How long is the flight from Des Moines to San Antonio?

A quick flight from Des Moines to San Antonio can take about 6h 34m. Delta provides one of the quickest options available for as low as $251. The distance from Des Moines to San Antonio is about 872 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Des Moines to San Antonio round-trip?

Currently priced at $271, American Airlines will fly you from Des Moines to San Antonio and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $283 and $302, respectively. These flights start at 32% lower than the current average price 3 months from now.

What are the cheapest airlines to fly from Des Moines to San Antonio one-way?

The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $126. However, be on the lookout for offers from United Airlines and Frontier, as they are both options that can get you from Des Moines to San Antonio for a low price.

What is the cheapest day to fly from Des Moines to San Antonio?

Travelers seeking maximum savings on their Des Moines to San Antonio flight should consider departing on Monday evenings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in San Antonio ranges from 1.6 - 3.7 inches per month. May is typically the wettest month, when rainfall can reach 3.7 in. December is typically the driest time to visit San Antonio when rainfall is around 1.6 in.

If weather is an important factor for your trip to San Antonio, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the most popular airlines that fly from Des Moines to San Antonio?

American Airlines, Delta and United Airlines are the most popular airlines when flying from Des Moines to San Antonio.

Most accurate provider : When it comes to deals on Des Moines-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Antonio flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to San Antonio that include hotel bookings?

Yes. In addition to deals on Des Moines to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to San Antonio?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Antonio.

Can I find deals for business class flights from Des Moines to San Antonio?

Yes. Cheapflights offers flight deals from Des Moines to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$126+ Flights from Des Moines to San Antonio

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Des Moines to San Antonio with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to San Antonio are usually found in August or July, booked 63 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Cheap flight deals from Des Moines to San Antonio

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$251 (Delta)
One-way from	$126 (Delta)
Popular in	September
Cheapest in	August
Average price	$485

Provider with most accurate pricing for Des Moines-San Antonio flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-San Antonio flights.

Search Deals

From Des Moines to San Antonio

Search Deals

One-way flight from Des Moines to San Antonio

Search Deals

High demand for flights, 1% potential price rise

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

Search Deals

Find flight deals from Des Moines to San Antonio

Cheapest flights from Des Moines to San Antonio
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 30, 2025.

mié. 11/122:45 pmDSM - SAT

1 stop6h 34mDelta

mié. 11/192:39 pmSAT - DSM

1 stop6h 36mDelta

Deal found 9/28

$251

jue. 10/3010:00 amDSM - SAT

1 stop5h 56mDelta

mar. 11/45:14 amSAT - DSM

1 stop8h 14mDelta

Deal found 9/29

$268

jue. 10/22:25 pmDSM - SAT

1 stop21h 21mFrontier

sáb. 10/43:22 pmSAT - DSM

1 stop22h 18mFrontier

Deal found 9/28

$276

mar. 10/2111:06 amDSM - SAT

1 stop6h 11mDelta

sáb. 10/252:31 pmSAT - DSM

1 stop6h 32mDelta

Deal found 9/29

$284

jue. 11/1311:30 amDSM - SAT

1 stop5h 30mAmerican Airlines

jue. 11/2010:33 amSAT - DSM

1 stop4h 18mAmerican Airlines

Deal found 9/29

$286

mar. 10/217:25 amDSM - SAT

2 stops13h 50mSouthwest

sáb. 10/255:30 amSAT - DSM

1 stop6h 40mSouthwest

Deal found 9/29

$295

mié. 11/57:03 amDSM - SAT

1 stop4h 47mDelta

vie. 11/72:31 pmSAT - DSM

1 stop6h 32mDelta

Deal found 9/29

$302

mié. 11/125:42 amDSM - SAT

2 stops8h 25mAmerican Airlines

mié. 11/1910:33 amSAT - DSM

1 stop6h 18mAmerican Airlines

Deal found 9/28

$307

jue. 11/62:16 pmDSM - SAT

1 stop6h 43mAmerican Airlines

dom. 11/96:00 amSAT - DSM

1 stop4h 40mAmerican Airlines

Deal found 9/28

$336

jue. 10/309:01 amDSM - SAT

1 stop7h 57mUnited Airlines

mar. 11/49:45 amSAT - DSM

2 stops11h 00mUnited Airlines

Deal found 9/29

$343

jue. 12/2511:32 amDSM - SAT

1 stop7h 48mAmerican Airlines

mar. 12/306:00 pmSAT - DSM

1 stop5h 33mAmerican Airlines

Deal found 9/29

$363

Best flights from Des Moines to San Antonio
Discover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated septiembre 30, 2025.

mié. 11/122:45 pmDSM - SAT

1 stop6h 34mDelta

mié. 11/192:39 pmSAT - DSM

1 stop6h 36mDelta

Deal found 9/28

$251

mar. 10/217:25 amDSM - SAT

2 stops13h 50mSouthwest

sáb. 10/255:30 amSAT - DSM

1 stop6h 40mSouthwest

Deal found 9/29

$295

mié. 11/56:01 pmDSM - SAT

1 stop4h 14mAmerican Airlines

vie. 11/76:20 pmSAT - DSM

1 stop5h 30mAmerican Airlines

Deal found 9/28

$302

jue. 10/92:37 pmDSM - SAT

1 stop5h 04mFrontier

mar. 10/143:59 pmSAT - DSM

1 stop21h 53mFrontier

Deal found 9/28

$302

jue. 10/305:14 pmDSM - SAT

1 stop5h 13mUnited Airlines

mar. 11/45:30 amSAT - DSM

2 stops10h 37mUnited Airlines

Deal found 9/28

$343

jue. 10/302:13 pmDSM - SAT

1 stop6h 15mDelta

mar. 11/410:54 amSAT - DSM

1 stop6h 50mDelta

Deal found 9/28

$268

mar. 10/2111:06 amDSM - SAT

1 stop6h 11mDelta

sáb. 10/252:31 pmSAT - DSM

1 stop6h 32mDelta

Deal found 9/29

$284

jue. 11/62:16 pmDSM - SAT

1 stop6h 43mAmerican Airlines

dom. 11/96:00 amSAT - DSM

1 stop4h 40mAmerican Airlines

Deal found 9/28

$336

mié. 11/121:35 pmDSM - SAT

2 stops9h 21mUnited Airlines

mié. 11/195:30 amSAT - DSM

2 stops8h 49mUnited Airlines

Deal found 9/28

$397

lun. 12/296:50 pmDSM - SAT

1 stop5h 25mSouthwest

vie. 1/25:00 amSAT - DSM

1 stop6h 00mSouthwest

Deal found 9/28

$417

Last-minute flights from Des Moines to San Antonio
Discover last-minute flight deals from Des Moines to San Antonio. Data last updated septiembre 30, 2025 and is based on user searches.

jue. 10/22:25 pmDSM - SAT

1 stop21h 21mFrontier

sáb. 10/43:22 pmSAT - DSM

1 stop22h 18mFrontier

Deal found 9/28

$276

lun. 10/65:51 pmDSM - SAT

2 stops29h 49mMultiple Airlines

jue. 10/97:00 amSAT - DSM

1 stop15h 40mMultiple Airlines

Deal found 9/29

$437

jue. 10/92:37 pmDSM - SAT

1 stop5h 04mFrontier

mar. 10/143:59 pmSAT - DSM

1 stop21h 53mFrontier

Deal found 9/28

$302

vie. 10/103:40 pmDSM - SAT

1 stop8h 00mMultiple Airlines

lun. 10/137:00 amSAT - DSM

1 stop15h 37mMultiple Airlines

Deal found 9/29

$427

lun. 10/132:40 pmDSM - SAT

1 stop6h 30mDelta

jue. 10/165:14 amSAT - DSM

1 stop8h 14mDelta

Deal found 9/29

$447

lun. 10/133:40 pmDSM - SAT

1 stop8h 00mMultiple Airlines

jue. 10/162:42 pmSAT - DSM

2 stops31h 55mMultiple Airlines

Deal found 9/29

$448

dom. 10/197:03 amDSM - SAT

1 stop4h 47mDelta

sáb. 10/252:31 pmSAT - DSM

1 stop6h 32mDelta

Deal found 9/29

$382

mar. 10/2111:06 amDSM - SAT

1 stop6h 11mDelta

sáb. 10/252:31 pmSAT - DSM

1 stop6h 32mDelta

Deal found 9/29

$284

mar. 10/217:25 amDSM - SAT

2 stops13h 50mSouthwest

sáb. 10/255:30 amSAT - DSM

1 stop6h 40mSouthwest

Deal found 9/29

$295

jue. 10/3010:00 amDSM - SAT

1 stop5h 56mDelta

mar. 11/45:14 amSAT - DSM

1 stop8h 14mDelta

Deal found 9/29

$268

jue. 10/309:01 amDSM - SAT

1 stop7h 57mUnited Airlines

mar. 11/49:45 amSAT - DSM

2 stops11h 00mUnited Airlines

Deal found 9/29

$343

One-way flights from Des Moines to San Antonio
Search for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated septiembre 30, 2025.

mar. 12/165:34 amDSM - SAT

1 stop8h 09mDelta

Deal found 9/29

$126

mar. 12/161:31 pmDSM - SAT

2 stops9h 28mUnited Airlines

Deal found 9/29

$131

vie. 10/172:37 pmDSM - SAT

1 stop26h 00mFrontier

Deal found 9/29

$154

vie. 10/173:40 pmDSM - SAT

2 stops24h 57mMultiple Airlines

Deal found 9/29

$217

dom. 12/213:14 pmDSM - SAT

1 stop7h 40mUnited Airlines

Deal found 9/29

$370

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mié. 11/12

2:45 pm-9:19 pm

1 stop6h 34m

San Antonio

mié. 11/19

2:39 pm-9:15 pm

1 stop6h 36m

$251

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jue. 10/30

2:13 pm-8:28 pm

1 stop6h 15m

San Antonio

mar. 11/4

10:54 am-5:44 pm

1 stop6h 50m

$268

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mar. 10/21

11:06 am-5:17 pm

1 stop6h 11m

San Antonio

sáb. 10/25

2:31 pm-9:03 pm

1 stop6h 32m

$284

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mar. 10/21

7:25 am-9:15 pm

2 stops13h 50m

San Antonio

sáb. 10/25

5:30 am-12:10 pm

1 stop6h 40m

$295

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mié. 11/5

6:01 pm-10:15 pm

1 stop4h 14m

San Antonio

vie. 11/7

6:20 pm-11:50 pm

1 stop5h 30m

$302

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jue. 10/9

2:37 pm-7:41 pm

1 stop5h 04m

San Antonio

mar. 10/14

3:59 pm-1:52 pm

1 stop21h 53m

$302

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jue. 11/6

2:16 pm-8:59 pm

1 stop6h 43m

San Antonio

dom. 11/9

6:00 am-10:40 am

1 stop4h 40m

$336

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jue. 10/30

5:14 pm-10:27 pm

1 stop5h 13m

San Antonio

mar. 11/4

5:30 am-4:07 pm

2 stops10h 37m

$343

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mié. 11/12

1:35 pm-10:56 pm

2 stops9h 21m

San Antonio

mié. 11/19

5:30 am-2:19 pm

2 stops8h 49m

$397

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

lun. 12/29

6:50 pm-12:15 am

1 stop5h 25m

San Antonio

vie. 1/2

5:00 am-11:00 am

1 stop6h 00m

$417

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/29

Showing 1-10 of 14 results

Compare providers for flights from Des Moines to San Antonio

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Antonio in September.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Mytrip	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Antonio flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Antonio

How far ahead should I book a flight from Des Moines to San Antonio?

The price you pay for your flight from Des Moines to San Antonio may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to San Antonio?

Currently, August is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $295). Flying from Des Moines to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SAT?

One of the essential ways to save on airfare from Des Moines to San Antonio is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 26% on airfare.

Reviews of airlines servicing San Antonio

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,248 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Southwest

8.0

Very good

4,248 reviews

Southwest

8.0

Very good

4,248 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Delta

8.0

Very good

7,964 reviews

Southwest

8.0

Very good

4,248 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

United Airlines

7.4

Good

8,931 reviews

Southwest

8.0

Very good

4,248 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,248 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

How long is the flight from Des Moines to San Antonio?
A quick flight from Des Moines to San Antonio can take about 6h 34m. Delta provides one of the quickest options available for as low as $251. The distance from Des Moines to San Antonio is about 872 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Des Moines to San Antonio round-trip?
Currently priced at $271, American Airlines will fly you from Des Moines to San Antonio and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $283 and $302, respectively. These flights start at 32% lower than the current average price 3 months from now.
What are the cheapest airlines to fly from Des Moines to San Antonio one-way?
The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $126. However, be on the lookout for offers from United Airlines and Frontier, as they are both options that can get you from Des Moines to San Antonio for a low price.
Can I find deals for flights from Des Moines to San Antonio that include hotel bookings?
Yes. In addition to deals on Des Moines to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to San Antonio?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Antonio.
Can I find deals for business class flights from Des Moines to San Antonio?
Yes. Cheapflights offers flight deals from Des Moines to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to San Antonio?
Currently, August is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $295). Flying from Des Moines to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

New Braunfels

Kerrville

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Des Moines to San Antonio

Omaha to Dallas/Fort Worth flights

Omaha to Hobby flights

Des Moines to Dallas/Fort Worth flights

Cedar Rapids to Dallas/Fort Worth flights

Omaha to George Bush Intcntl flights

Des Moines to Hobby flights

Des Moines to George Bush Intcntl flights

Cedar Rapids to Hobby flights

Moline to Dallas/Fort Worth flights

Omaha to Love Field flights

Cedar Rapids to George Bush Intcntl flights

Omaha to Austin flights

Des Moines to Love Field flights

Cedar Rapids to Austin flights

Cedar Rapids to San Antonio flights

Moline to San Antonio flights

Omaha to San Antonio flights

Moline to McAllen flights

Moline to Austin flights

Omaha to McAllen flights

Moline to Hobby flights

Cedar Rapids to Brownsville flights

Des Moines to Austin flights

Cedar Rapids to McAllen flights

Moline to Brownsville flights

Cedar Rapids to Love Field flights

Moline to George Bush Intcntl flights

Moline to Love Field flights

Des Moines to McAllen flights

Omaha to Corpus Christi flights

Des Moines to El Paso flights

Omaha to Brownsville flights

Omaha to Harlingen flights

La Crosse to Hobby flights

Omaha to El Paso flights

Cedar Rapids to Harlingen flights

Sioux City to Dallas/Fort Worth flights

Cedar Rapids to El Paso flights

Omaha to Lubbock flights

Moline to El Paso flights

Waterloo to Dallas/Fort Worth flights

Des Moines to Harlingen flights

Des Moines to Brownsville flights

Cedar Rapids to Corpus Christi flights

La Crosse to George Bush Intcntl flights

Dubuque to Austin flights

Des Moines to Amarillo flights

Omaha to Amarillo flights

Other flights to San Antonio

Sky Harbor Intl to San Antonio flights

Las Vegas to San Antonio flights

Los Angeles to San Antonio flights

Denver to San Antonio flights

Atlanta to San Antonio flights

George Bush Intcntl to San Antonio flights

San Antonio to San Luis Potosí flights

San Antonio to Las Vegas flights

San Antonio to Orlando Airport flights

San Antonio to Los Angeles flights

San Antonio to Fort Lauderdale flights

San Antonio to Monterrey flights

San Antonio to León, Guanajuato flights

San Antonio to Denver flights

San Antonio to Mexico City flights

San Antonio to Phoenix Sky Harbor Intl Airport flights

San Antonio to Houston Hobby Airport flights

San Antonio to Santiago de Querétaro flights

San Antonio to Atlanta flights

San Antonio to Dallas Love Field Airport flights

San Antonio to Nashville flights

San Antonio to San Luis Potosí flights

San Antonio to Denver flights

San Antonio to Dallas Love Field Airport flights

Top 4 airlines flying from Des Moines to San Antonio

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$271	Average$397	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$283	Average$365	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$302	Average$453	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$327	Average$382	FlexibilityNo cancel fee	On-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$126+ Cheap flights from Des Moines to San Antonio (DSM - SAT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to San Antonio with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Des Moines to San Antonio are usually found in August or July, booked 63 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Cheap flight deals from Des Moines to San Antonio

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to San Antonio

Cheapest flights from Des Moines to San AntonioExplore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 30, 2025.

Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 30, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Compare providers for flights from Des Moines to San Antonio

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Antonio in September.

Best time to book a flight from Des Moines to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Antonio

How far ahead should I book a flight from Des Moines to San Antonio?

What is the cheapest month to book a flight from Des Moines to San Antonio?

What is the cheapest time of day to fly from DSM to SAT?

Reviews of airlines servicing San Antonio

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Des Moines to San Antonio?

What are the cheapest airlines flying from Des Moines to San Antonio round-trip?

What are the cheapest airlines to fly from Des Moines to San Antonio one-way?

Can I find deals for flights from Des Moines to San Antonio that include hotel bookings?

How can I find direct flights from Des Moines to San Antonio?

Can I find deals for business class flights from Des Moines to San Antonio?

What is the cheapest month to book a flight from Des Moines to San Antonio?

Traveling to a place near San Antonio?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to San Antonio

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Des Moines to San Antonio

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to San Antonio
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 30, 2025.