HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Antonio

$466+ Cheap flights from Florence, SC to San Antonio (FLO - SAT)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SAT
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Florence to San Antonio with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florence to San Antonio

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$466
(American Airlines)
From Florence to San Antonio
Search Deals

Find flight deals from Florence to San Antonio

Cheapest flights from Florence to San Antonio
Explore the most affordable flight options available from Florence to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:14 amFLO - SAT
1 stop5h 06mAmerican Airlines
Sun 10/128:10 amSAT - FLO
1 stop4h 54mAmerican Airlines
Deal found 9/14$466
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/265:15 amFLO - SAT
1 stop6h 53mAmerican Airlines
Fri 11/285:39 pmSAT - FLO
1 stop5h 02mAmerican Airlines
Deal found 9/15$497
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/285:15 amFLO - SAT
1 stop6h 53mAmerican Airlines
Mon 12/15:39 pmSAT - FLO
1 stop5h 02mAmerican Airlines
Deal found 9/14$522

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Florence to San Antonio that are best for you.

Fly from

Florence

Fly to

San Antonio

Route

Depart

Return

Price

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Tue 10/7

6:14 am-10:20 am

1 stop5h 06m

San Antonio

Sun 10/12

8:10 am-2:04 pm

1 stop4h 54m

$466

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Wed 11/26

5:15 am-11:08 am

1 stop6h 53m

San Antonio

Fri 11/28

5:39 pm-11:41 pm

1 stop5h 02m

$497

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Fri 11/28

5:15 am-11:08 am

1 stop6h 53m

San Antonio

Mon 12/1

5:39 pm-11:41 pm

1 stop5h 02m

$522

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Best time to book a flight from Florence to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Antonio

What is the cheapest month to book a flight from Florence, South Carolina to San Antonio?

Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to San Antonio (average of $295). Flying from Florence, South Carolina to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to San Antonio?

    American Airlines can get you from Florence, South Carolina to San Antonio in just under 5h 06m. Your travel time can differ by up to . Florence, South Carolina and San Antonio are separated by a distance of 1143 mi.

  • Can I find deals for flights from Florence to San Antonio that include hotel bookings?

    Yes. In addition to deals on Florence to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to San Antonio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Antonio.

  • Can I find deals for business class flights from Florence to San Antonio?

    Yes. Cheapflights offers flight deals from Florence to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to San Antonio?

    Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to San Antonio (average of $295). Flying from Florence, South Carolina to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florence to San Antonio

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Dallas/Fort Worth flights
Charlotte to Hobby flights
Charlotte to George Bush Intcntl flights
Charlotte to Love Field flights
Charlotte to Austin flights
Greenville to Dallas/Fort Worth flights
Charleston to Hobby flights
Charleston to Dallas/Fort Worth flights
Charleston to George Bush Intcntl flights
Charlotte to San Antonio flights
Columbia to Dallas/Fort Worth flights
Greenville to Hobby flights
Savannah to Hobby flights
Savannah to Dallas/Fort Worth flights
Charleston to Austin flights
Greenville to George Bush Intcntl flights
Charleston to Love Field flights
Myrtle Beach to Dallas/Fort Worth flights
Columbia to Hobby flights
Greenville to Love Field flights
Savannah to Austin flights
Greenville to Austin flights
Columbia to George Bush Intcntl flights
Greenville to San Antonio flights
Myrtle Beach to Hobby flights
Savannah to Love Field flights
Charleston to San Antonio flights
Augusta to Dallas/Fort Worth flights
Savannah to George Bush Intcntl flights
Columbia to Austin flights
Myrtle Beach to George Bush Intcntl flights
Savannah to San Antonio flights
Augusta to Hobby flights
Myrtle Beach to Austin flights
Columbia to Love Field flights
Savannah to El Paso flights
Augusta to George Bush Intcntl flights
Myrtle Beach to Love Field flights
Charlotte to El Paso flights
Columbia to San Antonio flights
Augusta to Austin flights
Augusta to El Paso flights
Columbia to El Paso flights
Hilton Head Island to Austin flights
Augusta to Love Field flights
Myrtle Beach to San Antonio flights
Charlotte to Midland flights
Greenville to Amarillo flights
Charleston to Amarillo flights
Charlotte to McAllen flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.