$125+ Cheap flights from Knoxville to San Antonio (TYS - SAT)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAT
Apr 7 — Apr 141
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to San Antonio with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to San AntonioExplore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
Explore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:28 pm
TYS
- SAT
1 stop22h 51m
Frontier
Sat 5/93:34 pm
SAT
- TYS
1 stop22h 59m
Frontier
Deal found 3/3![Frontier logo]()
$175
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:50 pm
TYS
- SAT
1 stop6h 25m
Southwest
Sat 5/96:35 am
SAT
- TYS
1 stop4h 05m
Southwest
Deal found 3/3![Southwest logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:20 pm
TYS
- SAT
1 stop8h 59m
Multiple Airlines
Fri 4/176:00 am
SAT
- TYS
1 stop29h 06m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:28 pm
TYS
- SAT
1 stop22h 51m
Multiple Airlines
Mon 5/1110:23 am
SAT
- TYS
1 stop11h 01m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$226
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:05 am
TYS
- SAT
1 stop4h 35m
Southwest
Sat 4/256:35 am
SAT
- TYS
1 stop4h 05m
Southwest
Deal found 3/4![Southwest logo]()
$227
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:30 am
TYS
- SAT
1 stop8h 27m
Delta
Wed 9/912:15 pm
SAT
- TYS
1 stop5h 02m
Delta
Deal found 3/3![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:50 pm
TYS
- SAT
1 stop6h 25m
Southwest
Sat 5/99:15 am
SAT
- TYS
2 stops8h 15m
Southwest
Deal found 3/8![Southwest logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/149:40 pm
TYS
- SAT
1 stop27h 11m
Multiple Airlines
Wed 5/203:14 pm
SAT
- TYS
1 stop21h 45m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$245
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/44:55 pm
TYS
- SAT
2 stops8h 00m
Southwest
Sat 4/116:05 am
SAT
- TYS
1 stop12h 30m
Southwest
Deal found 3/5![Southwest logo]()
$248
Best flights from Knoxville to San AntonioDiscover carefully curated flight deals from Knoxville to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
Discover carefully curated flight deals from Knoxville to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:10 am
TYS
- SAT
1 stop10h 45m
Southwest
Wed 7/157:15 am
SAT
- TYS
1 stop5h 50m
Southwest
Deal found 3/3![Southwest logo]()
$243
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:20 pm
TYS
- SAT
1 stop6h 07m
Delta
Mon 5/186:21 pm
SAT
- TYS
1 stop4h 35m
Delta
Deal found 3/7![Delta logo]()
$275
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:00 am
TYS
- SAT
1 stop6h 15m
United Airlines
Sat 5/235:57 pm
SAT
- TYS
1 stop4h 15m
United Airlines
Deal found 3/5![United Airlines logo]()
$277
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:01 pm
TYS
- SAT
1 stop5h 53m
United Airlines
Sun 5/106:02 pm
SAT
- TYS
1 stop4h 42m
United Airlines
Deal found 3/6![United Airlines logo]()
$280
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:05 am
TYS
- SAT
1 stop4h 41m
Delta
Thu 7/162:51 pm
SAT
- TYS
1 stop5h 53m
Delta
Deal found 3/3![Delta logo]()
$293
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:35 am
TYS
- SAT
2 stops7h 40m
Southwest
Wed 5/2011:20 am
SAT
- TYS
2 stops7h 20m
Southwest
Deal found 3/7![Southwest logo]()
$327
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:33 pm
TYS
- SAT
1 stop6h 11m
Delta
Mon 5/186:50 am
SAT
- TYS
1 stop6h 43m
Delta
Deal found 3/7![Delta logo]()
$304
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:05 am
TYS
- SAT
1 stop4h 45m
United Airlines
Tue 4/144:17 pm
SAT
- TYS
1 stop6h 24m
United Airlines
Deal found 3/7![United Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:38 pm
TYS
- SAT
1 stop6h 47m
Delta
Sun 4/195:20 am
SAT
- TYS
1 stop4h 57m
Delta
Deal found 3/6![Delta logo]()
$311
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:35 am
TYS
- SAT
2 stops7h 40m
Southwest
Sun 4/196:10 am
SAT
- TYS
2 stops6h 55m
Southwest
Deal found 3/3![Southwest logo]()
$355
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/317:20 pm
TYS
- SAT
1 stop5h 55m
Delta
Fri 9/46:15 pm
SAT
- TYS
1 stop4h 32m
Delta
Deal found 3/3![Delta logo]()
$319
Last-minute flights from Knoxville to San AntonioDiscover last-minute flight deals from Knoxville to San Antonio. Data last updated March 8, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Antonio. Data last updated March 8, 2026 and is based on user searches.
This Priceline deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:20 pm
TYS
- SAT
1 stop8h 57m
Frontier
Mon 3/306:45 am
SAT
- TYS
1 stop7h 40m
Frontier
Deal found 3/8![Frontier logo]()
$234
This Priceline deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SAT
1 stop8h 59m
Frontier
Mon 4/66:45 am
SAT
- TYS
1 stop7h 43m
Frontier
Deal found 3/7![Frontier logo]()
$250
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/49:00 am
TYS
- SAT
1 stop5h 08m
United Airlines
Sat 4/114:17 pm
SAT
- TYS
1 stop6h 24m
United Airlines
Deal found 3/5![United Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/44:55 pm
TYS
- SAT
2 stops8h 00m
Southwest
Sat 4/116:05 am
SAT
- TYS
1 stop12h 30m
Southwest
Deal found 3/5![Southwest logo]()
$248
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:35 am
TYS
- SAT
1 stop4h 55m
Southwest
Wed 4/812:35 pm
SAT
- TYS
1 stop6h 05m
Southwest
Deal found 3/5![Southwest logo]()
$253
This Priceline deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:20 pm
TYS
- SAT
1 stop8h 59m
Frontier
Mon 4/136:45 am
SAT
- TYS
1 stop7h 43m
Frontier
Deal found 3/8![Frontier logo]()
$256
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:15 pm
TYS
- SAT
1 stop4h 48m
United Airlines
Fri 4/172:02 pm
SAT
- TYS
1 stop7h 32m
United Airlines
Deal found 3/6![United Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:05 am
TYS
- SAT
1 stop4h 35m
Southwest
Sat 4/256:35 am
SAT
- TYS
1 stop4h 05m
Southwest
Deal found 3/4![Southwest logo]()
$227
One-way flights from Knoxville to San AntonioSearch for one-way flight options from Knoxville to San Antonio. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
Search for one-way flight options from Knoxville to San Antonio. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
This Priceline deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/204:20 pm
TYS
- SAT
1 stop8h 57m
Frontier
Deal found 3/6![Frontier logo]()
$125
This Frontier deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/164:20 pm
TYS
- SAT
1 stop8h 57m
Frontier
Deal found 3/8![Frontier logo]()
$150
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/259:00 am
TYS
- SAT
1 stop7h 33m
United Airlines
Deal found 3/8![United Airlines logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/193:55 pm
TYS
- SAT
1 stop18h 32m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$161
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:10 pm
TYS
- SAT
1 stop4h 20m
Delta
Deal found 3/8![Delta logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/169:54 pm
TYS
- SAT
2 stops36h 33m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$192
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/137:00 am
TYS
- SAT
1 stop6h 27m
United Airlines
Deal found 3/8![United Airlines logo]()
$210
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:55 am
TYS
- SAT
2 stops10h 51m
United Airlines
Deal found 3/8![United Airlines logo]()
$215
This Orbitz deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/134:20 pm
TYS
- SAT
1 stop17h 46m
Frontier
Deal found 3/8![Frontier logo]()
$221
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/125:40 am
TYS
- SAT
1 stop5h 15m
Delta
Deal found 3/8![Delta logo]()
$225
Find flight deals from Knoxville to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $175 (Kiwi.com) |
One-way from | $125 (Priceline) |
Popular in | October |
Cheapest in | July |
Average price | $372 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Wed 7/8
8:10 am-5:55 pm
1 stop10h 45m
San Antonio
Wed 7/15
7:15 am-2:05 pm
1 stop5h 50m
$243
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Wed 5/13
5:20 pm-10:27 pm
1 stop6h 07m
San Antonio
Mon 5/18
6:21 pm-11:56 pm
1 stop4h 35m
$275
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Wed 5/20
7:00 am-12:15 pm
1 stop6h 15m
San Antonio
Sat 5/23
5:57 pm-11:12 pm
1 stop4h 15m
$277
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Thu 5/7
6:01 pm-10:54 pm
1 stop5h 53m
San Antonio
Sun 5/10
6:02 pm-11:44 pm
1 stop4h 42m
$280
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Wed 7/8
10:05 am-1:46 pm
1 stop4h 41m
San Antonio
Thu 7/16
2:51 pm-9:44 pm
1 stop5h 53m
$293
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Fri 5/15
7:33 pm-12:44 am
1 stop6h 11m
San Antonio
Mon 5/18
6:50 am-2:33 pm
1 stop6h 43m
$304
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Sat 4/11
7:05 am-10:50 am
1 stop4h 45m
San Antonio
Tue 4/14
4:17 pm-11:41 pm
1 stop6h 24m
$307
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Fri 4/17
4:38 pm-10:25 pm
1 stop6h 47m
San Antonio
Sun 4/19
5:20 am-11:17 am
1 stop4h 57m
$311
Quickest round-trip
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Mon 8/31
7:20 pm-12:15 am
1 stop5h 55m
San Antonio
Fri 9/4
6:15 pm-11:47 pm
1 stop4h 32m
$319
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Thu 5/14
6:35 am-1:15 pm
2 stops7h 40m
San Antonio
Wed 5/20
11:20 am-7:40 pm
2 stops7h 20m
$327
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Antonio in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Knoxville with our price prediction graph.
TYS-SAT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Antonio
Prices
More
How far ahead should I book a flight from Knoxville to San Antonio?
Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Antonio. Price data was last updated on March 6, 2026.
To ensure you get the cheapest price possible for a flight from Knoxville to San Antonio, you should look to book at least 7 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Knoxville to San Antonio?
Currently, May is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $86). Flying from Knoxville to San Antonio in February is currently the most expensive (average of $238). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What’s the top layover airport for flights from Knoxville to San Antonio?
Share of 1-stop round-trip flights from Knoxville to San Antonio chosen by Cheapflights users in the past 12 months, using the same layover each way.
Chicago (ORD) – chosen by Cheapflights users on 50% of 1-stop itineraries from Knoxville to San Antonio on Cheapflights.
What’s the cheapest layover airport for flights from Knoxville to San Antonio?
Average round-trip fare for 1-stop flights from Knoxville to San Antonio, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $309.
What’s the fastest layover option from Knoxville to San Antonio?
Shortest average travel time for 1-stop one-way flights from Knoxville to San Antonio, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Chicago (ORD) have the shortest average one-way travel time for 1-stop routes: 6h 07m.
Which airport typically offers the quickest layover for flights from Knoxville to San Antonio?
Average layover duration for 1-stop one-way flights from Knoxville to San Antonio, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Chicago (ORD) offer the fastest connection on this route, with an average layover time of 2h 31m.
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated March 8, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Antonio to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Antonio?
Book flights to San Antonio if you plan to visit one of these locationsNew Braunfels
Kerrville
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Top 3 airlines flying from Knoxville to San Antonio
Discover the top 3 airlines that operate flights from Knoxville to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$232 | Average$339 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$313 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$237 | Average$362 | FlexibilityNo cancel fee | On-time69% |