$319+ Cheap flights from Roanoke to San Antonio (ROA - SAT)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — SAT
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Find cheap flights from Roanoke to San Antonio with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Roanoke to San Antonio
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Cheapest flights from Roanoke to San AntonioExplore the most affordable flight options available from Roanoke to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Roanoke to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:49 pm -
1 stop8h 09m
Wed 10/216:00 pm -
1 stop4h 44m
Deal found 9/14![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:52 pm -
1 stop8h 03m
Sat 11/77:00 am -
2 stops8h 22m
Deal found 9/18![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:12 pm -
1 stop7h 44m
Mon 10/126:00 pm -
1 stop4h 44m
Deal found 9/17![American Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:51 pm -
1 stop5h 59m
Wed 10/2811:45 am -
2 stops10h 59m
Deal found 9/15![United Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop7h 49m
Mon 10/56:10 pm -
1 stop4h 49m
Deal found 9/17![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:15 am -
2 stops9h 57m
Sun 10/42:00 pm -
1 stop7h 59m
Deal found 9/15![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:55 pm -
2 stops8h 56m
Sat 11/75:30 am -
2 stops7h 45m
Deal found 9/18![United Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
1 stop7h 49m
Wed 10/76:20 pm -
1 stop5h 07m
Deal found 9/17![Delta logo]()
$429
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/84:52 pm -
1 stop8h 03m
Sat 11/145:00 am -
2 stops7h 53m
Deal found 9/14![American Airlines logo]()
$434
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/53:05 pm -
1 stop6h 44m
Wed 12/96:45 am -
1 stop5h 38m
Deal found 9/15![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:49 am -
1 stop6h 22m
Wed 10/2111:47 am -
2 stops10h 57m
Deal found 9/14![United Airlines logo]()
$441
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am -
1 stop7h 49m
Wed 10/74:29 pm -
1 stop6h 58m
Deal found 9/17![Delta logo]()
$444
Best flights from Roanoke to San AntonioDiscover carefully curated flight deals from Roanoke to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Roanoke to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:00 am -
1 stop6h 18m
Sat 11/76:40 am -
1 stop5h 46m
Deal found 9/18![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:57 am -
1 stop6h 51m
Mon 11/167:15 am -
1 stop8h 07m
Deal found 9/13![American Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:29 pm -
1 stop5h 19m
Mon 11/164:32 pm -
1 stop6h 47m
Deal found 9/14![Delta logo]()
$349
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:49 pm -
1 stop8h 09m
Wed 10/287:10 am -
1 stop8h 08m
Deal found 9/15![American Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:55 pm -
1 stop6h 41m
Mon 12/216:29 pm -
1 stop4h 44m
Deal found 9/13![Delta logo]()
$374
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/114:10 pm -
2 stops8h 54m
Mon 11/167:15 am -
1 stop8h 07m
Deal found 9/14![American Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/53:05 pm -
1 stop6h 44m
Wed 12/96:45 am -
1 stop5h 38m
Deal found 9/15![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:49 am -
1 stop6h 22m
Wed 10/2111:47 am -
2 stops10h 57m
Deal found 9/14![United Airlines logo]()
$441
Last-minute flights from Roanoke to San AntonioDiscover last-minute flight deals from Roanoke to San Antonio. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to San Antonio. Data last updated September 18, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am -
1 stop7h 49m
Tue 10/64:29 pm -
1 stop6h 58m
Deal found 9/17![Delta logo]()
$444
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:15 am -
2 stops9h 57m
Sun 10/42:00 pm -
1 stop7h 59m
Deal found 9/15![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:15 am -
1 stop5h 49m
Wed 10/711:47 am -
2 stops10h 57m
Deal found 9/17![United Airlines logo]()
$449
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop7h 49m
Wed 10/76:20 pm -
1 stop5h 07m
Deal found 9/17![Delta logo]()
$399
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop7h 49m
Sat 10/105:30 am -
1 stop10h 58m
Deal found 9/17![Delta logo]()
$472
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop7h 49m
Sun 10/46:10 pm -
1 stop4h 49m
Deal found 9/17![Delta logo]()
$479
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
1 stop7h 49m
Wed 10/76:20 pm -
1 stop5h 07m
Deal found 9/17![Delta logo]()
$429
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:12 pm -
1 stop7h 44m
Mon 10/126:00 pm -
1 stop4h 44m
Deal found 9/17![American Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:49 pm -
1 stop8h 09m
Wed 10/216:00 pm -
1 stop4h 44m
Deal found 9/14![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:49 am -
1 stop6h 22m
Wed 10/2111:47 am -
2 stops10h 57m
Deal found 9/14![United Airlines logo]()
$441
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:49 pm -
1 stop8h 09m
Thu 10/227:10 am -
1 stop8h 08m
Deal found 9/14![American Airlines logo]()
$475
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:51 pm -
1 stop5h 59m
Wed 10/2811:45 am -
2 stops10h 59m
Deal found 9/15![United Airlines logo]()
$384
One-way flights from Roanoke to San AntonioSearch for one-way flight options from Roanoke to San Antonio. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Roanoke to San Antonio. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:12 am -
1 stop7h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1010:35 am -
2 stops11h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![United Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2410:53 am -
1 stop6h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![United Airlines logo]()
$459
Find flight deals from Roanoke to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $349 (American Airlines) |
One-way from | $319 (Delta) |
Popular in | March |
Cheapest in | November |
Average price | $464 |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Roanoke to San Antonio that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RoanokeSan Antonio
ROA Roanoke - SAT San Antonio
ROASAT
Roanoke
Sat 10/10
11:12 am-5:14 pm
1 stop7h 02m
San Antonio
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$319
RoanokeSan Antonio
ROA Roanoke - SAT San Antonio
ROASAT
Roanoke
Sat 10/10
10:35 am-9:31 pm
2 stops11h 56m
San Antonio
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$324
RoanokeSan Antonio
ROA Roanoke - SAT San Antonio
ROASAT
Roanoke
Mon 11/2
6:00 am-11:18 am
1 stop6h 18m
San Antonio
Sat 11/7
6:40 am-1:26 pm
1 stop5h 46m
$349
RoanokeSan Antonio
ROA Roanoke - SAT San Antonio
ROASAT
Roanoke
Thu 11/12
10:57 am-4:48 pm
1 stop6h 51m
San Antonio
Mon 11/16
7:15 am-4:22 pm
1 stop8h 07m
$349
RoanokeSan Antonio
ROA Roanoke - SAT San Antonio
ROASAT
Roanoke
Wed 11/11
3:29 pm-7:48 pm
1 stop5h 19m
San Antonio
Mon 11/16
4:32 pm-12:19 am
1 stop6h 47m
$349
RoanokeSan Antonio
ROA Roanoke - SAT San Antonio
ROASAT
Roanoke
Sat 10/24
4:49 pm-11:58 pm
1 stop8h 09m
San Antonio
Wed 10/28
7:10 am-4:18 pm
1 stop8h 08m
$349
RoanokeSan Antonio
ROA Roanoke - SAT San Antonio
ROASAT
Roanoke
Wed 11/11
4:10 pm-12:04 am
2 stops8h 54m
San Antonio
Mon 11/16
7:15 am-4:22 pm
1 stop8h 07m
$354
RoanokeSan Antonio
ROA Roanoke - SAT San Antonio
ROASAT
Roanoke
Wed 12/16
6:55 pm-12:36 am
1 stop6h 41m
San Antonio
Mon 12/21
6:29 pm-12:13 am
1 stop4h 44m
$374
RoanokeSan Antonio
ROA Roanoke - SAT San Antonio
ROASAT
Roanoke
Sat 12/5
3:05 pm-8:49 pm
1 stop6h 44m
San Antonio
Wed 12/9
6:45 am-1:23 pm
1 stop5h 38m
$439
RoanokeSan Antonio
ROA Roanoke - SAT San Antonio
ROASAT
Roanoke
Thu 10/15
6:49 am-12:11 pm
1 stop6h 22m
San Antonio
Wed 10/21
11:47 am-11:44 pm
2 stops10h 57m
$441
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Roanoke to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Roanoke to San Antonio in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Roanoke-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Roanoke-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Roanoke-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Roanoke-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Roanoke-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Roanoke to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Roanoke with our price prediction graph.
ROA-SAT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to San Antonio
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated September 18, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Roanoke to San Antonio have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Food
7.2
Overall
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Comfort
7.8
Food
7.2
Overall
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Comfort
7.8
Food
7.2
Overall
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Comfort
7.8
Food
7.2
Overall
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Roanoke to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Antonio?
Book flights to San Antonio if you plan to visit one of these locationsNew Braunfels
Kerrville
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Roanoke and San Antonio flights
Browse other Roanoke and San Antonio flight options. Last updated on September 18, 2026.
Other flights from Roanoke
Browse through other flights departing from Roanoke. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Antonio
Explore flights to San Antonio departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Top 3 airlines flying from Roanoke to San Antonio
Discover the top 3 airlines that operate flights from Roanoke to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$246 | Average$355 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$257 | Average$383 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$309 | Average$468 | FlexibilityNo cancel fee | On-time71% |