$178+ Cheap flights from Key West to San Diego (EYW - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
Apr 18 — Apr 251
Round-trip
1 adult, Economy
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Find cheap flights from Key West to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Key West to San Diego
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Best
Last-minute
One-way
Cheapest flights from Key West to San DiegoExplore the most affordable flight options available from Key West to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 19, 2026.
Explore the most affordable flight options available from Key West to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 19, 2026.
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:01 pm
EYW
- SAN
1 stop9h 49m
American Airlines
Mon 4/2712:53 pm
SAN
- EYW
1 stop7h 05m
American Airlines
Deal found 3/15![American Airlines logo]()
$355
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:29 pm
EYW
- SAN
1 stop9h 04m
American Airlines
Thu 5/710:40 pm
SAN
- EYW
1 stop10h 58m
American Airlines
Deal found 3/15![American Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:45 am
EYW
- SAN
2 stops10h 20m
American Airlines
Tue 5/2610:45 pm
SAN
- EYW
2 stops11h 20m
American Airlines
Deal found 3/17![American Airlines logo]()
$405
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:19 pm
EYW
- SAN
1 stop8h 08m
Delta
Fri 5/2910:25 pm
SAN
- EYW
1 stop9h 28m
Delta
Deal found 3/17![Delta logo]()
$445
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:40 pm
EYW
- SAN
1 stop9h 19m
American Airlines
Mon 3/3010:43 pm
SAN
- EYW
1 stop10h 18m
American Airlines
Deal found 3/15![American Airlines logo]()
$479
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:52 pm
EYW
- SAN
1 stop10h 07m
United Airlines
Sat 4/1810:20 pm
SAN
- EYW
1 stop12h 11m
United Airlines
Deal found 3/17![United Airlines logo]()
$509
Best flights from Key West to San DiegoDiscover carefully curated flight deals from Key West to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 19, 2026.
Discover carefully curated flight deals from Key West to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 19, 2026.
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:19 pm
EYW
- SAN
1 stop8h 08m
Delta
Fri 5/2910:25 pm
SAN
- EYW
1 stop9h 28m
Delta
Deal found 3/17![Delta logo]()
$445
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:45 am
EYW
- SAN
2 stops10h 20m
American Airlines
Mon 4/278:15 am
SAN
- EYW
2 stops11h 43m
American Airlines
Deal found 3/15![American Airlines logo]()
$461
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:52 pm
EYW
- SAN
1 stop10h 07m
United Airlines
Sat 4/1810:20 pm
SAN
- EYW
1 stop12h 11m
United Airlines
Deal found 3/17![United Airlines logo]()
$509
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:47 pm
EYW
- SAN
1 stop7h 38m
United Airlines
Mon 5/117:00 pm
SAN
- EYW
2 stops17h 07m
United Airlines
Deal found 3/18![United Airlines logo]()
$563
Last-minute flights from Key West to San DiegoDiscover last-minute flight deals from Key West to San Diego. Data last updated March 19, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Diego. Data last updated March 19, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:40 pm
EYW
- SAN
1 stop9h 19m
American Airlines
Mon 3/3010:43 pm
SAN
- EYW
1 stop10h 18m
American Airlines
Deal found 3/15![American Airlines logo]()
$479
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:52 pm
EYW
- SAN
1 stop10h 07m
United Airlines
Sat 4/1810:20 pm
SAN
- EYW
1 stop12h 11m
United Airlines
Deal found 3/17![United Airlines logo]()
$509
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:01 pm
EYW
- SAN
1 stop9h 49m
American Airlines
Mon 4/2712:53 pm
SAN
- EYW
1 stop7h 05m
American Airlines
Deal found 3/15![American Airlines logo]()
$355
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:29 pm
EYW
- SAN
1 stop9h 04m
American Airlines
Thu 5/710:40 pm
SAN
- EYW
1 stop10h 58m
American Airlines
Deal found 3/15![American Airlines logo]()
$375
One-way flights from Key West to San DiegoSearch for one-way flight options from Key West to San Diego. Find affordable one-way fares based on user searches. Data last updated March 19, 2026.
Search for one-way flight options from Key West to San Diego. Find affordable one-way fares based on user searches. Data last updated March 19, 2026.
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:45 am
EYW
- SAN
1 stop8h 08m
American Airlines
Deal found 3/15![American Airlines logo]()
$178
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:19 pm
EYW
- SAN
1 stop8h 08m
Delta
Deal found 3/18![Delta logo]()
$188
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:28 am
EYW
- SAN
2 stops10h 19m
American Airlines
Deal found 3/18![American Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/102:35 pm
EYW
- SAN
3 stops36h 27m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:22 pm
EYW
- SAN
3 stops54h 42m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:46 am
EYW
- SAN
2 stops36h 26m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:14 pm
EYW
- SAN
3 stops50h 29m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2510:31 am
EYW
- SAN
2 stops40h 19m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$268
Find flight deals from Key West to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $355 (American Airlines) |
One-way from | $149 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 19, 2026.
Use the filters below to find and compare flights from Key West to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Wed 5/27
6:19 pm-11:27 pm
1 stop8h 08m
San Diego
Fri 5/29
10:25 pm-10:53 am
1 stop9h 28m
$445
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Wed 4/22
6:45 am-2:05 pm
2 stops10h 20m
San Diego
Mon 4/27
8:15 am-10:58 pm
2 stops11h 43m
$461
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Fri 4/17
3:52 pm-10:59 pm
1 stop10h 07m
San Diego
Sat 4/18
10:20 pm-1:31 pm
1 stop12h 11m
$509
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Thu 5/7
4:47 pm-9:25 pm
1 stop7h 38m
San Diego
Mon 5/11
7:00 pm-3:07 pm
2 stops17h 07m
$563
Cheapest one-way
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Thu 5/28
2:00 pm-9:15 pm
1 stop10h 15m
$188
Quickest one-way
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Wed 5/27
6:19 pm-11:27 pm
1 stop8h 08m
$188
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Fri 4/10
2:35 pm-12:02 am
3 stops36h 27m
$202
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Thu 5/28
11:04 am-11:47 pm
3 stops39h 43m
$233
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Mon 5/25
10:31 am-11:50 pm
2 stops40h 19m
$268
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Tue 5/26
1:14 pm-9:12 pm
3 stops58h 58m
$280
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Key West to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to San Diego in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Key West-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Key West with our price prediction graph.
EYW-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Key West to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove
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