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$129+ Cheap flights from Key West to San Diego (EYW - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/4. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from Key West to San Diego

Best flights from Key West to San Diego
Discover carefully curated flight deals from Key West to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 15, 2025.

This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/114:37 pmEYW - SAN
1 stop9h 32mAmerican Airlines
Wed 2/189:15 amSAN - EYW
2 stops10h 39mAmerican Airlines
Deal found 12/13$266
This United Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/234:15 pmEYW - SAN
1 stop9h 18mUnited Airlines
Sun 1/2510:40 pmSAN - EYW
1 stop11h 23mUnited Airlines
Deal found 12/12$357

Find flight deals from Key West to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$261
(Delta)

One-way from

$129
(Delta)
Provider with most accurate pricing for Key West-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-San Diego flights.
Search Deals
From Key West to San Diego
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One-way flight from Key West to San Diego
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Key West to San Diego that are best for you.

Fly from

Key West

Fly to

San Diego

Route

Depart

Return

Price

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 2/11

4:37 pm-11:09 pm

1 stop9h 32m

San Diego

Wed 2/18

9:15 am-10:54 pm

2 stops10h 39m

$266

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Fri 1/23

4:15 pm-10:33 pm

1 stop9h 18m

San Diego

Sun 1/25

10:40 pm-1:03 pm

1 stop11h 23m

$357

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 2/4

1:16 pm-10:26 pm

1 stop12h 10m

$129

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 2/4

2:45 pm-8:37 pm

1 stop8h 52m

$129

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Tue 2/3

4:01 pm-10:26 pm

1 stop9h 25m

$129

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 3/18

2:06 pm-9:04 pm

1 stop9h 58m

$133

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 3/18

12:25 pm-5:38 pm

2 stops32h 13m

$220

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Sun 12/21

6:20 pm-11:28 pm

1 stop8h 08m

$223

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Sun 12/21

11:47 am-6:37 pm

2 stops9h 50m

$228

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Sun 12/21

8:55 am-1:15 pm

3 stops31h 20m

$242

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/13

Compare providers for flights from Key West to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to San Diego in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Key West-San Diego flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Key West-San Diego flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Key West-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-San Diego flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to San Diego

What is the cheapest time of day to fly from EYW to SAN?

Find hourly flight availability from Key West to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 38% on flights from Key West to San Diego by exploring options for tickets in the evening.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to San Diego?

    Departing from Key West to San Diego will take you 9h 18m. Key West and San Diego are separated by a distance of 2209 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Key West to San Diego that include hotel bookings?

    Yes. In addition to deals on Key West to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Diego.

  • Can I find deals for business class flights from Key West to San Diego?

    Yes. Cheapflights offers flight deals from Key West to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
Julian
National City

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