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$73+ Cheap flights from Des Moines to San Antonio (DSM - SAT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAT
Thg. 8 22 — Thg. 8 291
Th. 6 8/22
Th. 6 8/29
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to San Antonio are usually found in August or July, booked 63 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Cheap flight deals from Des Moines to San Antonio

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated Tháng Tám 17, 2025.

Round-trip from

$171
(FlightHub)

One-way from

$73
(Priceline)

Popular in

June

Cheapest in

August

Average price

$323
From Des Moines to San Antonio
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One-way flight from Des Moines to San Antonio
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Highest demand for flights based on searches. 1% potential increase in price ($6 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Des Moines to San Antonio

Cheapest flights from Des Moines to San Antonio
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Tháng Tám 17, 2025.

This FlightHub deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 6 9/52:25 pmDSM - SAT
1 stop24h 02mFrontier
CN 9/78:20 pmSAT - DSM
1 stop17h 20mFrontier
Deal found 8/16$171
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 5 10/304:35 pmDSM - SAT
1 stop7h 05mSouthwest
Th. 3 11/43:05 pmSAT - DSM
1 stop4h 50mSouthwest
Deal found 8/15$223
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 3 9/307:00 amDSM - SAT
1 stop4h 50mDelta
Th. 3 10/76:25 amSAT - DSM
1 stop7h 34mDelta
Deal found 8/16$277
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 5 10/3010:00 amDSM - SAT
1 stop5h 56mDelta
Th. 3 11/45:14 amSAT - DSM
1 stop8h 14mDelta
Deal found 8/15$291
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 5 10/309:01 amDSM - SAT
1 stop7h 57mUnited Airlines
Th. 3 11/45:30 amSAT - DSM
2 stops10h 37mUnited Airlines
Deal found 8/14$298
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 4 9/174:09 pmDSM - SAT
1 stop4h 42mAmerican Airlines
CN 9/215:27 pmSAT - DSM
1 stop6h 48mAmerican Airlines
Deal found 8/16$322
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 6 9/196:30 pmDSM - SAT
1 stop5h 29mDelta
Th. 2 9/223:25 pmSAT - DSM
1 stop7h 12mDelta
Deal found 8/15$329
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 6 9/196:15 amDSM - SAT
1 stop4h 22mUnited Airlines
Th. 2 9/225:30 amSAT - DSM
2 stops8h 50mUnited Airlines
Deal found 8/15$334

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Tháng Tám 17, 2025.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Des Moines

Fly to

San Antonio

Route

Depart

Return

Price

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Th. 6 9/5

2:25 pm-2:27 pm

1 stop24h 02m

San Antonio

CN 9/7

8:20 pm-1:40 pm

1 stop17h 20m

$171

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Th. 6 10/3

2:25 pm-2:27 pm

1 stop24h 02m

San Antonio

CN 10/5

8:20 pm-1:40 pm

1 stop17h 20m

$171

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Th. 5 10/30

5:04 am-9:19 am

1 stop4h 15m

San Antonio

Th. 3 11/4

6:05 pm-10:59 pm

1 stop4h 54m

$223

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Th. 5 10/30

4:35 pm-11:40 pm

1 stop7h 05m

San Antonio

Th. 3 11/4

3:05 pm-7:55 pm

1 stop4h 50m

$223

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Th. 3 9/30

7:00 am-11:50 am

1 stop4h 50m

San Antonio

Th. 3 10/7

6:25 am-1:59 pm

1 stop7h 34m

$277

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Th. 5 10/30

5:47 am-11:28 am

1 stop5h 41m

San Antonio

Th. 3 11/4

3:04 pm-10:30 pm

1 stop7h 26m

$284

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Th. 6 10/24

2:37 pm-7:41 pm

1 stop5h 04m

$73

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Th. 3 9/9

3:50 pm-11:34 pm

1 stop7h 44m

$139

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Th. 3 9/30

10:55 am-5:15 pm

1 stop6h 20m

$139

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Th. 3 9/9

1:10 pm-10:48 pm

2 stops9h 38m

$144

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/15

Showing 1-10 of 14 results
1
2

Best time to book a flight from Des Moines to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Antonio

How far ahead should I book a flight from Des Moines to San Antonio?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Antonio. Price data was last updated on August 8, 2025.

The price you pay for your flight from Des Moines to San Antonio may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to San Antonio?

Currently, August is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $295). Flying from Des Moines to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SAT?

Find hourly flight availability from Des Moines to San Antonio. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated Tháng Tám 17, 2025.

One of the essential ways to save on airfare from Des Moines to San Antonio is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 26% on airfare.

Reviews of airlines servicing San Antonio

Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated Tháng Tám 17, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,986 reviews
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,919 reviews
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to San Antonio round-trip?

    Currently priced at $284, American Airlines will fly you from Des Moines to San Antonio and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $289 and $302, respectively. These flights start at 26% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to San Antonio one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $73. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Des Moines to San Antonio for a low price.

  • Can I find deals for flights from Des Moines to San Antonio that include hotel bookings?

    Yes. In addition to deals on Des Moines to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to San Antonio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Antonio.

  • Can I find deals for business class flights from Des Moines to San Antonio?

    Yes. Cheapflights offers flight deals from Des Moines to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to San Antonio?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $295). Flying from Des Moines to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville

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Top 4 airlines flying from Des Moines to San Antonio

Discover the top 4 airlines that operate flights from Des Moines to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Tháng Tám 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$284Average$396FlexibilityNo cancel feeOn-time71%
DeltaCheapest$289Average$365FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$302Average$452FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$327Average$386FlexibilityNo cancel feeOn-time63%

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