$123+ Cheap flights from Des Moines to San Antonio (DSM - SAT)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAT
Apr 30 — May 71
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Antonio with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Antonio
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Best
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One-way
Cheapest flights from Des Moines to San AntonioExplore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2026.
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2026.
This CheapOair deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- SAT
1 stop25h 05m
Frontier
Tue 5/57:54 pm
SAT
- DSM
1 stop17h 37m
Frontier
Deal found 3/29![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- SAT
1 stop25h 05m
Frontier
Sun 4/262:59 pm
SAT
- DSM
1 stop22h 10m
Frontier
Deal found 3/27![Frontier logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- SAT
1 stop25h 05m
Frontier
Thu 4/303:00 pm
SAT
- DSM
1 stop22h 09m
Frontier
Deal found 3/27![Frontier logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- SAT
1 stop28h 43m
Multiple Airlines
Mon 5/187:54 pm
SAT
- DSM
2 stops41h 05m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$242
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:20 am
DSM
- SAT
1 stop4h 48m
United Airlines
Wed 4/296:49 am
SAT
- DSM
1 stop5h 40m
United Airlines
Deal found 3/26![United Airlines logo]()
$263
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- SAT
1 stop28h 05m
Frontier
Fri 4/106:45 am
SAT
- DSM
1 stop12h 29m
Frontier
Deal found 3/27![Frontier logo]()
$271
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:55 am
DSM
- SAT
2 stops10h 05m
Southwest
Wed 4/291:25 pm
SAT
- DSM
2 stops7h 50m
Southwest
Deal found 3/26![Southwest logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/273:32 pm
DSM
- SAT
2 stops23h 37m
Multiple Airlines
Thu 4/303:00 pm
SAT
- DSM
1 stop22h 09m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- SAT
1 stop25h 05m
Multiple Airlines
Tue 4/284:04 pm
SAT
- DSM
2 stops52h 09m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$276
Best flights from Des Moines to San AntonioDiscover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 31, 2026.
Discover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 31, 2026.
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2811:28 am
DSM
- SAT
2 stops8h 20m
United Airlines
Wed 4/296:49 am
SAT
- DSM
1 stop5h 40m
United Airlines
Deal found 3/26![United Airlines logo]()
$268
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:25 pm
DSM
- SAT
1 stop5h 07m
Delta
Tue 5/266:50 am
SAT
- DSM
1 stop6h 47m
Delta
Deal found 3/26![Delta logo]()
$290
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:55 am
DSM
- SAT
1 stop5h 00m
Southwest
Wed 4/292:35 pm
SAT
- DSM
1 stop7h 35m
Southwest
Deal found 3/30![Southwest logo]()
$335
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Sat 5/166:50 am
SAT
- DSM
1 stop8h 20m
Delta
Deal found 3/26![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:35 am
DSM
- SAT
2 stops9h 15m
Southwest
Sat 5/1612:45 pm
SAT
- DSM
2 stops8h 10m
Southwest
Deal found 3/26![Southwest logo]()
$373
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:31 pm
DSM
- SAT
1 stop6h 15m
Delta
Sun 4/265:20 am
SAT
- DSM
1 stop5h 45m
Delta
Deal found 3/27![Delta logo]()
$382
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:20 pm
DSM
- SAT
1 stop8h 10m
Southwest
Tue 4/282:00 pm
SAT
- DSM
1 stop7h 15m
Southwest
Deal found 3/29![Southwest logo]()
$392
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Fri 5/156:08 am
SAT
- DSM
1 stop6h 16m
Delta
Deal found 3/28![Delta logo]()
$382
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1512:25 pm
DSM
- SAT
2 stops10h 30m
Southwest
Tue 5/191:25 pm
SAT
- DSM
2 stops7h 50m
Southwest
Deal found 3/29![Southwest logo]()
$392
Last-minute flights from Des Moines to San AntonioDiscover last-minute flight deals from Des Moines to San Antonio. Data last updated March 31, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Antonio. Data last updated March 31, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- SAT
1 stop28h 05m
Frontier
Fri 4/106:45 am
SAT
- DSM
1 stop12h 29m
Frontier
Deal found 3/27![Frontier logo]()
$271
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/142:44 pm
DSM
- SAT
1 stop5h 46m
Delta
Sat 4/185:20 am
SAT
- DSM
1 stop5h 45m
Delta
Deal found 3/27![Delta logo]()
$314
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:44 pm
DSM
- SAT
1 stop7h 41m
Delta
Wed 4/225:20 am
SAT
- DSM
1 stop5h 45m
Delta
Deal found 3/26![Delta logo]()
$290
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- SAT
1 stop25h 05m
Frontier
Sun 4/262:59 pm
SAT
- DSM
1 stop22h 10m
Frontier
Deal found 3/27![Frontier logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- SAT
1 stop25h 05m
Multiple Airlines
Tue 4/284:04 pm
SAT
- DSM
2 stops52h 09m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- SAT
1 stop25h 05m
Multiple Airlines
Wed 4/294:49 pm
SAT
- DSM
2 stops25h 12m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- SAT
1 stop25h 05m
Frontier
Thu 4/303:00 pm
SAT
- DSM
1 stop22h 09m
Frontier
Deal found 3/27![Frontier logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/273:32 pm
DSM
- SAT
2 stops23h 37m
Multiple Airlines
Thu 4/303:00 pm
SAT
- DSM
1 stop22h 09m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- SAT
1 stop25h 05m
Multiple Airlines
Wed 4/294:49 pm
SAT
- DSM
2 stops25h 12m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$281
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:20 am
DSM
- SAT
1 stop4h 48m
United Airlines
Wed 4/296:49 am
SAT
- DSM
1 stop5h 40m
United Airlines
Deal found 3/26![United Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:55 am
DSM
- SAT
2 stops10h 05m
Southwest
Wed 4/291:25 pm
SAT
- DSM
2 stops7h 50m
Southwest
Deal found 3/26![Southwest logo]()
$273
One-way flights from Des Moines to San AntonioSearch for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated March 31, 2026.
Search for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated March 31, 2026.
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- SAT
1 stop25h 05m
Frontier
Deal found 3/30![Frontier logo]()
$123
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:31 pm
DSM
- SAT
1 stop6h 15m
Delta
Deal found 3/26![Delta logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- SAT
2 stops16h 55m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$167
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:45 pm
DSM
- SAT
1 stop7h 55m
Southwest
Deal found 3/30![Southwest logo]()
$168
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:27 am
DSM
- SAT
1 stop5h 36m
Delta
Deal found 3/30![Delta logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:30 am
DSM
- SAT
2 stops28h 47m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:30 am
DSM
- SAT
2 stops22h 57m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$205
Find flight deals from Des Moines to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 31, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $191 (CheapOair) |
One-way from | $123 (CheapOair) |
Popular in | March |
Cheapest in | August |
Average price | $587 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 4/28
11:28 am-7:48 pm
2 stops8h 20m
San Antonio
Wed 4/29
6:49 am-12:29 pm
1 stop5h 40m
$268
Quickest round-trip
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 5/23
4:25 pm-9:32 pm
1 stop5h 07m
San Antonio
Tue 5/26
6:50 am-1:37 pm
1 stop6h 47m
$290
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Thu 5/14
6:41 pm-12:44 am
1 stop6h 03m
San Antonio
Sat 5/16
6:50 am-3:10 pm
1 stop8h 20m
$317
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 4/28
6:55 am-11:55 am
1 stop5h 00m
San Antonio
Wed 4/29
2:35 pm-10:10 pm
1 stop7h 35m
$335
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 5/9
5:35 am-2:50 pm
2 stops9h 15m
San Antonio
Sat 5/16
12:45 pm-8:55 pm
2 stops8h 10m
$373
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 4/22
6:31 pm-12:46 am
1 stop6h 15m
San Antonio
Sun 4/26
5:20 am-11:05 am
1 stop5h 45m
$382
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 5/12
6:41 pm-12:44 am
1 stop6h 03m
San Antonio
Fri 5/15
6:08 am-12:24 pm
1 stop6h 16m
$382
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Fri 4/24
4:20 pm-12:30 am
1 stop8h 10m
San Antonio
Tue 4/28
2:00 pm-9:15 pm
1 stop7h 15m
$392
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Fri 5/15
12:25 pm-10:55 pm
2 stops10h 30m
San Antonio
Tue 5/19
1:25 pm-9:15 pm
2 stops7h 50m
$392
Cheapest one-way
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 4/22
6:31 pm-12:46 am
1 stop6h 15m
$132
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Antonio in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.
DSM-SAT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Antonio
How far ahead should I book a flight from Des Moines to San Antonio?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Antonio. Price data was last updated on March 13, 2026.
The price you pay for your flight from Des Moines to San Antonio may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Antonio?
Currently, July is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $83). Flying from Des Moines to San Antonio in November is currently the most expensive (average of $142). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Antonio?
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated March 31, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Des Moines and San Antonio flights
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Top 4 airlines flying from Des Moines to San Antonio
Discover the top 4 airlines that operate flights from Des Moines to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$238 | Average$316 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$266 | Average$368 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$456 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$327 | Average$427 | FlexibilityNo cancel fee | On-time63% |