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$170+ Cheap flights from Key West to San Diego (EYW - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Key West to San Diego

Cheapest flights from Key West to San Diego
Explore the most affordable flight options available from Key West to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/133:51 pm
EYW
-
SAN
1 stop9h 49m
American Airlines
Mon 2/166:20 am
SAN
-
EYW
1 stop7h 04m
American Airlines
Deal found 1/28$405
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 pm
EYW
-
SAN
1 stop7h 58m
Delta
Sun 5/3110:40 pm
SAN
-
EYW
1 stop9h 18m
Delta
Deal found 1/27$410
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:34 pm
EYW
-
SAN
2 stops11h 12m
American Airlines
Sun 5/317:00 am
SAN
-
EYW
1 stop8h 52m
American Airlines
Deal found 1/27$462
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/52:45 pm
EYW
-
SAN
1 stop11h 00m
Delta
Sat 2/710:30 pm
SAN
-
EYW
1 stop9h 55m
Delta
Deal found 1/27$465
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/51:16 pm
EYW
-
SAN
1 stop12h 10m
American Airlines
Sat 2/79:21 am
SAN
-
EYW
2 stops11h 35m
American Airlines
Deal found 1/28$470
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/144:34 pm
EYW
-
SAN
1 stop8h 26m
United Airlines
Wed 2/185:00 pm
SAN
-
EYW
1 stop26h 09m
United Airlines
Deal found 1/28$517

Find flight deals from Key West to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$405
(American Airlines)

One-way from

$170
(American Airlines)
Provider with most accurate pricing for Key West-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-San Diego flights.
Search Deals
From Key West to San Diego
Search Deals
One-way flight from Key West to San Diego
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Key West to San Diego that are best for you.

Fly from

Key West

Fly to

San Diego

Route

Depart

Return

Price

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Fri 2/13

3:51 pm-10:40 pm

1 stop9h 49m

San Diego

Mon 2/16

6:20 am-4:24 pm

1 stop7h 04m

$405

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 5/28

6:00 pm-10:58 pm

1 stop7h 58m

San Diego

Sun 5/31

10:40 pm-10:58 am

1 stop9h 18m

$410

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 5/28

1:34 pm-9:46 pm

2 stops11h 12m

San Diego

Sun 5/31

10:45 pm-1:04 pm

2 stops11h 19m

$511

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Sat 2/14

4:34 pm-10:00 pm

1 stop8h 26m

San Diego

Wed 2/18

5:00 pm-10:09 pm

1 stop26h 09m

$517

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 3/18

2:06 pm-9:07 pm

1 stop10h 01m

$170

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 2/4

2:45 pm-10:45 pm

1 stop11h 00m

$233

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Tue 2/3

12:20 pm-6:51 pm

1 stop9h 31m

$233

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Sun 2/15

2:25 pm-8:24 pm

3 stops56h 59m

$237

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Sun 2/15

5:56 pm-10:48 pm

1 stop7h 52m

$313

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Tue 2/3

4:15 pm-2:52 pm

3 stops25h 37m

$559

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Compare providers for flights from Key West to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to San Diego in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Key West-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to San Diego?

    Departing from Key West to San Diego will take you 7h 58m. Key West and San Diego are separated by a distance of 2209 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Key West to San Diego that include hotel bookings?

    Yes. In addition to deals on Key West to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Diego.

  • Can I find deals for business class flights from Key West to San Diego?

    Yes. Cheapflights offers flight deals from Key West to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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