

Route

Depart

Return

Price

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Mon 11/10

10:45 pm-3:00 pm

2 stops21h 15m

San Diego

Fri 11/14

11:02 am-8:50 am

2 stops16h 48m

$487

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Sat 11/1

10:45 pm-4:00 pm

2 stops21h 15m

San Diego

Thu 11/13

8:00 am-8:50 am

1 stop19h 50m

$497

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Fri 10/31

9:45 pm-8:48 pm

2 stops27h 03m

San Diego

Fri 11/7

1:47 pm-8:50 am

1 stop14h 03m

$497

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Fri 10/31

9:45 pm-5:28 pm

2 stops23h 43m

San Diego

Thu 11/13

11:02 am-8:50 am

2 stops16h 48m

$497

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Thu 10/30

9:45 pm-9:53 pm

1 stop28h 08m

San Diego

Thu 11/6

1:47 pm-8:50 am

1 stop14h 03m

$498

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Fri 10/31

10:10 pm-9:20 pm

1 stop27h 10m

San Diego

Fri 11/7

6:15 am-7:40 am

1 stop20h 25m

$505

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Wed 10/29

8:15 am-11:06 pm

2 stops18h 51m

San Diego

Sun 11/2

5:15 am-6:40 am

1 stop20h 25m

$514

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Wed 10/29

9:45 pm-4:25 pm

1 stop22h 40m

San Diego

Sun 11/2

8:00 am-8:50 am

1 stop19h 50m

$514

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Mon 9/22

11:30 pm-10:02 pm

2 stops26h 32m

$323

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Mon 9/22

11:05 pm-7:06 pm

1 stop24h 01m

$332

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 16 results
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Best time to book a flight from Santiago to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to San Diego

How far ahead should I book a flight from Santiago to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to San Diego. Price data was last updated on September 12, 2025.

Booking 37 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santiago to San Diego. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Santiago to San Diego?

Currently, August is the cheapest month in which you can book a flight from Santiago to San Diego (average of $286). Flying from Santiago to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Santiago to San Diego?

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 17, 2025.
Get a feel of what it's like to fly with Delta and LATAM Airlines from Santiago to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
LATAM Airlines
7.5
Good
1,849 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Santiago to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago to San Diego?

    Departing from Santiago to San Diego will take you 21h 15m. Airlines will cover a distance of 5471 mi.

  • What are the cheapest airlines flying from Santiago to San Diego round-trip?

    Our cheapest airline available from Santiago to San Diego is LATAM Airlines. Our recent data shows that you can find tickets from as low as $497 on this airline. An additional option worth looking into is Delta, starting at $702. LATAM Airlines is currently priced 43% below the average price you’ll pay for this route.

  • Can I find deals for flights from Santiago to San Diego that include hotel bookings?

    Yes. In addition to deals on Santiago to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to San Diego.

  • Can I find deals for business class flights from Santiago to San Diego?

    Yes. Cheapflights offers flight deals from Santiago to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Santiago to San Diego (average of $286). Flying from Santiago to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Santiago to San Diego

Discover the top 2 airlines that operate flights from Santiago to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$497Average$933FlexibilityNo cancel feeOn-time81%
DeltaCheapest$702Average$853FlexibilityNo cancel feeOn-timeN/A

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