HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Diego

$224+ Cheap flights from Key West to San Diego (EYW - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
Oct 14 — Oct 211
Tue 10/14
Tue 10/21
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key West to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Key West to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 14, 2025.

Round-trip from

$575
(Delta)

One-way from

$224
(Priceline)
From Key West to San Diego
Search Deals
One-way flight from Key West to San Diego
Search Deals

Find flight deals from Key West to San Diego

Cheapest flights from Key West to San Diego
Explore the most affordable flight options available from Key West to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2025.

This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/226:10 pmEYW - SAN
1 stop8h 14mDelta
Mon 9/296:15 amSAN - EYW
1 stop8h 00mDelta
Deal found 9/12$575
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/221:59 pmEYW - SAN
2 stops11h 37mAmerican Airlines
Mon 9/2910:45 pmSAN - EYW
1 stop9h 09mAmerican Airlines
Deal found 9/12$588
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/253:12 pmEYW - SAN
2 stops22h 15mUnited Airlines
Mon 9/294:05 pmSAN - EYW
3 stops19h 24mUnited Airlines
Deal found 9/13$916
This Gotogate deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2212:32 pmEYW - SAN
3 stops27h 04mBreeze Airways
Mon 9/291:12 pmSAN - EYW
2 stops41h 55mBreeze Airways
Deal found 9/12$1,023
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/223:50 pmEYW - SAN
3 stops22h 05mUnited Airlines
Mon 9/298:08 pmSAN - EYW
2 stops15h 21mUnited Airlines
Deal found 9/12$1,477

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
Use the filters below to find and compare flights from Key West to San Diego that are best for you.

Fly from

Key West

Fly to

San Diego

Route

Depart

Return

Price

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 9/25

2:00 pm-8:25 pm

1 stop9h 25m

San Diego

Mon 9/29

6:15 am-5:15 pm

1 stop8h 00m

$575

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 9/25

12:50 pm-6:42 pm

1 stop8h 52m

San Diego

Mon 9/29

6:20 am-6:59 pm

2 stops9h 39m

$588

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Tue 3/10

4:53 pm-9:53 pm

1 stop8h 00m

San Diego

Wed 3/11

9:55 pm-12:05 pm

1 stop11h 10m

$785

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Tue 3/10

3:08 pm-9:38 pm

2 stops9h 30m

San Diego

Wed 3/11

6:30 am-6:30 pm

2 stops9h 00m

$887

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 9/25

3:12 pm-10:27 am

2 stops22h 15m

San Diego

Mon 9/29

4:05 pm-2:29 pm

3 stops19h 24m

$916

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Mon 1/26

12:07 pm-8:08 pm

1 stop11h 01m

$224

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Mon 1/26

1:06 pm-10:46 pm

2 stops36h 40m

$245

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Mon 1/26

7:57 pm-11:21 am

1 stop18h 24m

$316

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Sun 9/21

12:29 pm-9:24 pm

3 stops59h 55m

$326

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Sun 9/21

2:00 pm-6:07 pm

1 stop7h 07m

$465

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Best time to book a flight from Key West to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to San Diego

What is the cheapest time of day to fly from EYW to SAN?

Find hourly flight availability from Key West to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 14, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 36% on flights from Key West to San Diego by exploring options for tickets in the afternoon.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 14, 2025.
Read reviews from past customers who have flown American Airlines from Key West to San Diego. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Entertainment

6.9

Boarding

7.5

Overall

7.2

Crew

8.0

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Entertainment

6.9

Boarding

7.5

Overall

7.2

Crew

8.0

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to San Diego?

    Departing from Key West to San Diego will take you 8h. Key West and San Diego are separated by a distance of 2209 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Key West to San Diego round-trip?

    According to our current data, American Airlines ($299), offers the cheapest pricing from Key West to San Diego.

  • Can I find deals for flights from Key West to San Diego that include hotel bookings?

    Yes. In addition to deals on Key West to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Diego.

  • Can I find deals for business class flights from Key West to San Diego?

    Yes. Cheapflights offers flight deals from Key West to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Key West to San Diego (average of $286). Flying from Key West to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City
Alpine

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key West to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Las Vegas flights
Fort Lauderdale to Las Vegas flights
Tampa to Las Vegas flights
Orlando to Los Angeles flights
Miami to Los Angeles flights
Miami to Las Vegas flights
Fort Lauderdale to Los Angeles flights
Tampa to Los Angeles flights
Miami to San Francisco flights
Fort Lauderdale to San Francisco flights
Orlando to San Francisco flights
Jacksonville to Las Vegas flights
Tampa to San Francisco flights
Tampa to San Diego flights
West Palm Beach to Las Vegas flights
Orlando to San Diego flights
Fort Lauderdale to Burbank flights
Miami to Ontario flights
Fort Lauderdale to Santa Ana flights
Orlando to Ontario flights
Orlando to Santa Ana flights
Fort Myers to Las Vegas flights
Tampa to Ontario flights
Tampa to Santa Ana flights
Miami to San Diego flights
West Palm Beach to Los Angeles flights
Orlando to Sacramento flights
Miami to Santa Ana flights
Fort Lauderdale to San Diego flights
Fort Lauderdale to Ontario flights
Orlando to Burbank flights
Pensacola to Las Vegas flights
Jacksonville to San Francisco flights
Sarasota to Las Vegas flights
Fort Myers to Los Angeles flights
Miami to Burbank flights
Orlando to San Jose flights
Valparaiso to Las Vegas flights
Panama City to Las Vegas flights
Orlando Sanford Intl to Las Vegas flights
West Palm Beach to San Francisco flights
Orlando to Palm Springs flights
Tampa to Burbank flights
Orlando to Oakland flights
West Palm Beach to San Diego flights
Jacksonville to San Diego flights
Miami to San Jose flights
Valparaiso to Los Angeles flights
Tampa to Reno flights
Tampa to Sacramento flights

Top airline flying from Key West to San Diego

Discover the top airline that operate flights from Key West to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$299Average$468FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.