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$409+ Cheap flights from Florence, SC to San Antonio (FLO - SAT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/23. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SAT
Apr 12 — Apr 191
Sun 4/12
Sun 4/19
1 adult, Economy
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Cheap flight deals from Florence to San Antonio

Cheapest flights from Florence to San Antonio
Explore the most affordable flight options available from Florence to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.

This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:15 am
FLO
-
SAT
1 stop5h 50m
American Airlines
Sat 3/283:24 pm
SAT
-
FLO
1 stop7h 33m
American Airlines
Deal found 3/9$473
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:34 pm
FLO
-
SAT
1 stop6h 21m
American Airlines
Sun 8/236:05 am
SAT
-
FLO
1 stop7h 04m
American Airlines
Deal found 3/9$521
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:20 pm
FLO
-
SAT
1 stop5h 35m
American Airlines
Sun 4/55:53 pm
SAT
-
FLO
1 stop5h 04m
American Airlines
Deal found 3/11$548
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:05 am
FLO
-
SAT
1 stop5h 05m
American Airlines
Mon 6/226:00 am
SAT
-
FLO
1 stop7h 10m
American Airlines
Deal found 3/11$582
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:16 am
FLO
-
SAT
1 stop5h 04m
American Airlines
Mon 3/305:53 pm
SAT
-
FLO
1 stop5h 04m
American Airlines
Deal found 3/11$603

Find flight deals from Florence to San Antonio

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$473
(American Airlines)

One-way from

$409
(American Airlines)
Provider with most accurate pricing for Florence-San Antonio flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-San Antonio flights.
Search Deals
From Florence to San Antonio
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One-way flight from Florence to San Antonio
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from Florence to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Tue 3/24

6:15 am-11:05 am

1 stop5h 50m

San Antonio

Sat 3/28

7:00 am-5:50 pm

2 stops9h 50m

$478

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Fri 8/21

2:34 pm-7:55 pm

1 stop6h 21m

San Antonio

Sun 8/23

6:05 am-2:09 pm

1 stop7h 04m

$521

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Thu 6/18

5:05 am-9:10 am

1 stop5h 05m

San Antonio

Mon 6/22

6:00 am-2:10 pm

1 stop7h 10m

$582

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Thu 4/2

5:16 am-9:20 am

1 stop5h 04m

San Antonio

Sun 4/5

10:14 am-5:50 pm

1 stop6h 36m

$603
Quickest round-trip

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Thu 3/26

5:16 am-9:20 am

1 stop5h 04m

San Antonio

Mon 3/30

5:53 pm-11:57 pm

1 stop5h 04m

$603
Cheapest one-way
Quickest one-way

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Sat 5/23

5:05 am-9:10 am

1 stop5h 05m

$421

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Sat 3/21

6:25 pm-10:55 pm

1 stop5h 30m

$421

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Fri 5/22

2:35 pm-5:58 pm

2 stops28h 23m

$441

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Sun 5/24

2:35 pm-11:06 pm

2 stops9h 31m

$452

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/10

Sorted by cheapest first

Compare providers for flights from Florence to San Antonio

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to San Antonio in March.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Florence, South Carolina-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-San Antonio flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Florence, South Carolina-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Florence to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Antonio

What is the cheapest month to book a flight from Florence, South Carolina to San Antonio?

Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to San Antonio (average of $129). Flying from Florence, South Carolina to San Antonio in June is currently the most expensive (average of $246). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to San Antonio?

    American Airlines can get you from Florence, South Carolina to San Antonio in just under 6h 21m. Your travel time can differ by up to . Florence, South Carolina and San Antonio are separated by a distance of 1143 mi.

  • Can I find deals for flights from Florence to San Antonio that include hotel bookings?

    Yes. In addition to deals on Florence to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to San Antonio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Antonio.

  • Can I find deals for business class flights from Florence to San Antonio?

    Yes. Cheapflights offers flight deals from Florence to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to San Antonio?

    Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to San Antonio (average of $129). Flying from Florence, South Carolina to San Antonio in June is currently the most expensive (average of $246). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville

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