HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Antonio

$127+ Cheap flights from Knoxville to San Antonio (TYS - SAT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAT
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to San Antonio with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Antonio are usually found in July or January, booked 60 days in advance, depart on a Friday or Wednesday and return on a Wednesday

Cheap flight deals from Knoxville to San Antonio

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 20, 2025.

Round-trip from

$179
(FlightHub)

One-way from

$127
(FlightHub)

Popular in

March

Cheapest in

July

Average price

$334
From Knoxville McGhee Tyson to San Antonio
Search Deals
One-way flight from Knoxville McGhee Tyson to San Antonio
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Knoxville to San Antonio

Cheapest flights from Knoxville to San Antonio
Explore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:17 pmTYS - SAT
1 stop21h 20mFrontier
Sun 10/198:26 pmSAT - TYS
1 stop22h 06mFrontier
Deal found 8/18$179
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/174:37 pmTYS - SAT
1 stop5h 14mAmerican Airlines
Mon 9/226:49 pmSAT - TYS
1 stop4h 32mAmerican Airlines
Deal found 8/18$233
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/117:45 amTYS - SAT
1 stop7h 50mDelta
Sat 10/182:55 pmSAT - TYS
1 stop7h 12mDelta
Deal found 8/19$237
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/305:30 amTYS - SAT
1 stop4h 46mAmerican Airlines
Tue 9/26:00 amSAT - TYS
1 stop4h 30mAmerican Airlines
Deal found 8/18$238
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/47:50 amTYS - SAT
1 stop6h 13mDelta
Sat 9/135:45 pmSAT - TYS
1 stop4h 59mDelta
Deal found 8/19$254
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/261:53 pmTYS - SAT
1 stop4h 13mDelta
Wed 9/35:10 amSAT - TYS
1 stop5h 24mDelta
Deal found 8/19$274
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/285:45 amTYS - SAT
1 stop4h 55mDelta
Mon 9/15:10 amSAT - TYS
1 stop5h 24mDelta
Deal found 8/18$284
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/298:30 amTYS - SAT
1 stop13h 22mMultiple Airlines
Thu 10/28:20 pmSAT - TYS
2 stops26h 16mMultiple Airlines
Deal found 8/19$287
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/279:10 amTYS - SAT
1 stop4h 54mUnited Airlines
Mon 12/12:04 pmSAT - TYS
1 stop7h 51mUnited Airlines
Deal found 8/19$303
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:10 pmTYS - SAT
1 stop5h 25mDelta
Mon 12/16:20 pmSAT - TYS
1 stop4h 26mDelta
Deal found 8/19$304
This Mytrip deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/57:15 amTYS - SAT
2 stops11h 57mMultiple Airlines
Mon 9/812:45 pmSAT - TYS
1 stop8h 49mMultiple Airlines
Deal found 8/18$306

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.

Fly from

Knoxville

Fly to

San Antonio

Route

Depart

Return

Price

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 10/17

8:17 pm-4:37 pm

1 stop21h 20m

San Antonio

Sun 10/19

8:26 pm-7:32 pm

1 stop22h 06m

$179

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 9/17

4:37 pm-8:51 pm

1 stop5h 14m

San Antonio

Mon 9/22

6:49 pm-12:21 am

1 stop4h 32m

$233

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 10/11

7:45 am-2:35 pm

1 stop7h 50m

San Antonio

Sat 10/18

2:55 pm-11:07 pm

1 stop7h 12m

$237

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 8/30

5:30 am-9:16 am

1 stop4h 46m

San Antonio

Tue 9/2

6:00 am-11:30 am

1 stop4h 30m

$238

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Mon 9/1

5:45 am-9:40 am

1 stop4h 55m

San Antonio

Mon 9/8

6:11 pm-11:48 pm

1 stop4h 37m

$254

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 9/5

7:50 am-1:03 pm

1 stop6h 13m

San Antonio

Mon 9/8

6:11 pm-11:48 pm

1 stop4h 37m

$254

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 9/5

2:07 pm-5:43 pm

1 stop4h 36m

San Antonio

Mon 9/8

5:00 am-1:12 pm

1 stop7h 12m

$254

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 9/4

6:14 pm-11:57 pm

1 stop6h 43m

San Antonio

Sat 9/13

5:45 pm-11:44 pm

1 stop4h 59m

$254

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 8/26

1:53 pm-5:06 pm

1 stop4h 13m

San Antonio

Wed 9/3

5:10 am-11:34 am

1 stop5h 24m

$274

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 8/28

5:45 am-9:40 am

1 stop4h 55m

San Antonio

Mon 9/1

5:10 am-11:34 am

1 stop5h 24m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/19

Showing 1-10 of 14 results
1
2

Best time to book a flight from Knoxville to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Antonio

How far ahead should I book a flight from Knoxville to San Antonio?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Antonio. Price data was last updated on August 8, 2025.

To ensure you get the cheapest price possible for a flight from Knoxville to San Antonio, you should look to book at least 60 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Knoxville to San Antonio?

Currently, August is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $295). Flying from Knoxville to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SAT?

Find hourly flight availability from Knoxville to San Antonio. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 20, 2025.

It’s optimal to fly from Knoxville to San Antonio in the evening. By choosing this option you can save up to 19% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing San Antonio

Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated August 20, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Antonio to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,928 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to San Antonio?

    Departing from Knoxville to San Antonio will take you 5h 14m. The distance between Knoxville and San Antonio is about 945 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to San Antonio round-trip?

    Our cheapest airline available from Knoxville to San Antonio is Delta. Our recent data shows that you can find tickets from as low as $207 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $244 and $286 round-trip. Delta is 40% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Knoxville to San Antonio that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Antonio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Antonio.

  • Can I find deals for business class flights from Knoxville to San Antonio?

    Yes. Cheapflights offers flight deals from Knoxville to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Antonio?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $295). Flying from Knoxville to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to San Antonio

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Dallas/Fort Worth flights
Nashville to Hobby flights
Memphis to Dallas/Fort Worth flights
Nashville to George Bush Intcntl flights
Memphis to Hobby flights
Memphis to George Bush Intcntl flights
Nashville to Love Field flights
Knoxville to Dallas/Fort Worth flights
Nashville to Austin flights
Memphis to Love Field flights
Memphis to San Antonio flights
Knoxville to Hobby flights
Nashville to San Antonio flights
Knoxville to George Bush Intcntl flights
Chattanooga to Dallas/Fort Worth flights
Memphis to Austin flights
Chattanooga to Hobby flights
Chattanooga to San Antonio flights
Knoxville to Love Field flights
Chattanooga to George Bush Intcntl flights
Chattanooga to Love Field flights
Blountville to Hobby flights
Blountville to George Bush Intcntl flights
Knoxville to Austin flights
Chattanooga to Austin flights
Memphis to El Paso flights
Blountville to San Antonio flights
Blountville to Dallas/Fort Worth flights
Nashville to El Paso flights
Nashville to Corpus Christi flights
Blountville to Austin flights
Nashville to Brownsville flights
Memphis to Lubbock flights
Nashville to Waco flights
Memphis to McAllen flights
Knoxville to El Paso flights
Knoxville to McAllen flights
Nashville to Lubbock flights
Blountville to Love Field flights
Chattanooga to El Paso flights
Nashville to Harlingen flights
Memphis to Laredo flights
Nashville to McAllen flights
Nashville to Amarillo flights
Nashville to College Station flights
Nashville to Tyler flights
Knoxville to San Angelo flights
Blountville to El Paso flights
Nashville to Killeen flights

Top 3 airlines flying from Knoxville to San Antonio

Discover the top 3 airlines that operate flights from Knoxville to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$207Average$312FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$244Average$328FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$286Average$425FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.