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$5,475+ Cheap flights from Mayagüez (MAZ) to San Diego (SAN)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
MAZ — SAN
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheap flight deals from Mayagüez to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Mayagüez (MAZ) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$5,475
(United Airlines)
Provider with most accurate pricing for Mayagüez Eugenio M De Hostos-San Diego flight deals.
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Provider most trusted by Cheapflights users for Mayagüez Eugenio M De Hostos-San Diego flights.
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From Mayagüez Eugenio M De Hostos to San Diego
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Find flight deals from Mayagüez to San Diego

Best flights from Mayagüez to San Diego
Discover carefully curated flight deals from Mayagüez to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 16, 2025.

This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/271:19 pmMAZ - SAN
3 stops33h 14mUnited Airlines
Tue 3/38:35 amSAN - MAZ
2 stops27h 36mUnited Airlines
Deal found 10/13$5,475

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mayagüez to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Mayagüez to San Diego that are best for you.

Fly from

Mayagüez

Fly to

San Diego

Route

Depart

Return

Price

MayagüezSan Diego

MAZ - SAN

MAZSAN

Mayagüez Eugenio M De Hostos

Fri 2/27

1:19 pm-6:33 pm

3 stops33h 14m

San Diego

Tue 3/3

8:35 am-4:11 pm

2 stops27h 36m

$5,475

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/13

  • Most accurate provider: When it comes to deals on Mayagüez-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Mayagüez-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Mayagüez-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mayagüez-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mayagüez-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mayagüez to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Mayagüez with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mayagüez to San Diego

What is the cheapest month to book a flight from Mayagüez to San Diego?

Currently, March is the cheapest month in which you can book a flight from Mayagüez to San Diego (average of $155). Flying from Mayagüez to San Diego in April is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mayagüez to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mayagüez to San Diego?

    A quick flight from Mayagüez to San Diego can take about 33h 14m. United Airlines provides one of the quickest options available for as low as $5,475. Airlines will cover a distance of 3243 mi.

  • Can I find deals for flights from Mayagüez to San Diego that include hotel bookings?

    Yes. In addition to deals on Mayagüez to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mayagüez to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mayagüez to San Diego.

  • Can I find deals for business class flights from Mayagüez to San Diego?

    Yes. Cheapflights offers flight deals from Mayagüez to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mayagüez to San Diego?

    Currently, March is the cheapest month in which you can book a flight from Mayagüez to San Diego (average of $155). Flying from Mayagüez to San Diego in April is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
Imperial Beach
National City

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