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$160+ Cheap flights from Knoxville to San Antonio (TYS - SAT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAT
Nov 19 — Nov 261
Wed 11/19
Wed 11/26
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Antonio are usually found in July or January, booked 60 days in advance, depart on a Friday or Wednesday and return on a Wednesday

Cheap flight deals from Knoxville to San Antonio

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$163
(American Airlines)

One-way from

$160
(United Airlines)

Popular in

December

Cheapest in

July

Average price

$480
Provider with most accurate pricing for Knoxville McGhee Tyson-San Antonio flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Antonio flights.
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From Knoxville McGhee Tyson to San Antonio
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One-way flight from Knoxville McGhee Tyson to San Antonio
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Highest demand for flights based on searches. 5% potential increase in price ($20 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Knoxville to San Antonio

Cheapest flights from Knoxville to San Antonio
Explore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2025.

This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:40 amTYS - SAT
1 stop5h 51mDelta
Sat 12/61:16 pmSAT - TYS
1 stop4h 42mDelta
Deal found 10/19$243
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:30 amTYS - SAT
1 stop8h 41mMultiple Airlines
Sat 12/612:45 pmSAT - TYS
2 stops31h 52mMultiple Airlines
Deal found 10/19$264
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:56 pmTYS - SAT
1 stop5h 27mDelta
Mon 12/88:00 amSAT - TYS
1 stop5h 51mDelta
Deal found 10/18$269
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/411:23 amTYS - SAT
1 stop8h 09mMultiple Airlines
Sat 11/83:12 pmSAT - TYS
1 stop26h 10mMultiple Airlines
Deal found 10/20$272
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:00 amTYS - SAT
1 stop4h 19mAmerican Airlines
Sat 11/86:05 pmSAT - TYS
1 stop5h 03mAmerican Airlines
Deal found 10/18$274
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/14:18 pmTYS - SAT
1 stop6h 16mAmerican Airlines
Wed 11/56:00 amSAT - TYS
1 stop4h 23mAmerican Airlines
Deal found 10/18$279
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/11:52 pmTYS - SAT
2 stops8h 28mUnited Airlines
Sat 11/82:04 pmSAT - TYS
1 stop5h 29mUnited Airlines
Deal found 10/18$289
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/259:00 amTYS - SAT
1 stop10h 16mMultiple Airlines
Mon 12/18:33 pmSAT - TYS
1 stop20h 10mMultiple Airlines
Deal found 10/18$306
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/24:18 pmTYS - SAT
1 stop7h 47mAmerican Airlines
Fri 12/56:48 amSAT - TYS
1 stop8h 06mAmerican Airlines
Deal found 10/18$319
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/259:00 amTYS - SAT
1 stop10h 16mMultiple Airlines
Sun 11/308:33 pmSAT - TYS
1 stop18h 16mMultiple Airlines
Deal found 10/18$323
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/38:30 amTYS - SAT
1 stop26h 33mMultiple Airlines
Fri 11/77:37 pmSAT - TYS
1 stop13h 27mMultiple Airlines
Deal found 10/19$327
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:00 amTYS - SAT
1 stop13h 06mMultiple Airlines
Mon 11/103:23 pmSAT - TYS
2 stops18h 11mMultiple Airlines
Deal found 10/20$328

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.

Fly from

Knoxville

Fly to

San Antonio

Route

Depart

Return

Price

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 1/13

12:00 pm-3:31 pm

1 stop4h 31m

San Antonio

Tue 1/20

5:20 am-11:47 am

1 stop5h 27m

$217

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 1/14

6:45 am-12:19 pm

1 stop6h 34m

San Antonio

Wed 1/21

5:20 am-11:47 am

1 stop5h 27m

$217

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 1/13

2:30 pm-8:27 pm

1 stop6h 57m

San Antonio

Wed 1/21

2:00 pm-11:00 pm

1 stop8h 00m

$217

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 1/16

6:45 am-12:24 pm

1 stop6h 39m

San Antonio

Tue 1/20

5:59 pm-11:44 pm

1 stop4h 45m

$243

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 12/4

5:40 am-10:31 am

1 stop5h 51m

San Antonio

Sat 12/6

1:16 pm-6:58 pm

1 stop4h 42m

$243

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 1/14

6:45 am-12:19 pm

1 stop6h 34m

San Antonio

Sat 1/17

7:00 am-1:26 pm

1 stop5h 26m

$268

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 1/17

2:30 pm-8:27 pm

1 stop6h 57m

San Antonio

Wed 1/21

2:00 pm-11:00 pm

1 stop8h 00m

$268

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 1/17

2:30 pm-8:27 pm

1 stop6h 57m

San Antonio

Tue 1/20

5:20 am-11:47 am

1 stop5h 27m

$268

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 12/5

3:56 pm-8:23 pm

1 stop5h 27m

San Antonio

Mon 12/8

8:00 am-2:51 pm

1 stop5h 51m

$269

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 1/17

6:45 am-1:19 pm

1 stop7h 34m

San Antonio

Sun 1/18

2:05 pm-9:02 pm

1 stop5h 57m

$287

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/18

Showing 1-10 of 19 results
1
2

Compare providers for flights from Knoxville to San Antonio

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Antonio in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Antonio flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Antonio

How far ahead should I book a flight from Knoxville to San Antonio?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Antonio. Price data was last updated on October 17, 2025.

To ensure you get the cheapest price possible for a flight from Knoxville to San Antonio, you should look to book at least 60 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Knoxville to San Antonio?

Currently, May is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $86). Flying from Knoxville to San Antonio in November is currently the most expensive (average of $125). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SAT?

Find hourly flight availability from Knoxville to San Antonio. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 20, 2025.

It’s optimal to fly from Knoxville to San Antonio in the evening. By choosing this option you can save up to 18% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing San Antonio

Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated October 20, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Antonio to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,978 reviews

Overall

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,978 reviews
Delta
7.9
Good
7,978 reviews

Overall

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,991 reviews
Delta
7.9
Good
7,978 reviews

Overall

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,024 reviews
Delta
7.9
Good
7,978 reviews

Overall

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to San Antonio?

    Departing from Knoxville to San Antonio will take you 4h 31m. The distance between Knoxville and San Antonio is about 945 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to San Antonio round-trip?

    Our cheapest airline available from Knoxville to San Antonio is Delta. Our recent data shows that you can find tickets from as low as $205 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $248 and $248 round-trip. Delta is 42% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Knoxville to San Antonio that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Antonio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Antonio.

  • Can I find deals for business class flights from Knoxville to San Antonio?

    Yes. Cheapflights offers flight deals from Knoxville to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Antonio?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $86). Flying from Knoxville to San Antonio in November is currently the most expensive (average of $125). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville

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Top 3 airlines flying from Knoxville to San Antonio

Discover the top 3 airlines that operate flights from Knoxville to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$205Average$310FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$392FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$331FlexibilityNo cancel feeOn-time71%

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