HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Antonio

$98+ Cheap flights from Knoxville to San Antonio (TYS - SAT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAT
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to San Antonio with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Antonio are usually found in July or January, booked 60 days in advance, depart on a Friday or Wednesday and return on a Wednesday

Cheap flight deals from Knoxville to San Antonio

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$217
(American Airlines)

One-way from

$98
(Kiwi.com)

Popular in

October

Cheapest in

July

Average price

$320
From Knoxville McGhee Tyson to San Antonio
Search Deals
One-way flight from Knoxville McGhee Tyson to San Antonio
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($42 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Knoxville to San Antonio

Cheapest flights from Knoxville to San Antonio
Explore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/215:00 amTYS - SAT
1 stop6h 20mAmerican Airlines
Tue 10/286:00 amSAT - TYS
1 stop4h 45mAmerican Airlines
Deal found 9/14$217
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:59 pmTYS - SAT
1 stop5h 34mDelta
Sun 12/78:00 amSAT - TYS
1 stop5h 51mDelta
Deal found 9/15$269
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:08 pmTYS - SAT
1 stop6h 51mDelta
Sat 10/45:45 pmSAT - TYS
1 stop4h 59mDelta
Deal found 9/15$279
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:00 amTYS - SAT
1 stop13h 48mMultiple Airlines
Fri 10/317:35 pmSAT - TYS
1 stop13h 28mMultiple Airlines
Deal found 9/15$285
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/108:17 pmTYS - SAT
1 stop21h 20mMultiple Airlines
Thu 10/168:26 pmSAT - TYS
2 stops47h 38mMultiple Airlines
Deal found 9/14$293
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/147:20 pmTYS - SAT
1 stop6h 08mAmerican Airlines
Sun 11/166:00 amSAT - TYS
1 stop4h 16mAmerican Airlines
Deal found 9/14$294
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/108:17 pmTYS - SAT
1 stop21h 20mMultiple Airlines
Wed 10/157:00 amSAT - TYS
2 stops37h 07mMultiple Airlines
Deal found 9/14$305
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/175:45 amTYS - SAT
1 stop4h 47mDelta
Mon 9/225:10 amSAT - TYS
1 stop5h 31mDelta
Deal found 9/15$309
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/94:41 pmTYS - SAT
1 stop7h 15mAmerican Airlines
Mon 10/136:39 pmSAT - TYS
1 stop4h 12mAmerican Airlines
Deal found 9/14$319
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:20 pmTYS - SAT
1 stop6h 16mAmerican Airlines
Sun 9/287:00 amSAT - TYS
1 stop5h 09mAmerican Airlines
Deal found 9/15$329
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:28 pmTYS - SAT
2 stops17h 49mMultiple Airlines
Sun 11/166:00 amSAT - TYS
1 stop15h 59mMultiple Airlines
Deal found 9/15$337

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.

Fly from

Knoxville

Fly to

San Antonio

Route

Depart

Return

Price

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 10/30

10:05 am-4:07 pm

1 stop7h 02m

San Antonio

Sun 11/2

5:14 am-11:22 am

1 stop5h 08m

$269

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 12/4

7:59 pm-12:33 am

1 stop5h 34m

San Antonio

Sun 12/7

5:10 am-11:45 am

1 stop5h 35m

$269

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 9/30

6:08 pm-11:59 pm

1 stop6h 51m

San Antonio

Sat 10/4

5:45 pm-11:44 pm

1 stop4h 59m

$279

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-10:14 am

2 stops15h 57m

San Antonio

Fri 10/31

7:35 pm-10:03 am

1 stop13h 28m

$287

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 11/14

7:20 pm-12:28 am

1 stop6h 08m

San Antonio

Sun 11/16

6:00 am-11:16 am

1 stop4h 16m

$294

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 10/9

4:41 pm-10:56 pm

1 stop7h 15m

San Antonio

Mon 10/13

6:39 pm-11:51 pm

1 stop4h 12m

$319

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 11/14

9:28 pm-2:17 pm

2 stops17h 49m

San Antonio

Sun 11/16

6:00 am-10:59 pm

1 stop15h 59m

$337

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Mon 9/29

8:35 pm-8:52 pm

2 stops25h 17m

San Antonio

Fri 10/3

7:17 pm-10:18 am

1 stop14h 01m

$339

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 2/19

6:45 am-12:22 pm

1 stop6h 37m

$109

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-10:14 am

2 stops15h 57m

$138

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 17 results
1
2

Best time to book a flight from Knoxville to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Antonio

How far ahead should I book a flight from Knoxville to San Antonio?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Antonio. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Knoxville to San Antonio, you should look to book at least 60 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Knoxville to San Antonio?

Currently, August is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $295). Flying from Knoxville to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SAT?

Find hourly flight availability from Knoxville to San Antonio. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

It’s optimal to fly from Knoxville to San Antonio in the evening. By choosing this option you can save up to 19% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing San Antonio

Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated September 16, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Antonio to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Overall

8.0

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Overall

8.0

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,929 reviews
Delta
8.0
Very good
7,954 reviews

Overall

8.0

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Overall

8.0

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to San Antonio?

    Departing from Knoxville to San Antonio will take you 7h 02m. The distance between Knoxville and San Antonio is about 945 mi.

  • What are the cheapest airlines flying from Knoxville to San Antonio round-trip?

    Our cheapest airline available from Knoxville to San Antonio is Delta. Our recent data shows that you can find tickets from as low as $207 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $248 and $258 round-trip. Delta is 43% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Knoxville to San Antonio one-way?

    The cheapest airlines for a one-way flight from Knoxville to San Antonio are United Airlines ($109), Frontier ($138), and Delta ($160).

  • Can I find deals for flights from Knoxville to San Antonio that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Antonio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Antonio.

  • Can I find deals for business class flights from Knoxville to San Antonio?

    Yes. Cheapflights offers flight deals from Knoxville to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Antonio?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $295). Flying from Knoxville to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to San Antonio

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Hobby flights
Nashville to Dallas/Fort Worth flights
Memphis to Dallas/Fort Worth flights
Nashville to George Bush Intcntl flights
Memphis to Hobby flights
Knoxville to Dallas/Fort Worth flights
Nashville to Love Field flights
Memphis to Love Field flights
Memphis to George Bush Intcntl flights
Nashville to Austin flights
Knoxville to Hobby flights
Knoxville to George Bush Intcntl flights
Chattanooga to Dallas/Fort Worth flights
Memphis to Austin flights
Nashville to San Antonio flights
Nashville to El Paso flights
Memphis to San Antonio flights
Chattanooga to San Antonio flights
Chattanooga to Hobby flights
Blountville to Dallas/Fort Worth flights
Chattanooga to Love Field flights
Knoxville to Love Field flights
Chattanooga to George Bush Intcntl flights
Knoxville to Austin flights
Chattanooga to Austin flights
Blountville to San Antonio flights
Blountville to Hobby flights
Blountville to George Bush Intcntl flights
Memphis to El Paso flights
Memphis to Lubbock flights
Memphis to Waco flights
Memphis to McAllen flights
Knoxville to El Paso flights
Nashville to Waco flights
Chattanooga to El Paso flights
Blountville to Austin flights
Knoxville to McAllen flights
Nashville to Corpus Christi flights
Nashville to McAllen flights
Memphis to Laredo flights
Chattanooga to Midland flights
Blountville to Love Field flights
Nashville to College Station flights
Nashville to Killeen flights
Chattanooga to Killeen flights
Nashville to Abilene flights
Blountville to El Paso flights
Knoxville to Waco flights
Nashville to Harlingen flights

Top 3 airlines flying from Knoxville to San Antonio

Discover the top 3 airlines that operate flights from Knoxville to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$207Average$308FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$339FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$258Average$416FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.